Articles tagged with Alzheimer Disease
A new study demonstrates that glyphosate successfully crosses the blood-brain barrier and enhances TNF-α levels in mice. The herbicide is linked to increased production of soluble beta amyloid and reduced neuron viability, suggesting potential hazards to neurological health.
Researchers have found correlations between retina and brain structures altered in Alzheimer's disease in healthy subjects at risk. These findings suggest the retina may provide information on brain state and changes, paving the way for new diagnostic tools.
A team of UTHSC investigators is testing a new otulin-inhibiting drug to promote tau clearance and reduce neurotoxicity in Alzheimer's patients. The study aims to investigate the link between oxidative stress and otulin activity, which may lead to breakthroughs in treating neurodegenerative disorders.
A new study led by researchers from the University of Michigan and Penn State College of Medicine compared two approaches for people with early form of memory loss: mnemonic strategy training and spaced retrieval training. Mnemonic strategy training showed increased brain activity in areas often affected by Alzheimer's disease, while s...
A recent PLOS Biology study examines the limitations of current anti-amyloid therapies for Alzheimer's disease, suggesting abnormal microglial function and tau tangles as key mechanisms. The authors review clinical trial results and propose new strategies for treating the disease, bringing hope for a cure.
Researchers have developed a new test that can detect even slightly elevated levels of tau protein in cerebrospinal fluid, potentially identifying Alzheimer’s disease at its earliest stages. The method uses optical sensors and 'lab-on-fiber' technology to achieve high sensitivity.
Researchers developed an immuno-infrared sensor that detects Alzheimer's disease biomarkers, including amyloid-beta misfolding, up to 17 years before clinical symptoms. The sensor shows high accuracy in identifying individuals at risk of developing Alzheimer's dementia.
Researchers at University of California - San Diego launch nationwide clinical trial to investigate benfotiamine as a metabolic treatment approach for Alzheimer's disease. The trial aims to determine the effectiveness of high doses of benfotiamine in benefiting people with mild AD or mild cognitive impairment.
Researchers analyzed data from wearable activity monitors on nearly 600 participants to identify changes in movement patterns that may predict cognitive decline. The study found significant differences in activity during waking hours and afternoons, with fragmented activity being a key indicator of mild cognitive impairment or Alzheime...
Researchers found reduced levels of Histone Deacetylase I (HDAC I) in the brains of patients with Alzheimer's disease, linked to deleterious effects of misfolded beta-amyloid and tau proteins. HDAC inhibitors, currently being tested against mild Alzheimer's disease, may be harming patients rather than helping them.
A new study suggests that a unique gene variant supporting cognitive health in older humans may have first emerged to protect against infectious pathogens like gonorrhea. This variant, linked to CD33, allows brain immune cells to break down damaged brain cells and amyloid plaques associated with Alzheimer's disease.
A world-first study has confirmed the link between Alzheimer's Disease and multiple gut disorders, revealing shared genetic architecture. The study suggests that abnormal cholesterol levels play a key role in both conditions, and may lead to new potential treatments for Alzheimer's and gut disorders.
A Colombian woman lived dementia-free for three decades due to a rare genetic mutation, providing valuable insights into the pathology of dementia. Her brain showed distinct patterns of abnormal tau protein aggregation, which may impact treatment and prevention strategies for Alzheimer's disease.
Researchers found evidence of how destructive proteins attack human brain cells and destroy surrounding tissue. The study identified a pivotal mechanism that could be a potential therapy for the disease.
A new study from UTHealth Houston found that whole blood exchange treatments decreased amyloid plaque formation in mice with Alzheimer's disease-causing amyloid precursor proteins. This approach has the advantage of treating the disease in the circulation instead of the brain, potentially bypassing the blood-brain barrier.
A study of almost 21,000 people found that moderate drinking is associated with higher iron levels in the brain and poorer cognitive function. Iron accumulation is a potential mechanism for alcohol-related cognitive decline, which can lead to Alzheimer's and Parkinson's diseases.
A Tokyo University of Science study found that fluoride nanoparticles enhance β-sheet formation in amyloid β proteins, a common feature of Alzheimer's disease. The researchers also discovered that surrounding ions can control this process, paving the way for targeted treatments.
A new Baycrest study found that individuals with no dementia risk factors have similar brain health as people who are 10 to 20 years younger. Lifestyle factors such as managing diabetes, addressing hearing loss, and quitting smoking can reduce cognitive decline by up to three years of aging.
A recent study discovered that brain inflammation may be a key link between Alzheimer's disease risk and sleep disturbance. The research found that age-related increases in brain inflammation can disrupt fast sleep spindles, which are crucial for long-term memory retention. This disruption contributes to age-related memory impairment i...
Studies suggest a link between Fusobacterium nucleatum and Alzheimer's disease, with the bacteria generating systemic inflammation and exacerbating symptoms. Targeting the bacteria could slow periodontal disease progression and potentially slow Alzheimer's progression as well.
The study found that engaging in physical activity reduced the decline in global and domain-specific cognitive function over time, particularly in women. The researchers recommend highlighting the benefits of physical activity to promote brain health and encourage patients to participate. Dr. Geda and Dr. Krell-Roesch are joint recipie...
Researchers at Boston University developed an AI-powered computational model that can detect cognitive impairment from audio recordings of neuropsychological tests. The model was trained on over 1,000 individuals and accurately distinguished between healthy individuals and those with dementia.
Research at Massachusetts General Hospital has identified plasma biomarkers Tau-PT217 and Tau-PT181 as predictors of postoperative delirium. High preoperative concentrations of these biomarkers are associated with increased risk, suggesting a potential early warning sign for patients.
Researchers at the University of Illinois Urbana-Champaign have developed a low-cost ultrasound imaging method to study the relationship between Alzheimer's disease and the brain's vascular system. The technique, which provides high-resolution images of animal microvasculature, may aid in early detection of the disease.
A long-term high-fat diet has been shown to cause significant weight gain and metabolic disorders in mice, leading to anxiety, depression, and worsening Alzheimer's disease. The study suggests a clear link between chronic obesity and diabetes with cognitive decline.
A Flinders University study reveals how a protein called tau transforms into a disease state, providing hope for preventing this process and reducing toxic effects on brain cells. The researchers identified 'master sites' in tau that govern subsequent modifications, leading to a similar state seen in Alzheimer's patients.
A pooled data analysis of available research found that ADHD drugs may successfully treat key aspects of Alzheimer's disease. Noradrenergic drugs, which target the neurotransmitter noradrenaline, showed a small but significant positive effect on overall cognition and a large positive effect on apathy in patients with Alzheimer's disease.
The Nutrition for Dementia Prevention Working Group recommends improving clinical nutrition trials by considering biomarkers, genetic testing, and microbiome analysis. The group suggests utilizing a wider variety of study designs and more personalized approaches to guide future research.
Researchers develop speckle-based compressive imaging technique to improve deep-tissue imaging in Alzheimer's disease studies. The method reduces pixel measurements needed, producing high-resolution images up to 11 times faster and three times bigger than traditional raster-scan approach.
A study published by researchers at the University of Colorado Anschutz Medical Campus found that psychiatric drugs imipramine and olanzapine can improve symptoms of Alzheimer's disease, including boosting cognition and reversing clinical diagnoses.
Researchers at Simon Fraser University developed a biomarker that combines genetic features and brain MRI data to predict the future conversion to Alzheimer's disease. This combination improves the performance in predicting dementia progression, especially for patients with mild cognitive impairment.
A study found that men exhibiting mild behavioural impairment symptoms are at risk of faster cognitive decline compared to women. Researchers identified key behavioral changes, such as apathy and false beliefs, which may help identify people at higher risk of developing dementia.
Researchers elucidated the molecular mechanisms of acetylcholine in learning and memory, revealing a signaling cascade involving protein kinase C. The study opens doors to new therapeutic strategies for Alzheimer's disease.
A new UCLA study found that fixed vial sizes for the controversial Alzheimer's drug aducanumab could result in significant wasteful spending of up to $605 million per year on Medicare. The researchers suggest reducing vial sizes to contain costs and improve the value of future Medicare spending.
A new GPU-based machine learning algorithm, ReAL-LiFE, can rapidly analyze large amounts of data from diffusion Magnetic Resonance Imaging (dMRI) scans of the human brain. This allows for faster analysis and prediction of brain connectivity, enabling better understanding of brain-behaviour relationships at scale.
A comprehensive survey of scientific literature suggests that nearly all known biological pathways are linked to Alzheimer's disease. The study found that immune, metabolic and depression-related pathways were consistently cited as major mechanisms contributing to the disease.
Researchers found that Treponema denticola, a periodontal pathogen, induces Alzheimer-like tau hyperphosphorylation in mice. The study showed that T. denticola promotes neuroinflammation and increases tau phosphorylation at specific sites.
A new study from UTHealth Houston found that flu vaccination was associated with a 40% lower risk of developing Alzheimer’s disease in US adults over a four-year period. The study analyzed a large sample of patients and found that consistent flu vaccination every year had the strongest protective effect.
Researchers found that COVID-19 positive individuals had a higher risk of developing Alzheimer’s disease, Parkinson’s disease, and ischaemic stroke compared to those who tested negative. The study also revealed increased risks for intracerebral haemorrhage and decreased frequencies for other neurodegenerative illnesses.
Researchers at Karolinska Institutet have improved the ability of a protein to repair oxidative DNA damage, creating a new drug development concept. The technique can lead to improved treatments for diseases involving oxidative stress.
Researchers at Boston University School of Medicine have discovered that the APOE4 gene is unique to patients with Alzheimer's disease and causes specific defects in human brain cells. The study provides new insights into the underlying mechanisms of the gene, which may lead to new therapeutic strategies to combat the condition.
Researchers discovered a link between the astrocytic urea cycle and Alzheimer's disease memory loss. The study found that the urea cycle helps clean up toxic amyloid-beta aggregates, but its activation also causes the production of harmful byproducts, leading to neuronal death.
A recent study published in eLife has revealed that high levels of soluble tau protein impair signaling between neurons, leading to cognitive decline. The research suggests that targeting the binding site of dynamin, a protein that binds to microtubules, may rescue synaptic transmission and prevent memory impairment.
Researchers are developing a health scorecard to predict dementia risk using brain scans, genetics, and biomarkers. The study will analyze diverse populations between ages 65-90, providing insights into contributing factors like diabetes or hypertension that can be addressed to modify the risk.
Researchers from Boston University School of Medicine provide comprehensive information on mass spectrometry-based studies of the brain's extracellular matrix in neurological disorders. The study highlights changes in ECM molecule expression associated with neurodegenerative diseases, providing new avenues for treatment and diagnosis.
A new approach uses a single magnetic resonance imaging (MRI) brain scan to diagnose Alzheimer's disease with high accuracy, identifying changes in regions not previously associated with the condition. This method has the potential to revolutionize diagnosis and treatment, allowing for early intervention and improved patient outcomes.
A new study reveals that inhaled fine particles can take a direct route from lungs to brain through blood circulation, potentially contributing to brain disorders. The particles were found to stay longer in the brain than in other organs, raising concerns about the long-term effects of air pollution on cognitive function.
A study published in JMIR Formative Research reveals that automated analysis of a common clinical drawing task can be used to estimate cognition in older adults from Japan and the USA. Researchers found that people with lower cognitive scores had more variability in their drawing speed, angle, and time spent paused during the task.
A new study from Keck School of Medicine of USC suggests that willingness to give away money may be linked to the earliest stages of Alzheimer's disease. Participants who gave more money scored significantly lower on cognitive tests known to be sensitive to Alzheimer's disease.
Researchers have developed a new probe to detect Alzheimer's disease biomarkers using near-infrared fluorescence, which may help diagnose the disease early and prevent its progression. The probe binds oligomeric Aβ proteins, a hallmark of Alzheimer's disease, offering a potential alternative to existing treatments.
Researchers found that healthy choices, such as no smoking, high leisure-time exercise, and adequate sleep, are associated with a reduced risk of Alzheimer's disease. Additionally, intakes of certain polyphenols, commonly found in tea and other foods, may also play a role in protecting brain health among Black participants.
Researchers found brain changes from LATE may be 40% in older adults and 50% in people with Alzheimer's. The study analyzed over 6,000 brains and included data from international cohorts, providing insight into the prevalence of this form of dementia.
A new study published in Nutrients found that individuals with higher red blood cell DHA levels have a 49% lower risk of developing Alzheimer's disease. The study, conducted on 1,490 participants aged 65 and older, suggests that increasing dietary omega-3 DHA levels may slow the development of the disease.
A large-scale study found that having multiple heart-related conditions significantly increases dementia risk, even for those with high genetic risk. Researchers analyzed data from over 200,000 people and discovered widespread brain damage among those with more than one cardiometabolic condition.
Researchers will track changes in the blood-brain barrier, neurovascular function, and cognition in over 850 participants with genetic variants at risk of developing Alzheimer’s disease. The study aims to improve understanding of the onset and progression of Alzheimer’s disease and identify effective interventions.
Researchers at UT Health San Antonio found that rapamycin causes an increase in beta-amyloid protein plaques in mouse models, contradicting its potential benefits. However, a novel method to decrease plaques was discovered by deleting the Tsc1 gene from microglia, leading to increased Trem2 levels and decreased plaques.
A new study shows that hospice patients with dementia receive excellent care and have their anxiety and sadness managed more often than those without dementia. However, the Medicare hospice model's limitations can lead to gaps in care, leaving patients with dementia at risk of disenrollment.
Researchers at Karolinska Institutet found a link between genetic variants in diabetes drug targets and lower Alzheimer's disease risk. The study suggests that the target protein, KATP channel, may be a therapeutic target for treating and preventing Alzheimer's disease.
Researchers found that neuronal damage in Alzheimer's disease originates from within brain cells' lysosomes, where amyloid beta appears. This discovery could explain why drugs designed to remove amyloid deposits have failed to stop the disease.
A recent study at UC San Francisco discovered that fragmented tau protein in diseased neurons could be a new target for existing drugs, potentially improving diagnosis and treatment of Alzheimer's. The researchers found that measuring the fragments in cerebrospinal fluid may help distinguish between different forms of dementia.