Articles tagged with Corticosteroids
A real-world study evaluating the benefit of treating asthma with small particle treatments like QVAR compared to larger particle treatments revealed interesting differences in asthma exacerbation outcome rates. The study found that initiating dosing with small versus large particle ICS treatments can impact asthma control rates.
Researchers at the University of Cincinnati have discovered a treatment for life-threatening ACE inhibitor angioedema, allowing patients to be discharged sooner. The study found that Ecallantide was more effective in reducing swelling and side effects compared to conventional therapy.
Researchers at University of British Columbia and Vancouver Coastal Health study show that a combination asthma therapy does not harm British Columbians, contradicting FDA safety concerns. The study, covering 46,000 people over 15 years, found no statistically significant increase in hospitalization rates for users.
Researchers found that adding a corticosteroid to standard treatment significantly improves both short- and long-term visual acuity in patients with nonarteritic anterior ischemic optic neuropathy (NAION). The study showed that patients treated with the combination therapy had better long-term vision compared to those only treated with...
A study published in JAMA Pediatrics found that multiple courses of prenatal corticosteroids did not increase the risk of death or disability in children. The study included over 1,700 mothers and their children, with no significant difference in outcomes between those who received single vs. multiple courses of corticosteroid therapy.
A University of Alberta research team found that inhaled corticosteroid use was associated with a 90% increase in risk for repeat pneumonia episodes among elderly patients. The study, published in Clinical Infectious Diseases, suggests health professionals should exercise caution when prescribing the drugs to high-risk patients.
A recent study published in JAMA found that a combination of pentoxifylline and prednisolone did not improve 6-month survival rates in patients with severe alcoholic hepatitis. Despite being the only and most successful medical treatments available, corticosteroids and pentoxifylline provide only modest improvements in mortality.
People with severe asthma are less likely to respond to corticosteroid treatment, even when taking high doses. Researchers found that 55% of adults with severe asthma showed greater airway obstruction despite regular oral corticosteroids. The study aims to develop personalized medicine for individual patients with asthma.
Researchers found that corticosteroid injections helped NFL players recover 10 days sooner than those without treatment, with a median recovery time of 15 days. The study involved 31 players from two teams and showed no complications from the injections.
A recent study published in The Lancet Respiratory Medicine found that a single inhaler therapy using beclometasone/formoterol combination is more effective in preventing asthma attacks than the traditional combination of corticosteroid and rapid-onset long-acting β2 agonist. This approach reduces hospital admissions and healthcare cos...
A study published in JAMA found that corticosteroid injections did not provide significant long-term improvement for patients with 'tennis elbow', and neither option was effective compared to placebo. However, physiotherapy provided some short-term benefits despite no long-term effects.
Researchers found that prophylactic use of probiotics significantly reduces the incidence of Clostridium difficile-associated diarrhea (CDAD) in adults and children taking antibiotics. In contrast, epidural corticosteroid injections offer only short-term relief from sciatica pain and disability for patients with this condition.
A new study found no significant association between corticosteroid use and increased bleeding events after tonsillectomy. The research suggests that the commonly used corticosteroid dexamethasone does not significantly increase the risk of serious bleeding in children undergoing the procedure.
A new study found that people with mild asthma who take inhaled steroids only when symptoms occur have similar outcomes as those who use them daily. This could lead to reduced medication costs and more flexible treatment options.
Researchers investigated three strategies for adjusting asthma therapy in adults with mild to moderate persistent asthma. The study found no significant differences in treatment failure rates among the groups, including those based on physician assessment, biomarkers, or symptom occurrence.
A new study suggests a personalized approach to treating mild persistent asthma, where patients take inhaled corticosteroids only when needed. This approach, called 'temporal personalization,' has been shown to reduce medication usage and severity of symptoms without impacting quality of life.
A Mayo Clinic study developed an infection risk score for rheumatoid arthritis patients, using factors like age, corticosteroid use and inflammation levels. The score helps physicians identify high-risk patients and take measures to prevent infections.
A study published in The Lancet found that mepolizumab significantly reduced severe asthma exacerbations, emergency room visits, and hospitalizations. The treatment also showed promise in reducing the need for oral corticosteroids, a common trigger for these flare-ups.
A randomized controlled trial found that corticosteroids have no clinical benefit in treating acute sinusitis. Researchers from the Netherlands conducted a study involving 174 adults with clinically diagnosed acute rhinosinusitis and found that oral corticosteroids had no significant effect on facial pain or pressure.
A new study found that asthma treatment with inhaled corticosteroids is less effective in children with vitamin D deficiency, leading to poorer lung function. Vitamin D supplementation may enhance the anti-inflammatory properties of corticosteroids, improving outcomes for asthmatic children.
Prior ICS treatment before CAP diagnosis is associated with lower incidence and severity of parapneumonic effusion. Patients treated with ICS had a significantly lower risk of developing this complication, regardless of their baseline chronic respiratory condition.
Researchers found that nearly three-quarters of asthma patients with well-controlled symptoms can safely reduce their ICS dose by half. However, common respiratory measurements are not effective in determining which patients will tolerate lower doses without risk of flare-ups or exacerbations.
A randomized trial of 829 patients with Bell palsy found that prednisolone treatment significantly reduced mild and moderate sequelae at 12 months. The study also showed that valacyclovir alone did not affect the severity of sequelae, while the combination of prednisolone plus valacyclovir did not offer additional benefits.
A review of 30 years of life-threatening asthma cases found annual ICU admissions have dropped significantly. Education programs and adherence to controller medications, such as inhaled corticosteroids, are credited for the decline.
Researchers found that using LABAs in combination with ICS reduces asthma attacks as well as or better than corticosteroids alone. The study showed the greatest benefits to African-American patients, males, and those with moderate to severe asthma.
Research found that antenatal corticosteroids reduced the risk of infant death or neurodevelopmental impairment in very preterm infants born between 23-25 weeks' gestation. The study included data from 10,541 infants and found significant improvements in outcomes for those exposed to antenatal corticosteroids.
Research by Wally Carlo found that antenatal corticosteroids significantly reduce mortality and neurodevelopmental impairments in extremely preterm infants from 22 to 25 weeks gestation. The study showed a 33% decrease in mortality and a 20% decrease in neurodevelopmental impairments.
A randomized, triple-blind, placebo-controlled trial found that lower doses of corticosteroids were just as effective as higher doses in reducing shoulder pain and improving range of motion. The study suggests using a lower dose at the initial treatment stage to minimize potential complications.
A UCSF study found significant vision improvement in patients with severe bacterial corneal ulcers who received steroid therapy. Researchers tested 500 participants from the US and India, and results showed no harm but a benefit for those with more serious forms of ulcers.
Researchers discovered that corticosteroids are ineffective for COPD patients due to reduced HDAC2 activity, which is caused by S-nitrosylation from cigarette smoke. Sulforaphane treatment restored HDAC2 activity and improved corticosteroid sensitivity in COPD patients.
Researchers identified sulforaphane as a potential therapeutic to augment anti-inflammatory effects of corticosteroids in individuals with COPD. This broccoli-based compound targets Nrf2 and restores glucocorticosteroid sensitivity in macrophages from COPD patients.
The American Thoracic Society has issued guidelines on interpreting fractional exhaled nitric oxide (FENO) levels in various clinical settings. FENO can detect eosinophilic airway inflammation, determine corticosteroid responsiveness, and monitor airway inflammation to guide treatment decisions.
A new study published in Archives of Dermatology found that beta-blocker propranolol was more effective than oral corticosteroids in treating infantile hemangiomas, with higher rates of lesion clearance and fewer adverse effects. Propranolol treatment also led to significant cost savings.
A Johns Hopkins-led research study found that patients with chronic obstructive pulmonary disease (COPD) who use long-term inhaled corticosteroids have a 27% increased risk of bone fractures. This increased risk is particularly concerning for women, who are already at a higher fracture risk than men.
A new study finds that corticosteroid treatment can reduce disease severity and improve recovery rates in patients with community-acquired pneumonia. Corticosteroids were added to standard antibiotic treatment, resulting in faster patient recovery and reduced length of hospital stay.
A recent study found no association between corticosteroid use during pregnancy and orofacial clefts in infants. However, dermatological corticosteroids were linked to an increased risk of cleft lip with or without cleft palate. The study's results add to the safety information for corticosteroids commonly used during pregnancy.
A randomized trial found hydrocortisone therapy reduced hospital-acquired pneumonia rates by 35.6% compared to placebo, resulting in shorter mechanical ventilation-free days and ICU stays. Corticosteroid insufficiency was also associated with higher pneumonia rates.
A new study from the University of Montreal found that a short burst of oral steroids may temporarily depress the immune system in children with asthma, leading to reduced antibody production. However, this effect is considered transient and rare, occurring only when exposed to new antigens during an asthma attack.
Researchers found that rescue therapy was effective in reducing asthma exacerbations and treatment failures, with linear growth not affected. The study suggests using rescue inhaled corticosteroid as a step-down alternative for mild persistent asthma.
Researchers developed an intravitreal, bioerodible implant that delivers dexamethasone to the back of the eye chamber. The study found significant improvements in intraocular inflammation and visual acuity with a single dose of the implant.
Researchers have identified a new drug class that can enhance red blood cell production in anemic patients, potentially treating Diamond-Blackfan anemia and other conditions. The discovery was made by determining how corticosteroids act to increase the production of red blood cell progenitors.
Research found no evidence that doubling inhaled corticosteroids reduces need for rescue oral steroids, contradicting common practice. Increasing doses may provide false reassurance and undermine effectiveness of daily inhaled steroids.
Researchers at the NHLBI found that adding tiotropium bromide to low-dose inhaled corticosteroids is more effective than doubling corticosteroids alone and as effective as adding a long-acting beta agonist. The treatment showed significant improvements in asthma control, including increased symptom-free days.
A decade-long trial confirms that early corticosteroids withdrawal improves graft survival rates, patient survival rates, and reduces cardiovascular events in transplant patients. The study shows a significant reduction in non-PTLD cancer risk among ECSWD patients.
Researchers found that proactively disclosing medical errors decreased new legal claims and costs for health care systems. Collaboration between internists and specialists improved care for patients with chronic hepatitis C virus infection by increasing adherence to quality-of-care measures. However, administering corticosteroids to de...
A study published in Nature found that high doses of corticosteroids given repeatedly over several weeks may help individuals with lupus by killing off the cells producing interferon alpha. This approach is more effective than standard treatment, which can lead to long-term side effects.
Researchers found that a novel internet-supported strategy with daily FENO measurements and supervision by an asthma nurse reduced cumulative 6-month dosing of oral corticosteroids in severe asthma patients. This approach improved asthma control without worsening quality of life.
Researchers found post-transplant patients off steroids have similar graft-function outcomes as those on steroids but with fewer cardiovascular events. This study contributes to a reduction in patient exposure to corticosteroids during post-transplantation treatment, improving graft survival rates and reducing early mortality.
Research at National Jewish Health found low vitamin D levels in children with asthma were associated with poorer lung function, higher allergy markers, and increased medication use. Vitamin D supplementation may help reverse steroid resistance and reduce medication needed for asthmatic patients.
Sudden sensorineural hearing loss (SSNHL) affects one ear, often associated with tinnitus and vertigo. Short-course corticosteroids are recommended for patients with suspected SSNHL after ruling out life-threatening causes.
A new study found that increasing dosage or adding asthma drugs to low-dose inhaled corticosteroids improves asthma control in 98% of children. LABA shows the highest response rate, but individual patients require personalized treatment due to factors like Asthma Control Test score, eczema, and ethnicity.
A long-acting beta-agonist (LABA) is the most effective step-up treatment for children with poorly controlled asthma, according to a new study. The study found that children responded differently to different treatments, with African-Americans equally likely to respond best to LABA or corticosteroid step-up.
A new study published in the American Journal of Respiratory and Critical Care Medicine found that prednisolone therapy does not provide clinical benefits for patients with mild to moderate community-acquired pneumonia. Instead, it may lead to a higher rate of late failures and recurrence of symptoms after withdrawal.
Treating adults with septic shock with intensive insulin therapy did not result in a reduced risk of in-hospital death compared to conventional insulin therapy. Patients treated with intensive insulin experienced significantly more episodes of severe hypoglycemia than those in the conventional treatment group.
Researchers found that injecting corticosteroids into the eye slowed the progression of diabetic retinopathy in a study involving 840 eyes. The treatment reduced the risk of vision loss associated with proliferative diabetic retinopathy, which affects 700,000 Americans annually.
A large trial has shown that patients with specific genetic makeups do not respond differently to treatment for asthma, regardless of their genotype. The study found substantial improvements in airway function when patients received longacting β2 agonists plus moderate-dose inhaled corticosteroids.
A study found laser therapy equivalent to corticosteroid medications in treating vision loss from BRVO, with lower complication rates. Laser treatment showed no significant difference in visual improvement compared to corticosteroid injections.
A new corticosteroid medication has been shown to improve vision and reduce vision loss in patients with central retinal vein occlusion. The treatment, which involves eye injections of the medication, has been proven effective in reducing vision loss by five times.
A 22-year-old woman, recently undergoing chemotherapy for Hodgkin's disease, survives severe swine-flu infection after receiving unlicensed intravenous Relenza treatment in combination with corticosteroids. Her condition improved significantly within 48 hours, and she was discharged after 24 days in ICU.
A systematic review of 18 studies found corticosteroids alone reduce unsatisfactory recovery by 9%, while combined therapy with antiviral agents may offer a 5% absolute risk reduction. Corticosteroids are also associated with reduced synkinesis and autonomic dysfunction.