Researchers developed a machine learning model to quickly recognize predictive risk factors and their importance for undesirable hospitalization outcomes. The model achieved an accuracy of 95.6% and identified modifiable risk factors that can be mitigated through clinical interventions.
SourceHouston Methodist·JournalAlzheimer s & Dementia Translational Research & Clinical Interventions·TypeData/statistical analysis·DateSep 29, 2022
Alzheimer's researchers highlight the need for more diverse participation in clinical trials, citing underrepresentation of African Americans and Latinos. They offer solutions to improve recruitment, including culturally sensitive cognitive tests and partnerships with community organizations.
SourceKeck School of Medicine of USC·JournalJAMA Neurology·TypeNews article·DateSep 29, 2022
Scientists have made a groundbreaking discovery about the role of 'junk' DNA in neurological disorders such as Motor Neurone Disease and Alzheimer's. The research found that breaks in this type of DNA can lead to oxidative genomic damage, which can accelerate aging and disease progression.
SourceUniversity of Sheffield·JournalNature·TypeExperimental study·DateSep 28, 2022
A new study finds that high blood pressure speeds up cognitive decline in both Hispanic and non-Hispanic white adults. However, differences in blood pressure control do not fully explain the higher risk of dementia in Hispanic adults.
SourceMichigan Medicine - University of Michigan·JournalJournal of Alzheimer’s Disease·TypeData/statistical analysis·DateSep 28, 2022
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
Researchers from Xi'an Jiaotong-Liverpool University found that brain stimulation combined with a nose spray containing nanoparticles can improve recovery after ischemic stroke. The treatment increased cognitive and motor functions, and weighed more quickly than those treated with TMS alone.
SourceXi'an Jiaotong-Liverpool University·JournalMaterials Today Chemistry·TypeExperimental study·DateSep 28, 2022
Researchers have discovered that neurons with double-stranded breaks (DSBs) in their DNA actively trigger an inflammatory response, which is mediated by the activation of the NFkappaB transcription factor. This process elicits an immune response from microglia, leading to synaptic loss and cognitive function impairment.
SourcePicower Institute at MIT·JournalScience Advances·TypeExperimental study·DateSep 28, 2022
The fasting-mimicking diet reduced Alzheimer's pathology in mice, including amyloid beta and tau protein levels, and showed less brain inflammation. Mice on the diet also performed better on cognitive tests, with some showing improved performance comparable to non-Alzheimer's mice.
SourceUniversity of Southern California·JournalCell Reports·TypeExperimental study·DateSep 27, 2022
A mortality prediction model for older adults with dementia can guide discussions about financial resources, treatment preferences, and reduce unnecessary medical interventions. The model considers factors such as age, sex, body mass index, chronic conditions, and ability to perform daily activities.
SourceUniversity of California - San Francisco·JournalJAMA Internal Medicine·DateSep 26, 2022
Researchers at FIU Stempel College are investigating the translocator protein 18 kDa (TSPO) in relation to Alzheimer's disease. They aim to determine if an increase in TSPO levels is harmful and may be a potential target for treatments.
Garmin GPSMAP 67i with inReach
Garmin GPSMAP 67i with inReach provides rugged GNSS navigation, satellite messaging, and SOS for backcountry geology and climate field teams.
A new study proposes reducing toxic proteins in the blood as a potential therapy for Alzheimer's disease. By doing so, it aims to improve memory and learning capacity, as well as correct cognitive impairments. The next step is to test this treatment at a clinical level.
SourceUniversity of Malaga·JournalMolecular Psychiatry·TypeExperimental study·DateSep 23, 2022
Researchers have cloned minipigs with a mutation in the SORL1 gene, which is linked to early onset Alzheimer's disease. The pigs can be used to test new drugs and understand the early changes in brain cells that occur before dementia sets in.
SourceAarhus University·JournalCell Reports Medicine·TypeExperimental study·DateSep 22, 2022
A global consortium study aims to understand the impact of SARS-CoV-2 on the brain, with researchers evaluating over 1,000 participants worldwide. The study, led by UT Health San Antonio, uses advanced brain imaging and neuropsychological tests to assess cognitive function and identify potential causes of long-term brain changes.
SourceUniversity of Texas Health Science Center at San Antonio·JournalAlzheimer s & Dementia Translational Research & Clinical Interventions·TypeObservational study·DateSep 22, 2022
New research shows that COVID-19 infections can lead to a range of neurological complications in the first year after infection, including strokes, cognitive decline, depression, anxiety, and migraine headaches. The study analyzed over 14 million medical records and found that COVID-19 survivors were at increased risk of developing the...
SourceWashington University in St. Louis·JournalNature Medicine·TypeData/statistical analysis·DateSep 22, 2022
GQ GMC-500Plus Geiger Counter
GQ GMC-500Plus Geiger Counter logs beta, gamma, and X-ray levels for environmental monitoring, training labs, and safety demonstrations.
The University of California, Irvine has received a $47 million grant from the National Institute on Aging to develop mouse models for studying late-onset Alzheimer's disease. The project aims to better understand the biology of the most common form of the disease and set the stage for preclinical drug testing.
A new study reveals that European moles reduce their brains by 11% in winter and regrow them by 4% in summer to conserve energy. This phenomenon, known as Dehnel's phenomenon, is driven by cold conditions rather than food shortage alone.
SourceMax-Planck-Gesellschaft·JournalRoyal Society Open Science·TypeMeta-analysis·DateSep 20, 2022
A mutation in the SHMOOSE protein is associated with a 20-50% higher risk of Alzheimer's disease across four cohorts. The researchers suggest that targeting SHMOOSE may prove beneficial in neurodegenerative and other diseases of aging.
SourceUniversity of Southern California·JournalMolecular Psychiatry·TypeExperimental study·DateSep 20, 2022
The study used a weakly supervised deep learning algorithm to analyze human brain autopsy tissues and predict the presence or absence of cognitive impairment. The model identified a signal associated with decreasing myelin staining, which was linked to cognitive impairment in the white matter.
SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·JournalActa Neuropathologica Communications·DateSep 20, 2022
Scientists at UCLA discovered several molecules that can destroy tau fibers, long filaments thought to cause Alzheimer’s and similar diseases. The green tea molecule EGCG helped identify these molecules, which could lead to new treatments for Alzheimer’s and related conditions.
SourceUniversity of California - Los Angeles·JournalNature Communications·DateSep 20, 2022
GoPro HERO13 Black
GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.
A new study has found associations between plasma miRNAs and cognitive function among cognitively normal men, including those with higher MMSE scores and slower rates of cognitive decline. These findings suggest that extracellular microRNAs may play a role in the early stages of cognitive decline.
SourceImpact Journals LLC·JournalAging-US·TypeObservational study·DateSep 15, 2022
A new study published in PLOS Medicine found that people with hospital-treated infections in early- and mid-life had a higher risk of developing Alzheimer's disease (AD) and Parkinson's disease (PD). The research analyzed data on over 291,000 cases and matched controls to identify the association between infections and neurodegenerativ...
SourcePLOS·JournalPLOS Medicine·TypeObservational study·DateSep 15, 2022
A new study published in Alzheimer's & Dementia found that daily multivitamin-mineral supplementation resulted in statistically significant cognitive improvement in older adults. The researchers estimated that three years of multivitamin supplementation roughly translated to a 60% slowing of cognitive decline.
SourceAtrium Health Wake Forest Baptist·JournalAlzheimer s & Dementia·TypeRandomized controlled/clinical trial·DateSep 14, 2022
Researchers discovered that dense liquid droplets in human cells can act as 'computers' by recognizing and calculating responses to incoming chemical signals. The formation of these condensates is driven by molecular crowding and can influence the activity of enzymes called kinases, which are involved in various cellular processes.
SourceNYU Langone Health / NYU Grossman School of Medicine·JournalMolecular Cell·TypeExperimental study·DateSep 14, 2022
A three-year study of over 2,200 older adults found daily multivitamin-mineral supplementation resulted in a statistically significant cognitive benefit. The Alzheimer's Association emphasizes the need for independent confirmatory studies to establish effectiveness.
SourceAlzheimer's Association·JournalAlzheimer s & Dementia·DateSep 14, 2022
Sky-Watcher EQ6-R Pro Equatorial Mount
Sky-Watcher EQ6-R Pro Equatorial Mount provides precise tracking capacity for deep-sky imaging rigs during long astrophotography sessions.
New research estimates the overall disease burden of genetic risk factors on healthy life years lost, prioritizing interventions using genetic information. The study found that common genetic variants for cardio-vascular diseases and Alzheimer’s disease have a substantial population-level impact.
SourceUniversity of Helsinki·JournalNature Medicine·DateSep 13, 2022
A newly developed agonistic antibody targeting TREM2 reduced amyloid burden and alleviated cognitive decline in mice with Alzheimer's disease. The study suggests that increasing TREM2 activation could have therapeutic effects such as improved cognition.
SourceUniversity of Texas Health Science Center at Houston·JournalScience Translational Medicine·DateSep 7, 2022
A recent study found that people with dementia are at higher risk of SARS-CoV-2 infection and COVID-19 mortality due to underlying health conditions. The research identified risk factors such as comorbidities, anxiety, and delayed symptom recognition.
SourceIOS Press·JournalJournal of Alzheimer’s Disease·TypeMeta-analysis·DateSep 7, 2022
Researchers at the University of Pittsburgh have identified a universal mechanism for lysosomal repair, known as the PITT pathway, which helps maintain cellular longevity. The study reveals that damaged lysosomes are quickly repaired through the PITT pathway, but defects in this process can contribute to age-related diseases such as Al...
SourceUniversity of Pittsburgh·JournalNature·DateSep 7, 2022
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
A team of researchers at Sanders-Brown Center on Aging has been awarded a grant to study the role of astrocytes in neurodegenerative diseases, aiming to develop treatments for Alzheimer's and related dementias. The project focuses on understanding astrocyte function and dysfunction in disease pathology.
A study led by the University of Pittsburgh found that the TV drama 'This Is Us' reduced stigma around Alzheimer's disease and encouraged family discussions about aging plans. The narrative was developed in consultation with experts and met with the show's writers to ensure accuracy.
SourceUniversity of Pittsburgh·JournalJournal of Health Communication·DateSep 1, 2022
Researchers have developed a novel DNA-based method to identify people at greater genetic risk of developing Alzheimer's disease before symptoms appear. The method uses data on common DNA variants from over 7.1 million individuals and predicts a person's risk of Alzheimer's, depending on which DNA variants they have.
SourcePLOS·JournalPLOS Genetics·TypeObservational study·DateSep 1, 2022
Researchers used novel 3D imaging technology to study a human brainstem nucleus and found intriguing complexity and previously undescribed cellular forms of tau pathology. The study reveals dendritic atrophy as an early sign of tau-bearing neuron degeneration, potentially contributing to symptoms like sleep disturbances and anxiety.
SourceKarolinska Institutet·JournalActa Neuropathologica·TypeImaging analysis·DateAug 30, 2022
Creality K1 Max 3D Printer
Creality K1 Max 3D Printer rapidly prototypes brackets, adapters, and fixtures for instruments and classroom demonstrations at large build volume.
A new study from USC researchers uncovers the sequence of early molecular changes caused by APOE4, a discovery that may help identify potential treatment targets in the brain's blood vessels. The research reveals problems with the blood-brain barrier and synapses, leading to behavioral deficits and cognitive dysfunction.
SourceKeck School of Medicine of USC·JournalJournal of Experimental Medicine·TypeExperimental study·DateAug 30, 2022
A recent study published in Nature Neuroscience found that a 20-minute non-invasive treatment regimen can improve both short-term and long-term memory in individuals 65 years and older. The treatment involves electrical brain stimulation delivered through scalp electrodes, and its effects were observed to last at least one month.
SourceBoston University·JournalNature Neuroscience·TypeExperimental study·DateAug 29, 2022
Neurobiologists identified mechanisms underlying atypical protein tangles that kill neurons in neurodegenerative disorders. Engineering Drosophila adults with human Tau revealed a 'traffic jam' effect, where reduced retromer activity accelerates neurodegeneration. Inhibiting the shortened form of Tau could stall neuron loss.
SourceEcole Polytechnique Fédérale de Lausanne·JournalNature Communications·DateAug 29, 2022
A team of researchers from Florida Atlantic University and Tel Aviv University are investigating the connection between neuroimmune serotonergic interactions and Alzheimer's-related mood disorders. By studying mice with AD-linked mutations, they aim to determine if immune-serotonin crosstalk plays a role in depressive traits.
Davis Instruments Vantage Pro2 Weather Station
Davis Instruments Vantage Pro2 Weather Station offers research-grade local weather data for networked stations, campuses, and community observatories.
A new music intervention called Musical Bridges to Memory sparks an emotional connection between patients with dementia and their caregivers. The program enhances social engagement and reduces neuropsychiatric symptoms in both patients and caregivers.
SourceNorthwestern University·JournalAlzheimer Disease & Associated Disorders·DateAug 29, 2022
New research reveals that tau protein can self-assemble to form an envelope around microtubules, compacting them and affecting how other proteins attach. This novel behavior may play a regulatory role in healthy brain tissue, bringing us closer to understanding its connection to disease.
SourceUniversity of California - Davis·JournalNature Chemical Biology·TypeExperimental study·DateAug 25, 2022
Researchers at Washington University School of Medicine have discovered a new pathway that could help prevent Alzheimer's dementia. Increasing the clearance of waste products in the brain by ramping up a genetic quirk known as readthrough may be effective for other neurodegenerative diseases, such as Parkinson's disease.
SourceWashU Medicine·JournalBrain·TypeExperimental study·DateAug 24, 2022
DJI Air 3 (RC-N2)
DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.
A large study of over 296,000 patients found that being overweight was negatively associated with dementia in women, while underweight was positively linked to an increased risk of dementia in men. The results suggest that moderate weight gain may be beneficial for cognitive health in older women.
SourceIOS Press·JournalJournal of Alzheimer’s Disease·TypeMeta-analysis·DateAug 23, 2022
A recent study has identified the tau protein's involvement in normal learning and memory processes in the healthy brain. The researchers used proximity labelling to map out all proteins that interact with tau and found that it interacts with enzymes controlling vesicles and cell surface receptors for neurotransmitters.
SourceFlinders University·JournalThe EMBO Journal·TypeObservational study·DateAug 22, 2022
Researchers found that increasing new neurons in mice with AD rescues their memory defects by restoring neural circuits and dendritic spines. Boosting neurogenesis may be a viable strategy to treat AD patients.
SourceRockefeller University Press·JournalJournal of Experimental Medicine·TypeExperimental study·DateAug 19, 2022
Sony Alpha a7 IV (Body Only)
Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
The University of Kentucky's Sanders-Brown Center on Aging has received a $1.5 million grant to further research a possible treatment for Alzheimer's disease. The grant will help move work forward on a brain-penetrant, small molecule drug candidate called MW189.
A new study found that Alzheimer's disease damages a circuit that connects the vision processing centers of each brain hemisphere, leading to disrupted visual memory. The researchers discovered neurons that extend axons across the corpus callosum, which connect the hemispheres, and showed that these cells play a crucial role in synchro...
SourcePicower Institute at MIT·JournalNeuron·TypeExperimental study·DateAug 19, 2022
A new UCLA-led study has identified multiple new risk genes for Alzheimer's disease and progressive supranuclear palsy (PSP) by combining new testing methods. The researchers used high-throughput testing to simultaneously test 5,706 genetic variants in 25 loci associated with Alzheimer's and nine loci associated with PSP.
SourceUniversity of California - Los Angeles Health Sciences·JournalScience·DateAug 18, 2022
A study found a strong link between post-COVID loss of smell or taste and memory problems in patients. Those with the most severe sensory disorders performed worse in cognitive tests, especially memorization.
SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalEuropean Archives of Psychiatry and Clinical Neuroscience·DateAug 17, 2022
Researchers at Florida International University discover that DDT causes an increase in toxic amyloid beta, a characteristic of Alzheimer's disease. By blocking sodium channels with tetrodotoxin, the production of toxic amyloid-beta species is prevented.
SourceFlorida International University·JournalEnvironmental Health Perspectives·TypeExperimental study·DateAug 17, 2022
Kestrel 3000 Pocket Weather Meter
Kestrel 3000 Pocket Weather Meter measures wind, temperature, and humidity in real time for site assessments, aviation checks, and safety briefings.
Researchers found that the APOE4 gene variant associated with Alzheimer's disease decreases risk of glaucoma by blocking a disease cascade. They also identified a potential treatment strategy using Galectin-3 inhibitors to prevent vision loss in mice with glaucoma.
SourceMass Eye and Ear·JournalImmunity·TypeExperimental study·DateAug 16, 2022
Researchers developed a peptide that can be administered through nasal spray to reduce seizure activity and protect neurons in both Alzheimer's and epilepsy. The A1R-CT peptide inhibits neurabin, a protein that prevents the overactivation of neurons, allowing for increased action by adenosine receptors.
SourceMedical College of Georgia at Augusta University·JournalJCI Insight·DateAug 16, 2022
The expert panel identified actionable and inclusive solutions to accelerate the development of novel therapies for Alzheimer’s disease. The panel suggested strategies such as increasing diverse population representation, addressing logistical, financial, and trust barriers to participate in trials.
SourceUniversity of Southern California·JournalAlzheimer s & Dementia·TypeCommentary/editorial·DateAug 16, 2022
Researchers at UC San Francisco have discovered how to shift damaged brain cells from a diseased state into a healthy one using CRISPR technology. The study found that reprogramming microglia cells can help remove protein plaques and protect synapses, potentially treating Alzheimer's and other forms of dementia.
SourceUniversity of California - San Francisco·JournalNature Neuroscience·DateAug 11, 2022
This special collection of articles explores the 'dark side' of Alzheimer's Disease, revealing new biomarkers for brain hyperexcitability and its impact on vigilance and sleep-wake cycle. The findings provide a foundation for an extended model to speed up research lines and discovery.
SourceIOS Press·JournalJournal of Alzheimer’s Disease·TypeMeta-analysis·DateAug 11, 2022
Celestron NexStar 8SE Computerized Telescope
Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.
Researchers at UNH will develop and test social assistive robots to aid in the care of individuals with Alzheimer’s disease and related dementia in their own homes. The robots will be equipped with smart home devices, artificial intelligence, and wearables to track patients' activity levels and health management.
Research led by Drs. Yuhai Zhao and Walter J Lukiw reports a pathway from the gut to the brain that contributes to Alzheimer's disease development. Adequate dietary fiber intake can prevent this process. The study suggests a potential means to modify the abundance of microbes in the microbiome.
SourceLouisiana State University Health Sciences Center·JournalFrontiers in Neurology·TypeObservational study·DateAug 9, 2022
A new study found that rural Americans with early-onset Alzheimer's are less likely to be seen by specialists and receive essential tests, which can impact diagnosis, symptom management, and disease progression. This disparity puts rural patients at a disadvantage and overburdens primary care providers.
SourceOhio State University·JournalJAMA Network Open·DateAug 5, 2022
Aranet4 Home CO2 Monitor
Aranet4 Home CO2 Monitor tracks ventilation quality in labs, classrooms, and conference rooms with long battery life and clear e-ink readouts.
A team of researchers from The Mount Sinai Hospital has made a groundbreaking discovery into the genetic and molecular mechanisms that predispose individuals to Alzheimer's disease. They identified 21 candidate risk genes, including SPI1, which regulates microglia and AD risk.
SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·JournalNature Genetics·DateAug 5, 2022
Microglia that express the APOE4 gene cannot metabolize lipids normally, leading to a buildup of excess lipids that interferes with nearby neurons' ability to communicate. Restoring normal lipid metabolism in microglia may help treat some symptoms of Alzheimer's disease.
SourceMassachusetts Institute of Technology·JournalCell Stem Cell·DateAug 4, 2022
A 60-year study found that building mental resilience through education, socializing, and exercise can reduce dementia risk even among those with low childhood cognition or genetic predisposition. Participants with higher cognitive reserve index and reading ability showed slower cognitive decline.
SourceUniversity of Sussex·JournalNeurology·TypeObservational study·DateAug 4, 2022
Fluke 87V Industrial Digital Multimeter
Fluke 87V Industrial Digital Multimeter is a trusted meter for precise measurements during instrument integration, repairs, and field diagnostics.
Researchers at KAIST developed a novel fusion protein drug, αAβ-Gas6, which efficiently eliminates amyloid beta (Aβ) without causing inflammatory side effects. The study showed that αAβ-Gas6 promoted the robust uptake of Aβ without inflammation and neurotoxicity.
SourceThe Korea Advanced Institute of Science and Technology (KAIST)·JournalNature Medicine·TypeExperimental study·DateAug 4, 2022
Researchers discovered that vitamin K acts as an antioxidant, inhibiting ferroptotic cell death and identifying FSP1 as the warfarin-insensitive enzyme responsible. This finding has implications for treating Alzheimer's disease and acute organ injuries.
SourceUniversity of Ottawa·JournalNature·TypeNews article·DateAug 3, 2022
Research reveals that physical activity has a noticeable effect on almost all brain regions, with higher intensity and duration increasing brain volume and cortical thickness. The hippocampus, a key memory center, benefits most from physical activity, which can help counteract age-related loss of brain matter.
SourceDZNE - German Center for Neurodegenerative Diseases·JournalNeurology·TypeObservational study·DateAug 3, 2022
AmScope B120C-5M Compound Microscope
AmScope B120C-5M Compound Microscope supports teaching labs and QA checks with LED illumination, mechanical stage, and included 5MP camera.