Researchers identified three subtypes of fibroblasts in skin cancer: myofibroblast-like RGS5+ CAFs, matrix CAFs (mCAFs), and immunomodulatory CAFs (iCAFs). The distribution of these subtypes varies with tumor aggressiveness. iCAFs produce signaling factors to activate immune cells, while mCAFs prevent T cell invasion.
A recent clinical study confirms kimchi's ability to reduce body fat and improve gut health, with a notable 31.8% reduction in body fat among animal models. Additionally, human studies show a 15% reduction in BMI and 12% decrease in obesity incidence among middle-aged males.
A team of researchers has developed Janus crystals that capture humidity from the air with high efficiency, enabling a spontaneous and energy-free process for collecting potable water. The discovery could provide an endless source of clean water, addressing global water scarcity issues.
A new Israeli study explores physician attitudes toward emerging anti-amyloid treatments for Alzheimer's disease. Key findings highlight the need for multidisciplinary collaboration to address financial and logistical barriers, emphasizing education, cost-benefit analysis, and improved insurance coverage.
Residents of Senboku New Town in Japan transformed vacant buildings into supportive housing, community restaurants, and group homes to address aging population challenges. The Senboku Hottokenai Network Project showcases the importance of community-led co-creation in creating Healthy New Towns.
A team of physicists studied the unique motion of Champati seeds rolling down slopes, revealing a spread-out, then collapse-like behavior akin to rock avalanches. The research may provide valuable insights into geological flows and contribute to resolving challenges in this area.
A recent special issue of Criminology & Public Policy explores the impact of legislative policies, criminal justice practices, and community-based efforts on gun violence. The studies featured in this issue aim to provide timely solutions to addressing this significant concern in the United States.
Users value interacting with others and customizing their avatars in metaverse-based events. The study suggests that organizers must focus on the entire user experience to drive attendance.
Researchers found four molecular networks in ciliate and mammalian cells that exhibit hallmarks of habituation, suggesting single cells process and remember information over different time spans. This finding opens up new mysteries about how cells without brains manage complex behaviors.
A 30-year database analysis shows variable weather reduces the effectiveness of post-emergence herbicides against major corn and soybean weeds. Air temperature, precipitation patterns, and dry/wet conditions all impact herbicide effectiveness, making weed control more difficult for farmers.
The discovery provides a unique way to investigate the extreme phase of stellar evolution, bridging the gap between the earliest and final stages of binary star systems. This breakthrough could help explain cosmic events like supernova explosions and gravitational waves.
According to a recent study published in The Journal of Nutrition, over 90% of pregnant individuals are potentially failing to get enough iron, vitamin D, or vitamin E from the food they eat. Almost two-thirds were found to be getting insufficient dietary folate, a critical nutrient that helps prevent birth defects.
Researchers have discovered that seemingly 'broken' genes in coronaviruses are retained due to their functional role beyond protein production. These extra genes help control the activity of other viral genes.
Researchers found that landfills retain most plastic waste but release high levels of PFAS into leachate, while wastewater treatment plants remove microplastics but accumulate PFAS in biosolids. The study highlights the need for pollution prevention and reduces to landfill disposal.
Researchers have trained AI models to distinguish brain tumors from healthy tissue using convolutional neural networks and transfer learning. The models achieved an average accuracy of 85.99% at detecting brain cancer, with the ability to generate images showing specific areas in its tumor-positive or negative classification.
A new review highlights the differences in brain aging and Alzheimer's disease between humans and non-human primates, revealing that primate brains are more resistant to aging-related damage. The study suggests that tau tangles play a critical role in Alzheimer's progression, challenging the amyloid cascade hypothesis.
Scientists have investigated the degradation pathways of layered Li-rich oxide cathodes, revealing changes in morphology and structure with each charging cycle. The study provides valuable insights into the chemical processes involved in battery aging.
A new study reveals that the San Joaquin Valley in California has been sinking at an average rate of nearly an inch per year between 2006 and 2022. The researchers estimate that the land sank by over 12 inches during the four-year gap in satellite data, highlighting the urgent need for mitigation strategies.
A new study uses machine learning to predict pedestrian crash frequency by severity levels, providing insights for road authorities to prioritize actions. The research demonstrates a significant increase in performance compared to conventional methods.
A new composite phase change material composed of Na2SO4·10H2O and expanded graphite has been developed to regulate battery temperatures and mitigate thermal runaway risks. The material's dual-stage temperature control mechanism effectively manages LIB heat, reducing peak temperatures and delaying the onset of TR events.
Researchers created digital reconstructions of Aztec death whistles and found they produce unique air turbulence, creating a chilling sound. Listeners perceived the whistle's sound as natural and organic, similar to human voices or screams, suggesting a symbolic association with mythological entities.
A new study by the CHAMPS network reveals that meningitis contributes to higher child mortality rates than estimated by the WHO, with 7% of deaths attributed to the disease. The study also highlights the shift towards antibiotic-resistant bacteria, particularly in hospital-associated cases.
A cohort study of adults with outpatient RSV infections found that approximately 1 in 20 experienced all-cause hospitalization within 28 days. The results highlight the need for RSV prevention and treatment to address public health concerns.
A new study published in Academic Emergency Medicine evaluates the use of a cranial accelerometry device to detect large-vessel occlusion strokes in prehospital settings. The research demonstrates that obtaining adequate recordings with this device is highly feasible, marking an important step forward in stroke management.
Researchers at Texas A&M have made breakthroughs in understanding the Y chromosome in horses, enabling tracing of paternal lineages for breeding and conservation purposes. This discovery will help identify optimal lineages for breeding and preserve breed diversity.
Researchers from Kyushu University have developed an antibody that targets and prevents the dysfunction of hepatocyte growth factor (HGF), a critical protein for skeletal muscle development, regeneration, and repair. The new antibody, 1H42F4N, blocked nitration of HGF and did not disrupt its activity.
A study published in Radiology found that radiologists and physicians who received local explanations from artificial intelligence (AI) systems performed better and made faster diagnoses than those who received global explanations. The researchers also found that AI advice was trusted more quickly when it provided local explanations.
The National Academies report outlines nine actionable recommendations to advance the responsible use of race and ethnicity in biomedical research, including community engagement and data inclusivity. The report aims to provide a key guide for researchers considering using race and ethnicity throughout their research process.
A USC Schaeffer study found that over half of Medicare beneficiaries with stand-alone Part D plans did not switch due to lack of plan comparisons, with many unaware of how to change plans or missing out on better coverage options. This complacency allows insurers to exploit beneficiaries' inattention and boost profits.
Piangua populations are experiencing a significant loss of genetic diversity due to intense harvesting, reducing their ability to adapt to environmental challenges. The study reveals subtle genetic variations among local populations, highlighting the need for targeted conservation strategies.
A recent study surveyed over 1,000 English-dominant, bilingual, and Spanish-dominant Latino users of Facebook and Instagram in the US. Latinos who use Spanish-language social media for news were found to be more susceptible to false political narratives, with a 11 percentage point increase in belief in these claims.
A new study from the UBC Sauder School of Business found that dominant group employees can learn and become allies, leading to growth in organizations. Employers should encourage dialogue through various means to alleviate fears and generate new allies.
A new supplement published by JDR Clinical & Translational Research examines the connections between oral health, behavior, and overall well-being. The study reveals strong evidence for the importance of integrated healthcare systems addressing these interconnected aspects.
The American Gastroenterological Association (AGA) has released a new clinical guideline on the pharmacological management of moderate-to-severe ulcerative colitis. The guideline groups available treatments into 'efficacy buckets' to facilitate personalized treatment planning, taking into account patient risk factors and disease severity.
Researchers propose quasi-convolution coding to simplify reservoir computer design, enhancing memory capacity and reducing complexity. The approach leverages dual polarization modes of commercial lasers, offering a feasible strategy for constructing integrated deep RC systems.
Geology researchers from UTEP are partnering with Bhutanese scientists to better understand and mitigate the impact of glacial floods on rural mountain villages. The project aims to use geophysical methods to identify changes in water levels and sediment transport, potentially helping vulnerable villages create early warning systems.
Researchers propose a new matrix for orthogonal matrix of polarization combinations to enhance polarization multiplexing in holography. The method enables the recording and simultaneous reconstruction of multiple polarized holograms at a single location, with high contrast and robustness.
Research suggests that lifestyle modifications and metformin do not improve atrial fibrillation (AFib) burden or progression when compared to standard care. In contrast, weight loss and exercise resulted in decreased AFib symptoms in patients with the condition.
Researchers at Kyushu University develop a novel technique for building complex 3D microfluidic networks using plant roots and fungal hyphae in silica nanoparticles. This bio-inspired method enables the creation of intricate biological structures, opening new opportunities for research in plant and fungal biology.
Researchers have identified alternative transcription initiation sites for over 40,000 soybean genes, revealing widespread variations outside the traditional TATA box region. This discovery challenges current assumptions about gene expression and has significant implications for plant breeding and genetics research.
A new study by University of Surrey and University of Aberdeen researchers found that jetlag impacts metabolism, causing reduced energy spent processing meals and changes in blood sugar and fat levels. The metabolic effects are temporary, recovering within 2-3 days, while impairment of sleep and alertness takes longer to recover.
Researchers use AI to predict COPD flare-ups based on daily urine tests, potentially allowing for proactive treatment and prevention. The study identifies biomarkers in urine that can forecast a flare-up seven days prior to symptoms.
Researchers found a 10.8% price discount in the AEP 100 flood zone and a 4.4% discount in the AEP 500 flood zone, highlighting the financial burden of flood risk on homebuyers. The study emphasizes the need for policymakers to safeguard communities and manage real estate markets as climate patterns intensify.
A new framework describes the balance between automatic responses and goal-directed control in habit formation. This imbalance can lead to everyday action slips and compulsive behaviors. The research provides a 'playbook' for behavior change, including strategies like implementation intentions and clinical interventions.
Researchers create system to manipulate cell behavior using 'crowd control' technique, enabling predictable patterns and structures. Cell density plays key role in guiding cellular development, offering potential for medical applications such as tissue engineering and organ regeneration.
A new study from Karolinska Institutet found that long-term use of common cardiovascular drugs is associated with a lower risk of dementia. The study, which analyzed data from over 880,000 people, shows that these medications can reduce dementia risk by 4-25%.
A new machine learning algorithm reconstructs wind fields quickly and accurately, even with limited observational data. This enhances storm forecasting and hazard preparedness by providing valuable data on a tropical cyclone's intensity and potential impact.
A study of 61,214 dementia-free individuals found that high cardiorespiratory fitness was associated with better cognitive performance and a lower risk of dementia. The findings suggest that enhancing cardiorespiratory fitness could be a strategy for preventing dementia in people with a genetic predisposition.
A new study reveals that Latino Facebook and Instagram users are significantly more vulnerable to political misinformation when consuming news in Spanish, compared to those using English. The research found a strong link between Spanish-language social media consumption and less informed election knowledge among Latinos.
Repeated exposure to online lies can lead content moderators to believe false claims, as demonstrated by the illusory truth effect. The study suggests that this phenomenon is not limited to Western populations, which may lead to decreased effectiveness among content moderators over time.
Researchers at the University of Arizona Health Sciences have identified a potential new drug, PNA5, that targets cognitive symptoms in Parkinson's disease. The study found that PNA5 dials back inflammation in brain cells, which may prevent further degeneration and alleviate cognitive decline.
A 10-year study found that short-term exposure to heat and air pollution was associated with an increase in medical imaging exams, particularly for chest, neuro, and musculoskeletal imaging. High temperatures had a greater impact on X-ray utilization, while high particulate matter levels were linked to increased CT scans.
A 7-year study found a significant increase in centimetre-sized plastic fragments in the North Pacific Garbage Patch, surpassing larger floating plastics. The research, conducted by The Ocean Cleanup, reveals an unexpected rise in mass concentration of these fragments, likely originating from decades-old plastics discarded globally.
A recent study published in Nutrition & Diabetes found that consuming over 45% of daily calorie intake after 5 p.m. is associated with increased glucose levels, regardless of individual weight or body fat composition. This can lead to a higher risk of type 2 diabetes, cardiovascular disease, and chronic inflammation.
Researchers developed a novel lentivirus-based gene therapy strategy in CD34+ hematopoietic progenitor cells, which showed therapeutic levels of expression of the anti-sickling beta globin protein. Cyclosporin improved transduction efficiency and preserved cell viability.
A new USC study reveals that face masks make it harder for people of all ages to recognize emotions, especially sadness, behind masks. Parents reporting high stress levels struggle even more to decode sad emotions.
A survey of GI fellows found that gastroenterologists providing inpatient care improve education through enhanced endoscopy teaching and longitudinal feedback. This model is expected to create more robust fellowship programs across the US, combining benefits of both GI Hospitalist and non-GI Hospitalist faculty.
A new paper predicts that AI will influence human evolution through natural selection, including changes in brain size, attention spans, and social behaviors. The author argues that human-AI interactions can resemble human-human social interactions, leading to potential evolutionary consequences.
Researchers propose a new working definition for CVI, a leading cause of blindness and visual impairment in children. The definition is based on five key elements and includes early detection, neuroplasticity, and functional deficits.
A new approach could overcome major barriers to practical fusion energy production by adjusting fuel properties using spin polarization. This method could increase tritium burn efficiency, reducing the amount needed and lowering operating costs.