A new high-throughput method has revealed metals previously undetected in 3-D protein structures, correcting up to half of the errors in global repository of protein structures called PDB.
An international team sequenced the genomes of 78 individuals from five indigenous groups in Mexico to understand the demographic history and genetic variation of pre-Hispanic populations. They identified 120,735 single nucleotide variants and found that certain genes were associated with adaptation to physical endurance and other traits.
Research from UVM and MITRE shows that near-light-speed differences in stock prices create opportunities for latency arbitrage, costing investors at least $2 billion annually. High-frequency traders exploit faster information systems to buy stocks at better prices and sell them quickly, resulting in significant profits.
A new study predicts 13 million US residents will be forced to relocate due to rising sea levels by 2100. Cities like Atlanta, Houston and Denver are expected to experience significant population growth, with effects on jobs, housing prices and infrastructure.
A study published in PLOS ONE reveals that prehistoric Italian communities traded copper across complex networks, with most coming from Tuscany. Non-Tuscan copper was also a significant import to the region, contributing to a growing picture of independent metal exchange networks.
A new study proposes that the first building blocks of life on Earth were not uniform but rather patchwork molecules containing bits of RNA and DNA. The 'RNA World' hypothesis has been revised to suggest a Frankenstein-like beginning, with RNA emerging from a mixture of nucleotides.
A Tel Aviv University study finds two writers composed 31 of 100 inscriptions from 8th-century BCE Samaria, providing insights into the logistical infrastructure of the kingdom of Israel and limited literacy rates in the early eighth century BCE.
A protein found in the bran of foxtail millet has been shown to reduce plaque buildup and inflammation in mice with genetic predispositions to atherosclerosis. The study suggests that this natural compound may have great potential in preventing and treating heart disease.
Researchers identified a highly competitive bacterium in the gut microbiota that protects against enteric pathogens. This discovery offers new avenues for developing antibiotic-free treatments.
Scientists at Curtin University have discovered the Yarrabubba crater, dated to 2.229 billion years ago, coinciding with the end of a global deep freeze known as Snowball Earth. The research suggests that the asteroid impact may have influenced global climate by vaporizing ice and releasing greenhouse gases.
A new geochemical model suggests that Enceladus' subsurface ocean may be habitable due to chemical reactions at its seafloor, which could provide energy sources for life. The study reveals a complex core structure with diverse environments, including hydrothermal vents and carbonated rocks.
Scientists investigate three 67 million year old oviraptorid egg fossils, determining that the embryos were at different developmental stages and likely hatched at different times. The findings suggest a unique nesting biology similar to modern birds, challenging previous assumptions about oviraptorids.
In 2019, the pharmaceutical industry approved 48 new medicines, including treatments for various cancers, sickle cell disease, and migraines. The majority of these drugs had novel mechanisms of action, such as antibody-drug conjugates and small interfering RNA.
A randomized controlled trial found that the ACE method was as effective as a specialist stop smoking service in quitting smoking. The study's results suggest that ACE may offer a viable cost-effective alternative for public-funded healthcare settings.
Researchers have successfully disrupted viral latency in monkeys and mice, a crucial step towards an HIV cure. The approach uses a combination of immune stimulation and depletion to reactivate the dormant virus, offering new avenues for treatment.
Researchers discovered that two types of 'kinesin' molecular motors coordinate differently, with kinesin-1 working independently and kinesin-14 interacting to tune transport speed. This breakthrough expands understanding of cellular processes and basic life functions.
A recent study discovered a connection between glioma cells expressing the protein TAU and better patient outcomes. The presence of TAU helped regulate blood vessel formation, contributing to tumor aggression. Researchers suggest TAU levels could serve as a biomarker for tumor progression in IDH1/2 mutant gliomas.
Scientists at UNC-Chapel Hill and Emory University successfully reversed HIV latency in animal models using compound AZD5582. The study, published in Nature, demonstrated the ability to activate latently infected CD4+ T cells without toxicity, paving the way for further research towards a cure.
Researchers have developed a method to synthesize large-area, atomically thin molybdenum disulfide films with modified structures depending on the synthesis temperature. The resulting films show promise for use in electronic devices and optical communication, with potential breakthroughs in transparent and flexible electronics.
Researchers found that Antarctic Bottom Water, a deep-water mass in the Southern Hemisphere, was disrupted from spreading northwards into the South Atlantic and Indian Oceans during peak ice ages. The study suggests that weaker circulation in the Southern Ocean during cold periods may have interrupted this process.
Researchers found that animal carcasses contribute to increased plant growth, attracting herbivorous insects and their predators. This has a positive impact on the local food chain, persisting even five months after death.
A RAND Corporation analysis suggests that Medicare overpays surgeons for postoperative care, with only a small share of the care provided. Adjusting payments could reduce reimbursements by 28% and result in increased payments to primary care providers.
Researchers from Washington University found that adding orthophosphate to the water supply before switching to chloramine can prevent lead contamination. In their experiment, lead levels remained below 10 micrograms/liter in pipes treated with orthophosphate, whereas levels rose above 80 micrograms/liter in control pipes.
Researchers have developed a method to link fingerprint compounds with their age, allowing for more precise timing of prints. By analyzing triacylglycerol degradation rates, scientists can estimate the time elapsed since fingerprints were left behind.
Researchers have identified blood-based biomarkers associated with both delirium duration and severity in critically ill patients. These biomarkers can help identify individuals at risk for longer delirium duration and higher delirium severity, potentially leading to new treatments.
New Zealand researchers reveal a significant gender pay gap, with men earning an average of NZ$400,000 more than women over their lifetime. Only 40-70% of the pay gap can be attributed to research performance and age.
A Japanese survey reveals differing perceptions of gene-edited crops among experts and the general public. Experts see benefits, while the public perceives risks despite acknowledging value. The findings shed light on the deficit model's boundaries in science communication.
A skin cream used to treat warts and skin cancer has been found to prevent infection from viral diseases like Zika and dengue when applied after a mosquito bite. The cream works by activating the skin's immune response, preventing the virus from spreading throughout the body.
A global study on the impacts of human land-use found that predators and small ectotherms are disproportionately affected, with abundance reductions of 25-50% compared to natural habitats. The researchers analyzed over 1 million records from 80 countries and 25,000 species.
A randomized clinical trial evaluated the absorption of six sunscreen active ingredients in four formulations, with all ingredients surpassing FDA thresholds for potentially waiving additional safety studies. The study highlights the need for further research on sunscreen ingredient exposure and its effects.
New research finds that preparing land for palm oil plantations releases more greenhouse gases than mature plantations, accounting for almost a quarter of regional emissions. Laboratory analysis reveals significant CO2 emissions during drainage and young oil palm stages.
A new study published in Clinical Infectious Disease found that fully vaccinating children reduced the risk of hospitalization for influenza complications by 54%. The research, led by Dr. Hannah Segaloff and Prof. Mark Katz, validated guidelines recommending two vaccine doses for children under 8 who have never been vaccinated or recei...
Researchers have identified a new protein called 'aggregatin' that accumulates in brain plaques and may be linked to Alzheimer's disease progression. Suppressing this protein could lead to future treatments aimed at slowing the disease's advance.
Researchers at the University of Illinois constructed synthetic microbial communities to study their dynamics and predict behavior. The study found that increasing variability in microbial interactions drives community structure, and that characterizing this variation can empower predictions of ecosystem succession.
Researchers analyzed data from over 100 youth football players, finding that they are more susceptible to concussion at lower levels of acceleration than older athletes. The study's findings provide critical information for designing and testing protective equipment.
A novel pharmacological chaperone has been shown to restore levels of the sorting molecule VPS35 and prevent the accumulation of abnormal proteins in mice with Alzheimer's disease. This treatment approach has been proven to improve memory and learning, reducing tau tangles and amyloid-beta plaques.
A study published in PNAS reveals that the blood-brain barrier's impermeability is linked to depression symptoms and that restoring its integrity may lead to improved treatment outcomes. Researchers found that a decrease in claudin-5 protein and increased HDAC1 enzyme are associated with depressive symptoms.
Commercially insured children in the US see pediatricians less often, with primary care visits decreasing by 14% and problem-based visits declining by 24%. The trend may be driven by higher out-of-pocket costs and changes in healthcare behaviors, including increased use of telemedicine and urgent care.
Researchers at Hokkaido University developed a stacked nanocarbon antenna that makes europium shine brighter than previous designs, with potential to create more efficient photosensitizers. The new design uses low-energy blue light absorption, reducing energy loss and enabling photodynamic therapy applications.
Despite reports of near elimination, global HFC-23 emissions are growing at record values, contradicting expectations. Scientists attribute the rise to increased production in developing countries.
A study led by McGill University found that anti-inflammatory medications are most effective when taken during the active periods of our biological clocks, promoting post-operative healing and recovery. This discovery suggests a new approach to treating pain and inflammation following surgery.
Scientists are exploring genetic changes that make brain tumors resistant to BRAF inhibitors, a common treatment for certain types of brain cancer. The study aims to identify new potential targets for combination therapy to keep cancers from developing resistance.
Researchers created an artificial electron transfer system by modifying a protein from bacteria, which can be used to produce medicines and biofuels. The system works by guiding electrons through short 'pit stops' made of heme molecules, allowing for more efficient energy transfer.
A new study published in Hypertension found that reducing sodium intake decreases thirst and urine volume, but does not affect metabolic energy needs. This results support the traditional notion that decreasing sodium intake is critical to managing hypertension.
Female and male soccer players had similar rates of head collision events during elite tournaments, but female players received more medical assessments. The median time for medical assessments was shorter for female players compared to the minimum required duration.
Researchers found that neonicotinoid seed treatments have driven a significant increase in insecticide toxicity to honey bees, particularly oral-based toxic loads, which rose by 9-fold across the US. The study highlights the need for mitigation and conservation efforts in regions with high levels of insecticide use.
Researchers tracked pollutants from Canadian and US wildfires to reach NYC, causing significant increases in air quality advisories. The study highlights the need for policy-makers to consider long-term air quality management plans due to increasing wildfire smoke.
A new study found HIV hides in every organ site, including the brain and liver, causing inflammation-related diseases. The study used serial blood samples from terminally ill participants with HIV to identify where HIV hides, shedding light on potential new therapies.
A combination of two experimental drugs has reversed osteoarthritis in rats, with improved cartilage thickness and reduced cell death. The treatment may potentially translate to human use, offering a promising therapy for millions of adults affected by the disease.
Researchers have found a possible link between a genetic variation and atrial fibrillation in zebrafish, suggesting a structural defect in the heart muscle and mitochondria. Early treatment with antioxidants may prevent the disorder in fish, but more research is needed to understand its human implications.
New statements from ACR and NKF clarify risk of contrast-induced acute kidney injury and provide recommendations for use of intravenous contrast media in patients with varying degrees of impaired kidney function. The authors emphasize the need for prospective controlled data to further understand the risk.
Researchers developed a machine learning-based method to estimate life-years lost and cost associated with air pollution exposure. The study found that the elderly population is most vulnerable, with those with chronic conditions facing over 30 times higher mortality risk than typical Medicare beneficiaries.
A study found that one in 18 physicians received pharmaceutical marketing for stimulant medications, often in the form of food or beverage. The study suggests that subtle marketing tactics may contribute to the increasing prescribing and misuse of these medications.
A study using quahog clam shells and climate models reveals Arctic sea ice can't 'bounce back' if climate change causes it to melt. Human activity is now massively forcing the system, exacerbating warming and sea ice loss.
A study led by Michigan State University researchers found that a collective model created by over 200 anglers and fishing club members accurately predicted pike populations, habitat, and fishing pressure. The results show that involving diverse interest groups improves the accuracy of the solution.
A new device uses magnetic fingerprinting to identify hidden metal objects, offering a smaller and cheaper alternative to traditional security systems. It can detect a wide range of metallic objects, from cellphones to hammers, with improved accuracy and low power consumption.
The U-MATTER program uses a deflection approach, directing people with opioid use disorders towards treatment and services. The initiative has seen positive outcomes, including 71 individuals receiving full clinical intake assessments and 40 committing to long-term treatment.
Researchers have developed a new method to measure ultrafine particles in exhaust gas, which are harmful to health. The process provides a better understanding of the formation of secondary aerosols by car exhaust gases and can help reduce vehicle emissions.
A new study by Flinders University finds that teenagers' online impulsivity is a significant risk factor for cybercrime. The internet's blurring of social boundaries encourages thrill-seeking behavior, which can lead to digital piracy, pornography, and hacking. The researchers suggest that policy interventions should take into account ...
The study, conducted by the University of Córdoba, demonstrates the feasibility of using recycled demolition waste to build roads. The results show that recycled aggregates from mixed materials and concrete foundations performed better than natural aggregates in terms of surface properties and mechanical development.