Researchers found that women with poorer quality of life, higher pain and endocrine symptoms, and negative beliefs about medication effectiveness are more likely to stop taking aromatase inhibitors. Patient-reported outcomes can act as biomarkers, predicting non-adherence and informing personalized treatment strategies.
Engineers at Duke University create a bandage that traps and holds the pro-healing molecule adenosine, accelerating callus formation and vascularization to improve bone repair. The results show better bone formation, higher bone volume, and better vascularization in mice treated with adenosine-laced bandages.
A novel noninvasive technique using acoustofluidics analyzes saliva for the presence of human papilloma virus-16 (HPV-16), associated with oropharyngeal cancers. The test detected OPC in 40% of patients tested and 80% of confirmed cases, offering early detection, risk assessment, and screening.
A new non-invasive imaging technique using 89Zr-immuno-PET can measure target engagement of therapeutic antibodies in tumors, enabling personalized treatment. This method provides a significant advance over current invasive methods and has important implications for patient care.
Physicists have discovered that an existing technique is more accurate in explaining the 'critical temperature' of superconductivity in pure, single-layer graphene. This finding has significant implications for understanding graphene's diverse structural properties and potentially aiding the development of new technologies.
Researchers have developed a method to produce astaxanthin, a natural antioxidant, in a faster and more efficient way than previous methods. The new process uses the fast-growing marine cyanobacterium Synechococcus sp. PCC7002 as a host and requires only water, light, and CO2 to produce the valuable substance.
Researchers discovered a hotspot in Earth's radiation belt where killer electrons form, which can cause serious anomalies in satellites. The finding improves the accuracy of forecasting when these high-speed electrons will form, potentially impacting space weather science.
This observational study examines US Army suicides from 1819 to 2017, revealing a significant increase in rates over time. The peak suicide rates occurred during the 1960s and 1970s, with a total of 4,000 deaths recorded during this period.
Researchers found that women who used ibuprofen or naproxen had a 40% reduced breast cancer risk, while aspirin use offered no benefit. Young women with HER2-positive breast cancer may preserve fertility by choosing less intensive chemotherapy regimens.
Researchers at UCSF-Kaiser Permanente found that primary care patients with 'unhealthy alcohol use' were 15% more likely to take benzodiazepines than moderate drinkers and nondrinkers. This increased risk was associated with a higher likelihood of overdose, accidents, falls, and exacerbation of psychiatric conditions.
A new study reveals that molecular chaperones play a crucial role in preventing the misfolding of alpha-synuclein protein, which is associated with diseases like Parkinson's. By inhibiting these chaperones, researchers found that alpha-synuclein aggregates can form at the amino acid level.
The wild relatives of chile peppers, pumpkins, carrots, and lettuce are imperiled, with many species not well-represented in gene banks or protected areas. These plants possess genes that can help their cultivated cousins withstand harsh climate conditions.
Research shows that collaborating on waiting area entertainment can increase revenue and customer loyalty. By working together, businesses can offset high operational costs and compete on other dimensions like prices.
A study led by the University of Arizona College of Medicine-Phoenix found that elevated levels of IL-36y are associated with bacterial vaginosis. The researchers also discovered that infection with BV-associated bacteria induces IL-36y in a species-specific manner.
A new approach to trapping light in artificial photonic materials could revolutionize data transfer speeds online. Researchers at City College of New York led by Alexander B. Khanikaev have made a significant breakthrough, enabling the design of new optical resonators that may impact devices used daily.
A newly proposed model suggests the HIV-1 viral shell has a spherical matrix shape that fuses to host cells, releasing the viral capsid inside. This structure may help scientists understand the infection process and develop new treatments, such as blocking the viral entry mechanism.
The Wyss Academy for Nature tackles biodiversity losses, climate change, and land resource demands by bringing together experts from policy, business, and civil society. The initiative aims to develop forward-looking solutions on a global scale.
Researchers demonstrate direct emission of orthogonal handed circular polarization from achiral luminophore using liquid crystalline phase. The twisted structure allows for the generation of CP light with various polarization states.
A team of Brown University researchers used a brain-computer interface to reconstruct English words from neural signals recorded in the brains of nonhuman primates. The study showed that neural data produced high-fidelity reconstructions that were clear to a human listener, using multielectrode arrays for the first time.
A study published in the Journal of Allergy and Clinical Immunology identified over 300 genes and 200 CpG sites associated with reaction severity. The research suggests that neutrophil-mediated immunity plays a prominent role in peanut allergy reactions, offering potential new targets for treatment.
Research led by UMass Amherst scientist Alexander Suvorov identified the mechanism responsible for flame retardant's effect: an altered liver epigenome. Perinatal exposure permanently changed liver metabolism in rats, potentially applicable to humans.
A recent study published in Journal of Archaeological Science reveals that the Moai statues were believed to aid in agricultural fertility and production. The analysis of soil samples from two excavated Moai found high levels of essential nutrients, supporting the Rapanui people's practice of planting multiple crops together.
Researchers found that residual cancer burden index and classification are accurate and reliable tools to assess patient prognosis. The results suggest that continuous RCB index can predict risk of breast cancer recurrence across all four breast cancer subtypes.
Researchers found that female mongooses abort pregnancies more frequently during times of food scarcity and high competition. The study suggests that this adaptive strategy enables females to save energy for future breeding attempts.
A community-based program enables patients to donate tumor tissue and blood samples for research, allowing researchers to study genetic and molecular makeup of tumors after treatment failure. Analysis reveals similar DNA mutations and varying protein biomarker expression among samples from the same patient.
A Dartmouth study finds that conscious visual perception of location occurs in the frontal lobes, contradicting previous assumptions about its location. The research used fMRI data and multivariate pattern analysis to investigate where conscious perception emerges and how the brain codes this.
A new international project will utilize pluripotent stem cells to preserve bird genetic resources. The project, led by Kazan Federal University, will analyze genomes and study genetic mechanisms of suspended embryogenesis in birds.
Researchers found that standard pathology tests provide better information on likely outcome and best treatment options for patients with bladder cancer than molecular subtyping techniques. The study suggests that more study is needed before molecular subtypes are used to guide patient care.
Scientists and innovators present the concept of the Circular Carbon Economy, a system where carbon emissions are reduced, reused, recycled, and removed. This approach is inspired by nature and aims to restore the balance of the carbon cycle.
A new study by Bocconi University finds that private companies with similar organizational structures display higher accounting quality than public ones. This is particularly true for standalone firms, which tend to underreport earnings to save taxes, whereas business groups exhibit more reliable accounts.
A new study by University of Alberta ecologists reveals that male squirrels who move outside their population live longer and have more offspring. In contrast, female squirrels do not reap the same benefits, losing out on family support and facing fitness costs after dispersal.
Scientists developed flexible and efficient transparent solar cells with colour-neutrality using silicon microwires embedded in a polymer matrix. The devices demonstrate transparency of up to 55% and excellent flexibility, making them promising for future transparent solar cells.
A Duke University study finds that baby pandas' bones mature at the same rate as other mammals, but are developed at an accelerated pace. The researchers used micro-CT scans to create 3D digital models of each baby's bony interior and discovered that giant panda skeletons are just like those of closely related animals, but smaller.
A retrospective study found that women with government insurance had lower survival rates, increased risk of dying, and were more likely to stop treatment early in breast cancer clinical trials. The study also did not find a significant association between neighborhood socioeconomic status and trial outcomes.
A team of researchers extracted large air samples from Antarctica's Law Dome site, dating back to the 1870s, to track the history of hydroxyl and its impact on climate models. The analysis aims to produce a concentration curve for carbon-14 monoxide and hydroxyl over the decades, shedding light on past and future climate changes.
A new study found that people who presented to California emergency departments with deliberate self-harm had a suicide rate 56.8 times higher than demographically similar Californians. Patients with suicidal ideation had a suicide rate 31.4 times higher, reinforcing the need for universal screening and follow-up care.
Scientists have obtained precise measurements of a pulsar's size and mass, as well as the first-ever map of hot spots on its surface using NASA's NICER telescope. The new data reveals that pulsars are not simple objects with powerful magnetic fields, but rather complex systems with multiple hot spots.
Researchers at Georgetown University Medical Center used fMRI to categorize Gulf War illness patients into two distinct groups based on brain activity changes after exercise. The study suggests that different brain regions are associated with two subtypes of GWI, leading to potential new diagnosis and treatment strategies.
A recent study published in the Journal of Telemedicine and Telecare found that a telehealth program increased primary care physicians' accurate diagnosis of skin conditions by nearly 84% for adult cases and 72% for pediatric cases. The program provided expert recommendations through videoconferencing sessions with dermatologists, redu...
Scientists develop an all-optical switch operating in the femtosecond range with low energy consumption, breaking the trade-off between switching speed and energy. The device uses a nanoscale waveguide based on plasmonics and graphene to control optical signals.
A new model predicts that deforestation and small-scale gold mining in the Peruvian Amazon increase mercury levels in local rivers, with effects lasting for decades. The research suggests that policies can be developed to mitigate these impacts and protect public health.
The NGC 5394/5 galaxies are engaging in a slow and intimate dance, fueled by their gravitational interactions. This process has already led to the coalescence of hydrogen gas into regions of star formation, resulting in the sparkling of new stars.
A University of Maryland-led study found that climate cycles and insect pests drive caribou migration timing. Caribou herds across North America synchronize their migrations at roughly the same time due to ocean-driven climate cycles, but arrival times depend on previous summer's weather conditions.
Researchers have successfully determined the three-dimensional structure of a vaccinia virus RNA polymerase at atomic resolution, providing key findings on virus multiplication. The complex is composed of various subunits and relies on host tRNA molecules to function, enabling an essential step in the pathogen's life cycle.
The study identifies hundreds of proteins involved in the cell division cycle of Trypanosoma brucei gambiense and rhodesiense parasites. This discovery holds promise for developing targeted drugs that can treat sleeping sickness without harming humans or animals.
Researchers challenge the theory of a descended larynx, which proposes that speech can only emerge with the larynx in a low position. However, monkeys produce well-differentiated proto-vowels, suggesting control of articulators is key to vocalization. This finding opens up new perspectives on the emergence of articulated speech.
A recent study has provided new insights into the early development of PTSD, revealing that it proceeds along two independent tracks. The research, which tracked symptoms over 30 days after a traumatic event, suggests potential interventions to prevent its development and proposes different treatment approaches for fear-based and depre...
A systematic review and meta-analysis found no conclusive evidence supporting the safety of ivermectin administration among pregnant women. The studies included in the analysis reported some adverse events, but the number of cases was too low to be conclusive.
The study found that Norwegian, Swedish, and Danish languages use topicalization to move sentences elements to the front, making them stand out from other languages. This feature allows speakers to emphasize certain words without changing the overall meaning of the sentence.
Eating added sugars during the holidays can trigger metabolic, inflammatory and neurobiological processes tied to depressive illness. A minimally processed diet rich in plant-based foods and Omega-3 fatty acids may help alleviate symptoms.
Researchers are developing a framework to assess the 'intelligence' of AI systems by grading them on problem-solving skills and adaptability. The AIQ test will evaluate systems based on accuracy, time taken, and data requirements.
Chen WeiQiu's team discovers a way to tailor topological states in acoustic materials by selecting specific boundaries, enabling dual-channel propagation and one-way propagation of sound waves. This breakthrough leads to the design of tunable acoustic devices with new possibilities.
The IBIS-II study confirms anastrozole offers long term protection for women at high risk of developing breast cancer, with a 49% reduction in breast cancer incidence 12 years after stopping treatment. This is significantly higher than the 28% decrease in breast cancer recorded for women who take tamoxifen.
Researchers have discovered that the Canadian tundra was once home to a vibrant, temperate forest, featuring plants such as birch, alder, and elms. The ancient plant fossil record provides valuable insights into how ecosystems responded to greenhouse climates in the past.
A recent study published in Cephalalgia highlights an overlooked relationship between migraine and exercise. Anxiety sensitivity is found to be associated with physical activity avoidance in women with probable migraine, particularly with vigorous intensity.
Researchers have identified 150 possible inhibitors of the Nipah virus, a highly deadly disease with no licensed drugs against it. The study found that 13 proposed inhibitors showed high potential against all strains of the virus.
Researchers found that pre-operative depression and anxiety can lead to poorer outcomes after hip surgery, including increased pain and slower recoveries. The study proposes screening for mental health issues before hip surgery to improve treatment outcomes.
Researchers have developed a theoretical mechanical model to study how spider orb-webs detect prey through vibrations. The model reveals that web dynamics are crucial in localizing prey, and it has potential applications for bioinspired materials.
Researchers used ghost imaging to enhance the speed of super-resolution microscopy, achieving nano-scale resolution in just 10 image frames. The new approach resolves structures with spatial and temporal resolutions at which biological processes take place.
Researchers found that out-of-network, non-emergency hospital costs rose rapidly from 2012 to 2017, affecting 16% of individuals with an average cost of $621. Average costs for emergency and non-emergency care increased significantly.