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Machine learning predicts behavior of biological circuits

Researchers at Duke University use machine learning to model complex biological circuits, achieving speeds of hours instead of years or months. By training a deep neural network on large datasets, they uncover patterns and interactions between variables that were previously impossible to discover.

SourceDuke University·JournalNature Communications·DateOct 2, 2019

Gene therapy helps functional recovery after stroke

Researchers have developed a new gene therapy that converts glial cells into neurons, improving motor function in mice and potentially treating stroke. The treatment uses the NeuroD1 gene and has been shown to increase neuronal density and reduce brain tissue loss in mouse models of stroke.

SourcePenn State·JournalMolecular Therapy·DateSep 11, 2019

Innovative technique for labeling and mapping inhibitory neurons reveals diverse tuning profile

Researchers at Max Planck Florida Institute for Neuroscience developed a strategy to label and map local inhibitory inputs onto cells. They found that inhibitory inputs may parallel or diverge from target neurons, revealing a diverse palette of inhibition. This discovery suggests complex functional connectivity in the visual cortex.

Brain waves detected in mini-brains grown in a dish

Scientists have successfully grown miniature brains from stem cells that exhibit functional neural networks and produce brain waves resembling those of preterm babies. The study marks a significant breakthrough in understanding human brain development and may lead to new insights into diseases such as autism, epilepsy, and schizophrenia.

SourceCell Press·JournalCell Stem Cell·DateAug 29, 2019

All-optical diffractive neural network closes performance gap with electronic neural networks

Researchers have developed an all-optical diffractive neural network that achieves unprecedented levels of inference accuracy, closing the performance gap with electronic neural networks. The design incorporates a differential detection scheme, which enables specialized sub-networks to recognize specific object classes.

New software brings lower-resolution cryo-EM maps into focus

Researchers at Purdue University have developed a new software called Emap2sec that can identify secondary structures in proteins from lower-resolution cryo-EM maps. This technique has the potential to speed up protein structure analysis and improve accuracy, enabling researchers to develop more effective drugs for various diseases.

SourcePurdue University·JournalNature Methods·DateJul 29, 2019

Hidden dynamics detected in neuronal networks

Researchers from Forschungszentrum Jülich and RWTH Aachen University have identified a second critical mode in neuronal networks, allowing for parallel information processing. This newly discovered dynamics permits the network to represent signals in numerous combinations of activated neurons.

SourceForschungszentrum Juelich·JournalProceedings of the National Academy of Sciences·DateJul 23, 2019

Researchers grow active mini-brain-networks

Scientists have created functional neural networks derived from cerebral organoids, which can mimic the development of the human brain. The study provides a new tool for understanding brain function and may lead to breakthroughs in drug discovery, modeling neuropsychiatric disorders, and regenerative medicine.

SourceCell Press·JournalStem Cell Reports·DateJun 27, 2019

Can science writing be automated?

A team of scientists at MIT developed a neural network that can read scientific papers and generate a plain-English summary. The system, called RUM, uses vectors rotating in multidimensional space to represent words and improve memory and recall capabilities.

SourceMassachusetts Institute of Technology·JournalTransactions of the Association for Computational Linguistics·DateApr 18, 2019

New microscope captures large groups of neurons in living animals

Researchers developed a new 'multi-z' confocal microscopy system for imaging large groups of cells, enabling fast and detailed imaging across a wide field of view. The instrument captured cellular details at high speeds over a large 3D volume, providing unprecedented insights into how neurons interact during various behaviors.

SourceOptica·JournalOptica·DateMar 21, 2019

A very human machine

Researchers at Harvard University have developed a novel brain implant that mimics the appearance, size, and flexibility of real neurons, allowing for stable monitoring of neural signals and potential treatment of neurological disorders. The implants inspire negligible immune response and may even encourage tissue regeneration.

SourceHarvard University·JournalNature Materials·DateFeb 25, 2019