A new AI model can estimate the long-term risk of over 1,000 diseases and forecast human health changes over a decade. The model was trained on anonymised patient data from 400,000 participants and tested on data from 1.9 million patients in the Danish National Patient Registry.
Researchers reprogrammed the epigenetic code to affect tumour growth and survival in multiple myeloma. This study presents a comprehensive map of epigenetic alterations in multiple myeloma, highlighting site-specific increases in DNA and protein methylation that control gene activity.
A UCLA research team led by Dr. Donald Kohn has developed a one-time stem cell gene therapy treatment for alpha thalassemia major that could be curative. The therapy involves adding the missing alpha-globin gene to patient cells using a viral vector, enabling them to produce functional hemoglobin.
Researchers at the University Hospital Bonn have identified a neurobiological mechanism that could be responsible for post-ictal symptoms after an epileptic seizure. They found that spreading depolarization waves, or SD, are more common in people with temporal lobe epilepsy and may cause disorientation and wandering after seizures.
A new Canadian evidence-based framework has identified pathogens driving antimicrobial resistance risks in both healthcare and community settings. The framework highlights the growing threat of sexually transmitted infections as a significant risk factor.
A McGill University study reveals that mothers who experienced sexual violence during the Rwandan genocide often struggled with feelings of guilt, while their children displayed remarkable compassion and empathy. The research also found that these children formed peer support networks to cope with stigma and discrimination.
New research suggests that technological alien life may be rare on planets without plate tectonics and too little carbon dioxide. The study found that a planet with 10% carbon dioxide could maintain a biosphere for up to 4.2 billion years, while one with 1% carbon dioxide would last only 3.1 billion years.
Dr. Matthew Walker brings a multi-disciplinary approach to sleep research, focusing on the impact of sleep on human health and disease, and developing new tools and technologies to measure and improve sleep quality. The Sleep Innovation Laboratories will serve as a vital hub for discovery, innovation and public education.
A new study reveals how Moso bamboo degrades under fluctuating hygrothermal conditions, causing dramatic fluctuations in mass, dimensions, and appearance. Machine learning was integrated to predict changes in compressive strength and color difference with high accuracy.
Researchers developed Ovatools, a tool combining blood test results and age to identify women at higher risk of ovarian cancer. The approach is accurate for women over 50 and represents good value for the NHS, detecting more cancers earlier while remaining within affordability thresholds.
A large meta-study of over 12,000 participants reveals that APOE ε4 genotype, female gender and advanced age are significant risk factors for Alzheimer’s disease. The study confirms previous research and provides highly reliable prevalence estimates.
Researchers developed a fully automated finite element analysis pipeline to transform spine diagnostics and personalized treatment planning. The new approach enables rapid, patient-specific simulations that support preoperative planning, spinal implant optimization, and early detection of degenerative spine conditions.
New research finds that GLP-1 receptor agonists (GLP-1RAs) significantly reduce the risk of death and major cardiovascular events in psoriasis patients. GLP-1RAs also show promise in reducing alcohol and substance abuse, with a 65% lower risk of alcohol abuse.
Researchers have discovered a new type of tektite exclusively found in South Australia, recording an ancient asteroid impact event approximately 11 million years ago. The unique glasses provide valuable insights into the destructive power of past impacts and their importance for planetary defense.
Metabolic bariatric surgery shows promise as a cost-effective weight loss option for class II and III obesity patients. The study found bariatric surgery resulted in greater weight loss compared to GLP-1 receptor agonists.
A rare glimpse into Mars's north polar vortex has revealed that it produces a seasonal ozone layer. The extreme cold temperatures inside the vortex allow ozone to accumulate, making it essential for understanding Martian atmosphere chemistry. This finding has significant implications for the search for past life on Mars.
A Japanese study has identified four distinct patterns of immune response after COVID-19 vaccines, with a 'rapid-decliner' group experiencing faster decline in antibody levels. Monitoring changes in antibody levels may help identify individuals at greater risk of infection and inform more effective vaccination strategies.
The study highlights connections between tumor mechanics and extracellular vesicles, which may not be as different as they seem. Researchers are now investigating the interplay between mechanics and messaging in cancer progression.
Researchers at Boston Children's Hospital report an alternative local anesthetic, 2',6'-pipecolylxylidine (PPX), that selectively blocks pain while leaving motor function intact. PPX has been found to be less toxic than conventional anesthetics and may enable longer-lasting pain relief.
A new review article highlights the need for effective control and prevention strategies for sexually transmitted gut infections, which can persist longer and be harder to treat. The authors emphasize the importance of prompt diagnosis, appropriate treatment, and community-level education and testing.
Researchers developed a novel 3D printing technique that combines materials and design to create strong, biocompatible implants. The study found that varying printing angles and ink composition can significantly impact implant strength and bone cell growth.
Researchers at Tulane University have developed an enhanced CRISPR-based tuberculosis test that works with a simple tongue swab, detecting TB in samples with very low levels of bacteria. The new test shows high sensitivity and accuracy, offering a significant step forward toward effective diagnoses via a variety of samples.
A comprehensive review of recent advances in panel aeroelasticity in shock-dominated flow highlights the complex interplay between fluid-structure interactions and shock-boundary layer interactions. Understanding these dynamics is crucial for preventing catastrophic structural failures and improving supersonic vehicle design.
A new study reveals that small electric charges between particles play a crucial role in forming highly concentrated clusters in turbulent environments. This discovery has significant implications for climate research, medicine, engineering, and science, enabling better predictions and controls.
Researchers developed a photonic-acoustic analysis scheme that integrates dual optical combs, multi-sensor parallel processing and electronic signal processing for unparalleled capabilities in sound detection, localization and recognition.
Paperpal unveils a transformative brand strategy as an all-in-one AI toolkit for clear, confident, and ethical writing. The platform empowers students, researchers, and institutions to maximize their potential without losing their voice. With its secure and responsible approach, Paperpal enhances human expertise rather than replacing it.
A new targeted radiation approach has achieved a near-complete response in three patients with solitary fibrous tumor (SFT), a rare and aggressive form of cancer. The therapy significantly reduced cancer activity and provided symptom relief, highlighting its potential as a treatment option.
New research from Uppsala University reveals how plant-based meat alternatives became popular in Sweden through a combination of business, consumer and societal factors. Key findings include the role of documentaries like An Inconvenient Truth and the Swedish National Food Agency's sustainability recommendations.
A new algorithm developed by Núria Malats and her team can accurately predict the presence of metastasis in pancreatic cancer using medical images. The PMPD algorithm has shown promising results, classifying 56% of metastases with high accuracy and potentially avoiding unnecessary surgeries.
Keck Hospital has received the top performer recognition from Vizient for delivering high-quality care. The hospital achieved near-perfect scores in patient centeredness and ranked highly in all categories, making it one of the safest hospitals in the country.
A new study found that people are more likely to cheat when delegating tasks to AI systems, especially with ambiguous interfaces. Researchers warn of a rise in unethical behavior as AI agents become increasingly accessible.
The University of Ottawa Faculty of Medicine is awarded $1.25M in grants to support high-impact research projects focused on microbiome-informed nutritional strategies, skeletal muscle repair, and stroke recovery. The funding aims to improve health outcomes for Canadians.
Researchers have found that plastic nanoparticles can enter crops during growth, accumulating in edible parts and potentially affecting human health. The study used radishes to demonstrate the uptake of nanoplastics by plants, with nearly 5% of particles retained by the root system.
Researchers at WashU Medicine discovered a novel way brown fat burns calories and improves metabolic health by exploiting cellular parts called peroxisomes. Mice with increased peroxisome activity showed improved insulin sensitivity and weight control on high-fat diets.
A major report published by the European Society of Cardiology outlines expert recommendations for diagnosing, treating, and preventing COVID-19-related cardiovascular effects. The report emphasizes the importance of vaccination, cardiac rehabilitation programs, and equal access to services.
A NIH-funded study reveals that repeated head impacts from contact sports can cause early neuron loss and inflammation in the brains of young- to middle-aged athletes. The findings suggest that these changes may occur years before CTE develops its hallmark disease features.
A new study from Penn State researchers found that submerging hands and forearms in room-temperature tap water can effectively cool older adults and reduce their heart rate during extreme heat. The study demonstrated a reduction in core body temperature by about half a degree Fahrenheit, which may help prevent heat-related illnesses.
A new study reveals that Indo-Pacific fish species are being carried into the Mediterranean Sea through the Suez Canal and sea currents. Cargo shipping is now identified as a key driver of these invasions, with targeted management needed at major shipping hubs.
A new study published in PLOS One finds that high-intensity interval training (HIIT) is more effective than moderate exercise in making adolescent lab animals avoid cocaine. The researchers observed a dose-dependent effect on the brain's reward circuit, leading to increased aversion to the drug.
Researchers have developed a new technique to create all-solid-state sodium batteries that retain performance down to subzero temperatures. The breakthrough uses metastable sodium hydridoborate, which has high ionic conductivity, allowing for thick cathodes and improved energy density.
The American College of Chest Physicians has achieved a critical milestone in its advocacy efforts, leading to changes in federal coverage guidelines for noninvasive ventilation devices used in the home. These revised guidelines reflect major recommendations submitted by CHEST and aim to enhance patient care.
Research from the University of Copenhagen shows that exercising in nature improves mood, reduces stress levels, and boosts heart rate. Participants who exercised outdoors reported greater joy, satisfaction, and optimism than those who exercised in urban or indoor environments.
The complexity of the tumor microenvironment hinders therapeutic intervention; nanomedicine emerges as a promising tool to modulate it. Researchers have systematically reviewed four primary mechanisms by which nanomaterials enhance antitumor therapy, including modulation of complex components within the TME.
Researchers have discovered how a compound called naringenin chalcone 'reprograms' a light-sensing protein in plants, activating it to send growth-regulating signals even without UV light. This unexpected interaction could lead to crops with improved tolerance to harsh environments and more efficient use of light energy.
A new study finds that a 2°C warming intensifies the Arctic's ability to absorb greenhouse gases, but reduces its capacity in alpine regions. This imbalance has significant implications for global carbon budgets and climate projections.
A team of researchers developed a new manufacturing process using bio-based solvents to reduce the production cost of perovskite solar cells by half and decrease climate impact by over 80%. AI-based reverse engineering technology was used to identify optimal conditions for efficiency and sustainability.
The project aims to strengthen community involvement in water management, improve child health and reduce under-age mortality in Ecuador, Peru, Chile, Morocco and Tunisia amid global climate change. The research team will gather socioeconomic data and information on water governance, health risks and infant mortality.
Scientists at Linköping University develop artificial neurons made of conductive plastics that perform advanced functions like biological nerve cells. They simplify the basic structure to make it compact and biologically relevant.
Researchers have developed new eDNA tools to quantify kelp-derived biomass in sediments below commercial kelp farms. The study confirms that kelp aquaculture has little impact on the seafloor community and provides evidence for using eDNA to examine 'blue carbon' accounting efforts.
Researchers at Boston University School of Medicine will create a detailed postmortem cardiac and blood vessel tissue repository to study the relation between cardiovascular risk factors and structure. The project aims to identify new biomarker signatures for cardiovascular disease, advancing our understanding of CVD risk.
Researchers at Salk Institute and UC San Diego have identified a unique sugar called HSAT as a potential therapeutic target for slowing tumor progression and metastasis in pancreatic ductal adenocarcinoma. Boosting HSAT levels may slow the formation and spread of pancreatic cancer, leading to improved survival rates among patients.
Researchers identify basal stem-like cells as the origin of small cell lung cancer, providing a major shift in understanding this deadly disease. The study's findings allow for exploration of strategies to prevent the disease before it evades the immune system and spreads.
A new study found that people with three or more symptoms of physical frailty were nearly three times more likely to develop dementia than those without frailty. The researchers also discovered changes in brain structure and biomarkers in people with frailty, which may be a mechanism underlying the pathway from frailty to dementia.
A new study uses three wearable sensors to track eating behavior and identifies five distinct patterns, including late-night snacking and stress binging. The findings lay the groundwork for personalized interventions to help individuals overcome unconscious habits that drive overeating.
Researchers from St. Jude Children's Research Hospital have made a breakthrough in treating neuroblastoma by combining immunotherapy with the drug indisulam, achieving complete therapeutic responses in laboratory models regardless of cell state.
The PANORAMA microscope overcomes challenges of traditional microscopes by capturing submicron details across an area roughly the size of a U.S. dime without moving the sample. It produces gigapixel-scale images with high resolution, ideal for medical pathology and industrial inspection.
Researchers have identified a secreted form of a protein called Clever-1 that systemically suppresses T cells essential for fighting cancer. The investigational anti-Clever-1 antibody, bexmarilimab, directly inhibits the release of sClever-1, potentially predicting treatment resistance and paving the way for new combination treatments.
Researchers have developed a novel approach to control Dirac plasmon polaritons in topological insulator metaelements, enabling tunable terahertz optical devices with lower energy loss and enhanced performance.
Researchers Josh Frieman and Anowar Shajib found that physics-based models for evolving dark energy better explain current data than the standard model. The data suggests that dark energy density has decreased by about 10% over the last several billion years, changing the cosmic expansion history.
Researchers predict EU will need to meet 250 TWh annually for local battery cell production by 2050, offsetting 90 TWh of upstream fossil fuel energy. Maximizing recycling rates could reduce import dependency and future energy demand.