Articles tagged with Memory Disorders
A team led by Li-Huei Tsai has pinpointed the exact gene responsible for reversing Alzheimer's-like symptoms in mice. The researchers found that drugs targeting HDAC2 reverse cognitive function and boost memory formation, offering new hope for treating neurodegenerative diseases.
Research published in Neurology shows that Alzheimer's patients who develop delirium experience rapid cognitive decline, with a rate three times faster than those without. The study suggests that preventing delirium may improve or delay memory problems.
Research reveals that people with emerging symptoms of Alzheimer's disease are less efficient at remembering high-value information. Clinicians may be able to train them to improve their memory by teaching strategic and selective encoding techniques.
A study in PLOS Biology found that the intermediate hippocampus plays a critical role in translating rapid place learning into behavior. The researchers used a water maze experiment to test rats and found that disabling a specific region of the hippocampus impaired their ability to return to a platform.
Researchers identify specific brain regions affected by each disease, suggesting a common disease process among all forms of neurodegeneration. The discovery could lead to earlier diagnoses and novel treatment-monitoring strategies.
A new study by scientists from Imperial College London and University of Oxford found that young adults with a genetic variant associated with Alzheimer's Disease exhibit changes in brain activity decades before any symptoms appear. The researchers used functional Magnetic Resonance Imaging (fMRI) to compare the brains of healthy young...
Researchers studied autobiographical memory in semantic dementia patients according to disease progression, finding early-stage patients could recall recent and lasting memories. As dementia evolves, mechanisms behind autobiographical memory impairment result from storage deficits and faulty retrieval strategies.
Researchers at the University of Texas at Austin have discovered a method to manipulate memories of fear by timing the extinction process. By targeting the labile state of fear memories after retrieval, they found that rats exhibited reduced fear responses and smaller chances of spontaneous memory resurfacing. This breakthrough could l...
A study by UC Davis M.I.N.D. Institute found that children with ADHD exhibit variable response times during working memory tasks, even when accuracy is similar to typically developing peers. Higher levels of hyperactivity and impulsivity are associated with slower reaction times.
A new study led by the University of Leicester has found that people with mild cognitive impairment (MCI) have a lower risk of progressing to dementia than previously thought. The research suggests that only 5% of people with MCI develop dementia, contradicting previous estimates of up to 15% per year.
A recent study by UC Irvine researchers found that brief experiences activate neurons and genes associated with memory as effectively as repetitive activities. This discovery can help scientists design better therapies for diseases such as Alzheimer's, which impair the ability to form memories.
Researchers develop a novel approach to treating PTSD by selectively disrupting traumatic memories with a cortisol-blocking drug. The treatment's effectiveness is linked to the intensity of the initial trauma and can be administered shortly before recalling the memory.
Researchers found that DBS in either brain target effectively treated motor symptoms, but produced unique effects on mood and mental sharpness. The discovery may impact the selection of DBS patients, especially those with pre-existing memory or cognitive disabilities.
Researchers at Wellcome Trust Centre for Neuroimaging discovered that brain activity can be used to predict spatial memories and locations. The study's findings challenge current scientific thinking and offer insights into how memories are encoded across neurons.
A team of Dutch researchers successfully reduced the fear response in human volunteers using beta-blocker propranolol. The treatment weakened fear memories, allowing them to be erased from long-term memory. This breakthrough has implications for treating anxiety disorders and offers a new approach to intervention.
Researchers at Boston University School of Medicine found that people whose parents have Alzheimer's disease or dementia perform worse on formal memory testing. The study also identified a strong genetic link between ApoE ε4 gene and the transmission of Alzheimer's disease risk between generations.
A recent study found that individuals with parents diagnosed with Alzheimer's disease or dementia may experience low verbal and visual memory performances in middle age. The study suggests that the ApoEe4 gene plays a role in the transmission of Alzheimer's risk between generations.
A study of 197 people with mild cognitive impairment found that engaging in mental activities like reading, crafting, and playing games reduced the risk of memory loss by 30-50% compared to those who didn't participate. Participants who watched TV for less than 7 hours a day were also 50% less likely to develop memory loss.
Researchers at VIB confirm GPR3 protein's role in reducing amyloid plaques, a hallmark of Alzheimer's disease. The discovery paves the way for developing a new medicine to combat the disease and preserve brain cells.
Researchers found a statistically significant inverse relationship between A1C levels and cognitive test scores in people with type 2 diabetes. The study suggests that poorer blood glucose control is strongly associated with poorer memory function.
Researchers found that BDNF treatment can prevent or reverse memory loss, cognitive impairment, and brain cell degeneration in animal models of Alzheimer's disease. The study suggests a potential novel approach to treating the disease by slowing its progression.
A new study published by Elsevier found that nearly half of patients with heart failure have problems with memory and other aspects of cognitive functioning. Memory problems, especially short-term memory, were the most common type of cognitive deficit in these patients.
A new study published in Neurology, a journal of the American Academy of Neurology, found that higher education levels do not slow down the rate of memory loss. Despite initial improvements in memory and thinking skills with more education, these advantages did not translate to slower decline over time.
Researchers found that insulin shields neurons from toxic proteins in Alzheimer's disease, preserving memory-forming synapses. This discovery suggests a novel approach to treating the devastating disease by increasing insulin sensitivity in the brain.
A drug used to treat stroke patients may also improve learning and memory and reduce the risk of Alzheimer's disease, according to a new study. The active form of the parent drug Fasudil improved spatial learning and working memory in middle-aged rats.
A new study by UNC researchers found that postmenopausal women with hypoactive sexual desire disorder (HSDD) report poorer health status, worse quality of life, and physical symptoms such as back pain and memory problems compared to those without the disorder.
A study published in Cortex found that reducing attentional resources enhances memory accuracy in confabulating patients. By dividing their attention between tasks, these patients showed significantly reduced false-memory levels.
The DREAM gene plays a key role in regulating pain perception, learning, and memory. Mice without the gene show reduced sensitivity to pain but improved memory, suggesting a link between calcium regulation and brain function.
New studies have found a link between hormone therapy and brain shrinkage in postmenopausal women, with smaller brain volumes in areas involved in thinking and memory skills. However, hormone therapy was not linked to an increase in small vascular lesions or 'silent strokes' that are often the first sign of cerebrovascular disease.
Two new studies link hormone therapy to reduced brain volume in critical memory areas, accelerating loss of cognitive function in postmenopausal women. Researchers found no correlation between hormone therapy and increased brain lesions, contradicting previous hypotheses.
Researchers found MRI brain scans accurately diagnose Alzheimer's disease even before symptoms interfere with daily function. The study suggests incorporating MRIs into the assessment of patients with memory problems can standardize and improve early diagnosis.
Researchers found that older adults remember fewer negative events than younger counterparts due to differences in brain activity. The study suggests that seniors' brains use thinking rather than feeling processes to store emotional memories, which may improve understanding of mental health issues like depression and anxiety.
Decreasing FKBP12 gene activity in mice disrupted neuron-to-neuron communication, leading to enhanced long-term potentiation and repetitive behaviors. The study provides insight into the molecular mechanisms underlying neurodevelopmental disorders such as autism spectrum disorder and obsessive-compulsive disease.
A study reveals a link between dysregulation of a common signaling pathway and repetitive behaviors associated with multiple neurological disorders. Deletion of FK506-binding protein is associated with enhanced mTOR signaling, synaptic plasticity, and memory deficits.
Researchers used fMRI to find that patients with stress-related psychiatric disorders have abnormal brain activation in the prefrontal cortex and hippocampus, affecting memory suppression. This can lead to poor memory and increased anxiety due to lingering traumatic memories.
A large clinical trial found that ginkgo biloba has no effect on the onset of dementia or development of Alzheimer's disease. The study tested 120 milligrams of ginkgo twice daily versus placebo in 3,069 participants and showed that it had no impact on cognitive decline or mortality.
Researchers at Northwestern University's Feinberg School of Medicine discovered that super-aged brains have a lower number of fiber-like tangles, which accumulate inside brain cells and are thought to kill them. This finding suggests that individuals with fewer tangles perform better cognitively.
A Baylor College of Medicine neuroscientist has identified a single molecule that can affect memory, with findings showing that reducing activity of a key protein increases the expression of genes and proteins needed for long-lasting memories. The study also reveals that short exposure to experiences creates long-term memories.
Researchers found that valproic acid improved memory and reduced brain lesions in mice with an AD-like disease. The drug also prompted damaged nerves to start repairing themselves and improved performance in memory-related tests.
Researchers found two patients with hippocampal damage showed strikingly different patterns of memory performance, one with no deficit and the other impaired. The study suggests that subtle differences in brain pathology may be critical to understanding memory outcomes.
A study published in Neurology found that people with more education and mentally demanding occupations had significantly less brain damage from Alzheimer's disease than those with less education and less demanding jobs. Higher education was associated with a stronger brain reserve, allowing it to compensate for damage and maintain fun...
Researchers discovered specific fatty acids contributing to Alzheimer's disease progression and proposed a therapeutic strategy by inhibiting an enzyme regulating fatty acid levels. Lowering the enzyme's activity improved cognitive deficits in mouse models.
A new study suggests that people with Alzheimer's disease may have lower blood pressure because of cognitive decline. Failing memory causes forgetfulness, which can lead to a decrease in stress-related high blood pressure.
A study of 500 people aged 50-85 found a link between occasional memory lapses and smaller hippocampus volumes. Researchers discovered that these subjective memory complaints were associated with reduced brain volumes, potentially indicating early signs of cognitive decline.
A TGen-led team found a link between the brain protein KIBRA and reduced Alzheimer's disease risk in individuals with the T-allele gene. The study suggests that KIBRA may play a role in Alzheimer's disease, providing promising new targets for treatments.
Research reveals that chronic alcohol consumption alters neural systems in the brain, leading to cognitive deficits and disorders of memory and learning. Dynorphins, a key player in this process, are found to be upregulated in the prefrontal cortex and hippocampus, impairing learning and memory.
Research reveals that as we age, our brains struggle to ignore irrelevant information and process information rapidly, leading to decreased memory formation. This breakdown occurs early in visual processing and persists despite attempts to suppress extraneous information.
Researchers have discovered a new process that regulates adverse responses to bad memories by working on a tiny group of neurons inside the amygdala. By blocking or activating specific receptors, scientists can speed up or slow down traumatic responses, offering potential new treatments for panic disorders.
A small sample of adults with mild age-related memory loss showed increased brain metabolism and normalized brain function after taking Aricept for 18 months. The study suggests treating early symptoms of memory loss may protect the brain and help with mild age-related cognitive decline.
A study published in Neurology found that statin users were about half as likely to develop dementia as non-users. Researchers analyzed data from 1,674 Mexican Americans over 60 years old and found a significant association between statin use and reduced risk of cognitive decline.
Researchers found a significant association between mild memory impairment and impaired central auditory processing. Individuals with mild memory impairment showed lower scores on central auditory processing tests, indicating difficulty managing competing signals.
Researchers at Rutgers University have identified a key component of the amygdala's neural network involved in extinction, or elimination, of fear memories. Clusters of intercalated neurons inhibit amygdala outputs to brain stem structures generating fear responses, offering potential for pharmacological interventions.
A UCLA professor's analysis of over 160 studies reveals that a balanced diet rich in omega-3 fatty acids can enhance cognitive abilities, protect the brain from damage, and counteract aging. Omega-3s have been shown to improve learning and memory, fight depression and mood disorders, and even support synaptic plasticity.
A study from MIT researchers found that a dietary cocktail combining omega-3 fatty acid, uridine, and choline improves memory and learning in gerbils. The combination is being tested in Alzheimer's patients, suggesting a possible beverage-based treatment for the disease.
Researchers identify key role of endogenous opioids in alcoholism-related cognitive impairment. Innovative therapies may improve or prevent alcohol-induced memory problems in patients with alcohol dependence.
Researchers discovered that calpain inhibitors restore normal signaling between nerve cells, improving memory in APP/PS1 mice. Calpain inhibition may slow down or stop Alzheimer's disease progression by addressing impaired cognition.
Researchers from the American Heart Association report a link between low levels of high-density lipoproteins (HDL) and increased risk of memory loss and dementia. Studies found that participants with low HDL cholesterol showed a higher risk of memory decline compared to those with high HDL, particularly in late midlife.
Researchers analyzed brain activity using fMRI to identify differences in connectivity between Alzheimer's patients and healthy individuals. They found that patients had fewer functional hubs, compromising regional connections and contributing to memory loss.
Adults with type 2 diabetes who eat high-fat meals may experience immediate memory declines, but taking antioxidant vitamins with the meal can offset this effect. A study found that consuming healthy foods rich in fruits and vegetables is the best defense against cognitive decline.
Researchers at UCLA discovered that rapamycin reverses learning deficits caused by tuberous sclerosis complex (TSC), a genetic disorder also linked to autism. The study shows that the disease's impact can be reversed through biochemical changes, restoring normal brain function and memory.