Articles tagged with Gene Expression
A new gene therapy approach has been developed to deliver full-length versions of large genes, improving skeletal muscle function in patients with genetic disorders like dysferlinopathies. The strategy may hold new hope for treating limb girdle muscular dystrophy type 2B and other muscular dystrophies.
Exposure to environmental chemicals like PCBs in the womb causes long-term changes to the developing brain, leading to delayed puberty and disrupted reproductive cycles. The study identified five genes critical to normal hypothalamic control of reproduction, providing a potential target for interventions.
Gene therapy successfully replaces protein missing in Pompe disease when targeting liver cells, reducing immune system reaction. Combining liver-expressing vector with ubiquitously expressing vector boosts overall effectiveness of the treatment.
A new gene expression test can accurately classify thyroid nodules as low-risk, allowing for the avoidance of unnecessary surgeries and lifelong hormone replacement treatment. The test demonstrated a 92% correct identification rate and 85-95% negative predictive value, ruling out malignancy.
Researchers developed a single-dose vaccine that produces an antibody capable of binding to cocaine, preventing its entry into the brain. The vaccinated mice showed no effects from intravenous cocaine exposure, highlighting a potential novel approach to treating cocaine addiction.
A recent study found that gestational exposure to BPA leads to behavioral changes in mice for four generations, including increased anxiety and aggression. The study suggests that BPA exposure could have long-lasting impacts on human behavior if it generalizes to humans.
University of Minnesota public health researchers found two high-signal genetic markers correlated with coronary artery disease, which may help define genetic fingerprints for increased risk. The study analyzed data from over 75,000 patients and offers biological and clinical data supporting future research into the genetic markers.
Researchers have identified a new method for picking the 'right' egg in IVF by analyzing genes expressed in cumulus cells surrounding the eggs. This non-invasive approach may help avoid abnormal eggs with incorrect chromosomal make-up, increasing the chances of successful IVF cycles.
Scientists at Oregon State University have discovered that curcumin can increase levels of a protein that helps prevent infection, highlighting its potential as an alternative to vitamin D. The study found curcumin causes a modest but measurable increase in cathelicidin antimicrobial peptide (CAMP) levels.
A new study found that breast-fed babies have a more diverse bacterial colonization than formula-fed babies, leading to changes in the expression of genes involved in their immune system. The study also showed a link between the expression of genes in the bacteria and genes of the immune system in the baby.
Researchers found that epigenetic mechanisms, such as reduced DNA methylation, contribute to high blood pressure and increased susceptibility to forming blood clots in pregnant women with preeclampsia. Inhibition of thromboxane synthase or dietary supplementation with folate may provide potential treatments for this condition.
A study shows a botanical formula significantly suppresses tumor growth in aggressive human prostate cancer cells, demonstrating its safety and effectiveness. The formula inhibits several genes related to cancer proliferation and increases the expression of cancer-fighting genes.
The new IT application BootstRatio, developed by IDIBELL researchers, allows online statistical analysis of gene-expression data. It uses resampling techniques to generate a hypothetical distribution and provides comprehensible results for scientists.
A study published in the American Chemical Society found that capsaicinoids, a compound in chili peppers, can lower cholesterol levels and increase blood flow to the heart. The compounds may also reduce the formation of atherosclerotic plaques in blood vessels.
Researchers at Linköping University discovered epigenetic factors driving rapid changes in genome function, leading to diverse breeds of domestic fowl. The study found that domestication resulted in heritable epigenetic modifications, including DNA methylation, which may explain the swift evolution of domesticated chickens.
Researchers at the Salk Institute found that certain proteins, called extremely long-lived proteins (ELLPs), last a lifetime without being replaced. Damage to these proteins weakens the ability of transport channels to safeguard the cell's nucleus from toxins, leading to cellular aging.
A recent study on male and female mice has identified hormone-controlled genes in the brain as the key drivers of sex-specific behaviors, including mating and parental care. The research found that these genes can be individually manipulated to alter behavior, suggesting a modular control of sex-specific traits.
A study published in PLOS ONE found that circular RNA molecules are more abundant than previously thought, comprising a substantial fraction of all transcripts identified for many genes. This discovery opens up new avenues for research into the potential functions and relevance of circular RNAs in human biology and health.
A research group at Brown University has sequenced the entire transcriptome of the mouse neural retina, finding that disease genes are disproportionately highly expressed and have unique sequences. This study provides new insights into the genetic nature of neural diseases.
A blood-based gene expression test was found to be more effective than myocardial perfusion imaging (MPI) in ruling out obstructive coronary artery disease in stable symptomatic patients. The test demonstrated high sensitivity and negative predictive value, enabling clinicians to rule out patients with high accuracy.
Researchers chart gene expression in human brain from fetal development to aging, revealing coordinated changes that shape brain structure and function. The study found reversible gene expression changes after birth and during Alzheimer's disease, with distinct patterns of change at different life stages.
Researchers developed a novel bipartite gene therapy approach to temporarily preserve photoreceptors in a mouse model of retinitis pigmentosa. The treatment targets defective phosphodiesterase metabolism, reducing cGMP and Ca2+ levels, and showing promise for treating this genetic disorder.
Researchers identified a gene expression profile that can predict prognosis in patients with inflammatory bowel disease. The study found two subgroups of patients, one with mild disease and the other with treatment-nonresponsive disease, which will help physicians identify those who need aggressive therapies.
Researchers have discovered a method to visualize gene number and protein expression in individual cells, potentially leading to clearer understandings of cancer and complex diseases. The fluorescent in situ gene protein assay combines FISH and in situ proximity ligation to resolve individual protein molecules.
Research finds children with autism and GI disturbances have changed genes involved in digestion, altering intestinal bacteria. These changes may contribute to behavioral disturbances in some cases.
A team of researchers evaluated the effect of low-power Terahertz radiation on mouse stem cells, finding temperature increases were minimal and heat shock protein expression was unaffected. However, certain genes showed clear effects from THz irradiation, suggesting further investigations are needed to generalize findings.
A study published in Bioscience, Biotechnology, and Biochemistry found that pure maple syrup improved liver function tests in rats fed a diet with 20% pure maple syrup compared to a control group. The results suggest that maple syrup's polyphenolic antioxidants may help regulate glucose metabolism and reduce liver enzyme levels.
Researchers found that the circadian cycle, regulating day-night rhythms, drives gene expression in mussels more than previously thought. The tidal cycle's influence was less significant, with 80-90% of genes showing rhythmic expression linked to the circadian cycle.
Researchers found that photoreceptor cells in the retina had a defective phagocytosis process, leading to decreased rod and cone renewal. This discovery could lead to therapeutic agents for blinding diseases related to retinal cell renewal.
A recent study used genomics to unravel the immune response to the flu virus, finding significant and complex differences between those who got sick and those who remained asymptomatic. The research may lead to new therapies to prevent illness by detecting early warning signs of infection.
A new study published in The Journal of Molecular Diagnostics has demonstrated the feasibility of focused fetal gene expression analysis of target genes found in amniotic fluid. The analysis could be used to monitor fetal development and determine whether fetal organ systems are developing normally.
Researchers found that mannan oligosaccharides increase the total number of immune cells in pigs infected with porcine reproductive and respiratory syndrome virus. MOS also alleviates the overstimulation of the immune system, reducing fever and improving feed efficiency.
Johns Hopkins researchers have identified a natural mechanism to block the expression of the mutated gene causing HD, potentially slowing its progression. By manipulating a newly found 'brake' gene, they aim to stop or slow production of the toxic huntingtin protein.
A new study suggests that weight loss due to bariatric surgery may reduce the risk of Alzheimer's disease by lowering the expression of genes related to the condition. After a significant weight loss, patients showed a 22% decrease in amyloid precursor protein expression and a 31% decrease in messenger RNA for APP.
Pitt researchers created a mouse model of major depressive disorder (MDD) using a rare genetic mutation. The model exhibits alterations in brain anatomy, gene expression, behavior, and increased infant mortality, supporting the role of the genetic variant in MDD development.
Researchers have identified a set of genes within mitochondria crucial to understanding male infertility. Mutations in these genes can build up unnoticed and cause harm to males but not females due to maternal inheritance.
A new study confirms that 'healthy' smokers exhibit gene expression changes similar to those of patients with moderate and severe COPD. Smoking is identified as a critical factor in causing these alterations. The findings support the need for developing new therapies to slow down COPD progression.
A new study reveals that clock genes function in multiple areas of the human brain, affecting sleep patterns and cognitive function in Alzheimer's patients. The findings have significant implications for understanding and treating sleep disturbances associated with the disease.
A new study identifies SLC6A15 as a novel susceptibility gene for major depression, which may lead to the discovery of novel antidepressant drugs. The researchers found that lower expression of SLC6A15 in the hippocampus is linked to increased stress susceptibility and altered neuronal circuits.
Researchers from Mount Sinai School of Medicine have found that a ketogenic diet may reverse impaired kidney function in people with Type 1 and Type 2 diabetes. The study, published in PLoS ONE, also identified previously unreported genes associated with diabetes-related kidney failure whose expression was reversed by the diet.
A new study in fruit flies explores the potent effects of methamphetamine on the body, identifying molecular pathways and energy metabolism changes associated with the drug. The research found that sugar metabolism plays a role in reducing toxicity, while disruptions to calcium and iron balance may contribute to dysfunction.
Researchers identified a new treatment for periodic fever syndrome, targeting the body's immune response. The therapy shows promise in reducing fever and inflammation symptoms without increasing flare-ups, differing from current corticosteroid treatment. A larger clinical trial is planned to validate the findings.
Researchers found that fish oil increases expression of genes related to cellular specialization, differentiation, and immune defenses against tumors. However, it also triggers counterproductive immune responses like inflammation and allergic reactions.
Scientists discovered that the new plant species Tragopogon miscellus has relaxed gene expression control in its earliest generations, allowing it to rapidly adapt. After 80 years of evolution, different patterns of gene expression are now found in every plant, offering new ideas for agriculture.
Researchers identified molecular signatures of early glaucoma progression using clustered gene expression analysis. These findings suggest activation of the complement cascade and endothelin-2 may contribute to disease development.
The study found three genes that protect mice from brain amyloid accumulation, with lower expression in the liver protecting the mouse brain. One gene encodes Presenilin, a protein contributing to human Alzheimer's, which is expressed in the liver but not the brain.
Research identifies miR-143 and miR-145 as downregulated biomarkers in esophageal squamous cell carcinoma, showing anti-oncogenic activity. These findings suggest that microRNAs may serve as useful biomarkers for early detection and therapeutic targets.
Scientists at Albert Einstein College of Medicine successfully visualized single molecules of naturally-occurring messenger RNA (mRNA) transcribed in living mammalian cells. This breakthrough technique has important consequences for human disease like cancer, as mRNA localization within tumor cells correlates with metastasis.
A study published in Science reveals that satellite repeats, previously thought to be inactive, are actively expressed in many types of epithelial cancers. This discovery may lead to the development of a new cancer biomarker for early detection and improved understanding of tumor behavior.
Researchers at U-M Medical School have found a potential therapeutic target for the adult form of Fragile X Tremor Ataxia Syndrome by modifying brain changes associated with FXTAS, which is caused by overproduction of toxic mRNA.
Researchers have identified a key role for a protein called RyR2 in the development of long-term changes in brain connectivity associated with learning, memory, and addiction. By upregulating RyR2, nicotine can trigger the formation of new connections in the brain, leading to addictive behavior.
The study sequenced the human methylome from peripheral blood mononuclear cells, identifying allele-specific methylation differences associated with gene expression. The findings suggest that parental gene imprinting may be more common than previously thought, with implications for understanding human health and disease.
Christopher Gregg's groundbreaking research reveals how parental genetic cues influence brain development and disease, providing a roadmap for future research. His findings have major relevance for understanding brain evolution, function, and disease.
Scientists at the University of Illinois Chicago have found a gene expression mechanism that contributes to drug resistance in aggressive ER-positive breast tumors. The study reveals how estrogen and inflammatory proteins work together to drive cancer progression.
Researchers have discovered that RD114 envelope proteins can effectively pseudotype lentiviral vectors, offering an attractive alternative to VSV-G. This technology has the potential to enhance gene therapy approaches by increasing transduction efficiency and stability.
Researchers are calling for a new focus on hypertrophic cardiomyopathy (HCM), a genetic disorder causing sudden death in young people. A task force of cardiologists and cardiac biologists recommends studying the natural history of HCM, defining all genetic causes, supporting clinical trials, and preventing mutant gene expression.
A new software, Myrna, uses cloud computing to analyze RNA sequencing data at an unprecedented speed and cost-effectiveness. The software calculated differential expression from 1.1 billion reads in under 2 hours for a cost of around $66.
A $3 million NIH grant will help scientists at Jefferson Medical College study variations in platelet function, specifically the genetics of platelet gene expression. The goal is to identify biomarkers for predicting cardiovascular disease risk and developing novel therapeutic strategies.
Exposure to low doses of BPA affects the earliest stages of egg production in the ovaries of developing mouse fetuses. The study reveals a striking down-regulation of mitotic/cell cycle genes, raising concerns about the reproductive lifespan of female mice.
Researchers discovered a set of seven genes in whole blood that can diagnose major depressive disorder (MDD) with high accuracy. This breakthrough could lead to unbiased diagnosis and reduce stigma associated with mental health problems, ultimately helping patients receive better treatment.