Articles tagged with Neurophysiology
Researchers identify a neural circuit in midbrain, thalamus, and cortex that orchestrates neuronal activity to trigger planned movement. The discovery has important clinical implications for motor disorders like Parkinson's disease.
A study found that intact astrocyte networks are essential for neural homeostasis, synaptic plasticity, and spatial cognitive abilities in adult mice. Disrupting these networks impairs spatial learning and memory due to altered neuronal excitability and compromised synaptic transmission.
A new study found that increased dopamine levels in the brain's basolateral amygdala trigger the transition from non-rapid eye movement (NREM) to rapid eye movement (REM) sleep. This discovery raises hopes for developing targeted treatments for sleep disorders such as narcolepsy and Parkinson's disease.
Researchers found that mitochondria act as microlenses to focus light on outer segments where it's converted into nerve signals, shedding new light on the retina's optical properties. This discovery has potential clinical implications for detecting retinal diseases.
Researchers have developed an ultrasensitive bioelectronic tongue that mimics human taste buds to measure sweetness. The device responds to sweet-tasting compounds at the 0.1 femtomolar level, making it a powerful tool for industries such as healthcare and food.
Researchers from Karolinska Institutet developed a novel method to diagnose constant tinnitus using auditory brainstem responses (ABR). The study found that people with occasional tinnitus are at increased risk of developing constant tinnitus, while those with existing constant tinnitus are more likely to experience persistent symptoms.
Researchers from Tel Aviv University have identified the biological mechanism causing nerve destruction in ALS, a fatal neurodegenerative disease. They found that TDP-43 protein accumulation in neuromuscular junctions inhibits local protein synthesis and mitochondrial activity, leading to degeneration and death of motor neurons.
A new web-based application can predict which epilepsy patients will not benefit from stereo-electroencephalography (SEEG), a costly and invasive procedure. The '5-SENSE' score reliably identifies patients who will not have a focal seizure onset zone, allowing clinicians to avoid unnecessary procedures.
A recent study published in iScience found that congenitally blind individuals and normal sighted people are equally good at discriminating between sounds. However, those who lost sight later in life had more difficulties with tasks requiring detailed auditory processing, suggesting an adaptation to the new condition.
Researchers found that low-contrast preferring neurons in primary visual cortex increase after repeated experiences, enabling perception of familiar objects. This flexible mechanism allows for consistent perception of objects with varying contrast.
A new study in mice reveals that the insular cortex plays a crucial role in balancing fear responses, integrating sensory and bodily signals to maintain an adaptive range. The InsCtx function depends on bodily feedback signals, dampening excessive fear-evoked activity and promoting healthy fear regulation.
Researchers at the University of Bern have developed an approach called 'evolving-to-learn' (E2L) that enables computers to discover mechanisms of synaptic plasticity, leading to improved learning capabilities. The algorithm was tested in three scenarios and successfully solved new tasks by mimicking biological evolution.
Researchers at Duke University and UC Irvine identify Kenpaullone, a cancer drug, as an effective analgesic for chronic and challenging-to-treat pain. The compound enhances Kcc2 gene expression, which resets maladaptive genetic switches in neurons, leading to pain signal silencing.
A new study published in Scientific Reports found that lack of sleep affects gait control, with students who stayed awake all night performing poorly. However, those who compensated for lost sleep by catching up on weekends showed improved walking control.
Studies in rhesus monkeys and Egyptian fruit bats found that prefrontal neurons represent details of interactions, including identity context and history. This discovery sheds light on the neural mechanisms underlying complex social structures and group communication.
A new deep brain stimulation (DBS) method has been developed by researchers using optogenetics and machine learning to target specific neural circuits in the brain. This approach produced long-lasting effects in a mouse model of Parkinson's disease, with therapeutic benefits that lasted on average 4.5-fold longer than conventional DBS.
Researchers used fractal analysis to study brain network patterns while listening to a story. The results show that complex thoughts are reflected in high-order dynamic correlations in neural activity patterns.
Researchers discovered a two-cell color detection system in lampreys, which they propose could be the evolutionary ancestor of single-cell systems in fish and reptiles. The study found that this ancient system produces similar responses to UV and visible light as modern single-cell systems.
Research suggests that increased complement factor C1q expression is responsible for chronic inflammation and secondary neuronal loss after mild traumatic brain injury. Blocking C1q expression counteracts these outcomes, suggesting a potential role for this molecule in modifying post-TBI disease.
Researchers have discovered that elevated levels of serotonin can prevent the development of compulsive cocaine seeking and addiction in mice. This is achieved through the activation of serotonin receptors and inhibition of synaptic transmission between key brain regions, thereby reducing the risk of addiction.
A recent study by Mount Sinai researchers discovered that certain neurons in the brain's decision-making centers monitor body-state dynamics and hijack the decision-making process during intense states of arousal. This suggests that changes in heart rate and other bodily responses can impact the brain's ability to make rational decisions.
The Daylight Award 2022 is now open for nominations, honoring groundbreaking research on the effects of daylight on human health and well-being. The award also recognizes innovative architectural projects showcasing unique uses of daylight, aiming to improve living conditions and environmental impact.
Researchers found increased capillary blood flow in mice brains during REM sleep, indicating a possible role of adenosine A2a receptors in brain refreshing. This unique state may be crucial for waste removal from the brain, which is associated with Alzheimer's disease development.
Chronic light exposure disrupts circadian rhythms in rats, leading to memory deficits and amyloid β accumulation similar to Alzheimer's disease. Fluoxetine treatment prevents these effects, suggesting a potential therapeutic strategy.
Researchers developed a 'sensing leg' with sensors that detect pressure and movement, enabling users to navigate obstacles more efficiently. The system also includes a neuro-pacemaker mode that stimulates remnant nerves, reducing phantom limb pain and improving overall well-being.
A new study developed a wearable technology-based method to assess myoclonus symptoms in the home environment. The method, which measures electrical neuromuscular function and movement, correlates well with assessments performed by experienced physicians.
Researchers use X-rays to activate opsins in neurons, allowing for remote control of neural function and behavior. Scintillators emit visible light in response to X-ray irradiation, enabling the technique without tissue damage.
Researchers have discovered distinct populations of neurons in the mesencephalic locomotor region that control different body movements. These findings could improve therapies for Parkinson's disease by targeting specific neuronal populations involved in postural changes and body extension.
A research team at Toyohashi University of Technology has developed a lightweight, compact, Bluetooth-low-energy-based wireless neuronal recording system for use in mice. The system weighs less than 3.9g and offers high signal quality, good versatility, and low cost compared to wired recording.
Research reveals distinct brain regions process concrete and abstract word meanings separately, with a network of areas working together in different languages. The findings provide new insights into how our brains represent word-meaning structure.
Researchers at Cornell University found that mosquitoes can detect sound waves from distances of up to 10 meters, including human speech and the buzzing of female mosquitoes in flight. This discovery could lead to the development of more sensitive directional microphones and hearing aids.
A study of 154 individuals with near-death experiences found that while common phenomena like feeling peacefulness and seeing a bright light occur frequently, the order of appearance varies greatly between participants. The most commonly reported sequence was out-of-body experience followed by a tunnel, bright light, and finally peace.
Dr. Donald Schomer, a Harvard Medical School professor, is recognized for his pioneering work in comprehensive epilepsy programs and training fellow clinicians worldwide. He has trained 46 fellows since establishing the fellowship program at Beth Israel Deaconess Medical Center.
The American Academy of Neurology recommends monitoring the spinal cord during spinal surgery and certain chest surgeries to prevent paralysis. Intraoperative monitoring can alert surgeons to potential problems before damage occurs, reducing the risk of complications.
A new study published in Neuron found that the brain can split attention into multiple 'spotlights' when focusing on two or more objects. This challenges traditional views on multitasking and suggests a more efficient way of processing information.
A Barrow researcher has received a $120,000 grant to study flicker fusion and its impact on people with epilepsy. The goal is to develop safe brain products that can make artificial lighting appear stable to the brain.