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Journal of Dental Research to publish special issue on aging and oral health

The Journal of Dental Research (JDR) has published a special issue on aging and oral health, featuring research on biological mechanisms underlying age-related conditions such as cognitive decline. The issue aims to improve oral health care in older populations, promoting general health and well-being.

Study identifies genetic mutations that contribute to adult epilepsy

Researchers have identified 11 somatic mutations in the RAS/MAPK pathway that contribute to treatment-resistant adult epilepsy, suggesting the potential for repurposed anti-cancer agents as new treatments. This study provides insight into the genetic mechanisms underlying this form of epilepsy and opens up new avenues for targeted ther...

SourceMass General Brigham·JournalJournal of the American Medical Association·TypeCase study·DateMay 1, 2023

U.S. adults who felt discrimination at work faced increased risk of high blood pressure

A new study published in the Journal of the American Heart Association found that U.S. adults who experienced workplace discrimination were more likely to develop high blood pressure. The research, which analyzed data from over 1,200 adults, suggests that work-related stress due to discrimination may be an emerging risk factor for card...

SourceAmerican Heart Association·JournalJournal of the American Heart Association·DateApr 26, 2023

Pet rabbits need freedom to exercise, study finds

A new study finds that pet rabbits require daily freedom to exercise outside their home enclosure, even in larger hutches with access to an exercise area. The research highlights the importance of allowing pairs of rabbits to move freely throughout the day.

SourceUniversity of Bristol·JournalApplied Animal Behaviour Science·TypeObservational study·DateApr 25, 2023

Novel immunotherapy delivery approach safe and beneficial for some melanoma patients with leptomeningeal disease

Researchers at the University of Texas M. D. Anderson Cancer Center have developed a novel approach to administer intrathecal and intravenous immunotherapy to treat leptomeningeal disease (LMD) in melanoma patients, showing promising results in improving survival rates and quality of life for some patients.

ENGOT-EN6-NSGO/GOG-3031/RUBY trial results: The new standard of care in advanced/recurrent endometrial cancer

The ENGOT-EN6-NSGO/GOG-3031/RUBY trial reveals significant improvements in progression-free survival and overall survival for patients with primary advanced or recurrent endometrial cancer when treated with dostarlimab in combination with standard of care carboplatin/paclitaxel. The new treatment regimen offers a substantial increase i...

SourceThe GOG Foundation Inc·TypeRandomized controlled/clinical trial·DateMar 27, 2023

The GOG Foundation, Inc. (GOG) announced positive results from an investigator-initiated phase II trial, sponsored by the GOG, investigating the combination of ribociclib and letrozole in patients with recurrent low-grade serous ovarian cancer (LGSOC) (GO

A phase II trial investigating the combination of ribociclib and letrozole showed a response rate of 23%, progression-free survival of 19.1 months, and duration of response of 19.1 months in patients with recurrent low-grade serous ovarian cancer.

SourceThe GOG Foundation Inc·TypeRandomized controlled/clinical trial·DateMar 25, 2023

Dual immunotherapy plus chemotherapy before surgery improves patient outcomes in operable lung cancer

A Phase II trial led by researchers from the University of Texas MD Anderson Cancer Center demonstrated that adding ipilimumab to a neoadjuvant combination of nivolumab plus platinum-based chemotherapy resulted in a major pathologic response in half of all treated patients with early-stage non-small cell lung cancer. The treatment also...

Tak W. Mak, PhD, FAACR, selected for 2023 Pezcoller Foundation-AACR International Award for Extraordinary Achievement in Cancer Research

Dr. Tak W. Mak is being recognized for his groundbreaking work on cancer immunology, including the cloning of the human T-cell receptor beta chain and development of CAR T-cell technology. His research has led to significant advances in understanding immune responses and has paved the way for the development of new cancer therapies.

Too many babies are still dying from serious intestinal disease, as improvements slow and disparities persist

A recent study found that Black infants in the US were disproportionately affected by necrotizing enterocolitis, with higher mortality rates compared to White infants. Despite overall improvements in NEC-related deaths between 1999 and 2020, racial disparities persisted.

SourceNecrotizing Enterocolitis (NEC) Society·JournalJAMA Network Open·TypeData/statistical analysis·DateMar 3, 2023

New study shows how machine learning can improve care for people with Rett syndrome

A new study published in PLOS One demonstrates the potential of machine learning and artificial intelligence to aid in the development of new treatments for Rett syndrome. The researchers used a wearable electronic chest patch to monitor cardiac activity and movement, and developed an algorithm that identified patterns specific to seve...

SourceEmory Health Sciences·JournalPLOS ONE·TypeObservational study·DateMar 1, 2023

The Texas Heart Institute delivers a new first in heart failure treatment using cell therapy

A new cell therapy has demonstrated significant benefits in improving the heart's pumping ability and reducing the risk of cardiovascular death, heart attack, or stroke in patients with chronic heart failure. The therapy, using mesenchymal precursor cells (MPCs), also showed a strong signal in reducing inflammation and improving microv...

SourceTexas Heart Institute·JournalJournal of the American College of Cardiology·TypeRandomized controlled/clinical trial·DateFeb 27, 2023

Discovery suggests new way to prevent common causes of vision loss

UVA scientists have discovered a new contributor to abnormal blood vessel growth in the eye, which could lead to new treatments for macular degeneration and other vision loss conditions. The discovery identifies a key protein that determines VEGF levels, blocking it has reduced VEGF levels significantly without unwanted side effects.

SourceUniversity of Virginia Health System·JournalSignal Transduction and Targeted Therapy·DateFeb 24, 2023

Correspondence shows troubling interactions between US officials and the alcohol industry

Researchers found extensive interaction between US officials and the alcohol industry, including sharing scientific research and policy implications. The study suggests a significant influence of industry on public health science, threatening the integrity of NIAAA's funding.

SourceJournal of Studies on Alcohol and Drugs·JournalJournal of Studies on Alcohol and Drugs·TypeContent analysis·DateFeb 20, 2023

Single dose of common antibiotic reduces mothers’ risk of death during childbirth, study finds

A single dose of azithromycin has been shown to decrease sepsis and death by half in women in labor, making it an important tool for keeping mothers safe before, during, and after delivery. The antibiotic was found to be beneficial for vaginal childbirth as well, reducing mortality rates and the risk of developing sepsis.

SourceUniversity of Virginia Health System·JournalNew England Journal of Medicine·DateFeb 9, 2023

A severe begomovirus-satellite DNA disease complex in Texas lower Rio Grande valley okra fields and its potential threat to cotton production: New “focus on cotton” webcast

A severe begomovirus-satellite DNA disease complex has been detected in okra fields in the lower Rio Grande Valley area of Texas, posing a significant threat to cotton production. The complex involves the exotic cotton leaf curl Gezira virus and its associated satellite DNA molecules.