ECCITE-seq allows researchers to profile different types of biomolecules from thousands of single cells in parallel, offering a breadth of information that can be used as readout in CRISPR-based pooled genetics screens. This technique enables fine dissection of specific cell subtypes and helps reveal a transcriptomic signature of malig...
Researchers found higher rates of adaptive evolution in genes involved in resource allocation, particularly in seeds and endosperm tissues. This suggests that conflicts among kin can lead to rapid evolution, supporting the idea of an evolutionary arms race within plant families.
A study by MassGeneral Hospital for Children finds that dual-using parents are more likely to quit smoking, plan to quit in the next six months, and have attempted to quit in the past three months. However, they may not be getting the necessary help, as few pediatric offices deliver evidence-based tobacco control treatments.
The parasite induces overexpression of FOXP3 protein in infected animals, which sends a false message to the defense system, allowing it to eliminate the host's immune response. This study also validated three reference genes for quantitative PCR techniques, enabling future analysis of cytokine activity.
A study published in PNAS confirms that zoos and aquariums hold critical information about more than 98% of known species, including fertility and survival rates. By analyzing data from the Zoological Information Management System (ZIMS), researchers were able to fill large gaps in demographic knowledge for these species.
Researchers at MIT have created liquid-impregnated surfaces that can significantly reduce friction for yield-stress fluids like gels and pastes. These coatings enable the efficient processing of materials in industries such as food, cosmetics, and pharmaceuticals, reducing waste and improving product quality.
A new Stanford University study reveals that global warming has increased economic inequality globally. The study shows that most poor countries are poorer without climate change, while rich countries are richer. Economic growth in tropical countries is decreased by 17-30% due to warming.
Researchers discovered that bacteria can distinguish themselves from closely related competitors through the use of a virus. A novel phage, SW1, controls formation of a demarcation line by utilizing one of the host's cryptic prophage proteins, providing conditional benefits to E. coli K-12.
Researchers discovered that gasdermin E forms holes in cell membranes, leading to cell death and suppressing tumor growth. The protein's expression is lower in many types of cancer, suggesting it may be a useful target for improving cancer therapy.
Researchers warn that permanent daylight savings time could negate benefits from delaying school start times, which aim to give teens more sleep. The study suggests that schools would need to delay start times by one hour during winter months under permanent DST.
Researchers from TPU, Germany, and US successfully functionalized 'white graphene' using eco-friendly photopolymerization without altering its properties. The new material was used as a catalyst for splitting water into hydrogen and oxygen, offering a promising alternative to expensive platinum or gold.
The article discusses the potential of liquid biopsy in cancer diagnosis, focusing on targeted disease diagnosis and detection of cancer biomarkers. Researchers have successfully detected specific genetic mutations using digital PCR, identifying promising biomarkers for various cancers, including melanoma and lung squamous cell carcinoma.
A large national health survey found that transgender adults are more likely to experience poor health, fewer days of combined physical and mental well-being, and greater activity limitations. The study highlights the need for all states and territories to use a sexual orientation and gender identity module to inform policies affecting...
A study by Oregon State University researchers found that 14 common chemicals were detected in over 50% of wristbands from three continents. The wristbands, which absorb chemicals from the air and skin, are an excellent screening tool for population exposures to organic chemicals.
A study published in Annals of Internal Medicine found that metformin helped patients maintain weight loss over a period of 15 years. The researchers identified being older and losing a greater amount of weight in the first year as key predictors of lasting weight loss.
The UCI Skin Biology Resource-based Center will provide critical research infrastructure and resources for investigating skin biology and diseases. The center aims to discover fundamental mechanisms that may ultimately improve the understanding and treatment of skin diseases.
A team of Brown University scientists has developed a framework to apply mathematical models of uncertainty to social scenarios, proposing three interrelated methods people use to reduce social uncertainty. The first method, automatic inference, involves predicting another person's behavior based on appearance and social norms, while t...
A survey of 471 undergraduate women physicists found that nearly three-quarters had experienced gender harassment, leading to diminished sense of belonging and imposter phenomenon. The study emphasizes the need for a cultural shift in physics departments to address sexual harassment and promote diversity and inclusion.
Researchers at IBS report discovering spontaneous oscillations in microfluidic droplet networks, similar to our blood capillaries. Adding irregularities to the network relieves blood traffic cloggings, suggesting cell collisions or diameter variations help avoid dangerous oscillations.
A new study at New York University finds that team-based clinical experiences significantly improve interprofessional competencies among nursing, dental, and medical students. Students who participated in the program showed improvements in communication, collaboration, conflict management, and patient-centered approaches.
Researchers developed a method to detect and edit DNA methylation in individual mouse oocytes, enabling predictions of offspring phenotype. The technique allows for correction of genetic disorders, such as Angelman syndrome, and may facilitate study of epigenetic information.
Researchers find a long-overlooked molecular machine in the cell nucleus, the spliceosome, that produces mutant gene/protein fueling cancerous cells. Targeting this protein with existing and developing drugs may offer new treatment options for aggressive leukemia.
A new study reveals a strong connection between global warming and rising economic disparities worldwide. The research, led by Noah S. Diffenbaugh and Marshall Burke, suggests that long-term climate change has decreased economic growth in poor countries while increasing it in wealthy nations.
Researchers at Mass Eye and Ear have identified microglia as gatekeepers that orchestrate inflammatory responses in the retina during autoimmune uveitis. By depleting microglia, disease was completely blocked, suggesting a novel therapeutic target for this devastating eye disease.
Researchers created hydrogels that mimic muscle properties through mechanical training, producing strong, soft, and fatigue-resistant materials for medical implants and engineering applications. The trained hydrogels demonstrate improved tensile strength, soft flexibility, and high water content.
A new Iowa State University study found that rurality, education, and race significantly predicted the change from Democrat to Republican in Iowa. White, rural voters without a college education were more likely to switch to Republican. The research counters the narrative that economic anxiety was the reason for this shift.
Researchers at Tokyo Institute of Technology have discovered a way to make submicron-sized cylinders disappear using optical frequency illumination. This breakthrough could lead to new kinds of detectors and sensors for the medical and aerospace industries, without the need for expensive metamaterial coatings.
This study found that drinking water is associated with reduced calorie intake from sugary beverages. Not drinking water was linked to consuming an average of 93 extra calories and 4.5% more sugar among participants aged 2-19, with variations by age and racial/ethnic groups.
A new study published in the Journal of the American College of Cardiology found that a preschool health program significantly increased healthy habit awareness among children from an underserved community. The program resulted in a 2.2-fold higher score on overall knowledge, attitudes and habits towards a healthy lifestyle.
Researchers have identified three medicinal plants from Mauritius with effective inhibitors of esophageal cancer cells, stopping their growth and contributing to their death. The extracts contain natural chemical compounds that restrain the G2/M stages transition in malignant tumor cells by activating AMPK signaling pathway.
In a study published in Physical Review Letters, researchers reveal that repulsive interactions between Cooper pairs themselves hold them in check in insulating materials. This finding could lead to new manipulation methods for superconducting devices and the design of novel electronic components.
Researchers developed precision-guided anticancer nanoparticles that effectively target peritoneal cancer cells, reducing side effects. The use of guiding molecules improves drug solubility, selectivity, and release in tumor cells.
Researchers developed a new snake-inspired soft robot using programmable kirigami metamaterials, enabling responsive surfaces and smart skins. The robot can now change its shape in response to programmed sequences of pop-ups, improving speed and accuracy.
The survey found that nearly half of American workplaces, including small employers, now offer some level of health promotion or wellness programs. Comprehensive workplace health promotion programs are more common in larger employers with a budget, experience, and assigned responsibility.
A study by MIT neuroscientists found that a genetic mutation linked to Williams Syndrome leads to thinning of the fatty layer that insulates neurons. Reversing this effect with drugs improved symptoms, suggesting a new direction for treatment.
Researchers reconstructed Greenland Ice Sheet mass changes from 1972 to 2018 using data on ice velocity, thickness, and surface elevation. The study found a significant increase in ice loss, with an average of 290 Gt per year during 2010-2018, contributing to a 13.7 mm rise in global sea level.
Researchers found that slime molds can store knowledge of salty environments through absorption, allowing for up to a month of retention. The study suggests that the substance itself supports the slime mold's memory, rather than just the environment.
Researchers found that treating patients with personalized, combination therapies improved response rates and overall survival in patients with therapy-resistant cancers. Highly matched patients showed a 50% response rate compared to unmatched or less well-matched patients.
A study found that increasing physical activity can eliminate the association between sedentary behavior and increased mortality risk. Replacing sitting with standing or vigorous physical activity was more consistently associated with risk reduction in high sitters.
A study by Johns Hopkins Medicine researcher Junaid Razzak found a 6% increase in deaths due to emergency conditions between 1990 and 2015. The mortality burden was highest in low-income countries, with injuries, heart attacks, lung infections, and strokes being the top causes.
A new study by Harvard Medical School researchers found that nearly half of older adults who start dialysis die within a year, with death rates being almost twice as high as previously reported statistics. The study's results can help inform patient decisions and physician choice of treatment for end-stage kidney disease.
Researchers developed FitRec, a deep learning tool that analyzes past performance to predict speed and heart rate. The tool identifies important features affecting workout performance and recommends alternate routes for runners to achieve specific target heart rates.
Ten ASU engineering faculty members have received NSF CAREER Awards to fund their research projects, totaling $5 million over five years. The awards support various specialties, including nanoscale assembly and solar energy conversion.
A recent study found that 40.3% of people with cancer used marijuana in the past year, compared to 38.0% without cancer. Meanwhile, prescription opioid use was higher among those with cancer (13.9%) than without (6.4%).
A multinational study led by Vanderbilt University researchers has found that diabetes has reached epidemic proportions in Asia, dramatically increasing the risk of premature death, especially among women and middle-aged people. The study highlights the urgent need for tailored diabetes management programs for Asian populations.
Columbia engineers develop a nano-coating of boron nitride to stabilize solid electrolytes in lithium metal batteries, increasing battery life while ensuring safety. The new method achieves record-thin protection layers without lowering energy density.
Researchers from FEFU and international partners discover potential targets for glioblastoma multiforme treatment by studying proteins in the WNT signaling pathway. The findings could lead to improved antitumor therapy outcome through suppression of cancer stem cells, accelerating tumor growth rate.
A study published in Plastic and Reconstructive Surgery found that obese patients do not have a higher risk of complications after abdominoplasty, also known as tummy tuck surgery. The study included 82 patients who underwent the procedure over a seven-year period, with similar complication rates between obese and non-obese patients.
A new study found that plant-based diets can lower the risk of heart failure in adults without known heart disease, while Southern diets are linked to higher risk. The study examined five dietary patterns and their association with incident heart failure hospitalizations.
Researchers at Columbia University have discovered a new family of gravitational instabilities in granular particles, where lighter grains rise through heavier grains like 'fingers' and 'bubbles'. This phenomenon sheds light on geological processes and has potential applications in pharmaceutical production and carbon capture.
Researchers from the University of Surrey argue that a switch to permanent daylight saving time would undermine the sleep benefits of delaying school start times. This could lead to inadequate levels of sleep among teenagers, despite efforts to improve their health and graduation rates.
A recent study by Duan et al. has shown that human influence on climate change can be traced back to the late 19th century based on summer-winter temperature difference. The amplitude of seasonal temperature fluctuations has been decreasing widely, and this trend can be traced back to the 1860s.
A study found that exercise-induced cognitive improvements can be inherited by offspring via sperm. Exercise has been shown to increase the growth of immature neurons and improve mitochondrial function in the brain, leading to enhanced memory performance.
Researchers have identified two microRNA family members that can provide both immediate and long-term protection against heart damage. The therapy targets the miR-19a/b microRNAs, which regulate proliferation of cardiomyocytes and reduce inflammation, leading to improved heart function.
A deep-learning model developed using serial image scans of tumors from patients with non-small cell lung cancer (NSCLC) predicted treatment response and survival outcomes better than standard clinical parameters. The model's performance improved with the addition of each follow-up scan, predicting two-year survival with an accuracy of...
A study by Ohio State University found that customers left more negative remarks on comment cards on rainy days than dry days. The researchers linked this to bad moods, which were related to less positive views about the restaurants visited.
Researchers from Moscow Institute of Physics and Technology have found superinjection to be possible in homostructures, composed of a single material. This enables the creation of mass market devices, such as ultraviolet LEDs thousands of times brighter than previously thought possible.
Marine Skin, a polymer-based material with integrated electronics, revolutionizes sea life monitoring by tracking movement and diving behavior, as well as environmental health. The system can operate at unprecedented depths, with enhanced sensitivity, and plans include additional sensing capabilities.
A recent study found that mixing different cultivars of St. Augustinegrass reduced fall armyworm infestations in lawns. The researchers discovered that the caterpillars preferred single-variety plantings, but when multiple cultivars were planted together, it created a more pest-resistant lawn.
Researchers found curcumin has potential to prevent or treat stomach cancer by inhibiting histone modifications. Compounds like cholecalciferol, resveratrol and quercetin also show promise in modulating histone activity.