Researchers at LSU Health New Orleans and Karolinska Institutet found that intranasal application of pro-resolving lipid mediators arrested memory loss and brain degeneration in an experimental Alzheimer's model. This discovery opens up new possibilities for therapeutic interventions for Alzheimer's disease.
SourceLouisiana State University Health Sciences Center·JournalCommunications Biology·TypeExperimental study·DateMar 21, 2022
A team of researchers at MedUni Vienna's Center for Physiology and Pharmacology has discovered a key building block in immune cells that promotes immunotolerance and prevents T-cell attacks on the body's own tissues. The study suggests a potential new cell-based therapeutic approach to slow down autoimmune disease progression.
SourceMedical University of Vienna·JournalCell Reports·DateFeb 23, 2022
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SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
Researchers at Rice University have discovered that the Lefty protein plays a crucial role in regulating Nodal signaling during embryonic development. By visualizing the interaction between Nodal and Lefty, they found that cells relay the signal to produce new Nodals, triggering a wave of differentiation. This study provides new insigh...
SourceRice University·JournalNature Communications·TypeExperimental study·DateJan 25, 2022
A multidisciplinary team of researchers has identified a key signaling pathway involved in tumor formation in lymphoma. The study found that the SENP6 gene controls DNA repair and its loss leads to cancer development.
SourceCharité - Universitätsmedizin Berlin·JournalNature Communications·TypeExperimental study·DateJan 12, 2022
A new model suggests that cell-to-cell communication plays a crucial role in determining cell fate, particularly in the development of blood cell types. This finding has significant implications for understanding cancer development and identifying leukemia cells of origin.
SourceUniversity of Southern California·JournalDevelopment·TypeComputational simulation/modeling·DateDec 22, 2021
Researchers at Salk Institute discovered that neurons deep in the brain's cortex process information from borders first, then send clues back to upstream areas. This supports the importance of the 'feedback' pathway for deciphering borders.
Researchers identified brain cells called angular head velocity (AHV) cells that track head motion speed, which improves estimation of own head angular speed when visual cues are available. This study sheds light on the neural mechanisms underlying navigation and self-motion guidance in the brain.
SourceSainsbury Wellcome Centre·JournalNeuron·TypeExperimental study·DateNov 16, 2021
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Researchers at the University of Alabama at Birmingham have developed a method to identify non-responding tumors using hypoxia imaging, which shows promise for improving response rates. Investigational new drug evofosfamide was found beneficial in treating hypoxic tumors with immunotherapy.
SourceUniversity of Alabama at Birmingham·JournalClinical Cancer Research·TypeExperimental study·DateOct 28, 2021
Researchers found that slow release of TT-10 from nanoparticles improved heart function after a heart attack, accompanied by increased cardiomyocyte proliferation and smaller infarct size. The study suggests that PLGA nanoparticles could be used to improve treatment administration efficiency for cardiovascular drugs.
SourceUniversity of Alabama at Birmingham·JournalJCI Insight·TypeExperimental study·DateOct 22, 2021
Researchers at TTUHSC have identified novel targets for treating stroke, focusing on enhancing neurolysin activity. The study discovered small molecules that can selectively enhance the activity of neurolysin, which showed promise in reducing damage to the brain after a stroke.
SourceTexas Tech University Health Sciences Center·JournalJournal of Medicinal Chemistry·TypeExperimental study·DateOct 8, 2021
A recent study suggests that targeting alpha-synuclein protein in Parkinson's disease may not be sufficient to cure most patients. Instead, resolving brain inflammation caused by dysfunctional interferon-beta receptor signaling may hold the key to developing more effective treatments.
SourceUniversity of Copenhagen - The Faculty of Health and Medical Sciences·JournalAnnals of Neurology·DateOct 8, 2021
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
A study by University of Utah biologists discovered a mutation in the ROR2 gene is linked to short beak length in domestic pigeons. This mutation also underlies the human disorder Robinow syndrome, which shares striking facial features with the pigeon phenotype.
SourceUniversity of Utah·JournalCurrent Biology·TypeExperimental study·DateSep 21, 2021
Stabilizing the NO signaling pathway has been achieved through the use of zinc complexes, which can bind to thionitrite and perthionitrite anions. This breakthrough reveals the importance of these intermediates in cellular communication, shedding light on their roles in vasodilation and cell protection.
SourceWiley·JournalAngewandte Chemie International Edition·TypeExperimental study·DateAug 24, 2021
Researchers found that consuming dileucine enhances the metabolic processes driving muscle growth, resulting in a 42% increase in protein synthesis. In contrast, leucine alone showed no significant impact on protein breakdown, highlighting the molecule's potential as a signaling agent for muscle-building pathways.
SourceUniversity of Illinois at Urbana-Champaign, News Bureau·JournalJournal of Applied Physiology·TypeRandomized controlled/clinical trial·DateAug 9, 2021
Researchers have discovered folate metabolism as a common mechanism underlying aging and lifespan extension across different species. The study found that altering folate metabolism increases lifespan in worms and mice by up to 30 percent, suggesting a potential new approach to improving human health during aging.
SourceMax-Planck-Gesellschaft·JournalNature Communications·DateJun 16, 2021
Researchers at Johns Hopkins Bloomberg School of Public Health have discovered a cellular stress enzyme called MARK2 that controls protein synthesis in response to types of stress or damage seen in neurodegenerative disorders. The finding suggests that MARK2 may play a key role in diseases such as Alzheimer's, Parkinson's, and ALS.
SourceJohns Hopkins Bloomberg School of Public Health·JournalPLOS Biology·DateMar 11, 2021
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Researchers have identified a new signaling pathway that regulates the production of RNA-protein complexes in neurons, which are overproduced in neurodegenerative diseases such as ALS and senile dementia. This discovery may lead to better understanding and potential therapeutic options for these conditions.
SourceUniversity of Würzburg·JournalNature Communications·DateFeb 25, 2021
Researchers have identified a new signaling pathway, LIGHT/LTbR, that is specific to leukemic stem cells and can be targeted to eliminate them. Blocking this pathway has been shown to increase the survival of animals with leukemia.
SourceInselspital, Bern University Hospital·JournalNature Communications·DateFeb 16, 2021
Researchers at Inselspital and the University of Bern discovered that metoclopramide inhibits the proliferation of leukemia stem cells, a key target in CML treatment. The study identifies CD93 as a specific regulator responsible for leukemia stem cell growth, paving the way for potential new therapies.
SourceInselspital, Bern University Hospital·JournalCell Reports·DateJan 26, 2021
Researchers have developed two new web resources to study the effects of coronavirus infection on host molecular signaling pathways. These resources, freely available through the Signaling Pathways Project and Network Data Exchange, provide valuable information for accelerating the development of novel therapeutic strategies for COVID-19.
SourceBaylor College of Medicine·JournalScientific Data·DateSep 22, 2020
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Researchers at Helmholtz Munich identified hundreds of new information exchange points between plant proteins, revealing that most proteins function in multiple signaling pathways. This discovery may lead to new strategies for biotechnological development or breeding of plants to address climate change challenges.
SourceHelmholtz Munich (Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH))·JournalNature·DateJul 1, 2020
Researchers created 3D human gut organoids from patient cells to simulate leaky gut conditions, revealing new biomarkers and a potential pathway for tightening the gut lining. The study found that the diabetes drug metformin strengthens the junctions of mini-guts, increasing occludin levels up to six-fold.
SourceUniversity of California - San Diego·JournalLife Science Alliance·DateFeb 10, 2020
Researchers have discovered that mitochondria undergo reprogramming under low oxygen conditions, a process that could provide new therapeutic targets for pancreatic cancer. This reprogramming enables cancer cells to adapt to energy scarcity by switching to glycolysis, allowing them to continue growing despite limited nutrients and oxygen.
SourceMax-Planck-Gesellschaft·JournalNature·DateNov 11, 2019
A biomedical scientist is studying how the body's cannabis-like molecules affect feeding behavior and contribute to obesity. The research aims to identify novel therapeutic strategies for safely treating obesity and related metabolic disorders, which are currently lacking reliable options.
Researchers at PSI have produced the most detailed image to date of a type of membrane protein involved in signal transmission. They discovered that this protein inhibits itself, preventing overproduction of cAMP, an important secondary messenger in cell signaling.
SourcePaul Scherrer Institute·JournalScience·DateApr 25, 2019
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Sky & Telescope Pocket Sky Atlas, 2nd Edition is a durable star atlas for planning sessions, identifying targets, and teaching celestial navigation.
Scientists have created a novel tool that can both control and visualize serotonin receptor signals in neural cells using light. The tool, called Camello, uses fluorescent proteins to indicate activated signalling pathways and receptor trafficking in specific domains.
A root extract of Fallopia multiflora has been shown to extend the lifetime of nematodes by almost 19% and protect them from oxidative stress. The primary component of the extract, similar in structure to resveratrol, activates sirtuins that control ageing.
SourceMartin-Luther-Universität Halle-Wittenberg·JournalPlants·DateOct 8, 2018
Researchers at Kumamoto University have identified a new mechanism linking cytoskeletal dynamics and Wnt5a signaling, essential for planar cell polarity formation. This control system regulates the morphology and orientation of cells in animal tissues, crucial for tissue morphogenesis.
SourceKumamoto University·JournalEMBO Reports·DateJul 24, 2018
A research team led by Alexander G. Zestos has identified a key signaling pathway that activates beige fat cells to burn energy. The CHRNA2 pathway is crucial for understanding the communication between the immune system and beige fat cells, which could lead to obesity therapies.
SourceAmerican University·JournalNature Medicine·DateMay 21, 2018
Research team from the University of Freiburg found that termite queens can live up to 20 years due to their unique genetic profile, which differs significantly from older workers. The discovery suggests that the superorganism concept may hold the key to understanding longevity in social insects.
SourceUniversity of Freiburg·JournalProceedings of the National Academy of Sciences·DateMay 8, 2018
AmScope B120C-5M Compound Microscope
AmScope B120C-5M Compound Microscope supports teaching labs and QA checks with LED illumination, mechanical stage, and included 5MP camera.
Researchers at the University of Illinois discovered how Ras protein binding to cell membranes impact the signaling pathways that cause cancer's uncontrolled growth. The study found that KRas4b binds more tightly to the cell membrane, but it needs to attach on the correct side.
Congenital myotonic dystrophy (CDM) is characterized by progressive muscle wasting and weakness. Researchers have identified an upregulation of the interleukin-6 (IL-6) myokine signaling pathway in CDM muscles, suggesting that enhanced RNA toxicity contributes to severe CDM phenotypes through aberrant IL-6 signaling.
Johns Hopkins researchers identified a cellular pathway responsible for rapid heart failure in Marfan syndrome and reversed the disease in mouse models by increasing stress on the animals' hearts. The findings provide a potential model for treating this aggressive form of the disorder.
A new study from the Salk Institute discovered that the p75 protein plays a crucial role in pain signaling, supporting the survival of sensory neurons that transmit pain signals. This finding has significant implications for understanding neurological disorders and developing treatments for conditions such as spinal cord injury.
DNA damage accelerates aging in nematode worms, showing surprising similarities with aged humans. The study reveals comprehensive connections between metabolism, DNA preservation, and signaling pathways.
SourceUniversity of Cologne·JournalCell Reports·DateAug 30, 2017
Sky-Watcher EQ6-R Pro Equatorial Mount
Sky-Watcher EQ6-R Pro Equatorial Mount provides precise tracking capacity for deep-sky imaging rigs during long astrophotography sessions.
A crucial protein called Polydom is essential for developing a functioning lymphatic system. The protein promotes signaling by the Angiopoietin-2-Tie1/Tie2 pathway, which is vital for lymphatic vasculature maturation.
SourceOsaka University·JournalCirculation Research·DateApr 2, 2017
Researchers can now analyze biological signaling pathways with unprecedented accuracy thanks to OmniPath, combining 27 public databases on signalling interactions. The tool provides a comprehensive and unified collection of literature-curated signalling pathways based on an analysis of 41,000 scientific papers.
SourceEarlham Institute·JournalNature Methods·DateNov 29, 2016
A new University of Toronto study reveals widespread differences in protein biochemistry between healthy and diseased hearts, shedding light on the molecular causes behind dilated cardiomyopathy. The researchers mapped changes in protein signalling pathways, uncovering hundreds of signalling pathways that go off course in DCM hearts.
SourceUniversity of Toronto·JournalProceedings of the National Academy of Sciences·DateOct 10, 2016
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Apple MacBook Pro 14-inch (M4 Pro) powers local ML workloads, large datasets, and multi-display analysis for field and lab teams.
A team of scientists at the MBL Whitman Center successfully recreated a T-cell receptor signaling pathway, revealing novel insights into protein signaling and its role in the immune response. The study found that protein molecules separate into structures through phase separation, leading to efficient signal transduction.
SourceMarine Biological Laboratory·JournalScience·DateApr 11, 2016
Scientists have created an optogenetic tool that can control specific G-protein-coupled signalling pathways in the brain with high temporal precision. By using different-coloured light, researchers can switch these pathways on and off, offering new insights into the role of certain signalling pathways in disease.
SourceRuhr-University Bochum·JournalCurrent Biology·DateApr 8, 2016
A new study by UC Riverside-led researchers challenges the long-held assumption that steroid hormone release occurs through simple diffusion, instead suggesting a regulated vesicle-mediated release process. This discovery could lead to novel methods for manipulating biological processes and has potential health and agricultural benefits.
SourceUniversity of California - Riverside·JournalCell·DateNov 5, 2015
Researchers have deciphered a new molecular signaling pathway that promotes muscle loss in heart failure patients. The study found that suppressing this pathway may inhibit muscle atrophy, offering high potential for therapeutic options.
SourceCharité - Universitätsmedizin Berlin·JournalCirculation Research·DateAug 10, 2015
Scientists have developed a method to introduce non-native chromatin into cells, allowing them to systematically interrogate transcriptional signaling pathways. This approach enables researchers to propose mechanistic pathways and validate hypotheses in vivo, paving the way for potential therapeutic applications.
SourcePrinceton University·JournalNature Chemistry·DateApr 22, 2015
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Fluke 87V Industrial Digital Multimeter is a trusted meter for precise measurements during instrument integration, repairs, and field diagnostics.
Scientists have discovered a crucial signaling pathway in diffuse large B-cell lymphoma that can be targeted with substances already in clinical development for other diseases. This finding holds promise for diagnosis, prognosis, and treatment of the disease.
SourceUniversity of Zurich·JournalJournal of Experimental Medicine·DateApr 7, 2015
Scientists use advanced omics technologies to analyze the effects of substances on human cells, revealing potential health risks at very low concentrations. The study identifies changes in protein patterns and metabolism at non-toxic levels, which could inform the development of new risk assessment methods.
SourceHelmholtz Centre for Environmental Research - UFZ·JournalJournal of Proteome Research·DateMar 16, 2015
The study found that high doses of Notch-1 signaling pathway inhibitor prolonged the survival of PC12 cells after Aβ25-35 induction, decreasing apoptosis-related proteins and increasing antioxidant enzyme activity. The results suggest a protective effect against amyloid beta-peptide-induced cell death.
SourceNeural Regeneration Research·JournalNeural Regeneration Research·DateAug 7, 2014
A team of scientists reveals that a specific protein recognizes and repairs DNA crosslinks using the Fanconi anemia signal pathway. The study sheds light on the complex process of repairing damaged DNA, which can trigger cancer development. This new knowledge may lead to improved drugs for cancer treatment.
SourceUniversity of Zurich·JournalCell Reports·DateMay 27, 2014
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Kestrel 3000 Pocket Weather Meter measures wind, temperature, and humidity in real time for site assessments, aviation checks, and safety briefings.
Scientists at the Max Planck Institute found that inhibiting insulin/IGF signalling improves sleep quality in fruit flies and reverses age-related sleep deterioration. The study suggests a potential link between aging humans' sleep problems and the insulin/IGF pathway.
SourceMax-Planck-Gesellschaft·JournalPLOS Biology·DateApr 1, 2014
Scientists at the University of Bonn identified Creld1 as a crucial gene for heart valve development in mice, which also functions similarly in humans. This discovery may lead to improved diagnosis of unidentified heart valve diseases and better understanding of cardiac development.
SourceUniversity of Bonn·JournalDevelopmental Cell·DateMar 31, 2014
A large-scale protein interaction network for Huntington's disease has been identified, providing valuable insights into the disease's pathology. The network implicates the RhoGTPase signaling pathway, which affects cell motility, membrane dynamics, and cell attachment, offering potential therapeutic targets.
SourceBuck Institute for Research on Aging·JournalJournal of Biological Chemistry·DateFeb 27, 2014
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Meta Quest 3 512GB enables immersive mission planning, terrain rehearsal, and interactive STEM demos with high-resolution mixed-reality experiences.
The Parkin enzyme activates a signal pathway that protects neurons from damage, increasing the expression of protective factors. This process may provide novel therapeutic targets to halt or delay neurodegeneration in Parkinson's disease.
Researchers identified a molecular program controlling neuronal output connection growth via mitochondrial capture. The LKB1-NUAK1 signaling pathway spurs axon branching, pointing to its potential role in developmental brain disorders like autism and schizophrenia.
SourceScripps Research Institute·JournalCell·DateJun 20, 2013
Researchers at the Max Planck Institute have discovered how external signals regulate vascular remodelling through G protein-mediated signalling pathways. These pathways work together in other contexts but act as antagonists in blood vessel remodelling, balancing cell growth and regression.
SourceMax-Planck-Gesellschaft·JournalJournal of Experimental Medicine·DateNov 13, 2012
Sony Alpha a7 IV (Body Only)
Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
Researchers at University of California, Berkeley report that epithelial cells in cornea express small antimicrobial peptides to defend against bacterial infections. High levels of prolactin block expression of kisspeptin, a protein hormone that induces secretion of GnRH, leading to infertility in women.
SourceJCI Journals·JournalJournal of Clinical Investigation·DateSep 24, 2012
Researchers found that concussions and even lesser head impacts can speed up the brain's natural aging process, causing changes in gait, balance, attention, and impulse control. The study suggests a cumulative effect of repeated head impacts on the risk of cognitive decline and Alzheimer's disease.
SourceUniversity of Michigan·JournalExercise and Sport Sciences Reviews·DateJul 31, 2012
The March of Dimes Foundation has awarded UTMB assistant professor Muge Kuyumcu-Martinez a two-year $150,000 grant to support her research on congenital heart defects. The award will enable her to study the protein kinase C pathway and its interactions with genes using cell-culture and transgenic mouse experiments.
SourceUniversity of Texas Medical Branch at Galveston·DateApr 20, 2012
Inflammatory breast cancer cells use the anti-inflammatory response of white blood cells to increase fibronectin expression, a molecule involved in wound healing and cell migration. Monocyte-conditioned media stimulate this process through the IL-8 signaling pathway, allowing cancer cells to branch and invade, leading to metastasis.
SourceBMC (BioMed Central)·JournalCell Communication and Signaling·DateFeb 9, 2012
Researchers at UT Southwestern Medical Center have identified compounds that inhibit a signaling pathway in Huntington's disease, a fatal genetic disorder. The quinazoline-derived compounds block the store-operated calcium entry signaling pathway, potentially slowing the progression of degenerative nerve disorders.
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Researchers at Baylor College of Medicine identified the α3β4 nicotinic receptor as a key player in the appetite suppression pathway. When nicotine binds to this receptor, pro-opiomelanocortin neurons are activated, leading to reduced food intake.
SourceBaylor College of Medicine·JournalScience·DateJun 9, 2011
Researchers are using computational approaches to analyze and unify data on plant responses to environmental stresses, aiming to improve crop stress adaptation abilities. The Beacon database will facilitate the curation and archiving of signaling pathways for abiotic stress responses.