Researchers use PALM microscopy technique to analyze enzyme cocktails and find specific targets for cellulase synergy. This reveals how different combinations of enzymes can generate synergistic activity, increasing saccharification efficiencies and reducing biofuel production costs.
Researchers found that kieselguhr, a common filtering material in beer production, releases arsenic into the beverage. The levels of arsenic are considered low and unlikely to cause illness, but the study highlights the need for breweries to take precautions when using this substance.
Researchers have identified four genes newly associated with severe childhood obesity and found an increased burden of rare structural variations in severely obese children. These variations can delete sections of DNA that help maintain protein receptors involved in weight regulation, promising new drug targets against obesity.
Researchers discovered that cells beyond the nose have receptors for sensing odors, raising questions about whether organs 'smell' food. The study's findings could revolutionize our understanding of how we experience flavors and aromas.
A physician-researcher from The Children's Hospital of Philadelphia will lead the first-ever pediatric Dream Team to combine genomics and immunotherapy to increase cure rates in difficult childhood cancers. The team aims to develop more precise and effective treatments based on unique genetic characteristics of each child's tumor.
A new study by Cleveland Clinic researchers reveals a connection between red meat consumption and an increased risk of heart disease. The research found that a diet high in carnitine promotes the growth of bacteria that metabolize the compound, leading to the production of TMAO, which is associated with atherosclerosis.
Scientists analyzed patent medicines from the Henry Ford Museum collection to identify potentially toxic substances like arsenic, mercury and lead. The study found that some ingredients were actually healthy and mainstays in modern dietary supplements, while others posed significant health risks.
Researchers developed a tunable process that separates human induced pluripotent stem cells (hiPSCs) based on their adhesive properties. The method allows for high-throughput separation and produces pure cultures with up to 99% hiPSC purity, enabling improvements in cell reprogramming and disease modeling.
Researchers found that combining non-steroidal anti-inflammatory drugs with cholesterol-lowering medication Lipitor can effectively prevent colorectal adenomas in mice. In contrast, the same combination was only effective when administered to mice with existing tumors.
Researchers found that women with HIV are at risk of acquiring cancer-causing forms of HPV, including types 52 and 58, which are not covered by current vaccines. Treating HIV may also protect women from HPV-related cancers.
Reducing food waste is vital to feed a global population of 9 billion by 2050. Scientists estimate that up to half of the food harvested from farmers' fields in developing countries is lost due to spoilage and pests. In developed countries, households throw away about 4 out of every 10 pounds of food produced each year.
Researchers at CSHL found that transposons increase in abundance and activity in the brains of fruit flies as they age, correlating with neurological degeneration. This 'transposon storm' may contribute to age-related brain defects in humans.
A phase 1 clinical trial found that a combination of sapacitabine and seliciclib showed anti-cancer activity in patients with incurable solid tumors and inherited BRCA mutations. The treatment demonstrated partial responses in four patients, stable disease for over a year in three others.
Researchers found that resistance training promotes the growth of white muscle, which helps regulate blood glucose levels. The study also identified potential drug targets for obesity and metabolic disease.
Scientists have developed a technology that enables microalgae to produce multiple types of renewable oils for fuels, chemicals, foods, and personal-care products within days. Solazyme's biotechnology platform unlocks the power of microalgae, producing tailored oils with optimized properties for various applications.
A recent study found that male smokers with low levels of serum bilirubin are at a higher risk of developing lung cancer and dying from the disease. The researchers analyzed data from over 435,000 people in Taiwan and found that lower bilirubin levels were associated with significantly higher rates of lung cancer incidence and mortality.
Researchers visualize retinoic acid distribution for the first time in a live zebrafish embryo, observing two opposing concentration gradients along the head-to-tail axis. This discovery confirms retinoic acid as a morphogen, essential for understanding tissue development and regenerative medicine.
A multinational study reveals that dengue is more prevalent globally than previously estimated, with 390 million infections annually, and Asia accounting for 70% of the burden.
The American Chemical Society has awarded $3,000 grants to 11 local sections to promote the use of the ACS Climate Science Toolkit in engaging diverse audiences. This initiative aims to increase understanding of global climate change among thousands of people across the country.
At the ACS meeting, scientists will discuss new discoveries related to energy and food, including sustainable sources of renewable oil. The event is expected to generate at least $16 million for the local economy.
Researchers found that mannitol improved the movement of fruit flies with Parkinson's-like symptoms by reducing misfolded protein aggregation. Further studies are needed to confirm these results in humans, but the findings suggest a possible novel therapeutic direction.
A phase I trial involving 29 patients with platinum-resistant ovarian cancer found one complete response and four partial responses to the antibody-drug conjugate DMUC5754A. The drug targets high-expression MUC16 protein in ovarian cancer cells, reducing adverse effects on healthy tissues.
Researchers used advanced amplification technology to detect abnormal DNA in blood samples from patients with gastrointestinal stromal tumors (GIST). The new blood test found secondary resistance mutations in the KIT gene, which were missed by traditional tissue analysis.
A new two-step immunotherapy approach, combining dendritic cell vaccination and adoptive T-cell therapy, showed a 75% clinical benefit in 31 ovarian cancer patients. The treatment preserved tumor cells alive and used them to manufacture personalized vaccines that taught the immune system to attack the tumor.
Researchers found that children and adults with genetic liver disorders have good chances of survival five years after a liver transplant. High survival rates also imply that liver transplantation is the best available treatment for these patients.
Rice physicists Qimiao Si and Rong Yu discovered a new electronic state in which some electrons become frozen, while others remain mobile, leading to 'bad traffic' on the path to superconductivity. This phase, known as orbital-selective Mott phase, provides clues about the fundamental origins of superconductivity.
A research team developed a new protocol for X-ray single-crystal diffraction analysis that doesn't require crystallisation of the target molecule. This method allows for the analysis of scarce marine natural products and characterises many compounds previously impossible to analyze crystallographically.
A study from Newcastle University found that vitamin D supplements improve muscle efficiency in patients with severe deficiency, leading to reduced fatigue and improved mitochondrial oxidative function. The research suggests a link between vitamin D and mitochondrial function, potentially offering a new way to boost energy levels.
Current diabetes research prioritizes treatment over prevention, with most trials focusing on drug therapies rather than preventive measures. The studies excluded older people and those under 18, limiting the applicability of findings to these groups.
Researchers found that audiences affect quails' social status, with losers losing dominance when observed, but winners retaining it regardless of audience presence. Testosterone levels were raised in both winners and losers after fights, suggesting a secondary role for the hormone.
Researchers at Texas Biomedical Institute discovered a polymer hidden within the Ebola virus that can be targeted by llama antibodies, enabling the creation of highly sensitive test kits using a single antibody. This breakthrough may revolutionize emerging viral diagnostics and offer a promising tool for detecting other deadly pathogens.
Researchers used a fly model to study wound healing, discovering eight new genes involved in the process. The study reveals that wound healing is fine-tuned and requires a balance of gene activation and inhibition to prevent complications such as ulcers or thickened cuticles.
Akilah Dulin Keita, a Brown University Assistant Professor, has received a 24-month grant from the Robert Wood Johnson Foundation to examine risk and protective factors for childhood obesity among Southeast Asians. The grant will support her research through the New Connections program, which aims to increase diversity in health research.
Researchers used MRI to measure endothelial sheer stress (ESS) in atherosclerotic plaques, identifying high-risk plaques prone to disruption. The study found that low ESS was associated with unstable plaques, highlighting the importance of hemodynamics in atherosclerosis progression.
Research highlights the significant impact of traumatic brain injury (TBI) on sexuality, including cognitive deficits, medical issues, and relationship changes. Rehabilitation strategies are crucial to address these challenges and improve sexual functioning in TBI survivors.
A new study by Duke University suggests that tougher EPA air-quality standards may make nearly two-thirds of US coal-fired power plants as expensive to run as plants powered by natural gas. The stricter regulations could spur an increased shift away from coal towards natural gas, especially if fuel prices rise significantly.
A University of Houston research team partnered with NASA and astronauts on the International Space Station to examine how spaceflight affects the immune system. They will collect blood, saliva, and urine samples from two astronauts before, during, and after a mission to monitor natural killer cells and assess viral reactivation risks.
A new tool called P3 removes small amounts of data from photos and encrypts them, allowing cloud file-sharing services to use the unencrypted portion while keeping the owner's sensitive information secure. With P3, photo owners can choose how their photos are shared, retaining rights to the complete photo and ensuring privacy.
Chemical engineers at the University of Toronto have made an accidental discovery that could lead to improved commercial polymers. The researchers found a new side product in a common polymer synthesis technique, which could reduce inconsistency and increase quality.
A new study by the University of Luxembourg found that employment and health problems are the main reasons why migrants feel unhappy in their new country. Economic factors such as unemployment and low income, as well as health issues, were found to have a significant impact on migrants' wellbeing.
Research suggests that motor skills decline gradually after the age of 64, but healthy older adults can still create accurate internal models for action. This study aims to help clinicians identify abnormal loss of function in patients by pinpointing when deficits begin.
A five-year NIH grant will support research from the University of Houston College of Education to investigate mechanisms influencing drug-related health disparities in African-Americans. The study aims to understand how environmental stressors impact a person's regulatory system, potentially leading to substance abuse.
A new MRI-guided laser treatment has been found to be safe and effective in treating recurrent glioblastoma, a type of brain tumor. The procedure uses a minimally invasive approach to destroy tumors, with nine out of ten patients showing improved response and survival rates.
A team of SFU researchers has created a sequencing of the mountain pine beetle's genome, revealing large variations among individuals. The genome data will help scientists understand how the beetle causes damage and potentially stop its spread.
Researchers at the University of East Anglia have identified a population of stem cells capable of generating new appetite-regulating neurons in the brains of young and adult rodents. This discovery could lead to a permanent intervention for obesity, potentially offering a solution that lasts beyond dieting.
A study by Prof. Panos Patatoukas of the University of California - Berkeley Haas School of Business found that aggregate accounting earnings are tied to news about expected future cash flows and discount rates, impacting stock market valuation. The research suggests that capital market participants and policymakers can extract valuabl...
Researchers grew and analysed stem cells from patients with von Willebrand disease to identify the cause of the disease in individual patients, enabling more effective treatments. The technique may also be used to treat diseases of the heart, blood and circulation, including haemophilia.
Researchers at the Lactation Biology Symposium discovered that drinking milk at an early age can change how certain genes are expressed. This epigenetic effect can have long-term implications for behavior and cell development in offspring.
Researchers at National Jewish Health discovered that alum, a common vaccine adjuvant, works by coating with host DNA, inducing T cells to interact longer with the vaccine, resulting in a stronger immune response. This breakthrough could lead to more effective vaccines and improved public health outcomes.
The study found significant differences across US counties, genders, and ethnic groups in hypertension treatment and control. Despite high prevalence of hypertension in the southeast, the region also had the highest levels of treatment.
A recent review article highlights the need for preventive measures, genetic risk factors, and new diagnostic tools to identify the effects of traumatic brain injury (TBI) in athletes and soldiers. Researchers propose large-scale trials and genome-wide association studies to characterize CTE and develop prevention strategies.
Mercyhurst University has acquired a DNA sequencer, a multi-faceted machine that can identify over one million bacterial or viral species in a gram of soil or drop of water. The machine will be used for various university-driven research projects, including studying bacterial and viral pathogens in Lake Erie waters.
A study published in Diabetologia found that only 10% of diabetes trials focus on prevention or behavioral therapies. Most trials are small to medium-sized and prioritize drug treatments over preventive measures. The analysis highlights the need for more research addressing the needs of diverse populations affected by diabetes.
A three-year study by Professor Michael Blaber and his team suggests that proteins, not RNA, were the first molecules to form life. The researchers found that 10 prebiotic amino acids could be folded into complex protein structures in a high-salt environment, supporting a 'protein-first' view of abiogenesis.
Researchers have identified a substance that prevents fluid accumulation and edema formation in the body, offering new hope for treating excessive fluid retention in patients with chronic heart failure. The discovery also reveals a new molecular mechanism controlling water homeostasis in the kidneys.
Researchers at Scripps Research Institute illuminate the copper-catalyzed azide–alkyne cycloaddition (CuAAC) reaction, revealing key findings on its mechanism. The discovery enables better control, efficiency, and versatility in pharmaceutical synthesis, enabling the development of new reactions.
Research finds that graduates are taking up jobs that don't fully use their skills, causing high turnover for employers. The study identified five areas where emerging graduate occupations diverge from traditional graduate occupations, including job content, job security, and pay.
A mathematical model predicts that the world's population will stop growing around 2050. The study used data from the United Nations and applied rate equations to describe the evolution of a two-level system. This prediction aligns with lower estimates provided by the UN, suggesting a possible decline in population numbers.
Scientists have identified six basic lines of genetic variation on the horse Y chromosome, revealing a complex history of breeding practices and movement of stallions. The study sheds light on the development of modern sport horses and highlights the influence of ancient stallions like 'Eclipse'.
Research reveals that children's sense of having a body develops differently than adults', with an earlier reliance on visual cues. The study used the rubber-hand illusion to test age differences in body representation, finding that children respond more strongly to the illusion than adults.