Adrenal hormone function was restored in animal studies using implantable cell therapy, demonstrating potential for a functional cure for primary adrenal insufficiency. The treatment also followed the animals' natural circadian rhythm and showed improved survival rates.
A new study from UNC-Chapel Hill reveals repetitive flooding in North Carolina is far more common and widespread than previously recognized. Over 90,000 buildings flooded in at least one event, with 43% located outside of FEMA's designated high-risk areas.
Researchers at the University of Würzburg are developing a new therapy for KEAP1-mutated lung cancer using a sulfite inhibitor to block tumor cell growth. The team has identified a first-of-its-kind compound, SulfExstatin-1, which accumulates toxic sulfite in cancer cells, initiating their death.
Delays in hypertension diagnosis were common, associated with delayed treatment initiation and adverse cardiovascular outcomes. The study highlights the need for earlier identification and intervention to improve treatment and patient outcomes.
A team of astronomers detected a large gas giant between three and ten times the size of Jupiter hiding in the swirling disc of gas and dust surrounding a young star called MP Mus. The discovery was made using a combination of results from the Atacama Large Millimeter/submillimeter Array (ALMA) and the European Space Agency’s Gaia miss...
Researchers at Waseda University discovered myosin XI's critical role in plant drought response. Myosin XI enables plants to close stomata more effectively and conserve water by coordinating ROS signaling, microtubule remodeling, and gene activation in guard cells.
A new study found that anti-obesity medications can normalize testosterone levels in men with obesity or type 2 diabetes. This positive effect on reproductive health was observed after a 10% weight loss, with total and free testosterone levels increasing by 24%.
The discovery of 2023 KQ 14, a sednoid with an unusual orbit, challenges our understanding of the outer Solar System's structure. The object's stable orbit over 4.5 billion years suggests that the system is more diverse and complex than previously thought.
A study published by The Endocrine Society found that obesity and early type 2 diabetes in adolescence can interfere with bone development, potentially increasing the risk of fractures and osteoporosis later in life. Researchers followed 48 teenagers for a year, finding that teens with obesity and type 2 diabetes showed less improvemen...
A global ecology study reveals that birds migrating through tropical regions travel at a steadier pace but with more variation in altitude compared to temperate regions. Birds adjust their flight altitudes to avoid strong winds, a key finding with implications for conservation efforts in tropical cities.
Researchers developed a novel immunotherapy that disrupts the IL-33/IL1RL1 signaling loop to boost immune function and improve survival in leukemia patients. The treatment targeted leukemia stem cells, reducing relapse rates and improving survival without major side effects.
A new study projects significant ocean acidification around Hawaiian Islands within the next three decades, posing challenges to coral reefs and other marine organisms. Researchers found varying levels of acidity across different island regions, with windward coastlines exhibiting higher novelty in future conditions.
Researchers developed a user-friendly mapping system to track private wells, septic systems, and other community locations. This data helped distribute disaster relief in Western North Carolina after Hurricane Helene, providing actionable information for public health officials.
The National Science Foundation has awarded Spearhead Bio a Small Business Technology Transfer (STTR) Phase I grant to develop improved corn varieties. The company's breakthrough platform, TAHITI, enables precise and seamless gene insertion into crops.
Researchers found that friends tend to perceive products similarly and exhibit synchronized brain activity when viewed together, even predicting each other's purchasing intentions. As friendships deepen, this similarity strengthens.
A novel AI-powered retina tracker, SMART, analyzes retinal images with near-perfect accuracy in under one second, offering hope for sight-saving screenings for diabetic retinopathy. The tracker expands access to high-quality retinal assessments globally, reducing vision loss from diabetic retinopathy.
A new study from Uppsala University found that most men with prostate cancer who receive recommended treatment have a good prognosis, with a lower risk of dying from prostate cancer than other causes. The study's findings highlight the importance of assessing a patient's life expectancy in choosing an appropriate treatment strategy.
A multidisciplinary guideline panel has determined that guided-bronchoscopy sampling provides tissue of comparable adequacy to percutaneous biopsy for comprehensive biomarker testing, while delivering a superior safety profile. Modern navigational bronchoscopy offers a safer path to molecular insights in lung cancer care.
A study found that nearly half of gunshot wound injuries to the brain in children and young adults include penetrating cerebrovascular injuries, which can result in permanent disability and death. Hospitals prioritizing vascular cranial imaging can mitigate these devastating injuries.
Researchers found that the H5N1 virus enters the mammary glands through the teat, not via respiratory infection. Lactating cows' self-nursing or mutual-nursing behaviors may facilitate this transmission. Vaccination with two different vaccines showed complete protection against H5N1 infection in cattle.
A new study led by Brown University biologists found that different species of large herbivores have diets that are more diverse and complex than previously known. Researchers analyzed fecal and plant samples to identify the types of plants consumed by each species, revealing smaller dietary differences between species than expected.
Birgitta Schultze-Bernhardt is developing a portable device that can determine the concentration of several gaseous pollutants in ambient air with utmost accuracy, measuring three pollutants simultaneously. The device will enable real-time monitoring of pollution levels in cities and industrial areas.
Researchers from University of Zurich and Basel decode historical specimen to understand how 1918-1920 influenza pandemic evolved in Europe. The Swiss genome reveals three key adaptations that made the virus more resistant to human immunity and more infectious.
Researchers are creating generalized digital twins for machines, aiming to improve coordination up and down the production line. The center also plans to develop digital twins for human-robot collaboration and use software for simulation and analysis.
A novel copper nanocluster has been developed, demonstrating high stability and exceptional selectivity in electrochemical carbon dioxide reduction reactions. The incorporation of a single Cu(0) atom into the cluster significantly alters its electronic landscape, leading to improved product selectivity.
A study found that night shift work disrupts the body's internal timing, causing irregular reproductive cycles and hormonal imbalances. Women exposed to shiftwork-like light exposure had a higher risk of ovarian disruption, pregnancy complications, and difficult labor, even if they were not experiencing disrupted cycles.
Scientists have characterized the CODH/ACS enzyme complex in detail, revealing its movement and reaction sequence during chemical reactions. The discovery has significant implications for biofuel production from carbon dioxide.
Scientists have identified a new gateway into human cells that could make gene therapies safer and more effective. The discovery of AAVR2 receptor allows for lower doses of virus to be used in treatment, reducing side effects and costs while improving patient outcomes.
A new study by The Endocrine Society finds a strong link between acromegaly and an increased risk of various cancers, often at younger ages than expected. Patients with the rare growth hormone disorder had higher rates of certain types of cancer, including colon, gastric, breast, lung, ovarian, prostate, and blood cancers.
Researchers emphasize the need to distinguish between harmful PFAS and essential fluoropolymers used in medical devices, which have not been linked to health issues. Experts advocate for a balanced approach to protect both human health and environmental concerns.
Recent studies have revealed significant improvements in patient prognosis for chronic thromboembolic pulmonary hypertension (CTEPH) over the past few decades. Advances in surgical techniques, drug development, and multimodal therapies have led to increased treatment rates and improved survival rates among patients.
The Damon Runyon Cancer Research Foundation has awarded $4.2 million to five new Clinical Investigators conducting patient-oriented cancer research. The awards will support the development of new treatments for cancer patients, with a focus on enhancing efficacy and safety.
The EVOaware project aims to develop an innovative platform that addresses tumour resistance to therapies by using advanced tissue imaging technologies and integrating genetic screening, lineage tracing, and spatial omics techniques. This platform has the potential to accelerate the discovery and development of new cancer therapies.
A new study has provided insights into how blood stains cotton fabrics, allowing investigators to gather additional information from forensic evidence. The researchers found that the number and spread of 'fingers' in the bloodstain correlate to the velocity of the blood spatter, with faster-moving blood leaving more prominent tendrils.
Cal Poly biological sciences Professor Emily Taylor is co-organizing the worldwide awareness week for snakes, highlighting over 3,500 globally significant species. The event promotes peaceful coexistence between humans and snakes, educating people about their importance in food webs and disease control.
A new study by the University of Southampton found that adults with ADHD traits report lower quality of life and more severe insomnia. Insomnia was identified as a potential link in this association, suggesting that targeting insomnia complaints may improve the quality of life for people with ADHD.
A comparative study explores how different systems of professional development influence preschool teacher growth in Japan, China, and the United States. The findings highlight the importance of culturally rooted practices and institutional structures in shaping teacher development, revealing no universal model for this process.
The DFG Annual Meeting focused on the growing global threat to freedom of research, with a particular emphasis on the US situation and anti-intellectual currents in other countries. The DFG President proposed targeted support measures and mechanisms of resistance, including additional funding agreements and joint publications.
A 1,000-patient clinical study will use RNA-based stool and saliva tests to detect colon polyps, enabling early prevention of colorectal cancer. The study aims to develop an at-home RNA test that empowers people to take action before cancer takes hold.
Researchers developed Localizatome to study oxidative stress-related changes in protein localization. The database provides comprehensive information on subcellular protein localization and dynamic localization changes under stress.
Researchers at the University of Pennsylvania used AI-powered screen of global venom libraries to discover dozens of promising drug candidates. The top peptide candidates are being improved through medicinal-chemistry tweaks.
Researchers propose a novel method for detecting dark matter using thorium-229 nucleus properties, with potential to detect forces 10 trillion times weaker than gravity. The new approach aims to identify minute deviations in the absorption spectrum of thorium-229 to reveal dark matter's influence.
Researchers found that individuals affected by infectious disease outbreaks show significantly less trust in the political establishment. The study suggests that policymakers should integrate trust-preservation strategies into their epidemic response plans to maintain democratic norms.
Researchers used advanced techniques to study propylene electrooxidation on Pd and Pt catalysts, revealing that surface reconstruction governs reaction selectivity. The findings show that changes in the catalyst surface under working potentials determine which products are formed.
A genetic study in mice reveals that TB bacteria can survive in vaccinated or previously infected hosts by switching strategies and relying on different genes. The research could lead to the creation of treatments given alongside vaccines to help the immune system root out TB when it tries to hide.
Researchers developed a non-invasive, wearable sensor that measures hydration levels continuously using bioimpedance. The device has potential applications in healthcare, sports, and workplace settings, providing a simple and effective way to monitor hydration levels and prevent dehydration-related issues.
Researchers have successfully developed a method to probe how quantum theory and curved space-time intertwine, using quantum networks of clocks. This breakthrough allows for the first test of this kind, exploring unique effects such as time dilation near planets.
A team of researchers has proposed that massive star collapse can create a 'neutrino collider,' leading to dramatic changes in supernova outcomes. This process could produce a neutron core or even a black hole remnant, depending on the presence of secret neutrino interactions.
A Johns Hopkins Medicine team found the liver-damaging hepatitis C virus in the brain's choroid plexus, a structure targeted by viruses, in individuals with schizophrenia and bipolar disorder. The study suggests that HCV infections may be associated with disease cause rather than behaviors.
A recent study of over 5,500 widowed individuals found that emotional loneliness increases significantly after a spouse's death and continues for years. Despite stronger parent-child relationships, particularly among mothers who act as kin-keepers, social and emotional loneliness persists.
Researchers from Boston University and Northwestern University develop a system that integrates quantum light sources and control electronics on a single piece of silicon, creating reliable streams of correlated photon pairs. The advance enables mass-producible 'quantum light factory' chips and large-scale quantum systems.
A team led by Professor Masakatsu Murakami has proposed and simulated a unique scheme using micron-sized hollow cylinders with internal blades to achieve high-field levels. This approach generates intense axial magnetic fields exceeding 500 kilotesla, approaching the megatesla regime.
Scientists at the Stowers Institute for Medical Research identified two distinct genes that regulate regeneration of sensory cells in zebrafish. The discovery may guide future studies on hearing loss and regenerative medicine in mammals, including humans.
Researchers at the University of Illinois developed a model predicting contaminant influence on aerosol droplet size, finding it depends on oil layer thickness, viscosity, and surface tension. The study aims to understand airborne contaminants from oil spills and respiratory diseases.
A report by ICTA-UAB reveals that 40% of Spanish tenants spend more than 30% of their income on housing, with up to 28% experiencing energy poverty. The study highlights the need for coordinated reforms to address housing inequality and improve energy efficiency.
MiROM identifies proteins by detecting molecular vibrations and detects structural changes in proteins, such as misfolding, allowing for real-time assessments of treatment effectiveness. This technology holds great potential for other diseases linked to protein misfolding, including Alzheimer's and Parkinson's.
Scientists reconstructed ocean pH levels 201 million years ago and found a massive drop in acidity, leading to mass extinction. The research links this event to volcanic activity and a significant increase in atmospheric CO2.
A team at Yokohama National University has developed an electrochemical method for highly selective single-carbon insertion into polysubstituted pyrroles, enabling the creation of structurally diverse pyridine derivatives. This approach has significant implications for synthetic organic chemistry and pharmaceutical synthesis.
Researchers found that a specific wrist bone, called pisiform, appeared in bird ancestors millions of years earlier than previously thought. This discovery suggests that the integration of this bone into the wrist was crucial for stabilizing wings during flight, tying arm musculature to wrist motion.
A study found that early antibiotics exposure can impair infant immune systems, disrupting lung immunity and making them vulnerable to respiratory infections. Supplementing with a naturally occurring metabolite called inosine may help restore their ability to fight such infections.