Research on blood and what it reveals about health. Covers blood biomarkers, occupational exposure, cell-preservation for CAR-T therapy, and blood supply.
A team of researchers has discovered a biomarker, named cBIN1 Score, that measures muscle deterioration and protein regulation in the heart, indicating onset of heart failure. This simple blood test can aid doctors in diagnosing at-risk patients before symptoms appear.
Researchers are exploring a new treatment using two existing drugs to reduce heart damage during cardiac surgery. The team will test the treatment in pigs and assess its safety and feasibility before moving to human trials.
A University of Guelph study has found that opening up the blood vessels to an ovarian tumour can potentially improve the effectiveness of treatment. By creating a healthy blood supply, the tumour becomes more accessible to treatment, increasing success rates.
A new experimental vaccine has shown to reduce the risk of secondary strokes caused by blood clots for over two months without triggering an autoimmune response. The vaccine, S100A9, provides protection against blood clot formation and works as well as oral blood thinner clopidogrel in a major artery.
A recent study analyzed the impact of mass shootings on blood supply and demand for blood products. The research found that a call for immediate blood donation was unnecessary and resulted in wasted blood resources. The study suggests that cities develop protocols for mass casualty events, such as issuing calls for donations by ZIP code.
Stroke specialists often see conditions known as stroke mimics and 'chameleons' that can mimic ischemic strokes, making accurate diagnosis complicated. Accurate diagnosis requires a detailed history and neurologic examination to avoid administering clot-busting drugs incorrectly.
A clinical trial showed that low-phosphorus diets and medication can decrease FGF23 levels in hemodialysis patients. This reduction decreases the risk of cardiovascular problems and increases life expectancy.
A new blood test developed by UNC Lineberger researchers demonstrates the ability to track HPV-linked head and neck cancer patients after treatment, reducing the need for costly imaging scans. Preliminary findings show that patients with positive blood tests had a higher risk of developing recurrence.
A recent study published in JAMA Surgery found that patients taking aspirin alone had similar protection against blood clots as those on anticoagulant treatments. Aspirin use has become increasingly popular among Michigan surgeons, with 70% of surgeons prescribing it to patients after knee replacement surgery.
A trial revealed that nurse-led care significantly improves gout treatment outcomes, including higher ULT adoption and better patient adherence. Patients receiving nurse-led care had lower urate levels, reduced flare-ups, and improved quality of life.
A new blood test at emergency departments could quickly and accurately rule out heart attacks. A preliminary study of 350 patients found the test to be as effective as longer laboratory tests in ruling out heart attacks.
Researchers at UC Riverside successfully used CRISPR-Cas9 to disrupt serotonin receptor Aa5HT2B in mosquitoes, reducing body size, lifespan, egg development, and fat accumulation. This breakthrough offers a novel approach for controlling mosquito populations and diseases they carry.
A US study found that higher blood levels of omega 3 fatty acids from seafood are associated with a lower risk of unhealthy ageing, defined as survival free of major chronic diseases and without mental or physical dysfunction. Participants who consumed more seafood-derived EPA had a 24% lower risk of unhealthy ageing.
Researchers found that most hospital-acquired bloodstream infections come from patients' own gut, with 15 of 30 patients having the same strain in both stool and blood samples. The study used bioinformatics software to rapidly identify the source of infections, which could help address risk factors and prevent recurrence.
A new study suggests that a neck collar may help protect the brain of female high school soccer players from cumulative head impact exposure. The Q-Collar, designed to increase brain blood volume during collisions, showed no significant white matter changes in those who wore it.
Researchers at Rush University Medical Center developed a metal-coordinated molecule, poly-zinc-liothyronine (PZL), which works well in laboratory studies and may provide an improved therapy for all hypothyroid patients. PZL's slow release of active hormone can supplement standard therapy, offering a more effective solution for treatme...
A new study published in The BMJ suggests that genetics play a significantly larger role in the development of high serum urate levels than diet. Despite long-held assumptions about diet's impact on gout, researchers found that only a small percentage of variation in urate levels could be explained by food choices.
A study published in Neurology found that people with atrial fibrillation, an irregular heartbeat, are at a faster rate of decline in thinking and memory skills and a higher risk of dementia. Taking anticoagulants to prevent clots may decrease the risk of dementia.
Researchers developed Prescience, a system that uses patient charts and sensor data to predict hypoxemia. The system provides explanations for its predictions, enabling anesthesiologists to better understand patient risks and prevent complications.
Researchers used statistical tools to analyze data from 55 studies on dietary oils and found seed oils, such as sunflower oil and flaxseed oil, perform best in improving cholesterol. However, there are caveats, including the study only measured blood lipids and may not be applicable to clinical outcomes.
Researchers developed a glow-in-the-dark paper strip that can detect the presence of infectious diseases using antibodies in blood, offering a quick and affordable alternative to traditional lab tests. The test measures antibody concentration by analyzing blue-green light produced through bioluminescence.
Researchers found that SHBG levels at baseline can predict insulin resistance years later in both men and women. Lower SHBG levels are associated with higher insulin resistance, a precursor to type 2 diabetes.
A new accelerated diagnostic protocol, HEART Pathway, is effective in identifying low-risk ED patients with acute chest pain who can be safely sent home without hospitalization or comprehensive cardiac testing. The study found a 6% reduction in hospitalizations and significant decreases in median length of stay and use of stress testing.
A study by University of Pennsylvania researchers identified a rare example where being older improves tissue function, leading to reduced scar formation. The key factor is a compound called stromal cell-derived-factor-1 (SDF1), which is secreted in the bloodstream and is more abundant in younger individuals.
Researchers at UNC will investigate the epidemiology of Zika virus in pregnancy and its effects on infant neurodevelopment. The team will follow infants exposed to Zika in Nicaragua and test new diagnostic protocols to understand the virus's impact.
Colorado State University chemists are developing biologically friendly coatings to mitigate blood-device interactions in extracorporeal life support systems. These advancements aim to eliminate the need for blood thinners, reducing side effects and improving patient outcomes.
Researchers found that immediate compression therapy significantly reduced the risk of residual vein occlusion and post thrombotic syndrome in patients with DVT. The study suggests that starting compression therapy within 24 hours of diagnosis can prevent debilitating complications.
A blood test for microRNAs may help predict the likelihood of disease in dairy cows and improve animal welfare. This approach is already being applied to human disease diagnosis.
Researchers aim to develop and evaluate non-contrast based imaging methods to diagnose peripheral arterial disease without relying on gadolinium-based contrast agents. The proposed techniques have high applicability to other medical procedures, including venography and vessel wall imaging.
Researchers at Penn State are developing a new generation of blood pumps that use computational methods to predict clot formation and design safer devices. This could enable earlier intervention for patients with congestive heart failure, reducing recovery time and improving outcomes.
Researchers are developing portable sensors that can detect toxic metals like manganese in a single drop of blood. The sensors will enable faster and cheaper research as well as rapid detection of neurotoxins affecting cognitive development and neuromotor function.
A novel, paper-based method detects metabolite levels in blood using a bioluminescent sensor protein, measuring compounds like phenylalanine in minutes. The approach shows promise for point-of-care monitoring of diseases and injuries, potentially leading to faster diagnosis and management.
Researchers at Northwestern University developed a simple blood test called TimeSignature that can identify the body's precise internal time clock. The test measures gene expression markers and can be taken any time of day, allowing for more accurate diagnosis and treatment of diseases such as heart disease, diabetes, and Alzheimer's.
A new study published in the American Journal of Respiratory and Critical Care Medicine found that New York State's sepsis reporting mandate led to improved care and reduced mortality rates for critically ill patients. Patients who received standardized treatment protocols had shorter hospital stays and lower mortality rates.
A new lab-on-a-chip device developed by KU Leuven researchers can detect infections and viruses in blood with high accuracy, making it ideal for diagnosing people in developing countries. The device is simple, cheap to produce, and can be activated with a finger touch, allowing anyone to use it.
Sherpas' unique physiological adaptations to high altitude may help improve oxygen delivery in critically ill patients. By increasing blood flow and delivering oxygen to tissues, Sherpas thrive at low oxygen environments, offering a potential alternative to traditional high oxygen content strategies.
The National Heart Lung and Blood Institute will award $20 million to four academic centers over five years, with UC San Diego receiving $5 million. The program aims to correct the lack of attention given to glycans in biomedical research and train 18 early-career glycoscientists.
A study found that a specific E. coli strain from retail poultry products is causing urinary tract infections in people, with nearly 80% of meat samples and 72% of patient cultures positive for the bacteria. The research suggests that cooking poultry thoroughly and handling it carefully are crucial to prevent foodborne illnesses.
Researchers reduced household lead levels and found significant reductions in dust lead levels, especially among black children. However, the intervention did not result in significant neurobehavioral improvements, such as improved IQ or behavior. The study suggests that eliminating residential lead exposure may be necessary to fully p...
A new study found that using oral anticoagulants for 45 days after hospital discharge reduced the rate of non-fatal blood clots in medically ill patients. The trial, MARINER, showed no increase in major bleeding risk while offering protection against non-fatal blood clots.
A new study suggests that performing simple leg exercises while lying down can help prevent impairment of blood vessel function caused by a sedentary lifestyle. The research found that even a brief period of inactivity reduced the ability to rapidly increase blood flow to the lower legs.
A blood test can predict which patients with diffuse large B cell lymphoma are likely to respond positively to initial therapy. Researchers tracked circulating tumor DNA levels in 217 patients and found a correlation between rapid decline and improved outcome.
A blood test using Kidney-injury-molecule-1 (KIM-1) can predict clear cell kidney cancer risk and survival up to five years before diagnosis, with higher levels associated with poorer outcomes. The test substantially improves accuracy in predicting kidney cancer risk.
A new blood test can quickly detect early signs of liver disease in dogs, enabling prompt treatment and reducing the need for invasive biopsies. The test is based on insights from human patients and has been successfully tested on 250 dogs.
Researchers will develop a risk calculator using biomarkers and statistical modeling to predict blood clot formation in cancer patients. The goal is to identify patients at high risk and treat them proactively with blood thinners.
A new diagnostic test could help distinguish Kawasaki Disease from other conditions, enabling earlier diagnosis and treatment. The test targets a specific pattern of host gene expression in whole blood.
A Dartmouth study found that Arctic mosquito populations depend on aquatic habitats and blood meal availability. The research indicates that female mosquitoes carrying eggs were most abundant near ponds in areas frequented by animals.
Research led by LSU Health found that hypoxia decreases Protein S, a natural anticoagulant, increasing the risk of potentially life-threatening blood clots. The study identified the gene regulatory mechanism controlling PS production in response to oxygen levels.
A recent study found that just two weeks of inactivity can hasten the onset of Type 2 diabetes and elevate blood sugar levels among pre-diabetic patients. The study's findings suggest that seniors who experience periods of physical inactivity are more likely to suffer harmful consequences to their overall health.
A study found people with depression have lower blood levels of acetyl-L-carnitine than healthy individuals. The findings suggest a potential new class of antidepressants could be developed to treat severe or treatment-resistant depression.
Researchers from UNIGE have developed a portable device called TBIcheck that analyzes proteins in the blood to diagnose mild traumatic brain injury. The device can detect four biomarkers associated with brain injuries, including H-FABP, Interleukin-10, S100B, and GFAP.
Patients who underwent donor transplants in childhood have a higher risk of dying prematurely compared to the general population. The main causes of death were infection and chronic graft-vs-host disease, with patients' primary disease also contributing to their mortality.
Researchers have identified four biomarkers, including a new chemical called verruculotoxin, that may predict signs of first-trimester stillbirth. By analyzing maternal blood, scientists can develop tools to screen for preventable illnesses affecting both women and children.
A new Tel Aviv University study suggests that an intravenous injection of a potent enzyme can reduce inflammation and scarring that prevent neuronal regeneration after spinal cord injury. The treatment aims to lower levels of glutamate, released in toxic quantities after trauma, to moderate the damage and enable neuronal cells to survive.
A new blood test, Banyan Brain Trauma Indicator, has been approved to help diagnose traumatic brain injuries. The test detects two brain proteins in the blood after a head injury and can predict the presence of an intracranial injury on a head CT scan.
Research by UConn microbiologists found that tiny amounts of antibiotics in chicken blood can encourage bacterial resistance. The study used leeches as a perfect test case and discovered that low levels of ciprofloxacin in poultry blood were selecting for antibiotic-resistant Aeromonas bacteria.
Researchers found that proteins in saliva reflect high blood sugar levels in young patients with type 1 diabetes, allowing for early prediction of complications. A potential new preventive treatment has been identified using gene database searching.
Research found that invisible stool blood is associated with a heightened risk of death from bowel cancer, as well as circulatory, respiratory, digestive, and hormone diseases. A positive faecal occult blood test result was linked to an 8-fold increased risk of bowel cancer mortality.
Researchers found that lysophosphatidic acid levels increase after traumatic brain injury, particularly in areas associated with cell death and axonal injury. Elevated LPA may serve as a biomarker for TBI through blood testing, providing a prognostic indicator of injury and outcome.
An observational study published in the BMJ Open journal found a strong association between an unhealthy blood fat profile before pregnancy and lower fertility rates. Women with high cholesterol, triglycerides, and low HDL cholesterol were more likely to have only one or no children.