Articles tagged with Dementia
Researchers have discovered that the blood vessels at the back of the eye can show early signs of dementia, including narrower arterioles and thinner retinal nerve fibre layers. This finding offers new hope for early detection and treatment of Alzheimer's disease and related dementias.
A meta-analysis of randomized clinical trials found that glucagon-like peptide-1 receptor agonists (GLP-1RAs) were associated with a statistically significant reduction in all-cause dementia. Cardioprotective glucose-lowering therapies, however, did not show an overall reduction in dementia risk.
Research reveals that GLP-1RAs and SGLT2i medications significantly reduce the risk of Alzheimer's disease and related dementias in people with type 2 diabetes. No significant difference was found between these two treatments.
A new study by the University of Turku found that up to one in six Parkinson's disease diagnoses are later corrected, with most changes occurring within two years. The study highlights the challenges of distinguishing Parkinson's disease from other similar disorders and emphasizes the need for improved diagnostic processes and training.
A recent study published in Nature reveals a causal connection between the shingles vaccine and reduced risk of dementia. The analysis of data from a regression discontinuity design found a 20% reduction in dementia diagnosis risk among vaccinated individuals born on or after September 2, 1933.
A new simulation of brain metabolism has revealed potential targets for future dementia treatments, according to a study published in Frontiers in Science. The model, available on the Open Brain Platform, could help scientists accelerate research into interventions promoting healthy brain aging.
A new study published in PLOS Digital Health found that older drivers with GPS navigation systems tend to drive more frequently, suggesting these tools help maintain driving mobility. The research reveals that using GPS can alleviate spatial orientation difficulties and support older adults' independence on the roads.
Mass General Brigham researchers have identified 17 modifiable risk factors shared by stroke, dementia, and late-life depression. Modifying any one of these risk factors can reduce the risk of all three conditions, providing an opportunity to simultaneously reduce the burden of age-related brain diseases.
A new study by UCL researchers found that people with visual Alzheimer's disease have a unique distribution of proteins and markers in their brain, leading to symptoms such as reading difficulties. In contrast, those with memory-led Alzheimer's disease have different protein patterns, resulting in symptoms like memory loss.
A UC Irvine study found that machine learning algorithms using electronic health records can predict two-year dementia risk among American Indian/Alaska Native adults. The researchers identified novel predictors of all-cause dementia, including health service utilization.
A new study published in Nature found that the shingles vaccine may lower dementia risk by 20%, with researchers analyzing health records of over 280,000 older adults in Wales. The vaccine was shown to reduce the occurrence of shingles by 37% and is considered a promising preventive intervention for dementia.
People with low LDL-C levels have a lower risk of dementia, including Alzheimer’s disease related dementia. Statin use further reduces dementia risk in those with low LDL-C levels.
A University of Minnesota Medical School study identified a key heart marker predicting ischemic stroke and dementia, which could lead to improved patient outcomes. The left atrium's ability to stretch was found to be the most accurate predictor.
Researchers in New Zealand are shedding light on the prevalence of dementia in multicultural communities, revealing up to half of those affected are unaware they have the condition. Early diagnosis can be life-changing, providing access to social support and improving quality of life for both individuals and caregivers.
A new Electronic Frailty Index 2 (eFI2) system will improve the accuracy of identifying older people's frailty by integrating data on 36 health problems. This will enable GPs to provide personalized treatments to prevent costly loss of independence and falls in older age.
Researchers developed a blood test that accurately diagnoses Alzheimer's disease and measures its progression. The test correlates with the amount of tau aggregates in the brain, distinguishing between early- and late-stage diseases.
Researchers at UCalgary have discovered a protein called CD2AP that may hold the key to reducing Alzheimer's disease risk. Levels of this protein are lower in patients with AD, and its absence affects memory function, particularly in males. The study suggests a sex-dependent link between vascular system health and brain function.
Research shows that atrial fibrillation (AF) is linked to a higher risk of dementia, with a 21% increased risk at any age and a 36% increased risk for early-onset dementia. The association was strongest in younger adults and lost statistical significance in older adults over 70.
Researchers develop a powerful model to study TDP-43 pathology, which accumulates in the cytoplasm and depletes from the nucleus, leading to neuronal death. The 'seeded' protein aggregates recapitulate key features of ALS and frontotemporal dementia.
A UniSA-led study is trialing medication safety rounds in aged care homes to identify and address potential problems with medication use. The project aims to reduce medication-induced harm and improve residents' health and wellbeing through pharmacist-led safety rounds, adapting an existing palliative care need rounds model.
A new study from the University of Bath argues that digital technology and AI can help employees with dementia continue in employment. The research suggests that simple adjustments to the working environment and the use of AI can alleviate many problems faced by those with dementia, such as finding words and organizing text.
A recent expert review highlights the strong link between hypertension and atrial fibrillation, which can lead to thousands of strokes. Controlling high blood pressure could significantly reduce the likelihood of developing atrial fibrillation.
A study published in Neurology found that people living in disadvantaged neighborhoods may be more likely to develop dementia. Researchers analyzed data from four communities in Chicago and found that those in the most disadvantageous tracts were over twice as likely to develop dementia as those in the least disadvantageous.
Adults with ADHD have higher levels of brain iron and neurofilaments, associated with increased risk of dementia. The study provides first evidence for a neurological mechanism possibly involved in the link between ADHD and dementia.
A new open-source model of brain metabolism has shown how altering key chemicals can restore aged cells to their youthful activity and resilience. The detailed simulation provides a glimpse into the impact of aging on brain metabolism and highlights potential drug targets.
The study found that the 'About Me' Care Card helps clinicians identify patient concerns earlier, creating personalized care conversations. However, some patients with advanced cognitive challenges required assistance, highlighting the need for further development and refinement of the tool.
A study confirms plasma p-tau217 as a blood-based biomarker for early Alzheimer's detection in Asian populations. Higher levels correlate with faster cognitive decline, suggesting its potential role as both diagnostic and predictor tool.
Researchers at WashU Medicine have found that rejuvenating the network of vessels outside the brain can improve memory in old mice. The study lays the groundwork for developing therapies to overcome the challenges faced by conventional medications, which struggle to reach the brain due to the blood-brain barrier.
A study of 733 older female participants found that those with increasing sleepiness had double the risk of stable sleepers. Poor sleep quality in midlife and delayed dream phase are also linked to a higher risk of dementia. The study adds to recent research on the relationship between sleep patterns and dementia.
A recent study published by the American Academy of Neurology found that increased daytime sleepiness in older women is associated with a double risk of developing dementia. The study tracked 733 female participants over five years and observed significant changes in sleep patterns, including declining nighttime sleep and increasing sl...
A clinical trial shows that removing amyloid plaques from the brain can delay Alzheimer's symptoms, supporting the amyloid hypothesis. The treatment reduced the risk of developing dementia in people destined to develop early-onset Alzheimer's disease.
A recent study by the University of Eastern Finland reveals that linguistic barriers, lack of digital skills, and cultural differences hinder older immigrants' access to social and medical services. Family members and communities play a crucial role in facilitating access, but NGOs require state support to overcome resource limitations.
A new stem cell therapy trial at UTHealth Houston aims to reduce neuroinflammation in patients with presymptomatic Alzheimer's disease. The study, which is sponsored by Weston Brain Institute, will enroll 12 patients and use PET imaging to determine whether stem cells reduce brain inflammation before symptoms develop.
Researchers developed a portable system using AI to spot cognitive impairment by measuring subtle differences in motor function. The device accurately identified 83% of participants with mild cognitive impairment (MCI), offering potential for early intervention and improved outcomes.
A new study by NYU researchers found that adults living with HIV in Malawi are more than twice as likely to also have dementia compared to those without HIV. The study sheds light on the significant burden of dementia among people living with HIV in resource-poor settings.
The American Heart Association emphasizes the importance of brain health, citing a growing burden of dementia and neurological conditions worldwide. By adopting healthy behaviors and addressing modifiable risk factors, individuals can improve their cognitive function and reduce the risk of age-related decline.
Researchers have revamped a symptom assessment instrument to address pain, anxiety, and other symptoms of nursing home residents who are cognitively impaired. The new tool reliably captures physical and emotional distress, well-being, and end-of-life symptoms, providing guidance for expanding palliative care services in nursing homes.
A new study analyzing global data from 1990 to 2021 found significant cross-country disparities in Alzheimer's disease and other dementias, with approximately two-thirds of individuals living in low- and middle-income countries. The study highlights the need for targeted prevention and control strategies in different countries.
Researchers have discovered a blood test that can identify patients with a sleep disorder who are most likely to develop Dementia with Lewy Bodies. The blood test analyzes two proteins in the blood associated with Alzheimer's disease and predicted dementia risk in almost 90% of patients, four years before symptoms appeared.
A meta-analysis from the University of Georgia's College of Public Health found that factors like air pollution and access to green spaces can significantly raise or lower dementia risk. Living near major roadways was associated with a 10% higher risk, while exposure to fine particulate matter increased risk by 9%.
A new Cochrane review has found evidence that music-based therapy may benefit people living with dementia, particularly by improving symptoms of depression. The review suggests that music therapy probably improves depressive symptoms and may improve overall behavioural problems by the end of treatment.
A new study led by researchers at UCL has found that online brain speed tests can provide valuable insights into cognitive function and potentially shed light on dementia development. The tests, which measure reaction times, were designed to be easy and convenient for women in their 40s and older to participate from home.
Researchers at USC Stem Cell discovered a gene called KCTD20 that suppresses glutamate toxicity, leading to enhanced tau protein clearance. This approach offers a promising therapeutic strategy for patients with tau-related neurodegenerative diseases, including Alzheimer's disease.
A large prospective study found that long-term use of non-steroidal anti-inflammatory (NSAID) medications may help prevent dementia due to their anti-inflammatory effects. The study showed a 12% reduced risk of developing dementia among participants who used NSAIDs for an extended period.
A study of nearly 900 postmenopausal women found an association between perimenopausal symptom burden and later cognitive function and behavioral impairment. Women with higher menopausal symptom burdens were more likely to experience poorer cognitive function and mild behavioral impairments, both markers of dementia.
Researchers have discovered alarming levels of microplastics in human brain tissue, with concentrations 3-5 times higher in individuals with dementia diagnoses. The study highlights the need for large-scale human studies to determine dose-response relationships between microplastic exposure and chronic health outcomes.
A new study has found that widely used consumer-grade digital devices like smartphones and smartwatches can be effective in assessing cognitive health. This allows for early education and detection of cognitive changes, enabling individuals to enact lifestyle modifications and slow or prevent decline.
A unique case study reveals an unexpected discrepancy between Alzheimer's pathology and cognitive function in a woman with Down syndrome. The study highlights the need to expand inclusion criteria for therapeutic drug trials and uncover genetic or lifestyle factors that contribute to cognitive preservation.
The project aims to uncover mechanisms bridging MCI and CVD, developing an integrated approach to promote resilience and improve overall health in the ageing population. It will use real-world data, AI, and clinical variables to enable risk stratification and personalised treatment.
A 30-year study analyzing Catholic nuns' aging patterns has clarified key factors influencing dementia risk and protection. The research found that early-life linguistic ability and grammatical complexity correlated with a lower risk of impairment in later life.
A team of scientists at Indiana University School of Medicine has identified a potential link between retinal changes and Alzheimer's disease. The study found that the APOE4 gene variant impairs retinal function in mice, suggesting a direct link to visual processing deficits associated with Alzheimer's disease.
A study by Washington University in St. Louis researchers has found a critical role for the physical interfaces of amyloid beta peptides in determining their chemical dynamics, leading to neurodegeneration. The research identified small molecules capable of breaking the toxic feedback loop, providing evidence that proper nutrition may ...
A new observational study suggests that antidepressants can accelerate cognitive decline in people with dementia, while certain medications appear to be less harmful. Researchers analyzed data from 18,740 patients and found that selective serotonin reuptake inhibitors (SSRIs) were associated with the fastest cognitive decline.
A new University of Cincinnati trial is comparing two types of omega-3 supplements, LPC-DHA and TAG-DHA, to slow or prevent dementia progression in elderly adults. Researchers aim to investigate whether LPC-DHA supplementation increases CSF DHA levels and improves cognitive function.
Researchers from Cleveland Clinic’s Genome Center linked human herpesviruses to Alzheimer's disease via transposable elements. They identified TEs activated in HSV-1 infected brains and found that commercially available drugs can reverse this pathway.
A new study found that people from minority ethnic groups are more likely to report non-cognitive symptoms, such as pain and dizziness, before receiving a dementia diagnosis. This can lead to delays in diagnosis and impact health inequalities. The research aims to improve culturally fair recognition of possible dementia in primary care.
A new study found that engaging in as little as 35 minutes of moderate to vigorous physical activity per week significantly lowers the risk of developing dementia. Even frail older adults can benefit from low-dose exercise, with the risk decreasing by up to 69%.
Researchers at New Jersey Institute of Technology are working on assistive technology that allows people with mild dementia to customize tools and objects to provide assistance. The project aims to explore the use of smart objects as assistive technologies to support individuals in their daily lives.
Only about 1 in 5 older Americans have undergone cognitive screening in the past year, highlighting a persistent barrier to diagnosis and treatment. Researchers emphasize the importance of early conversations about cognitive health to prevent progression and improve outcomes.
A new study published in Annals of Neurology found that lower concentrations of vitamin B12 in healthy, older adults led to signs of neurological and cognitive deficiency. These individuals showed slower processing speeds, brain lesions, and delayed responses to visual stimuli compared to those with higher B12 levels.