Researchers at OIST identified 80 plasma membrane repair proteins in budding yeast, revealing a coordinated sequence of molecular events. The study provides a foundation for investigating plasma membrane repair mechanisms in higher eukaryotes, including human cells.
Emerging research across conceptual frameworks, biomarker science, digital phenotyping, and artificial intelligence synthesizes a translational pathway toward a more biologically grounded and clinically useful approach to psychiatric diagnosis. The current system falls short due to standardized clinical language and lack of biological ...
Researchers mapped GLP-1 expression in 25 brain regions in each sex, uncovering striking differences in key circuits. The atlas reveals sex-biased expression in certain medullary nuclei, with higher Glp1 densities and numbers of Glp1-expressing neurons in females compared to males.
A new study found that voluntary exercise reshapes the gut microbiota, leading to changes in tryptophan metabolism and serotonin signaling. Exercise decreased the relative abundance of certain bacterial genera, shifting neuroactive signaling and lowering a key receptor in the memory center of the brain.
Researchers have successfully reconstructed videos from mouse brain activity, allowing them to understand how the brain processes visual information. By analyzing the neural activity in the visual cortex, the team created high-quality reconstructions of 10-second video clips, revealing the brain's representation of visual cues.
A mini-review synthesizes large-scale genomic findings to illuminate the polygenic architecture underlying common epilepsies. Rare genetic variants contribute to epilepsy risk, with shared biological pathways involving ion channel function and synaptic excitability
A new study suggests that chemical weathering beneath thick continental ice sheets may have consumed atmospheric carbon dioxide and prolonged global glaciations during the snowball Earth event. This process could have slowed atmospheric warming and delayed deglaciation, helping to explain the long durations of some snowball Earth events.
The study found that managing nitrogen pollution requires coordinated strategies, as reducing one type of nitrogen compound can increase another's deposition to the oceans. Future emission changes could alter oceanic nitrogen deposition by 24-6% depending on emission pathways.
Recent scientific progress in nanotechnology has led to the development of engineered nanomaterials that can remove, transform, or immobilize heavy metals in contaminated environments. These nanomaterials possess unique properties that make them highly reactive and efficient at interacting with contaminants.
Generative AI in medical imaging enables data synthesis, image enhancement, and modality translation to improve diagnosis and treatment outcomes. The review discusses challenges and future prospects, including convergence with large-scale foundation models and multimodal information for holistic understanding.
The LeaN On platform offers a 12-step journey to educate users on lymphoedema signs, actions, and when to seek professional support. It will be tested in a research project to evaluate online lymphoedema support, including nurse-supported and self-directed options.
Researchers found that removing typhoon-induced precipitation leads to sharply declining soil moisture and more severe drought conditions worldwide. The effect of typhoons varies by region, acting as a condition that exacerbates drought in some areas, while mitigating it in others.
Researchers developed an undercoordinated chromium single-atom catalyst that enhances sulfur electrocatalytic activity and lithium-sulfur battery performance. The unique design regulates electronic states, increasing sulfur electrocatalytic activity and achieving outstanding cycling stability and rate capability.
Researchers propose Mo6+ doping to stabilize LNO cathodes under deep delithiation conditions through grain boundary strengthening. The strategy addresses mechanical degradation and enhances electrochemical stability.
A Ru-based porphyrin covalent organic framework catalyst enhances the epoxidation of inert olefins by air, producing high-value epoxides. The catalyst activates benzylic C-H bonds to generate peroxy species, regulating oxygen transfer for selective epoxidation.
Researchers at Tsinghua University Press have developed a novel nanodrop therapy to treat corneal neovascularization, a condition where new blood vessels grow on the cornea. The therapy, which is non-invasive and can be administered via eyedrops, has shown promising results in animal models and could pave the way for clinical translation.
Mn-doped MoS2-based nano-cored-yarn electrodes exhibit high capacitance and conductivity, leading to improved energy storage performance. The electrodes achieve a maximum energy density of 13.84 mWh/cm² and maximum power density of 5866.85 mW/cm².
Researchers summarize advances, challenges, and prospects in light management for all-perovskite tandem solar cells. Strategies focus on minimizing external optical losses and enhancing photon capture capability to improve photon-to-carrier conversion efficiency.
A new study reveals that volcanic eruptions can trigger rainfall patterns similar to those produced by natural climate variability, effectively 'projecting' their influence onto the ocean-driven cycles. The research identifies a complex interplay between natural climate phenomena and volcanic forcing, with implications for climate inte...
Researchers developed an integrated NMR and LC–MS approach to distinguish between stereochemical variants of methionine oxidation in antibody drugs. The method resolves subtle structural variations relevant to biologic drug quality, strengthening stability testing and quality assessment.
Researchers developed a novel NMR approach to analyze the structure of therapeutic antibodies without isotope labeling. The technique uses site-specific methyl signals to detect subtle structural variations, including glycosylation patterns and local flexibility. This method has significant implications for ensuring the quality of biol...
Researchers developed the Simplified Adolescent Factors for Endometriosis (SAFE) score, a 5-minute questionnaire to identify at-risk patients and fast-track specialist referrals. The test aims to reduce the average 6-8 year diagnostic delay, allowing for early treatment and improved quality of life.
A new study reveals that early breast cancer cells use intense mechanical pressure to their advantage, hijacking a sensor to multiply rapidly and migrate away from the primary tumour. The pressure also triggers a series of signals that promote aggressive behaviour in cancer cells, leaving a lasting mechanical memory.
Researchers developed an antibody test for Mpox that accurately identifies those with infection and vaccine-derived antibodies, helping authorities prioritize vaccine use and study disease transmission. The test, validated in Rwanda, uses only four key antibody signatures to ensure affordability and accessibility.
Researchers at Scripps Research have developed a blood-based approach that examines protein shape in the bloodstream, distinguishing cognitively normal individuals from those with Alzheimer's and mild cognitive impairment with high accuracy. The new test could help move diagnosis and intervention to an earlier stage.
A team of researchers achieved efficient bicarbonate-mediated integrated carbon dioxide capture and electrolysis to produce CO, reducing energy consumption and improving process performance. The new process couples CO2 capture with electrocatalytic conversion, enabling a closed-loop cycle.
A study from the University of Oregon found that virtual reality games can increase players' sense of altruism and influence levels of empathy. Participants in the game 'Empathy in Action' showed higher ratings of cognitive empathy but a decline in affective empathy, suggesting that players may feel motivated to help without directly e...
A team of researchers discovered that SYFO2, a poorly studied protein, plays a key role in the 'self-fertilization' of legumes by enabling rhizobia to enter root cells. This breakthrough could lead to more efficient nitrogen-fixing abilities in crops.
Researchers have developed an index to measure the health of mangrove soils, revealing that healthy mangroves provide ecosystem services at nearly maximum capacity. The Soil Health Index (SHI) helps managers set conservation and restoration priorities, providing a tool to monitor ecosystem restoration and recovery.
Perennial crops offer a promising solution to collective challenges, investing more energy into root systems, allowing for regeneration and persistence. This approach minimizes climate-warming emissions, producing diverse food sources while maintaining soil health and resilience.
The Global Virus Network has established its International Headquarters at the University of South Florida, bringing together leading virologists to advance research and pandemic preparedness. The partnership accelerates the path from discovery to real-world impact, improving global health.
Online spaces provide bodily comfort, relief, and inclusion for some autistic adults, allowing them to express themselves and connect genuinely without scrutiny. This challenges the assumption that in-person interaction is always more valuable.
Researchers developed a machine-learning system that predicts how molecules form, cutting lab work time from months to days and reducing costs. The system uses asymmetric cross-coupling reactions to build complex compounds and can be applied across fields, deepening our understanding of chemistry.
Two new ACP papers advocate for policy changes to improve healthcare access and inclusivity for people with disabilities. The papers offer recommendations to address health disparities, promote disability-inclusive medical education, and foster a supportive workplace environment.
Scientists at Arizona State University have developed new materials that can capture carbon dioxide from the air using a low-energy process called moisture-swing direct air capture (DAC). The materials, which are commercially available polymers, were found to capture more CO2 and release it faster when their pores were larger.
Researchers discovered Setd8 enzyme preserves retinal progenitor cell flexibility, enabling potential regenerative vision therapies. The study highlights a potential target for repairing damaged retinas, with implications for regenerative medicine and ophthalmology.
Telemedicine usage varies by patient demographics and location, with elderly people and Asian patients less likely to use it. Lower income brackets and those with better technology access are more likely to use telemedicine, with significant geographic and demographic disparities found.
A $1 million Sloan Foundation grant will track and monitor data center development in Tennessee, Georgia, and Virginia, exploring its impact on rural communities. The research aims to understand how different policies and regulations shape data center development and its effects on communities.
Researchers demonstrate nanosecond optical switching using a liquid crystal droplet that redirects stored energy without electrical input. This method manipulates stored optical energy inside a resonant structure, enabling ultrafast light-by-light switching.
Researchers developed a low-cost method to transform agricultural waste into high-quality biochar, increasing its ability to store carbon and combat climate change. The new method uses limewater treatment to improve biochar production, resulting in a 34% increase in carbon retention and improved soil structure and chemistry.
A study by McKenna Litynski reveals that ancient needles and awls enabled humans to survive in cold climates through tailored leather clothing and provided a range of purposes beyond clothing production. The research, published in PLOS ONE, shows that needles and awls were widely used for medical suturing, fishing, tattooing, and cerem...
Researchers have developed a novel approach to fight colorectal cancer using modified Listeria bacteria as a courier to deliver potent cancer-killing proteins into tumor cells. This method has shown significant anti-tumor activity and could potentially lead to the development of a safe and effective oral treatment.
A new study by UCL researchers found that increasing physical fitness leads to a bigger release of brain-boosting proteins after just one session of exercise. The 12-week training program improved cognitive function and boosted brain-derived neurotrophic factor (BDNF) levels, supporting the formation of new neurons and maintaining brai...
Researchers analyzed data from TikTok and Spotify's Top 100 hit song charts, finding significant differences in what makes a hit on each platform. On TikTok, dance genres and user engagement drive popularity, while on Spotify, songs about relationships and major labels dominate.
The study found that 73% of AIAN deaths from police violence occurred on or within 10 miles of reservations, despite only 40% of AIAN people living there. The authors argue that colonial policies and inequities in policing contribute to this disproportionate risk of fatal police violence.
A Rutgers researcher finds bacteria accelerate calcium carbonate dissolution in shallow seas, potentially slowing carbon sequestration and influencing climate change. The discovery sheds light on the ocean's biological carbon pump and its future implications.
A new study by Stockholm University researchers reveals distinct populations of Baltic Sea herring with varying levels of genetic adaptation to local conditions. The findings highlight the importance of genetic diversity in managing herring populations and suggest that current fishing practices may be detrimental to local populations.
Researchers at the University of California San Diego identified new genetic variants associated with autism spectrum disorder using long-read whole genome sequencing. The approach enhanced the discovery of genetic variants, offering new insights into the genetic origins of autism.
A new study finds hitchhiking bacteria dissolve essential ballast in ubiquitous
An international team of researchers calls for a coordinated effort to find room temperature superconductors, which could revolutionize technology and everyday life. The team proposes a strategy to systematically search for materials and manipulate their properties using advanced techniques.
Despite significant policy progress, 1 in 3 adults worldwide fail to meet the World Health Organization's physical activity guidelines, UTHealth Houston researchers discovered. The study proposes solutions for translating physical activity guidelines into action, emphasizing the need for stronger leadership and partnership networks.
A UBC study finds raccoons continue to solve puzzles even after food rewards are removed, suggesting intrinsic motivation and a desire for information. The raccoons' flexible problem-solving and exploration-exploitation trade-offs may contribute to their success in urban environments.
A University of Houston researcher disputes a study claiming multilingualism promotes healthy brain aging, finding that wealth and healthcare systems may drive longevity instead. Hernandez argues that individual behavioral solutions, such as learning a language, are oversold and distract from structural factors that support healthy aging.
A study of over 1 million diagnosed individuals reveals genetic links between 14 psychiatric conditions, grouping them into five major factors. The findings may facilitate future treatments and drug repurposing, with potential applications in schizophrenia and substance abuse
A new index maps state-level flu risk, highlighting regional disparities and socioeconomic factors contributing to vulnerability. Policymakers can use this tool to develop targeted strategies, strengthen epidemic preparedness, and address disparities in flu risk across the US.
Researchers genetically modified a probiotic yeast to reduce its virulence in immunocompromised patients. The modified yeast was found to be less likely to cause infection, with improved survival rates in animal models.
Scientists at St. Jude Children's Research Hospital developed BOUQUET to analyze 3D-enhancer architecture in machine learning-based graph theory framework, identifying protein condensates and predicting gene expression. The findings provide new insight into how cells regulate genes controlling specialized identities.
The Hubland Campus of the University of Würzburg is a rich habitat for 170 species of wild bees, with 31 species listed as endangered. Targeted measures, such as a hymenoptera garden and sustainable mowing, have created a species-rich and ecologically important environment for pollinators.
Engineers at the University of Pennsylvania have developed LIBRIS, an automated microfluidic platform capable of generating lipid nanoparticle formulations at high speed and scale. This enables the creation of large, systematic datasets needed to train predictive AI models, accelerating the design of lipid nanoparticles for mRNA delivery.
Research reveals altered brain networks in newborns with congenital heart disease, which may be linked to sensory perception, movement, and social behavior. After corrective surgery, these brain networks are improved, suggesting that cardiac surgery can improve brain health.