Mothers with a criminal record and care experience face negative judgements and excessive scrutiny due to their 'known' status. The study emphasizes the need for supportive dialogue across disciplinary boundaries to break cycles of stigma and social care involvement, focusing on safe spaces and trust-building for care-experienced mothers.
Researchers found that acute kidney injury does not predict worsening of kidney function trajectory in patients with CKD, suggesting that pre-existing kidney disease may be a major contributor. The study recommends focusing on flattening the eGFR slope and treating proteinuria to slow CKD progression.
A new study found critical gaps and disparities in access to Parkinson's disease care among Medicare beneficiaries. Only 9% of people with Parkinson's disease receive care from movement disorder specialists.
Researchers found that investors evaluate a company's environmental performance based on financial materiality, providing a better perspective for understanding environmental risks. The study analyzed data from 1,766 companies and identified three key findings: varying evaluation criteria, shareholder risk perception, and the importanc...
A team from the University of Ottawa has developed a comprehensive screening platform and cellular interrogation tool to facilitate novel drug discovery targeting various human diseases. The 'Tango-Trio' platform can identify small molecule modulators for orphan GPCRs, which have significant untapped therapeutic potential.
A survey of over 1,200 benzodiazepine users found persistent symptoms months or years after discontinuation, including anxiety, insomnia, memory loss and suicidal thoughts. Long-term use was associated with negative life impacts such as job loss and increased medical costs.
Research suggests that glioblastoma cells possess large-scale coordination, allowing them to respond unison to therapies. Disrupting this organization may result in more powerful treatments for brain tumors.
Researchers developed a biodegradable nanoparticle that reaches dendritic cells in mice with melanoma and colon cancer, activating an immune response. The nanoparticle improves survival rates for these cancers, with half of mice surviving long-term after treatment.
Academic scientists will receive funding to establish a pleiotropic brain-penetrant small-molecule to impede glioblastoma and develop an epigenetic therapy for Prader-Willi syndrome. The TRxA program aims to bridge the drug development 'valley of death' and advance novel therapeutics from lab to clinical trials.
A third of under-fives attending Paediatric Emergency Departments have unmet vaccination need, with tetanus and MMR vaccination coverage levels below target. Researchers call for catch-up campaigns to reach this vulnerable group.
Researchers at MD Anderson Cancer Center have engineered a new model of aggressive renal cell carcinoma, highlighting molecular targets and genomic events that trigger chromosomal instability. The loss of interferon receptor genes plays a pivotal role in allowing cancer cells to become tolerant of chromosomal instability.
The new institute will integrate vascular biomedicine, systems biology, and heart research to investigate mechanisms of interorgan communication and detect pathologies earlier. It aims to accelerate translation of findings into clinical applications.
A study by Flinders University researchers found that short exposure to wind farm and road traffic noise triggers a small increase in waking from slumber, fragmenting sleep patterns. However, wind farm noise wasn't more disruptive to sleep than road traffic, which was slightly more disruptive at higher audio levels.
The American Heart Association has launched a $20 million initiative to tackle health challenges in rural America, focusing on novel solutions to heart disease disparities. The Health Equity Research Network on Rural Health aims to explore innovative ways to address unique obstacles faced by rural communities.
Cartesian Therapeutics has successfully treated patients with generalized myasthenia gravis using an RNA CAR-T therapy. The trial demonstrated marked and long-lasting clinical improvement, with three patients achieving complete or near-complete eradication of disease symptoms.
Chenmin Yao, a young researcher from Wuhan University, China, received the 2023 IADR Toshio Nakao Fellowship to support her training and experience in dental materials science. She has published nine papers in peer-reviewed international journals with high impact factors.
The International Association for Dental Research (IADR) recognized six recipients of the 2023 IADR Colgate Research Travel Awards, which encourage research in preventing oral diseases. The award recipients received travel stipends and commemorative plaques to present their work at the annual conference.
Richard Niederman has dedicated his career to generating evidence for oral disease prevention and promotion. He pioneered large-scale school- and community-based oral health programs focusing on fluoride applications.
A research team from Taiwan has found a way to massively speed up aerial image simulations using wavelength scaling and fast Fourier transformation. The new algorithm improves computation speed by 4000-5000 times while maintaining only a slight intensity deviation.
The IADR LION Dental Research Award recognizes innovative research in basic dental science and applied research achievements that improve public dental health. The 2023 recipients were announced during the 101st General Session of IADR in Bogot , Colombia
Researchers at Weill Cornell Medicine have discovered a DNA molecule that folds into a four-way junction structure, allowing it to mimic the activity of green fluorescent protein (GFP). This breakthrough could lead to the development of new DNA-based fluorescent tags for rapid-diagnostic tests and various scientific applications.
Monasterio Ocares recognized for his research on oral tissue regeneration and intestinal disorders' impact on oral homeostasis. He receives funding to continue studying mechanisms of initiation and resolution of intestinal disorders in the mouth.
Domenick Zero, an Indiana University professor, received the William H. Bowen Research in Dental Caries Award for his groundbreaking research on caries prevention and early detection. His work has improved oral health through innovative methods and tools, shifting focus from invasive treatment to tooth preservation.
A new analysis found that expanding Medicaid eligibility to more people improved patient outcomes, prevention measures, and screening access. The study suggests that increasing health insurance coverage results in better health outcomes for those with heart disease.
The study analyzed data from 15 hospitals nationwide and found that nearly half of patients with symptomatic severe AS received transcatheter aortic valve replacement, while about 36% did not receive any treatment. The program aims to address healthcare disparities in AS care by identifying best practices for treating the disease.
A post-hoc analysis of the ASPREE trial found that low-dose aspirin was associated with a 20% increased incidence of anemia and decline in ferritin levels in healthy older adults. The study recommends periodic monitoring of hemoglobin for patients taking aspirin.
Scientists have discovered a rare type of white dwarf pulsar, shedding light on stellar evolution and the origin of strong magnetic fields. The newly detected pulsar, J1912-4410, has a size similar to Earth but a mass at least as large as the Sun.
A study by Chinese researchers found that financial reports produced during fiscal years mismatched with annual business activity may be less reliable due to rigid accounting regulations. This can result in higher abnormal accruals, lower analyst forecast accuracy, and longer audit reporting delays for affected companies.
A new study published in Aging-US has identified the p53-p16/RB-E2F-DREAM complex as a critical regulator of cellular senescence. The researchers found that this complex represses multiple target genes involved in cell cycle regulation, DNA repair, and chromatin structure, leading to the stability of the senescent arrest.
The FDA has issued a Biomarker Letter of Support for four novel biomarkers identifying drug-induced pancreatic injury. These microRNAs will enhance the detection of acute drug-induced pancreatic injury (DIPI) in phase 1 clinical trials, improving safety and accuracy.
A Dartmouth-led project has updated the Know Your Chances website to include smoking status as a major risk factor for mortality estimates. The new estimates provide more accurate predictions of cancer and disease risk, with smokers facing significantly higher risks after age 40.
A new study by Children's Hospital of Philadelphia found that the quality of life and self-esteem of children with short stature are associated with coping skills and social supports, rather than their height. The researchers suggest that addressing short stature through a broader, psychosocial approach might have a more positive impac...
The American Heart Association invites researchers to compete in a data challenge to better understand how lipoprotein(a) levels impact cardiovascular disease and stroke risk. The winning project can receive a $40,000 cash prize.
Researchers show that a single virus binds to a single receptor, opening the door for efficient infection. ACE2 receptors are present singly in the membrane, contradicting previous hypotheses about multiple receptor binding.
A new study from the Stowers Institute for Medical Research reveals the placenta's polyploid cells play a vital role in supporting healthy embryonic development. The modified cell cycle controlling polyploidy is governed by the regulatory gene Myc, which supports DNA replication and prevents premature cellular aging.
Researchers found GRB 221009A's jet exhibited a narrow core with wide sloping wings, differing from standard jets. This unique structure may explain the event's extreme energy release and prolonged visibility.
A new working group of the Global Research Council aims to map existing funding mechanisms for global research collaboration. The group will assess opportunities for multilateral engagement and figure out how to implement them, despite legal barriers that prevent public resources from crossing national borders.
Daniel Herwartz receives 2 million euros funding from ERC Consolidator Grant for his project KinO, which explores temperature fluctuations associated with mass extinction and improves temperature reconstructions of ancient ocean temperatures.
The Global Research Council has ratified a charter of principles to promote equitable and diverse research practices. The document aims to establish common standards for assessing the quality of science produced, facilitating international collaborations and recognizing the value of different research activities.
Experts at the Global Research Council's annual meeting emphasize the need for equal opportunities and local context-specific challenges to address climate change impacts. The assessment highlights the importance of global research collaboration, tailored solutions, and partnerships between countries to mitigate and adapt to climate ch...
Funding agencies emphasized the need for reciprocal collaborations, equal access to research data, and clear intellectual property standards. The discussion aimed to promote responsible internationalization and address concerns about politics and security issues among countries.
Researchers have identified 16 genes associated with an increased risk of Spontaneous Coronary Artery Dissection (SCAD), a type of heart attack primarily affecting young to middle-aged women. The study also found that patients with SCAD have some genetic protection from the risk of conventional coronary artery disease.
Researchers have discovered the formation and decay process of solvated dielectrons for the first time, using ammonia droplets containing a sodium atom. The process involves one electron migrating to solvent molecules while the other is ejected, with potential applications in reducing agents and chemical reactions.
Two researchers will receive $1 million each for their five-year studies on new medication-based approaches to repair damaged aortas, as well as the effects of exercise on healing heart muscle and brain tissue after a heart attack or stroke. The American Heart Association's Merit Award supports innovative research with high impact.
A nationwide study of nearly 10,000 adults identifies 12 hallmarks of long COVID, including debilitating fatigue, loss of smell or taste, and gastrointestinal symptoms. The findings provide a new scoring system for clinicians to define and investigate treatments for patients with long COVID.
The CALET team, including researchers from Waseda University, found that cosmic ray helium particles follow a Double Broken Power Law, indicating spectral hardening and softening in high-energy ranges. This deviation from expected power-law distribution suggests unique sources or mechanisms accelerating and propagating helium nuclei.
A nationwide VR research project is working to create diverse groups of participants to reflect real-world social dynamics. The Virtual Experience Research Accelerator (VERA) aims to provide researchers with access to large, reliable, and diverse groups for various VR research projects.
A new study found that neurons in a key brain region have different functions based on their genetic identity, which could lead to better understanding of the brain's computational flexibility and memory capacity. The diversity of neurons in the CA1 region of the hippocampus was previously unknown and is crucial for memory development.
A study by WVU researchers highlights the need for improved mental health programs for first responders, citing increased stress and stigma. The study recommends linking responders with culturally competent clinicians, establishing centralized organizations, and expanding research efforts to address these issues.
The SLU Institute for Healing Justice and Equity has launched a new podcast called Critical Futures, which explores alternative futures and anti-racist health policies. The first episode features discussions on reimagining community partnerships and addressing disparities in Black maternal health.
A new scientific statement co-authored by the American Heart Association recommends teaching CPR to school-aged children as early as age 4, with layers of skill-building throughout childhood. This approach aims to educate generations on responding to cardiac arrest and increasing survival rates globally.
Researchers developed a novel combination therapy that eradicates tumors in select patients, with prolonged survival rates. The therapy has shown promise in treating glioblastoma, a notoriously difficult-to-treat primary brain cancer.
A new study found that coastal light pollution causes corals to spawn one to three days closer to the full moon, reducing the likelihood of fertilized eggs surviving and producing new adult corals. This disrupts the natural spawning cycle, which is critical for reef recovery after mass bleaching events.
The statement highlights enormous inequities in stroke care, leading to significant gaps in functional outcomes for historically disenfranchised groups. Upstream interventions, such as policy changes and place-based initiatives, are crucial to address these disparities.
Researchers at the University of Illinois have developed a new procedure, SCRIBE, that enables precise printing of microdevices into existing materials. The technique uses multiphoton lithography to selectively modify regions of the material's interior and manufacture custom small-scale optical devices.
Anzela Niraula won the 2023 Endocrine Images Art Competition with her image of microglia mandala, highlighting its significance in endocrine research and obesity pathogenesis. The prize includes complimentary registration to ENDO 2023 or 2024.
Researchers found that immune-modulating cells may slow the expansion of bulges in the aorta by creating a less-inflammatory environment. A second study discovered evidence that a COVID-19 infection promotes the enlargement of abdominal aortic aneurysms, which are extremely dangerous and potentially fatal if they rupture.
West Virginia University is leading a $20 million project to elevate neuroscience research, diversify the workforce, and enhance education. The initiative aims to study synaptic plasticity, expand data science education, and promote participation from underrepresented groups.
Research highlights unique effects of Asian American subgroups on heart disease and Type 2 diabetes risk. Variations in cardiovascular risk among Asian Americans indicate the need for individual subgroup data to better understand health risks.
Dr Germain Honvo, a young investigator, receives the prestigious award for his international contributions to osteoarthritis research and publications on guideline development. He is recognized as a future thought leader in the musculoskeletal field.