University of Illinois engineers found that adding salt to water triggers a multistep assembly process, allowing for complex architectures and reconfigurable materials. This discovery may enable the development of new technologies such as solar cells and catalysis.
A new experimental compound inhibits clot formation without raising the risk of bleeding, providing an effective and safer alternative to current therapies. The study found that the drug is well-tolerated at high doses and has a rapid, specific, and reversible action on platelets.
Researchers at Tohoku University and Université Grenoble Alpes have demonstrated triplet superconductivity in the uranium-based material UBe13 using high pressure and magnetic fields. This phenomenon involves electrons forming parallel spin pairs, unlike conventional superconductors where opposite spins pair together.
Researchers discovered a key clue into pancreas development by studying rare patients born without a pancreas. A previously unexpected pathway was identified, confirming its role in human and mouse pancreas formation.
Researchers estimated that bacterial infections resistant to antibiotics resulted in a 20% higher death rate and an additional €1100 hospital stay cost. Infections accounted for 12% of all hospitalizations, with the majority caused by E.coli, MRSA, and P.areuginosa.
Researchers evaluated four state-of-the-art tools for recognizing names in text and found solutions to boost accuracy from 7% to 90%. They also extracted social networks from novels to explore differences in story structure. The study highlights the challenges faced by NLP tools in handling names in popular fiction.
According to a Concordia study, high-performing corporations are more likely to disclose hard information about their environmental practices, building trust with stakeholders. This transparency pays dividends in the long run, leading to increased public goodwill and market value.
Researchers tested spore-forming bacteria on antimicrobial paint surfaces and found that most died, but a few strains, like Bacillus timonensis, survived. This raises concerns about the effectiveness of these paints and potential risks to human health.
A study by EPFL researchers found that the KRAB domain-containing zinc finger protein Zfp30 initially repressed a retrotransposon, but later evolved to activate genes involved in fat-cell formation instead, surprising scientists
Research from Florida State University finds that pregnant women are more likely to feel 'pushed out' of their workplaces, leading them to opt-out. The study confirms inherent biases against expectant mothers and highlights the need for employers to provide equal career support to both men and women with children.
Researchers found that exercising in the morning resulted in higher utilization of carbohydrates and ketone bodies, as well as the breakdown of fats and amino acids. The study suggests that timing of exercise is a critical factor for metabolic benefits, contradicting previous assumptions that focused on food intake timing.
Scientists at Duke University discovered that general anesthesia works by hijacking the neural circuitry responsible for sleep and hormone regulation. The study found that certain anesthetic drugs activate a cluster of cells at the base of the brain, leading to unconsciousness and offering potential new avenues for developing pain-free...
Researchers have identified genetic variants in the MC4R gene that increase the activity of the brain receptor, providing protection against obesity and its complications. These variants may be used as models for developing new, safer weight loss therapies.
A team of researchers analyzed the DNA of nine 13th-century Crusaders, revealing a genetically diverse group that intermixed with local populations. The findings provide insights into the history of the Crusades and highlight the importance of ancient DNA in understanding historical events.
Researchers have developed a system that allows living cells to perform analog-to-digital signal processing, enabling precise control over cellular responses. This breakthrough expands the toolkit for synthetic biologists, who can now use genetic circuitry to process complex signals and make informed decisions.
Engineers used network science to map atomic forces onto a complex graph, simulating macroscopic material behavior. The method simplifies the graph, allowing researchers to replicate the process with other materials.
A new study found that a maternal vaccine can effectively protect against HSV-1 and HSV-2 infections in mouse offspring, transferring infection-fighting antibodies to their nervous system. The vaccine has shown promise in preclinical animal models and phase 1 human trials, offering new hope for preventing neonatal herpes infections.
A team of scientists at the Gladstone Institutes has developed a reliable method to identify potential off-target effects in therapeutically relevant cell types. The DISCOVER-Seq technique uses DNA repair factors to pinpoint exact sites where CRISPR cuts occur, enabling more accurate genome editing.
Researchers developed an effective harmonization method to reduce site-related differences in resting-state fMRI data, reducing bias by 29% and improving signal-to-noise ratios by 40%. This allows for the development of practical brain-circuit-based biomarkers of psychiatric disorders regardless of imaging site.
A study published in PLOS Pathogens reveals that hepatitis B viral protein HBeAg expands immune cells called MDSCs, impairing antiviral responses. The HBeAg-MDSC-IDO axis is a potential target for developing novel HBV therapeutics.
Researchers at KAUST have developed a compact radar with short wavelengths to enhance close-range detection capabilities. The device is capable of target detection, speed estimation, and tracking at ranges of up to 12 meters, making it suitable for visually impaired people and unmanned devices.
A comprehensive new earthquake catalog has identified 1.81 million quakes in southern California, 10 times more than previously detected, providing a more precise picture of stress evolution in fault systems. The catalog will help researchers detect and locate quakes more precisely, identifying key physical and geographic details to pr...
Researchers at KAIST have designed an ultrathin display that can project dynamic, multi-colored 3D holographic images using tiny pinholes in a thin film. The system is small and scalable, paving the way for widespread applications of 3D holographic displays.
Researchers create synthetic molecular components that interact with each other to process signals, enabling complex tasks like embryonic development and differentiation. The system allows for analog-to-digital conversion of cellular responses.
A new study by the University of South Florida finds ocean circulation was the major determinant of Florida's 2018 red tide blooms. The study used ocean circulation models and autonomous underwater gliders to pinpoint the initiation zone for the blooms, which were likely carried to the coastline by a rare upwelling circulation.
Researchers have found distinctive differences in white matter pathways among young people with conduct disorder, linked to callous behavior and reduced empathy. The study may help clinicians diagnose the condition more accurately and guide effective interventions.
Despite effective antiretroviral therapy (ART), five individuals experienced extreme immune decline, a rare phenomenon known as EXID, where CD4+ T cell levels declined by an average of 157 cells per microliter. Gene mutations and HIV strain variations may contribute to this paradoxical response.
Scientists have discovered a previously unknown mechanism by which cells sense proteasome dysfunction and respond by editing the amino acid sequence of a key sensing protein. This finding has important applications for treating cancer, aging, and neurodegenerative diseases.
A new study led by York University reveals the American Bumblebee is critically endangered due to a 70% reduction in its area of occurrence and an 89% decrease in relative abundance. Immediate conservation action may save the species from extinction, similar to the fate of the Rusty-patched Bumblebee.
A recent study of ancient DNA from Crusader skeletons confirms they intermingled with local populations, forming families and fighting alongside them. The researchers found that the Crusaders' genetic presence was short-lived, with no lasting impact on Lebanese genetics.
Researchers found that specific strains of Staphylococcus aureus delay healing and that some bacteria can even improve wound outcomes. Monitoring microbiomes may help doctors tailor treatments to enhance healing and prevent amputations.
A recent clinical trial found that longer hemodialysis sessions did not improve patient outcomes, while also highlighting the need for effective strategies to engage clinicians and patients in trials embedded within routine care. The study's findings suggest a pressing need for data-driven guidance in dialysis practice.
Researchers at Ann & Robert H. Lurie Children's Hospital of Chicago have discovered a protein that causes intestinal permeability in NEC, which can lead to sepsis or death. Inhibiting a special molecule called ROCK may prevent this process, offering a new potential treatment strategy.
Project Sidewalk uses crowdsourcing to collect street-level data on accessibility in cities. Volunteers use Google Street View to label curb ramps, missing sidewalks, and obstacles, providing valuable insights for government officials and people with mobility impairments.
A recent study published in the European Sociological Review found that having a female manager does not lead to higher earnings for women. Despite increasing representation of women in management positions, the gender gap in earnings remains significant, with women earning an average of 7% less than men.
Researchers found that KZFP proteins domesticate regulatory sequences in transposable elements, minimizing their impact on early embryonic development. This process allows for the incorporation of transposable element-based controlling sequences into transcriptional networks.
Researchers have discovered that amplifying the amount of VGLL3 in skin cells pushes the immune system into overdrive, leading to autoimmune responses. This finding may help explain why women are more likely to develop autoimmune diseases like lupus and could lead to new treatments.
A research team at Toyohashi University of Technology has developed a novel fire extinguisher concept called Vacuum Extinguish Method (VEM), which uses vacuum to suck in flames and combustion products. This method is suitable for enclosed spaces like spacecraft or submarines, where traditional extinguishers can spread harmful gases.
A breakthrough CRISPR gene-editing tool allows for the simultaneous execution of multiple edits in DNA extracted from human cells. This technology, developed by the Gene Editing Institute and licensed to NovellusDx, can rapidly reproduce an individual patient's cancer tumor genetic features and identify driver mutations.
Researchers found exercise decreases eye pressure, while swimming goggles modestly increase it, potentially reducing adverse effects on vision. The study suggests that increasing eye pressure with swim goggles may be a safe and effective method to mitigate spaceflight-related vision issues.
Researchers found that when we watch people perform actions, our expectations distort our perception of their behavior. However, this distortion does not occur with inanimate objects. The study suggests that our attributions of intention play a key role in shaping our understanding of others' actions.
Research suggests that exercise performed in the evening may be more productive due to increased levels of ZMP, a metabolite that activates metabolic pathways related to glycolysis and fatty acid oxidation. In human studies, lower oxygen consumption and better exercise efficiency were observed in the evening compared to morning.
Researchers discovered that reef fish rely heavily on food from the open ocean, with some species relying on more than 400 grams of plankton per kilogram of fish produced. The study found that areas of the reef exposed to the open ocean produce the largest quantities of fish, offering hope for resilient reefs.
BRB-seq, a novel approach to RNA sequencing, preserves strand-specificity and detects the same number of genes as gold standard methods. The technique is 25 times less expensive than commercial RNA sequencing technologies, enabling bulk RNA sequencing of large sets of samples.
A scientific breakthrough provides new hope for people with multiple sclerosis, as researchers have developed a compound that stimulates repair of the protective sheath that covers nerve cells in the brain and spinal cord. The study, published in JCI Insight, shows promising results in repairing damaged myelin without severe side effects.
Research published by the American Psychological Association found that children as young as 5 use facial information to determine how to behave toward people. The study also showed that children's judgments from faces have consequences for behavior, similar to adults.
Sargon II envisioned Karkemish as a royal palace and western capital of Assyria, rebuilding the city with ritual ceremonies. However, his death led to the city's decline and loss of interest from subsequent Assyrian kings.
Researchers at Johns Hopkins Medicine developed a gel-like platform that activates and multiplies cancer-fighting T-cells, outperforming traditional methods in mouse experiments. The artificial lymph node technology has potential for regenerative immunology-based therapy.
Researchers recreated ancient brewing techniques to analyze ceramic beer vessels from Cerro Baúl. They found that the vessels were made of clay from nearby sources and that the beer was made of pepper berries, a drought-resistant ingredient. This steady supply of beer helped keep Wari society stable by forming unity among populations.
The CRISPR Journal publishes research on gene editing technologies, including base editors that enable precise base substitutions without DNA cleavage. A new method for multiplex site-directed mutagenesis also offers great promise for studying gene function.
A systematic review of 631 pregnant women with Marfan Syndrome found an estimated 5.3% prevalence of acute aortic dissections during or after pregnancy. Conservative management with beta-blockers is recommended for type B dissections, while emergency surgical intervention is indicated for type A dissections.
The Massachusetts Medical Device Development Center's $200K Challenge recognized innovative medical device solutions for treating blood clots, congestive heart failure, and other conditions. The competition drew entrants from around the world and awarded shares of a $200,000 purse to 12 winners.
Researchers have developed a novel method to functionalize peptides using light-activated catalysis, allowing for the creation of new therapeutic agents. The method enables selective modification of the C-terminal position in peptides, opening up new possibilities for drug development.
Researchers introduce trace amounts of samarium into PMN-PT crystals, significantly enhancing their piezoelectric properties. The results show nearly double the performance of traditional materials.
Researchers have developed a scoring system based on genetic markers to predict an individual's inborn risk for obesity. The score accurately predicted BMI and obesity in over 300,000 individuals, with those in the top 10% being 29 pounds heavier on average and 25 times more likely to develop severe obesity.
Researchers developed a web-based game, Maladaptation Game, to improve understanding of climate change methods and adaptation strategies among Nordic farmers. The game presents players with four agricultural challenges and requires strategic decisions, providing a summary of potential negative outcomes.
Researchers found that neurons in the motor cortex divide into externally focused and internally focused groups, with externally focused neurons controlling different body parts and internally focused neurons communicating only within the group. The study's findings have implications for brain disorders such as Rett Syndrome, which may...
Researchers at Yale University identified a possible biological cause for behavioral disorders in kids with autism: altered emotion regulation. They found reduced brain connectivity between the amygdala and prefrontal cortex in autistic children exhibiting disruptive behavior.
Researchers have identified a gut microbe, Mucispirillum schaedleri, that helps protect against Salmonella infections. The bacterium competes with Salmonella for nutrients, such as nitrate, and prevents the growth of pathogens by reducing their ability to express virulence factors.
A US Department of Agriculture study found that cold exposure can cause weak honey bee colonies to fail during long-distance hauling. Colonies with fewer than 10 frames are more likely to lose bees and struggle to maintain stable temperatures, increasing the risk of failure and chilling.