Articles tagged with Psychiatry
The Pitt team discovered molecular changes in the brains of women with major depressive disorder, including reduced BDNF and GABA gene expression. These findings replicate changes seen in a mouse model, providing new insights into depression's biological mechanisms.
A comprehensive review of the first decade of gene-by-environment interaction research in psychiatry found that novel findings were more likely to be published but also more likely to be false positives. The study suggests a focus on replication is necessary to confirm accurate correlations between genes and environmental variables.
A new study investigates the paternal transmission of stress and its impact on children's mental health. Researchers found that male mice exposed to chronic stress passed those stress behaviors along to their offspring, increasing depression and anxiety-like behaviors in both males and females.
Research reveals that depression-related rumination is associated with a brain network imbalance, where the default mode network (DMN) dominates over the task-positive network (TPN). This imbalance leads to maladaptive thinking and less effective coping mechanisms, exacerbating depressive symptoms.
A new study suggests that differences in brain activity, particularly in the frontal lobe and visual areas, can predict depression relapse in formerly depressed patients. Those who ruminate and activate the frontal lobes are more likely to relapse.
Research shows antipsychotics are more effective than mood stabilisers in tackling acute mania. Haloperidol, olanzapine, and risperidone were ranked most effective antimanic drugs, with haloperidol outperforming other options.
A study published in Psychological Medicine found that psychiatrists are not regularly monitoring patients for metabolic complications associated with antipsychotic medication. The researchers reviewed over 300,000 individuals across five countries and found that only half of patients had blood pressure and triglyceride checks conducted.
A Johns Hopkins study found nearly four out of five antidepressant prescriptions are written by non-psychiatrist providers for individuals with no psychiatric diagnoses. The share of such providers increased from 30% in 1996 to 55.4% in 2007.
A Harvard study reveals that access to outpatient psychiatric care in Massachusetts is severely limited, even for those with private insurance. The researchers found that only a small percentage of facilities listed by the largest insurer offered appointments within two weeks of a simulated patient's call.
A study by Deborah Barnes found that low education, smoking, physical inactivity, depression, mid-life hypertension, diabetes, and mid-life obesity are associated with up to 51% of Alzheimer's cases worldwide. Lifestyle changes such as increasing physical activity and quitting smoking could potentially prevent some cases.
A new study suggests that a small hippocampus is more likely an effect of depression rather than a cause. Researchers found that individuals with depression declined in volume over time, but those with smaller hippocampus were not at higher risk to develop depression.
Researchers from NYU Langone Medical Center presented new research at the 2011 Alzheimer's Association International Conference. The study found that retired NFL players are more likely to experience mild cognitive impairment than expected, suggesting a possible link between repetitive head trauma and late-life cognitive disorders. Add...
New research explains how positivity bias in the brain contributes to successful aging, with increased engagement in positive emotions leading to greater emotional stability. The study suggests that focusing on the positive can help individuals age successfully.
Research found that premature infants with abnormal brain ultrasounds are at increased risk for specific psychiatric disorders. The study followed a group of premature infants until age 16 and found a relation between perinatal brain injuries and certain psychiatric disorders.
A meta-analysis of previous studies found that patients with eating disorders have an elevated rate of death, especially those with anorexia nervosa. The study also highlighted the seriousness of bulimia nervosa and disordered eating not otherwise specified, which are often overlooked due to limited published data.
A team of international researchers is re-examining the concept of abortion stigma, shifting focus from women who've had abortions to a broader context. The study aims to identify constituents, causes, and consequences of abortion stigma, with potential implications for improving access to care and better health outcomes.
A new study by the University of Leicester found that GPs struggle to identify people in the early stages of dementia, resulting in both missed cases and misidentifications. The research analyzed 15,277 patients with cognitive disorders, identifying a significant number of false positives.
A study by Brown University researchers found that certain stressful life events cause panic symptoms to increase steadily over succeeding months, rather than acutely. This challenges the common assumption that stress triggers immediate panic attacks.
Research finds one-third of pregnant women with depression have a history of eating disorders, while many others have experienced physical or sexual abuse. Mental health screenings are crucial to identify at-risk patients and provide early treatment.
Researchers have discovered how ketamine produces a fast-acting antidepressant effect, shedding light on its potential as an emergency room treatment for high-risk patients. The study's findings could lead to the development of faster-acting and longer-lasting antidepressants.
A recent study by Lynne Murray and colleagues found that postnatal depression in mothers is associated with a substantially increased risk of depression in their children until age 16. The researchers also discovered that infant attachment issues and lower child ego resilience are linked to the development of depression.
A study of over 2,900 pediatric patients found that 12% returned to the ER within six months of their initial visit, despite having an outpatient mental health provider. The majority of ER visits stemmed from behavioral problems or minor psychiatric crises.
A new study reveals that omega-3 fatty acids in fish oil can normalize behavior in mice models of bipolar disorder, reducing depressive symptoms and decreasing alcohol abuse. The researchers also found correlations between molecular changes and biomarkers, paving the way for targeted clinical studies in humans.
A new tool, REMIT, has been developed to improve the measurement of primary care depression outcomes. The tool adds a patient's subjective sense of recovery to existing measurements, showing that about one-third of patients with mild depression were not in remission, as their PHQ score would indicate.
Researchers used EEG to measure brain's response to tones, finding smaller mismatch negativity in individuals who developed schizophrenia. The test showed promise as a potential predictor of psychosis development.
Researchers at Washington University and King's College London have independently identified a DNA region on chromosome 3 associated with depression. The region contains up to 90 genes and shows genome-wide significance, suggesting that many genes may be involved in depression.
A recent survey led by McGill Psychiatry Professor Amir Raz found that one in five respondents, mostly psychiatrists, have administered or prescribed placebos. The majority of responding psychiatrists (more than 60%) believe that placebos can have therapeutic effects.
Research studies found that vulnerable individuals with genetic deletions on chromosome 22, known as velocardiofacial syndrome (VCFS), are at risk for developing schizophrenia. Progressive brain abnormalities emerge during adolescence, including deficits in the volume of temporal cortex gray matter, which predicts psychosis.
Children whose mothers are successfully treated for depression show progressive improvement in their own behaviors even a year after treatment discontinuation. The faster mothers get better, the faster and greater their children's improvements are.
Researchers at Wayne State University have found a new method to identify children with major depressive disorder (MDD), setting them apart from both healthy children and those with obsessive compulsive disorder (OCD). Cortical thickness in the brain was used as a key factor, revealing distinct differences between MDD patients and heal...
Researchers have developed a mouse model that mimics the social deficits of autism and schizophrenia, showing improved social behavior with oxytocin treatment. The study provides insights into biological factors related to social deficits and may be useful in evaluating new treatments for these disorders.
A study from Massachusetts General Hospital finds that siblings of individuals with both ADHD and emotional reactivity have a significantly greater risk of having both conditions. This suggests that heritable factors influence how we control our emotions, and that ADHD can impact emotional expression beyond classic symptoms.
A UK survey found that adults with autism were rarely aware they had the condition, with prevalence higher in males and lower educated individuals. The study suggests that changes in diagnosis methods may be responsible for recent increases in reported cases.
A new study suggests that individuals with autism have a weak mirror neuron system in their youth, but it increases with age and becomes unusually high thereafter. This delay in development may be related to increased capacity for social function or responsiveness to rehabilitative treatments.
A University of Melbourne study found that male doctors are four times more likely than female doctors to face disciplinary action for misconduct. The majority of cases involved sexual misconduct, which was responsible for 24% of all cases handled by tribunals.
Researchers analyzed data from the largest study on depression treatment, finding that even responders experience residual symptoms like insomnia and decreased concentration. The study suggests a need for more targeted antidepressant therapies to decrease depressive symptoms and understand their association with concentration.
Researchers found that a teacher-based intervention reduced PTSD symptoms in war-exposed children by 50% compared to a control group. The study suggests that this universal and cost-effective approach can enhance community preparedness for mass trauma and prevent PTSD development.
A new study published in Biological Psychiatry suggests that serotonin activity affects how people perceive intimate relationships. Healthy adults with lower serotonin levels rated couples as less intimate and romantic than those with normal serotonin activity.
Scientists have discovered how anti-depressants make new brain cells by regulating the glucocorticoid receptor, a key protein involved in stress response. This finding holds promise for developing more effective anti-depressant treatments to combat depression.
Researchers found that thiazolidinediones (TZDs) and fibrates, commonly used to treat type-2 diabetes, may help counteract nicotine and alcohol addiction by activating specific receptors in the brain. These drugs stimulate PPAR-α and PPAR-γ receptors, reducing inflammation and increasing high-density lipoprotein (HDL) levels.
Mexican migrants to the U.S. are at a higher risk of experiencing clinically significant depression and anxiety disorders compared to non-migrants. The study found that those between 18 and 25 years old have nearly four-and-one-half times greater odds of developing a depressive disorder.
Researchers found that people who experience stronger stimulating and lower sedative effects of alcohol are more likely to develop binge drinking problems. A new study published in Archives of General Psychiatry suggests that the 'double whammy' of alcohol effects predicts those who progress to severe drinking and alcohol-use disorders.
Seven GHSU investigators will present their research on schizophrenia and psychiatric disorders, including Dr. Peter Buckley's National Institutes of Mental Health-funded study on relapse prevention. Researchers also explore potential treatments for stress-induced anxiety behavior and prenatal stress-related neuropsychiatric illnesses.
A new study found that genetic variants in dopamine-related genes increased the risk of smoking initiation in adolescents, while variants in nicotinic cholinergic receptors influenced persistence in adulthood. These findings could lead to genetic testing and targeted drugs for nicotine dependence.
A new study published in Epilepsia found that children with epilepsy are at increased risk of developing behavioral and psychiatric problems. The study showed that girls were more likely to experience emotional problems, while boys had more hyperactivity/inattention issues and peer relationship problems.
Researchers found that four microRNAs (miR-22, miR-138-2, miR-148a, and miR-488) are associated with panic disorder, regulating genes related to anxiety pathways in the brain. The study suggests a coordinated involvement of multiple risk genes, implying the existence of molecular 'switches' that control gene function.
Researchers found that gut bacteria influence how the brain is wired for learning and memory, leading to anxiety-like behavior. The study also suggests that targeting the immune system and gut function could lead to new therapies for psychiatric illnesses.
A new study finds that larger hippocampal volumes are linked to recovery from post-traumatic stress disorder (PTSD), implying that the hippocampus may play a role in reversing damage caused by chronic stress. The research suggests that treatment for PTSD could be viewed as a form of brain restoration, rather than just symptom relief.
A recent study published in the Journal of the American Academy of Child and Adolescent Psychiatry found that adolescent girls exposed to heavy alcohol use during their first trimester were three times more likely to develop conduct disorder. The study examined 592 adolescents and their mothers or caretakers, utilizing data from a long...
A report from The Hastings Center finds that many children with problematic moods and behaviors receive inadequate care due to systemic and cultural pressures. Experts agree that diagnoses have unclear boundaries, leading to disagreements about treatment, but also conclude that environments contribute to problematic behaviors.
A new study found that naltrexone is effective in reducing alcohol-induced euphoria in women and individuals with the A118G polymorphism of the mu opioid receptor gene. This suggests that personalized treatment options may be possible for those with specific genetic variations.
Researchers at Wayne State University identified three potential subtypes of gamblers: emotionally vulnerable, behaviorally conditioned, and antisocial impulsive. However, their study found that subtyping did not predict treatment outcomes, with all groups showing similar recovery patterns despite varying levels of addiction severity.
A new collaborative care program has been shown to significantly improve depression, anxiety, and emotional quality of life in heart disease patients. After six and twelve weeks, participants in the program reported improved symptoms and better adherence to healthy activities compared to those receiving usual care.
The study found a global prevalence of 2.4% for bipolar spectrum disorder, with severe symptoms primarily affecting depressive episodes. Treatment needs are often unmet, especially in low-income countries where only 25.2% received mental health treatment.
As men lose their primary breadwinner roles, depression and marital conflict are likely to increase. Biological and sociological differences may also make it harder for men to care for young children.
Researchers have identified a genetic variation linked to bipolar disorder, suggesting that Piccolo contributes to the condition. The study used postmortem tissue and genome-wide association studies to find this link.
Deep brain stimulation therapy has shown promise in reducing symptoms of severe obsessive-compulsive disorder (OCD) for a small subset of patients. After years of research, Dr. Benjamin Greenberg presents the longest-term results of the technique, highlighting its potential to improve symptoms and quality of life.
A mega-analysis of brain imaging data found that individuals with bipolar disorder who took lithium had increased hippocampal and amygdala volumes compared to those not taking the medication. Lithium treatment also restored cerebral volume reductions associated with longer illness duration.
A new study by the VA Ann Arbor Healthcare System and University of Michigan Health System found that peer support programs reduce symptoms of depression better than traditional care alone. These programs, which involve patients and volunteers sharing information, were also as effective as cognitive behavioral therapy.
A study by Johns Hopkins Medicine found that civilians with noncombat injuries are more likely to be evacuated for treatment, but also more likely to return to work in war zones due to higher salaries. In contrast, soldiers are less motivated to return after such injuries, possibly due to the loss of hazardous duty pay.