Researchers have found a widely available drug combination to be an effective treatment for patients with systemically active Sjögren's disease. The combination of leflunomide and hydroxychloroquine reduced disease activity while maintaining a favorable safety profile.
Researchers from Virginia Tech found that airborne particles have an outer alkaline shell, contradicting the traditional view of uniform droplets. This discovery has significant implications for understanding air quality and climate change.
A new detection method for PFAS chemicals in drinking water has been developed by University of Kansas researchers. The fast-flow solid-phase extraction (SPE) approach reduces the time and cost required to analyze ultra-trace amounts, making it feasible for widespread implementation.
Scientists at the University of Groningen have successfully elucidated the exact composition of tiny pheromones produced by the Trichogramma turkestanica, a type of parasitoid wasp. The team used advanced techniques to separate and analyze the volatiles, ultimately synthesizing the pheromone and revealing its structure.
A WVU study found that pregnant women who spend more time sitting are at a greater risk of developing gestational diabetes and preeclampsia. Sitting for over 10 hours a day was associated with twice as many adverse pregnancy outcomes as shorter periods of sitting.
Journalists from eligible European countries can submit entries in two categories: Women’s Health and Pharmaceutical Strategies. The total prize fund is €45,000, with €10,000 awarded to the first prize winner.
Researchers found habits transition from goal-directed to habitual behavior in a matter of seconds, contrary to the long-held theory of gradual strengthening. This rapid transition suggests a brain region plays a key role in altering entrenched habits.
Researchers discovered that a common rifampicin-resistance mutation in tuberculosis creates subtle metabolic weaknesses, which could be exploited with future combination therapies. The most common mutation slows bacterial RNA polymerase, creating vulnerabilities that other therapies may target.
A new study identified key warning signs for infection after ankle fracture surgery in older patients. Low protein levels, chronic alcohol abuse, and poor post-operative care were found to increase the risk of infection.
Researchers developed a personalized risk prediction model to identify cancer patients who may struggle with treatment costs, medical debt, and anxiety. The model uses patient information to estimate the likelihood of financial toxicity, balancing detection sensitivity with minimizing false alarms.
Researchers developed a miniaturized human intestine model to study EV-A71 infection, revealing the virus's ability to evade the immune system and persist for extended periods. The model showed long-term viral replication without triggering a strong immune response.
Researchers developed a cathode-modulated vacuum/air-channel electron tube that eliminates gate leakage current, enabling vacuum tubes to function in integrated circuits. The device operates at room temperature and atmospheric pressure, offering non-saturating output characteristics and potential for high-frequency applications.
The project aims to expand University Hospitals' collaborative care model from 26 practices to all 88 practices within the UH Primary Care Institute. It will also broaden services to include screening and treatment for conditions such as bipolar disorder and post-traumatic stress disorder (PTSD).
A new study published in Nature Water finds that wetland loss across the US has increased residential flood insurance claim payments by more than $10 billion since 1985. The analysis links changes in upstream wetland area to downstream National Flood Insurance Program claims, highlighting the critical role of wetlands in reducing river...
Researchers developed ultrathin CdS nanosheets decorated with Ru single atoms and S vacancies, enabling record-high performance for ethanol photoreforming. The catalyst achieved a hydrogen evolution rate 81.5 times higher than pristine CdS and 100% selectivity for valuable chemicals.
Research found that active pharmaceutical ingredients degrade at a higher rate when stored in resealable plastic bags compared to original packaging, posing risks for astronauts during space missions.
Scientists found that epigenetic changes can be inherited without altering DNA in certain animals, such as sea anemones. These changes can alter gene expression and potentially disrupt development, highlighting the importance of ancient systems of gene regulation.
Researchers at Stanford University have identified a new type of immune cell called ruptoblasts in flatworms, which can kill surrounding cells through an explosive process called ruptosis. This discovery could hold important insights for modern medicine and may lead to targeted treatments for bacterial infections or tumors.
Prediagnostic statin use showed no association with higher survival rates, but postdiagnostic use was linked to lower all-cause and breast cancer-specific mortality among hormone receptor-positive subtypes. Statin therapy may improve survival of these patient groups.
A Japan-US collaborative team has developed the world's first integrated spintronic probabilistic bit on a silicon chip, paving the way for large-scale spintronic p-computers. The innovation addresses computational problems requiring parallel processing of enormous numbers of possible states.
A team of scientists has produced two complete telomere-to-telomere genome assemblies for cowpea, providing a stronger genomic foundation for research and trait discovery. The study reveals previously unannotated centromeric genes and chromosome regions linked to subspecies divergence.
A new study identifies five central lock-ins that slow down the transformation of Europe's food system, including fragmented policy, hard-to-change dietary habits, market structures, environmental costs, and crises. The researchers offer recommendations in the form of principles to address these interconnected problems.
Researchers developed a novel fluorescent nanosensor to detect IPA, an emerging biomarker linked to gut health and disease. The sensor offers rapid detection within minutes, distinguishing IPA from closely related metabolites, enabling accurate measurement even in complex biological environments.
Researchers discovered a key issue in the production of purines, molecules required for DNA repair, and its link to ALS. The mechanism may be reversible, offering new hope for therapeutic development.
A national cohort study found that living in high-segregation neighborhoods was associated with lower likelihood of live donor liver transplant (LDLT) access. Candidates from high-segregation neighborhoods with larger racial and ethnic minority populations had a lower likelihood of LDLT compared to those from white populations.
A new adaptive charging strategy for lithium-ion batteries reduces battery degradation and improves efficiency. The strategy uses real-time monitoring and adjusts charging currents to prevent lithium plating, resulting in improved charge capacity utilisation and charging efficiency.
Researchers developed a 'walking fish' robot that mimics modern fish's ability to walk on land, and computer models showed similar modes of locomotion across several unrelated species. This undulating tripod gait is one of life's most ancient solutions to escaping predators or moving habitats.
A study reveals that farmers' moral motivations are equally important as financial interests when adopting organic practices. The research found a strong balance between utilitarian and moral dimensions, highlighting the need for tailored policies to promote sustainable farming practices in Andalusia.
Researchers developed an ultra-stretchable, anti-freezing hydrogel electrolyte using liquid metal particles, enabling flexible energy storage devices to operate reliably in harsh environments. The material maintains stable electrochemical performance even at -20 °C and retains 98% of its performance after 45,000 charge-discharge cycles.
A recent study published in Science Direct found that patients with detectable circulating tumor DNA (ctDNA) benefit from chemotherapy, with a three-year relapse-free survival rate of 77 percent. The test can help identify patients who require more targeted treatment, potentially reducing the risk of recurrence.
Scientists at La Jolla Institute for Immunology have discovered that 'cross-reactive' T cells can recognize multiple species of paramyxovirus, including measles and Nipah viruses. This broad protection is essential in combating emerging diseases with unknown viral strains.
A Stanford-led team has identified the molecular basis of Hechtian structures, which maintain plant cell membranes connected to the wall during water loss. Plants with more Hechtian structures recover better once water returns.
The latest publication from Wroclaw Medical University reveals that gastrointestinal health is influenced by culture, social relationships, economic status, and individual functioning within society. Chronic stress disrupts communication between the brain and gut, leading to increased symptom severity and reduced quality of life.
A new study by the American Society of Hematology finds that stem cell transplantation is the most cost-effective option for long-term care of sickle cell disease in adults. Gene therapy, while promising, comes with an astronomical cost and requires a significant price reduction to be competitive.
A recent study published in Nature Food found that people without access to clean drinking water are more likely to experience food insecurity and food safety threats. The research analyzed survey data from over 124,000 respondents across 121 countries and highlights the urgent need for coordinated global action to address these issues.
The African Engineering and Technology Network (Afretec) has signed its tenth university partner, Addis Ababa Science and Technology University (AASTU), to drive digital transformation in Africa. The network, led by Carnegie Mellon University Africa, aims to create long-term sustained change across the continent through research, educa...
The State of Carbon Dioxide Removal report reveals that current pledges fall short of pathways limiting warming to 1.5°C by more than 5 billion tonnes of CO2 per year by 2050. CDR must grow at rates comparable to or faster than the most rapid clean energy transitions, including solar power.
The investigation highlights the lack of research on AI toys' impact on early cognitive and socioemotional development, while also raising concerns over security risks and potential harm to minors. Experts advocate for mandatory labeling and regulation to ensure safer deployment of these devices.
The first national audit of advanced heart failure referrals reveals significant gaps in access to life-prolonging therapies, particularly for women. Women represent just 1 in 3 referrals, despite comparable disease burden.
A new study published in the Journal of Big Data highlights the journal's emergence as a leading publication in data science and artificial intelligence research. The study found that JBD has become a central hub for high-impact research worldwide, with significant contributions from top researchers.
Researchers have discovered that different flu viruses use distinct strategies to infiltrate cells and found a cellular pathway that blocks virus entry into lung cells. This study provides fundamental insights into how seasonal influenza viruses infect people and illuminates a path for developing better medications.
The International Congress of Mathematicians (ICM) 2026 will take place in Philadelphia from July 23 to July 30, featuring the announcement of Fields Medals and top talks on cutting-edge developments in mathematics. The conference will also explore the impact of artificial intelligence on mathematics.
City of Hope launches nationwide platform to share messages of encouragement with cancer survivors and their loved ones, offering tailored survivorship care and coordination between specialists and primary care physicians. The organization's data-driven model integrates supportive care from diagnosis through decades of follow-up.
Scientists at The University of Osaka have successfully fabricated protein networks in living cells using a focused laser beam. The approach allows for non-invasive control over network formation and exhibits dynamic motions similar to those observed in living cells.
A team of researchers from the Norwegian University of Science and Technology conducted a study on 28 individuals who experience an unexplained buzzing or humming sound. The investigation tested two hypotheses: measuring the sound waves from human-made infrastructure and industry, as well as those produced by nature itself.
The Trace Institute aims to develop a unified mathematical theory of conscious observers and traces, potentially transforming our understanding of physics, neuroscience, and spirituality. With AI-assisted models, the institute seeks solutions to long-standing problems in these fields, innovating new technologies for society.
A new study maps careers as rivers to show how researcher independence unfolds over time, influenced by relationships, external conditions and internal growth. The findings reveal a dynamic, lifelong process formed by both individuals and the systems they work within.
Research finds that individuals who have overcome adversity are less likely to support reforms that make it easier for others to achieve similar goals. This is because they want to protect the value of their own hard work and achievements.
A new study found that adults feeling older than their chronological age experience more insomnia symptoms, less regular sleep, and greater daytime sleep-related impairment. The mismatch between subjective age and actual age is associated with poorer self-reported physical health.
A new study finds that individuals with later sleep schedules report poorer mental health, higher general loneliness, and greater nocturnal loneliness. Nighttime loneliness is a key pathway connecting later sleep patterns to anxiety.
The development of AI-enabled research platforms poses a risk of unequal access, potentially excluding scientists without resources or connections. As decisions about platform accessibility are made in the next five years, it will shape the geography of global discovery for generations.
A retrospective analysis of over 110,000 women found that GLP-1 medication users were 30% less likely to develop breast cancer. The study suggests that GLP-1s may inhibit tumor growth and reduce systemic inflammation, which could play a role in breast cancer development.
Binghamton University researchers have developed a new way to reduce troublesome fake information in AI chatbots, with high accuracy in identifying disease terms and drug names. The protocol harnesses multiple large language models to verify answers through 'voting', increasing confidence in the results.
AI models struggled to maintain focus on a task, degrading in accuracy as the word list length grew longer. Human performance, however, remained stable even with long lists, suggesting fundamental limitations in AI decision-making abilities.
Researchers have tested a new experimental cancer drug called gamitrinib in its first-in-human study. Gamitrinib is designed to target the mitochondria of cancer cells, where it can disrupt their energy systems.
A new study found that middle-aged women who experienced poor sleep problems had lower psychological well-being nine years later. The association remained significant even after adjusting for other health and lifestyle factors, suggesting that sleep may play an outsized role in how women feel and function later in life.
Women experience anxiety and depression at higher rates due to factors such as hormonal imbalances, violence, and discrimination. The authors advocate for evidence-based solutions like group therapy, telehealth, and policy changes to reduce women's stress, including paid maternal leave and financial support.
Researchers at Tokyo University of Science engineered CYP107J1 enzyme from Bacillus subtilis into a more practical tool for selective oxidation chemistry. The modified enzyme showed 28-fold higher catalytic activity and successfully converted indole into indigo, a commercially important blue dye.
Researchers identify previously unknown protein RAK1, crucial for three-dimensional growth and division in moss, a step towards understanding plant colonization of land. The study provides new insight into fundamental mechanisms underlying plant growth and evolution.
Researchers at ETH Zurich developed biohybrid microrobots that combine living neural progenitor cells with magnetoelectric nanoparticles to guide stem cells to injury sites and stimulate repair. The microrobots demonstrate promising results in animal experiments, including improved nerve cell regeneration and recovery of motor function.