Researchers at Max Delbrück Center developed a new model of the brain using human stem cells, which showed promise in treating HSV-1 induced encephalitis. By combining an anti-viral with an anti-inflammatory drug, they were able to prevent tissue damage and promote recovery.
Adding up to 20% soft rubber spheres improves packings' effective stiffness, while exceeding 30% reduces it. This behavior is explained by the length of force chains and coordination numbers of glass particles.
A study of 200 people aged 50-70 found that higher carotene levels in the blood were associated with lower atherosclerosis and reduced cardiovascular disease risk. A diet rich in fruits and vegetables, particularly those high in carotenes, may help lower the risk of heart disease.
Researchers from UNIGE have developed a new method to test the validity of Einstein and Euler's theories on the accelerating Universe expansion and dark matter. The study uses time distortion as a never-before-used measure, allowing for differentiation between the two equations.
The American College of Medical Genetics and Genomics has released its updated Secondary Findings Gene List (SF v3.2) with three new cardiovascular genes added, including CALM1, CALM2, and CALM3. The list provides guidance on reporting incidental findings in clinical exome and genome sequencing.
Incoming collegiate student-athletes who reported prior COVID diagnosis showed significantly higher depression scores, while most participants had mental health scores within established diagnostic thresholds. The study highlights the importance of monitoring mental health in this population after COVID recovery.
A small-scale clinical trial suggests a modified CAR-T therapy could effectively reduce myasthenia gravis symptoms, with three patients showing complete elimination of symptoms. The treatment was well-tolerated and has the potential for longer-lasting results compared to current treatments.
Research reveals liver dysfunction and alterations in the liver-brain axis are key features of Alzheimer's disease. The study highlights the importance of peripheral organs, such as the liver, in understanding the systemic aspects of the disease.
Children with parental cancer history face higher rates of unmet economic needs, including food security, housing affordability and transportation access. The study highlights the need for strategies to identify and support these vulnerable children.
The global prevalence of diabetes is expected to more than double from 6.1% to 12.8% by 2050, with every country experiencing an increase. The study found that high body mass index and dietary risks are primary contributors to type 2 diabetes.
Researchers have developed a high-energy cathode, Na4MnCr(PO4)3, capable of three-electron reactions. The material exhibits an ultra-high energy density of 523.6 Wh kg^-1, outperforming existing phosphate cathodes.
The study found that drug-resistant Leishmania parasites have distinct protein production profiles compared to sensitive parasites, suggesting a global reprogramming of protein synthesis. This pre-emptive adaptation enables the parasite to quickly respond to the presence of the drug and survive when it is absent.
Researchers discovered a way to strengthen polymers by introducing weaker bonds, increasing resistance to tearing up to tenfold. The approach doesn't alter other physical properties and can be used to improve the toughness of other materials like rubber.
US delivery-related hospital mortality decreased for all groups between 2008 and 2021, while severe maternal morbidity increased, particularly among older women and minority patients with comorbidities
Researchers at MedUni Vienna's Department of Thoracic Surgery have made key findings in small-cell lung cancer, including the identification of tumor subgroups associated with varying clinical behaviors. They also propose promising therapeutic strategies for patients with characteristic molecular profiles.
Astronomers discovered a new way to destroy stars, generating powerful gamma-ray bursts in the process. The study found that stellar collisions in dense environments surrounding supermassive black holes can create these explosive events.
Researchers outline a new approach to understanding complex ecosystems using complexity science, which could increase our understanding of the natural world. The study highlights the importance of nonlinearities, stability, and resilience in ecological systems.
Researchers discovered that leaf-cutting ants use the position of their hind legs gripping the leaf edge and head position to guide cutting trajectory. The ants adapt their technique to cut smaller elliptical portions when faced with thick leaves, using a combination of sensory information.
Researchers discovered a unique structure in the mussel shell's hinge that combines biomineralized aragonite nanowires with a softer organic matrix to resist brittle fracture. The nanowires provide rigidity and distribute stresses, while the soft matrix absorbs compressive and shear stresses.
A new study by University of California, Berkeley biologist Robert Dudley found that hummingbirds happily sip from sugar water with up to 1% alcohol by volume, without being repelled by it. The research suggests that birds are likely consuming ethanol produced by natural fermentation in flowers and nectar-filled feeders.
Researchers at University Hospital Bonn have developed a new approach to predict therapy response in patients with metastatic renal cell carcinoma by incorporating two simple blood parameters, CRP and albumin. This method improves the prediction of treatment response, especially in patients with disease control in the first follow-up.
Research on pregnant individuals faces challenges due to restrictive abortion laws, which can expose participants to health risks or compromise informed consent. Researchers must consider provisions for safe abortion access and explicit informed consent documents to advance scientific knowledge.
Researchers developed a model of the blood-brain barrier to prevent newborn meningitis treatment, with a 50% mortality rate in developing countries. The organ-on-a-chip platform enables rapid and accurate testing of drugs for safety and efficacy, promising to improve treatment outcomes.
Researchers from Hebrew University developed a microscope-integrated ellipsometer that enables fast and precise measurements of thin-film thicknesses in small areas. The Spectroscopic Micro-Ellipsometer successfully maps the thicknesses of diverse 2D material flakes, determining their number of atomic layers.
Cartesian Therapeutics has successfully treated patients with generalized myasthenia gravis using an RNA CAR-T therapy. The trial demonstrated marked and long-lasting clinical improvement, with three patients achieving complete or near-complete eradication of disease symptoms.
Researchers have identified over 30 previously unknown RNA viruses in sea lice, suggesting they may play a role in controlling sea-lice populations. The viruses' ability to rapidly replicate and weaken their hosts maintains balance in nature.
A recent study found that elderly patients treated in local intermediate care units have lower mortality rates and fewer hospital readmissions. The research suggests that Norway's healthcare system has improved with the introduction of these units, providing better integrated services adapted to individual users.
Peruvoside has been discovered to prevent up to 12 medically important viruses, including SARS-CoV-2, Hand, Foot and Mouth Disease (HFMD), and Influenza. The compound acts on GBF1 protein, disabling its functionality and stopping virus production.
A statewide study in Indiana found that pre-existing diseases significantly increased the risk of severe illness and death from COVID-19, particularly among Black patients. The research also highlighted racial disparities in healthcare outcomes and access to care.
A global analysis of pollinator decline in cities reveals that butterflies are most affected, with shrinking habitats and food availability causing populations to drop. Meanwhile, certain groups of wild bees, such as those nesting above ground, remain less impacted by urbanization.
The researchers have demonstrated significant improvements for chip-based sensing devices that can detect or analyze substances across widely varying concentrations. They developed signal-processing techniques that enable seamless fluorescence detection of a mixture of nanobeads in concentrations across eight orders of magnitude.
A study by John Innes Centre researchers has revealed how plants avoid cracking under stress by using a growth hormone called brassinosteroid to loosen the straitjacket effect on their skin. The findings, published in Science, have implications for our understanding of plant development and potentially improve crop yields.
The Lehigh University Industrial Assessment Center will conduct energy audits for manufacturing plants in the mid-Atlantic region, providing real-world training for students and professionals. The center aims to reduce industrial emissions and improve manufacturing competitiveness while enhancing workforce development in disadvantaged ...
A new study models the spread of African swine fever in US swine farms, finding that control actions can reduce secondary infections by up to 79% but an outbreak could still be persistent and costly. The model suggests that between-farm movements are the primary route of transmission.
The SEB Centenary Conference 2023 features over 800 talks on advances in animal, plant and cell biology. The conference marks the Society's 100th anniversary with special events and projects celebrating historically marginalised scientists.
Researchers establish a direct link between Covid-19 and Alzheimer's disease, attributing the connection to RAS overactivation caused by SARS-CoV-2 virus. This dysfunction leads to increased b-amyloid protein accumulation, impairing brain cell synaptic connections and cognitive functions.
BioAutoMATED is an all-in-one AutoML platform designed for biologists, enabling easy analysis and interpretation of biological sequences. The platform uses three existing AutoML tools to generate models that can predict biological functions from sequence information.
Researchers developed a pilot study to address the issue of thermal discomfort in social housing projects. They proposed replacing conventional windows with fully openable tilting windows, monolithic expanded polystyrene walls, and green-tinted tempered glass, which can reduce energy consumption and greenhouse gas emissions.
Researchers have identified anti-malarial properties in cancer drugs, offering a potential solution to the growing crisis of drug-resistant malaria. The study found that certain protein kinase inhibitors exhibited strong anti-malarial effects, highlighting a new approach to accelerating drug discovery.
Researchers at Purdue University have demonstrated tunable moiré magnetism in twisted double bilayers of chromium triiodide, a material that can be used for spintronics. This discovery suggests a new class of material platform for spintronics and magnetoelectronics.
Surrey researchers have made significant breakthroughs in capturing and converting carbon dioxide into useful products. The team's switchable DFM, 'NiRuNa/CeAl', captures CO2 in three chemical reactions: methanation, reverse water-gas shift, and dry reforming of methane.
Researchers have shed light on the optimal use of intravenous fluids to treat sepsis, a life-threatening condition that affects nearly a third of ICU patients. The review provides critical insights into dosage and timing of fluids to improve treatment outcomes and reduce mortality.
A new analysis reveals that a high proportion of essential medicines are not registered in Kenya, Tanzania, and Uganda, limiting their availability. The study found that up to 90% of certain medicine types were unregistered, while only 46% of highly registered antibiotics were essential medicines.
Researchers from Tokyo Institute of Technology explore co-polymerization of glycol nucleic acid monomers with dicarboxylic acids to produce branched and linear xeno nucleic acid polymers. These findings suggest that diverse prebiotic organic molecules could have led to population-level differences in abundance of genetic polymers.
Research from Keck School of Medicine of USC found that everyday air pollution can alter brain development patterns in adolescents, linked to changes in brain connectivity over time. Exposure to fine particulate matter and nitrogen dioxide was associated with increased or decreased functional connectivity between brain regions.
A new study reveals that the brain makes trade-offs between accuracy and speed in sensory perception. Initial visual processing is faster but less accurate compared to other parts of the brain. The findings contradict the efficient coding hypothesis, suggesting that the brain can process sensory inputs quickly with small errors.
A new study found that football players' cumulative repetitive head impact exposure was associated with chronic traumatic encephalopathy (CTE) status and severity. The study suggests that reducing both the number of head impacts and their force could lower CTE risk.
Domenick Zero, an Indiana University professor, received the William H. Bowen Research in Dental Caries Award for his groundbreaking research on caries prevention and early detection. His work has improved oral health through innovative methods and tools, shifting focus from invasive treatment to tooth preservation.
Researchers used fMRI to analyze brain activity in response to restaurant menu photos, finding a correlation between neural activity and dish sales. The study suggests restaurants can design menus based on predicted consumer preferences.
A specially designed garden, rain garden, can capture toxic tire chemicals associated with tires entering waterways by more than 90%. Researchers tested a Vancouver rain garden and found that it captured about 75% of the chemical, preventing it from entering salmon-bearing streams.
Research suggests that bamboo can be converted into bioethanol and biogas, offering an attractive alternative to fossil fuels. The chemical composition of bamboo varies across species, highlighting the need for further research on selecting optimal species for biomass production processes.
Researchers have developed a groundbreaking photonic integrated circuit chip that combines light source, modulator, photodiode, waveguide, and Y-branch splitter on a single substrate. The GaN-on-silicon platform reduces fabrication complexity and cost, enabling compact and high-performing devices.
Researchers have developed a microgel delivery system that keeps beneficial bacteria safe while actively clearing out harmful ones in the gut. In mice, this system treated intestinal inflammation without side effects and showed promise as a viable treatment strategy for intestinal diseases.
Research suggests climate change will impact insect biodiversity by throwing off the delicate balance between species that rely on each other for survival. As temperatures rise, insect life cycles may become out of sync with their host plants, leading to potential extinction.
Research from Cornell University estimates that wildfire smoke can cause between 4,000 and 9,000 premature deaths and cost between $36 to $82 billion per year in the United States. Metropolitan regions near fire sources are likely to experience a large health burden and economic loss.
Researchers developed a copper-based hydrogel that captures nitrate waste and transforms it into ammonia for reusable fertilizers. The system increased crop yields while reducing environmental impacts.
A study published in Brain and Behavior found that humor therapy reduced symptoms of depression and anxiety in participants from various countries. The analysis included 2,964 participants and nine different countries, suggesting that humor therapy may be a feasible complementary alternative for clinicians, nurses, and patients.
Researchers studied cation effect on CO coupling reaction using ab initio simulations and found correlations between ion hydration energy, double layer capacitance, and surface reaction energies. Different cations influence selectivity of C2 products in CO electro-reduction.
Researchers at the University of Colorado Anschutz Medical Campus have discovered a molecular mechanism contributing to congenital heart defects in infants with Down syndrome. The study found that an abnormal interferon response inhibits key molecular events required for heart development, leading to impaired cardiogenesis.
A team of engineers at RMIT University has developed a novel approach to recover heavy metals, including copper and zinc, from treated sewage sludge. The innovation enables the recycling of acidic liquid waste, reducing environmental harm and retaining nutrients for land applications.