High LDL-C led to 3.6 million deaths and 90.7 million disability-adjusted life years in 2023, despite declining mortality rates. The absolute burden increased due to population growth and aging, with regional disparities emerging.
A new study finds that climate change has slightly increased malaria overall, but rising temperatures could increase risk in southern and East Africa while reducing it in warm regions like West Africa.
Researchers developed boron-doped carbon nanotubes to boost NO3- reduction reaction performance, achieving high ammonia yields and positive-shifted onset potentials. The doping strategy offers a new way to tune complex electrocatalytic reactions.
Researchers developed ultrasound-responsive microspheres that release rhBMP-2 on-demand, promoting bone regeneration. The microspheres exhibit remarkable stability and trigger drug release via low-intensity ultrasound.
A new USC study found that LA County residents in evacuation zones experienced heightened levels of anxiety and depression after the 2025 wildfires. The effects were greatest among those facing social and economic hardship, highlighting the need for policies to bolster housing security and community support networks.
Researchers in India have identified β-esterase as the primary enzyme involved in α-cypermethrin detoxification, showing increased reactivity in response to the insecticide. This finding suggests that mosquitoes can dramatically increase production of a particularly effective enzyme when exposed to a threat.
The HULU framework accelerates clean energy materials discovery by integrating machine learning potentials with adsorption simulations. Researchers found that universal machine-learning potentials are reliable across different chemical systems, providing a roadmap for material screening.
A team of researchers has discovered that supermassive black hole winds are 100 times more powerful than previously thought, carrying energy across 300,000 light-year distances. This finding demonstrates the explosive winds' impact on space beyond galaxies.
A survey of 3,013 people found that 66% of respondents are influenced by animal welfare when making purchasing decisions. Shoppers would pay an average of £1.31 per week for improved farm animal welfare, with specific increases for eggs (£1.61), milk (£1.13), and beef (£0.46).
The study reveals that the amount of available resources determines whether an organism relies on its memory or makes decisions based on current sensory input. Memory becomes most useful when sensory information is moderately uncertain, providing a significant improvement in performance.
A phase 3 trial found that deramiocel, a heart-derived cellular therapy, slowed muscle weakening and preserved heart function in boys and young men with advanced Duchenne muscular dystrophy. The therapy also showed promise in reducing scarring in the heart.
A new fossil species, Eoceras shaanxiense, has been discovered in the early Cambrian of South China, providing insights into the earliest known siphuncle-bearing cephalopods. The find represents an intermediate evolutionary stage between earlier species and later species with more developed buoyancy systems.
Researchers have created an AI model that accurately predicts cardiac index, a metric used to evaluate heart function, using non-invasive sensors on patient skin. The system demonstrates potential for accessible cardiovascular assessment beyond major hospitals and specialized clinics.
The American College of Chest Physicians' open-access journal CHEST Critical Care has received its first Journal Impact Factor of 2.7, reflecting the dedication of its authors, reviewers, and readers. This recognition highlights the journal's growing impact in critical care medicine.
Researchers propose using a simple GKI test to track metabolic health in noncommunicable diseases like cancer and cardiovascular disease. The test measures glucose to ketone ratio and may help assess nutritional ketosis and adherence to metabolic interventions.
Researchers have developed a lightweight receiver that captures energy from laser beams and converts it into electricity, enabling wireless charging of drones in mid-air. The technology uses a perovskite laser cell-thermoelectric tandem device to generate power, overcoming the challenge of battery life for long-duration missions.
A research team developed a bioceramic material that releases magnesium ions in accordance with the stages of osteoporotic fracture healing, suppressing inflammatory immune responses. The study suggests advanced fracture treatment materials could regulate immune responses to promote bone regeneration.
Researchers discovered a small mutation in the RBM20 protein leads to vastly different disorders in heart muscle cells. The study identified molecular targets for patient-specific therapies and potential new active substances.
Researchers discovered a structural aberration in octopus ribosomes that enhances accuracy and reduces errors in protein synthesis. This finding may be linked to the evolution of the octopus's complex sensory system, which includes a highly sensitive 'taste by touch' system.
This new section in JMIR Pediatrics & Parenting explores the modern shift to data-driven parenting with digital technology guiding parental planning. Research topics include the impact of wearable devices, AI-powered apps, and tracking on child health outcomes, parental well-being, and the parent-child bond.
Researchers have developed a fully flexible sensing-memory integrated system for wearable physiological sensing, which integrates a pressure sensor with a floating-gate organic thin-film transistor memory. The device offers a short response time and long data retention capability compared to previously reported OTFT-based pressure sens...
A new method for three-dimensional visualization of nanoplastic distribution in the neonatal mouse brain has been established, revealing particle-size-dependent biodistribution patterns. The study found that smaller particles (50 nm) were widely distributed throughout the brain, while larger particles (500 nm) showed weaker accumulation.
Juno's Microwave Radiometer reveals Io's heat output by looking below the surface, breaking new observational ground for volcanic and icy worlds. The findings suggest a steep gradient of rising temperatures just several feet into Io's surface, with possible explanations including conductive crust heating or cooling lava flows.
The VALOR project aims to co-develop a comprehensive approach to understanding the impact of pollinator decline on food systems. A new collection in the Research Ideas and Outcomes journal provides an open-access hub for researchers, policymakers, and practitioners to access outputs and tools related to pollinator conservation.
A multidisciplinary study has identified a novel biofilm regulatory protein called Biofilm Architecture Regulator (BatR) and its role in Pseudomonas aeruginosa infections. The discovery may lead to new targets for anti-infective treatments, including those for people with cystic fibrosis.
Researchers at Duke University developed an AI framework called Raygun that can create modified versions of proteins while preserving structure and function. The tool uses protein language models to make extensive changes to existing proteins, opening up new avenues for engineering customized-sized proteins.
Researchers have developed an oxidation-free approach to oligonucleotide synthesis using P(V)-fluoridates, enabling rapid coupling and automated synthesis. The new platform offers improved efficiency and stability compared to conventional methods.
Researchers at UMass Chan Medical School have developed a microRNA-based gene therapy that suppresses mutant SOD1 production, delaying disease onset by 60 days and extending lifespan by 100 days in mice models of ALS. The therapy, delivered via adeno-associated virus (AAV) vector, preserves motor neurons and maintains neuromuscular con...
Researchers have developed a tool to design synthetic disordered proteins, untangling their functionality. This innovation accelerates the exploration of biology's vast and underexplored area.
Researchers developed a thermal engineering method to modify ZnMgO nanoparticles, reducing oxygen vacancies and increasing nanoparticle size. This approach improved QLED electroluminescence uniformity, brightness, and stability, tripling the device lifetime to 20,000 hours.
Researchers from Tsinghua University Press outline a roadmap for developing practical single-molecule spintronics devices, offering a pathway toward ultra-compact, low-power spintronic technologies. The review highlights various spin-related quantum effects that have been demonstrated in single-molecule devices.
Researchers discover diffraction behaviors never seen in conventional quasicrystals using a new type of monotile structure. The team's findings open a new direction for exploring the fusion of quasiperiodic order and chirality, with potential applications in light manipulation and optical devices.
Researchers at Science Tokyo developed iron-substituted calcium titanate as an environmentally friendly support material for chemical looping. The material improves CO2 conversion by accelerating ion and electron transport, enabling scalable carbon recycling with abundant, low-cost elements.
A new study found that conspiracy beliefs are more likely to translate into real-world behavior when held with greater certainty or regarded as personally important. The researchers also discovered that viewing conspiracy theories as 'actionable' further amplifies this tendency.
A cross-sectional study identified critical methodological limitations in RCTs of CHM, including unclear hypotheses and inadequate allocation concealment. The study highlights the need for improved planning and conduct of CHM RCTs, with superior designs published in English-language journals.
Researchers found that primates play, groom and care for animals from different species, hinting at social curiosity and readiness to form cross-species bonds. These behaviors may represent evolutionary building blocks for human-animal companionship.
Researchers have discovered that microorganisms actively contribute to mineral formation on the ocean floor, using compounds such as sulfate and sulfur to promote pyrite formation. The study reveals a complex interplay between biological and geological processes at the ocean floor.
Researchers found that immature NK cells in donated cord blood can undermine CAR NK cell therapy by creating false targets for therapeutic cells to attack. Removing these cells before manufacturing improves therapy outcomes, persistence and antitumor activity in preclinical models of lymphoma and ovarian cancer.
Intensive feeding by tourists is altering the island's ecosystem, leading to unusual interactions among animal species. The study highlights the need for careful management of wildlife tourism practices to avoid unintended consequences for the environment.
A project led by Michela Taufer aims to accelerate AI-driven scientific discovery by enabling secure data sharing across the nation's research infrastructure. The National Science Data Fabric (NSDF) will connect researchers, computing resources, and data repositories, making advanced AI-driven science accessible to all.
A new review explores innovative strategies for achieving ultralow-resistance Ohmic contacts in 2D materials, including van der Waals integration and interfacial doping. The study aims to overcome Fermi-level pinning and Schottky barrier limitations, enabling better devices and industrial realities.
A recent analysis found that while genomic testing increased among Medicare recipients, many patients still lack next-generation sequencing tests. This limits their access to precision medicine and targeted therapies. The study highlights the need for further research on how increased testing impacts patient outcomes.
A recent study found that exposure to specific bacteria in barn air can protect against allergies, asthma, and hay fever. Researchers identified two key bacteria, Romboutsia timonensis and Glutamicibacter arilaitensis, which mediate the farm effect through certain receptors.
Women who experience premature menopause are at a higher risk of developing high blood pressure, with the risk peaking among those who reach menopause between ages 25 and 35. The study suggests that clinicians should consider age at menopause as a distinct cardiovascular risk factor for women who reach menopause before age 40.
Researchers propose a user penalty-and-reward system to curb long lines caused by inefficient human queuing behavior. By incentivizing users to choose alternative routes, the system aims to balance congestion with addressing user needs.
Researchers discovered a novel signaling role for smooth septate junction proteins in regulating stem cell growth and preventing tissue disruption. By maintaining spatially localized aPKC enzyme, sSJ proteins prevent excessive intestinal stem cell proliferation.
A new study reveals that lake ice loss accelerates sharply once winter temperatures cross critical thresholds, leaving mid-latitude lakes vulnerable. The researchers found that the melting process accelerates considerably faster than the freezing process as the climate warms.
Scientists have uncovered a new mechanism used by heart cells to resist reprogramming and found that carbohydrate sulfotransferase 7 (CHST7) is the most potent preventer of reprogramming in mouse and human cells. By targeting CHST7, researchers may develop treatments to help the heart fix itself after injury.
The US government's withdrawal of funding for global HIV programs led to a sharp reduction in the number of people entering HIV care across East Africa. New patient enrollment dropped by 59% and viral load testing declined by 33% within weeks, according to findings from researchers at UC San Francisco.
A study by Rice University associate professor Tanika Raychaudhuri found that many Asian Americans learn about politics through social interactions with friends, classmates, co-workers, and neighbors. The research suggests that political identities are dynamic and influenced by evolving social networks.
Researchers propose using AI to track nitrogen flows, improve scientific models, and provide practical recommendations for farmers. This approach aims to rebuild the disrupted nutrient cycle and reduce nitrogen losses while increasing food productivity.
Researchers developed a physics-based framework to predict temperature-driven VOC emissions from automotive paint sludge. Higher temperatures increase the release rate of VOCs, with moderate changes leading to substantial increases in quantity and speed of diffusion.
Researchers from the University of Texas at Austin have developed a new approach to stress testing, which simulates multiple financial risks simultaneously to predict bank resilience. This method outperformed existing stress tests in identifying worst-case losses and captured more severe losses.
A study published in International Journal of Environmental Research and Public Health reveals that mobile addiction services can effectively treat people who use drugs, particularly those disconnected from traditional care. The Mass General Brigham Kraft Center for Community Health model proved successful in improving outcomes and red...
New research suggests that tire microplastics can create environmental hotspots that facilitate the persistence, transfer, and spread of antibiotic resistance genes through cities. The microplastics can develop dense microbial biofilms, release chemicals that select for resistant bacteria, and contribute to oxidative stress.
Scientists at the University of Osaka have created a new technique to build blood supply systems for artificial tissues. They successfully fabricated tubular hydrogel structures with controlled lumen sizes and complex geometries, paving the way for creating vascular models that can investigate the development of fully synthetic tissues.
A new study finds that global inequality has increased by 170-270% since 1960, challenging the idea of catch-up development. The research highlights the role of neoliberal policies and geopolitical strategies in perpetuating core-periphery inequality.
Researchers at UC Riverside identified a genetic marker that controls avocado tree flowering patterns, allowing breeders to determine flower type long before it blooms. This discovery could revolutionize avocado breeding by making decisions faster and more efficient, with potential benefits for high-quality fruit production.
A major study reveals the incidence of acute pancreatitis in South Australia has increased to above the global average, with growth rates highest among women and those living in wealthier areas. The condition is increasingly linked to gallstones and metabolic risk factors, shifting the profile of who is at risk.
The Texas A¼M University research team is developing a new approach to lithium recovery using tiny, fish-like swimming nanorobots that capture lithium ions from seawater. The project aims to create a more efficient and sustainable pathway to access a critical mineral needed for batteries, electric vehicles and energy storage technologies.