Blocking two key 'don't eat me signals' in cancer cells heightens the immune response and sensitizes tumors to immunotherapy in glioblastoma models. Researchers found that simultaneously blocking CD47 and CD24 improved immunotherapy response, allowing macrophages to better recognize and attack cancer cells.
Researchers develop axiomatic approach to understand principles behind simple risk-sharing rules, such as equal sharing and proportional forms. They show how familiar rules can be understood as unique outcomes of particular combinations of axioms, accommodating scenario-based approaches.
Researchers observe rare nuclear isomer in ytterbium-150, measuring its half-life and establishing its decay scheme. The study reveals an isomeric relay mechanism, shifting the configuration of nuclei within the 10+ isomeric chain, extending its persistence into the proton drip line region.
A novel strategy to regulate the buried interface through multifunctional molecular bridges enables efficient defect passivation and improved energy-level alignment. This results in improved efficiency and long-term stability of perovskite solar cells.
A recent survey highlights the importance of Clinical Practice Guidelines in managing rare cancers, with strong overall uptake but inconsistent use for diagnosis and research purposes. High guideline adherence is linked to tangible survival benefits, such as reduced mortality and improved outcomes in various rare tumour types.
A 20-minute VR training session improved nursing students' confidence in managing aggressive patients, with a statistically significant improvement found in their confidence levels. The study's findings highlight the potential for immersive technology to strengthen frontline healthcare skills quickly and effectively.
A new study found that high levels of air pollution can amplify the risk of suicide associated with heat stress, especially during the warm season. The researchers analyzed 7,500 suicide cases in Utah and found a strong synergistic effect of heat and nitrogen dioxide.
Researchers at KTH Royal Institute of Technology found that small vortices can create larger swirls of flow, challenging the traditional view of turbulence development. The study could impact industries such as aircraft engineering and mechanical heart valve design.
The Mayo Clinic team developed a quantum-powered model that can detect movement intention from brain activity, potentially helping people with paralysis. The achievement marks one of Mayo Clinic's first end-to-end clinical applications of quantum computing.
Researchers developed a nonparametric statistical inference theory for integrals of quantiles, applicable to various data settings. The framework offers unified large-sample arguments for classical estimators and insights into conditions for asymptotic results.
Researchers at OIST and University of Turin developed a general formulation for mixing heavy particles with fluid, enabling study of fundamental physics phenomena and applied research in fluid engineering. Simulations reveal the formation of sediment plumes and the role of friction in particle interactions.
Berberine's effects on metabolism are indirect and dependent on the intestinal environment, not a direct hormonal action. The gut-brain axis is a promising area, but more research is needed to understand its clinical significance. Individual variability plays a key role, with different effects in different people.
Research presented at EAU26 confirms that prostate cancer screening leads to a reduction in mortality, but also detects cancers that would otherwise remain undetected. The study's findings suggest that using MRI in prostate cancer screening can reduce overdiagnosis and unnecessary biopsies.
Researchers studied the Seychelles warbler's gut bacteria, finding that immune genes influence which microbes thrive, and that this relationship affects host health and survival. The study suggests a two-way relationship between immune genes and gut bacteria, with potential benefits for human health and disease prevention.
PsyMetRiC, a new web-based risk prediction tool, forecasts cardiometabolic disorders in young people with psychosis. The algorithm predicts significant weight gain, metabolic syndrome, and type 2 diabetes within specific time frames, enabling meaningful discussions and interventions.
A new review outlines the scientific explanations behind ketogenic diets' therapeutic benefits for epilepsy, including their ability to strengthen brain energy systems, reduce inflammation, and protect neurons. The review highlights the need for further research, particularly in adults, to develop new therapies that mirror the diet's e...
Research reveals associations between antiseizure drugs and neurodevelopmental disorders in children, with valproate and zonisamide linked to increased risks. The study highlights the need for continued monitoring of new antiseizure drugs and further evaluation of their safety during pregnancy.
The global cosmetic procedure market is projected to exceed $180bn by 2033, with invasive procedures becoming increasingly invasive and harms on the rise. Experts call for consistent regulation, public education, and advertising controls to protect patients and reduce cosmetic tourism.
Researchers at the University of East Anglia have developed a new encryption method using chaos theory to protect medical images from cyber-attacks. The approach, called 'image-level protection,' makes each scan its own 'fortress' by making it extremely difficult for hackers to access or decrypt the images without the correct key.
A new structured virtual palliative care program, SUPPORT-D, is designed to support patients and caregivers with dementia. The six-week program provides guided support in four main areas, including understanding the disease, patient self-care, caregiver care, and planning for the future, to reduce burdens and improve quality of life.
New research from FAMU-FSU College of Engineering proposes a way to integrate different flood models, improving predictions and supporting critical decision-making. The study suggests four key directives for future research, including hybrid frameworks, enhanced physical representation, and bridging science and practice.
A clinical trial is underway to assess the safety and efficacy of the UroActive implant for stress urinary incontinence in men. The trial aims to improve quality of life and provide a better treatment option compared to current SUI treatment.
Researchers engineered a dual metal modified biochar composite to enhance microbial electrochemical interactions and increase hydrogen yield. The study demonstrates the potential of biochar as an efficient electron mediator in light driven fermentation systems.
Researchers found that high levels of male harassment significantly reduced zooplankton abundance and decreased water flea size, highlighting the impact of social behavior on ecosystems. The study suggests that a specific behavioral threshold must be crossed before social interactions reshape an entire food web.
A Simon Fraser University study found cultural, administrative, and governance barriers reinforce mistrust and limit vaccine access. Community-led clinics and trusted messengers can increase access and trust, but remain underfunded and excluded from decision-making.
A large venous thrombosis trial has found that apixaban is safer than rivaroxaban, with 3.3% of participants experiencing clinically relevant bleeding compared to 7.1% with rivaroxaban. This trial has significant implications for clinical practice and patient care.
The University of Bonn has been awarded funding for a further seven years, solidifying its position as the most successful university in the Excellence strategy. With eight Clusters of Excellence, the university aims to establish itself in the leading pack of the world's best universities.
A study of 3,910 former college athletes found that those with three or more concussions had worse physical, mental, and cognitive health five years after graduation. Athletes with one to two concussions also showed signs of psychological distress, anxiety, and depression.
A new study by researchers from the University of Illinois has shown that bonneted bats can be lured to and inhabit safer bat boxes, which mimic their natural roosts and maintain a stable thermal environment. The study found that the external water jacket in the boxes provides a safer temperature for the bats, and that long-term follow...
A recent study by the Cary Institute of Ecosystem Studies reveals a concerning trend of ticks carrying multiple pathogens in the US Northeast. More than 1 in 10 nymphal ticks tested positive for at least two disease-causing pathogens, with co-infection rates approaching 11% for Lyme disease and babesiosis. This increase in co-infection...
Researchers have confirmed the Standard Model of particle physics with unprecedented accuracy, solving the proton radius puzzle and verifying predictions up to the 13th decimal place. The new results set a new benchmark in measuring the energy levels of hydrogen atoms.
The American Academy of Neurology provides guidance on the use of wearable devices for neurological care, highlighting their benefits and limitations. Wearable devices can serve as screening tools for heart rate and cardiac arrhythmia, and can be helpful in disease management for epilepsy, but their use also carries risks and limitations.
Scientists have identified specific proteins in common food sources like corn, soy, and wheat that signal to the immune system that they are safe to eat. Regulatory T cells, also known as Tregs, play a key role in this process, scanning food for these key proteins and calming the immune system when they find them.
Researchers developed a phosphorus-modified biochar that can simultaneously immobilize harmful metals and enhance soil fertility. The material showed remarkable adsorption capacity for lead and cadmium, with potential applications in soil remediation and sustainable agriculture.
Research reveals that aging significantly alters the electron transfer behavior of pyrogenic carbon in soils and environments, with some materials becoming more electron-conductive while others become less so. These changes can influence nutrient cycling, pollutant degradation, and microbial processes in environmental systems.
Researchers found that female mosquitofish resistance, not just mating choice, drives behavioral isolation and speciation. Female aggression is a key factor in reducing fertilization success, leading to reproductive isolation between populations with different ecological environments.
A large E. coli outbreak in Calgary daycare centers resulted in 285 children becoming infected, with daily laboratory monitoring and treating dehydration preventing complications and potentially saving lives. The study found that this approach reduced the number of children who developed life-threatening hemolytic uremic syndrome.
New study evaluates two prominent AI global weather models, finding they excel at forecasting storm tracks but struggle to reproduce realistic wind patterns and storm intensity. The researchers emphasize the need for bias corrections and interpretation to improve AI forecasting accuracy.
Researchers create polymer heat exchanger with 2-4 times more cooling capacity per dollar than metal versions, offering a cost-effective and scalable solution for industries. The design's deployable nature makes it ideal for space missions, drones, and compact electronics.
LMU Munich has been reaffirmed as a University of Excellence, solidifying its position as one of Europe's leading research universities. The institution's seven Clusters of Excellence, including a new humanities cluster, demonstrate its exceptional academic strength. With a focus on interdisciplinary research and collaboration, LMU aim...
The Butantan-DV dengue vaccine, developed in Brazil, shows 80.5% effectiveness against severe cases over five years, with no hospitalizations in the vaccinated group. The vaccine was 65% effective in preventing symptomatic dengue during the five-year monitoring period.
Researchers discover a potential chemotherapy agent that causes cancer cells to release signals similar to those released by infected cells, triggering an immune response. This finding could lead to a new approach in cancer treatment, using lower doses of chemotherapy drugs to recruit the immune system as an ally.
A multidisciplinary team proposes three principles for responsible authorship: transparency, credit, and accountability. The guidelines aim to address issues like gift or honorific authorship, ghost authorship, and coercive authorship, and promote a culture of trustworthiness in science.
The Harvard researchers' new device is elegantly designed to be tunable, with a bilayer design that becomes geometrically chiral and able to 'read' chiral light. By using the MEMS device to continuously vary the twist angle and interlayer spacing, the team showed they could tune the device's intrinsic ability to read different chiral l...
Scientists discovered that howler monkeys began eating leaves 13 million years ago, causing them to evolve larger body sizes and occupy a unique ecological niche. The analysis of two jaw fossils provides key information about the diet, body size, and biodiversity of these ancient monkeys.
A team of astronomers has detected rare evidence of two planets colliding, which could provide valuable insights into the formation of our solar system. The unlikely event was observed in a distant star, Gaia20ehk, which was found to have massive amounts of rocks and dust passing in front of it, blocking its light.
Researchers at the University of Gothenburg have identified a protein, ATF4, linked to increased metastasis and recurrence in lung cancer. The study reveals that older individuals' tumors are smaller and grow more slowly, yet more likely to have spread when detected.
The Human Organ Atlas offers detailed 3D images of human organs, enabling interactive exploration and understanding of human anatomy and diseases. The atlas, built using advanced imaging techniques, provides insights into various health conditions, including COVID-19, cardiac disorders, and gynecological disorders.
Researchers found that bonobos and chimpanzees exhibit similar levels of aggression in zoos, contradicting their differing reputations. The study suggests that aggression levels vary within each species, with some groups displaying higher aggression, and that environmental factors may play a role in shaping their behavior.
A 3D-printed robotic rattlesnake triggered an avoidance response in zoo animals, particularly those sharing distribution with rattlers. The study found that the multimodal display of rattlesnakes is an effective deterring signal that works best with sympatric species.
A new study reveals that NFAT controls uterine natural killer cells, which guide embryo implantation and placental growth. The findings offer fresh insight into preeclampsia, implantation failure, and inadequate placental blood flow, potentially benefiting all pregnant patients.
A recent study found that coral reefs in Moorea are struggling to recover from bleaching events due to the presence of algae encrusting dead coral skeletons. The algae, particularly Lobophora variegata, are stabilizing the dead corals, making it difficult for juvenile corals to establish themselves and rebuild the reef.
Researchers found that dual-positive cells, a type of circulating tumor cell, are associated with shorter survival times and increased risk of metastasis in patients with advanced breast cancer. The study highlights the potential importance of these under-studied cells in breast cancer progression.
A study published in PLOS One found that humans can recognize and mimic emotional expressions of non-human primates, indicating a strong empathetic response. The researchers assessed facial expressions and emotional states of participants, revealing a strong connection between humans and non-human primates
Researchers engineered a 3D-printed robotic rattlesnake to test how 38 zoo animals responded to rattling behavior. The study found that the rattling display functions as an effective deterrent, with species sharing natural geographic range with rattlesnakes exhibiting stronger fear responses.
Researchers at Cornell University found that AI writing tools can shift users' attitudes on societal issues, even when they're aware of the bias. The study involved over 2,500 participants who used biased AI writing assistants and saw their views gravitate toward the AI's positions.
Research analyzes news articles on childlessness, identifying themes that perpetuate stigma and structural imbalances, highlighting the need for media literacy initiatives and equitable health communication
A study analyzing US household data found that women's higher poverty rates reflect their differing circumstances, including higher childcare responsibilities and poorer health. Factors such as employment, education, and age also influenced poverty risk, but women saw fewer benefits from employment.
Researchers have discovered a simple fix to boost mRNA delivery and CRISPR gene editing efficiency by adding three common amino acids to lipid nanoparticle injections, increasing delivery up to 20-fold and efficiency to nearly 90%.
A new study found racial and ethnic disparities in fatal police shootings vary widely between states, with some states having much wider disparities than others. Firearm ownership rates did not explain the disparities, suggesting other factors may be at play.