New research reveals distinct features of membrane channels in skeletal and heart muscle cells, shedding light on the mechanisms behind inherited arrhythmias and providing a promising avenue for targeted drug development. The study also highlights the vital role of phosphatidylethanolamine in mitochondrial energy production.
At SAEM 2019, experts like Rebecca Cunningham emphasized the need for gun safety beyond 'gun control', focusing on injury prevention. Meanwhile, a study found opportunities to reduce over-testing in emergency departments through data analysis and targeted quality improvement initiatives.
Researchers have developed artificial molecules that selectively target abnormal vascular smooth muscle cells without affecting endothelial cells. This could lead to new, safer stent treatments.
Geoscientists have found evidence that material from the transition zone in Earth's mantle can percolate to the surface to form volcanoes. This discovery provides a new understanding of the relationship between the transition zone and volcanism, with implications for global geodynamics and the evolution of our planet.
Researchers used machine learning to predict mechanical properties of metal organic frameworks (MOFs), which could be used for water extraction, gas storage, and hydrogen fuel cells. The results enable faster material characterization and design at the molecular scale.
A Rutgers-led study found that the massive Laki volcano eruption in Iceland did not lead to an extreme summer heat wave in Europe. Instead, it caused unusually cold winters due to natural climate variability and high-pressure systems. The eruption also had devastating effects on Iceland's livestock and human populations.
A new study reveals striking variation in HIV prevalence across African countries, with some areas experiencing over a 5-fold difference in numbers of people infected. The study's findings highlight the need for targeted interventions to address persistent high infection rates in sub-Saharan Africa.
The study found that over 20 million babies were born with a low birthweight (less than 2500g) in 2015, with almost three-quarters of these babies born in Southern Asia and sub-Saharan Africa. The authors call for immediate action to tackle underlying causes of low birthweight and ensure clinical care for small babies.
Researchers evaluated 67 fitness apps on iOS and Android to assess their suitability for improving physical activity in cancer survivors. A fifth of the apps contained content suitable for people affected by cancer, focusing on aerobic-based activities with goal setting, monitoring, and feedback features.
BCL-2 protein deregulation and transcriptional reprogramming contribute to Venetoclax resistance; researchers suggest targeting CDK7 as effective strategy to prevent resistance. Studies provide insights into drug resistance mechanism in B-cell lymphomas, paving way for potential co-treatment strategies.
Researchers found widespread inconsistencies in antibody use, causing unreliable results and wasting $2 billion per year. They call for industry-wide standards to validate antibodies, especially in human tissue research.
Researchers tested natural and synthetic acoustic stimuli to determine their effectiveness in deterring bald eagles from flying into wind turbines. The study found that eagles were more responsive to natural calls than synthetic sounds, particularly a 'crow mobbing' signal.
A study published in PLOS ONE found that captive chimpanzees can spontaneously use tools to excavate underground food without prior experience. The chimps chose to use tools over bare hands and even reused them, similar to early human tool use.
Researchers from the University of Malaga have found that combining 'Bacillus subtilis' and 'Pseudomonas' bacteria can improve plant growth and health. This study reveals that these bacteria can live in harmony, increasing their positive effects when used together.
The new design achieves around 95% indistinguishability and three times higher efficiency than traditional cavities. It enables the production of high-quality single photons necessary for practical quantum computing, solving problems intractable for classical computers.
Researchers at Graz University of Technology have discovered two new security flaws, ZombieLoad and Store-to-Leak Forwarding, which allow attackers to read sensitive data from Intel processors. The vulnerabilities affect all processors developed by Intel between 2012 and 2018, requiring urgent updates to ensure system protection.
A large Dutch study found that transgender women using hormone treatment have an increased risk of breast cancer, while trans men have a lower risk. The absolute risk is still relatively low and sufficient for current screening guidelines.
A study published in Cell Host & Microbe identifies a previously unknown bacteria-killing protein RELMα that requires dietary vitamin A to work. The researchers found that mice fed a diet deficient in vitamin A made no RELMα, and those missing the protein were more susceptible to infection.
Northeast Ohio Medical University has received a $500,000 grant from the Ohio Department of Mental Health and Addiction Services to collaborate with other Ohio medical schools on developing a comprehensive curriculum for pain management and opioid use disorder treatment. The project aims to improve systems of prevention and treatment f...
Despite great progress in reducing under-five mortality rates, India still has a long way to go to meet the UN MDG target of 39 deaths per 1,000 live births. Infectious diseases such as pneumonia and meningitis account for a significant proportion of child deaths.
A University at Buffalo researcher emphasizes the importance of considering community realities and resources in treating postpartum depression among low-income mothers of color. The study's findings highlight the need for social workers to advocate for expanded services, including childcare, transportation, and access to healthcare.
Researchers will investigate stress chemicals and circuits in the brain to understand persistent changes in sleep and circadian rhythms. The study aims to develop new brain targets for medication development and improve diagnosis accuracy.
Researchers at the University of Cincinnati have created a lifelike robotic dog that can provide care in addition to companionship for older adults. The new prototype offers features such as fall detection, connectedness to caregivers and loved ones, vital sign monitoring, and helpful reminders.
A team of scientists has created a bowl-shaped electrode that efficiently converts CO2 from gas into carbon-based fuels and chemicals. The innovative design addresses two major obstacles in the conversion process, achieving higher conversion efficiency and sensitive detection of molecules.
A new study published in the Proceedings of the National Academy of Sciences reveals that tree distributions in African savannas follow distinct patterns, regardless of environmental factors. The research used LiDAR data to identify power law distributions that capture significant statistical correlations at large scales.
Regular use of glucosamine supplements is associated with a lower risk of cardiovascular disease events, including coronary heart disease and stroke. The study found a significant reduction in CVD events among glucosamine users, with stronger associations observed in smokers and those who mimic a low-carbohydrate diet.
A study found that 623,000 US parents with opioid use disorder live with children under 18, with few receiving treatment. Meanwhile, healthcare accounts for between 5-15% of premature death variation, with behavioral factors driving more mortality variation.
Scientists have identified a promising compound, PHT-7.3, that shrinks KRAS-driven tumors in mice by targeting the protein's partner, Cnksr1. The study provides a potential treatment for KRAS-positive cancers, which currently have no effective therapy.
A recent study found that women's gut microbiomes are more diverse and mature earlier than men's, with a positive association between age and bacterial diversity. The research suggests that sex hormones may play a role in the development of the female gut microbiome.
Researchers found that removing invasive shrubs restores native understory plant growth, with an unexpected ability and vigor to recolonize open spots. Native plants can thrive in areas previously occupied by invasive species, taking over with minimal additional effort.
Researchers developed cell membrane-coated nanocarriers to overcome immune clearance and biotoxicity issues. These biomimetic hybrids achieve improved biocompatibility, circulation time, and therapeutic efficiency.
Scientists create precise nitrogen-vacancy colour centres in diamonds using a new method, enabling the production of arrays of single NV centres with exactly one colour centre at each site. This facilitates the engineering of integrated devices and paves the way for the delivery of compact and robust quantum technologies.
A recent study has found that endosymbionts in amoebae significantly influence the proliferation and spread of Legionella pneumophila. The researchers discovered that these bacteria weaken the infectivity of Legionella by competing for nutrients, ultimately leading to slower multiplication and reduced virulence.
Researchers from the University of Edinburgh discovered a protein that switches on an immune response in stem cells, protecting them from viruses. This finding could help develop more efficient stem cell therapies to treat diseases like Parkinson's and diabetes.
Researchers at the University of Arizona have discovered a 'metabolic fingerprint' that distinguishes patients with cervical cancer from healthy women. The study identified three compounds that distinguish cervical cancer patients from healthy women, showing promise for future diagnostics, interventions or therapies.
A new theory in dissemination and implementation science empowers primary care practices to discover and enact their own wisdom, shifting the source of change from outside-in to inside-out. The authors highlight three pioneer practices that developed innovative business models and clinical care approaches, achieving success without dis...
A recent study by University of Kent researchers found that women are consistently ranked lower than men when considering leadership roles. The study suggests that women must demonstrate high performance to be considered for senior positions, while men are given preference due to their perceived potential.
Lab tests show plastic chemicals impair growth and function of ocean's most abundant photosynthetic bacteria, Prochlorococcus. Exposure to plastics alters gene expression, potentially harming entire ecosystem.
People with strong life purpose are more likely to accept health messages and experience less decisional conflict. A study found that those with a stronger sense of purpose have less activity in brain regions associated with conflict-processing, making it easier for them to make healthier choices.
Estimates suggest health care accounts for between 5% and 15% of the variation in premature death, while behavioral and social factors account for a much higher percentage. Health experts advocate for a diversified portfolio of national investments to generate a higher health yield.
A national study led by University of Washington professor Alexes Harris reveals the disproportionate impact of court-imposed fines and fees on low-income individuals and people of color. The study highlights how private companies profit from a captive population while government agencies direct them.
Research found that persistent picky eaters at age 3 had similar dietary differences by age 10, but these reduced by age 13. The diets of all children, including non-picky eaters, showed low fruit and vegetable intake, despite efforts to encourage healthy eating habits.
Transplanting islets of Langerhans into mice reveals early autoimmune markers of type 1 diabetes, allowing for intervention before beta cell destruction. The study's findings offer hope for developing new drugs and clinical transplantation strategies to prevent damage.
Scientists at the University of Bonn have developed a new method to study enzymes in action, allowing for the measurement of spatial positions and conformational changes. This breakthrough enables better understanding of biomolecules and potential insights into enzyme disorders.
A meta-analysis found that inappropriate prescribing in primary care is associated with emergency room visits, adverse drug events, and functional decline. The study highlights the need for effective interventions to address this issue and its impact on older adults' quality of life.
Researchers create high-performance organic phototransistors using a novel hybrid-layered architecture that combines charge-trapping effect and efficient carrier transport, enabling enhanced photodetection performance. The devices show excellent flexibility and reliability in photosensitive imaging systems.
Scientists at Johns Hopkins Medicine identified average brain changes linked to Alzheimer's disease that occur 3-10 years before symptoms appear. Researchers found subtle cognitive test score changes and protein increases in cerebrospinal fluid an average of 34.4 years before cognitive impairment onset.
A new study reveals that a previously unknown neural circuit, PPL2, plays a crucial role in regulating the strength of memories in fruit flies. The researchers found that activating this circuit can strengthen or weaken memories, depending on the context.
An estimated 623,000 US parents with opioid use disorder are living with children under 18, with fewer than one-third receiving treatment. Additionally, four million parents have other substance use disorders with low treatment rates.
Researchers at FAU have discovered a small RNA that prevents potato tuber formation at high temperatures. They created heat-resistant potato plants by deactivating this RNA, which can withstand temperatures above 29 degrees during the day or night. This breakthrough offers hope for securing crop yields in the face of climate change.
A new scale has been created to assess preschool-age children's behavior towards external food cues, such as marketing and social influence. The scale shows a positive association with overeating behaviors, highlighting the importance of understanding how young children's environment impacts their eating habits.
A study from Queen Mary University of London found that a tiny set of hypergiants dominate the complaint system, generating hundreds of millions of complaints about copyright. The researchers raise questions about the effectiveness of this model for web regulation.
Scientists at the University of Konstanz have demonstrated how skyrmions can be used for probability-based computing. They successfully developed a material where skyrmions can form and exploited thermal diffusion to create a reshuffler, a crucial component for probabilistic computing.
Researchers at UCLA have found a way to significantly reduce the duration of tuberculosis treatment using artificial intelligence and data analysis. The new approach identifies synergistic drug combinations that work together to cure TB more quickly and effectively.
The CUNY Graduate School of Public Health and Health Policy is part of a NYC consortium aiming to reduce opioid overdose mortality by 40% in 16 communities. The project focuses on whole-community approaches, including enhancing community engagement and increasing access to prevention and treatment.
Researchers have gained insight into how influenza A virus particles utilize the balance between HA and NA proteins to penetrate host mucus barriers. The proteins are organized asymmetrically, enabling persistent directional motion that allows the virus to effectively overcome its first line of defense.
Advanced Research Systems has licensed a technology to automatically refill liquid helium used in laboratory equipment, reducing downtime and increasing overall efficiency. The technology, developed by Oak Ridge National Laboratory, allows for weeks of uninterrupted operation and less helium loss compared to manual filling.
Researchers have shown that digital quantum simulations can be more robust and stable than previously assumed. By considering only relevant system values, a sharp threshold is reached where the Trotter error has limited impact, allowing for longer simulations of larger systems.
Researchers at the University of the Basque Country have developed a new method for producing 1-butene via ethylene dimerization using metal-organic frameworks (MOFs) without activators or solvents. The catalysts exhibit high selectivity and stability, making them a promising alternative to traditional homogeneous catalysis.
A new monkey species, Alophia, has been discovered in Africa at 22 million years old, bridging the 6-million-year gap in primate evolution. The discovery sheds light on the evolution of Old World monkeys and their dietary changes over time.