A new blood test has been developed to predict which patients with lung cancer will benefit from the newly approved immunotherapy drug tarlatamab. The test, based on circulating tumor cells, correctly identified 85% of patients who responded to the drug and 100% of those who did not.
Researchers have identified four synoptic patterns contributing to summer clustered extreme precipitation events in Northeast China, including eastward-moving low-altitude vortex and southwesterlies. The study provides a robust assessment of prerequisite conditions for these events and offers insights into short-term forecasting.
Researchers at Princeton University and the University of Arizona created a detailed map of groundwater levels across the US using direct measurements and AI methods. The map estimates 306,000 cubic kilometers of water, more than 13 times the volume of all Great Lakes combined.
Researchers develop a nanocomposite using gold nanoparticles and graphene oxide quantum dots to create superior antibacterial properties. The material enables rapid wound healing by promoting reactive oxygen species generation and enhanced biocompatibility.
Researchers from Korea University report a breakthrough in reviving an abandoned depression drug target by redesigning the molecular structure of neurokinin-1 receptor antagonists. New compounds exhibiting antidepressant-like effects have been identified, reducing depressive-like behavior and brain inflammation in mice.
The CRISPR-Cas3 system has been shown to induce reliable and extensive deletions of the TTR gene in mouse models of ATTR, reducing serum TTR levels by up to 80%. This technology holds promise for treating not onlyATTR but also other incurable inherited diseases.
Engineers at the University of Pennsylvania have discovered that foams exhibit internal motion resembling deep learning in AI systems. The study suggests a common mathematical principle underlying both foams and AI training, with implications for designing adaptive materials and understanding biological structures.
Researchers have developed bis-pseudoindoxyls, compact fluorophores with red-shifted absorption and fluorescence suitable for time-resolved bioimaging. The dyes exhibit low cytotoxicity and sufficient aqueous solubility, making them ideal for live-cell imaging.
Researchers identify bone-forming cells as driver of scoliosis caused by NF1. Blocking RAS-MAPK signaling pathway with medications halts progression of spinal deformity in genetically engineered mouse model.
Researchers at Umea University have discovered a bacterial toxin, MakA, that can inhibit colorectal cancer growth without causing damage to the body. The substance changes the immune microenvironment in tumors and boosts the immune system's ability to fight cancer.
Researchers highlight advancements in fluidized bed design, oxygen carrier materials, and performance of chemical looping systems. They emphasize the importance of controlling fluidization regime and developing physical standards for oxygen carriers.
Researchers discovered that frozen hydrogen cyanide crystals can trigger unexpected chemical reactions due to their highly reactive surfaces. These findings suggest that hydrogen cyanide could be a precursor to life's building blocks.
A new study reveals that Tyrannosaurus rex took 40 years to reach its full-grown size, growing at a slower and steadier pace than previously thought. The analysis provides a clearer picture of the dinosaur's life history, suggesting that its growth phase may have allowed it to fill various ecological roles in its environment.
Researchers identified metabolites associated with type 2 diabetes risk, revealing genetic and lifestyle factors that influence these metabolites. A unique signature of 44 metabolites improved prediction of future risk of type 2 diabetes beyond traditional risk factors.
A new WSU study reveals that medical students receive little or no formal training in end-of-life care, leading to confusion and unwanted treatment. Researchers advocate for integrated educational interventions across the medical school curriculum to address this critical gap.
Research highlights racial-ethnic differences in pregnancy-related high blood pressure risk, with Pacific Islanders and Filipinos more likely to develop a hypertensive disorder. Early identification and treatment can help prevent serious complications for both pregnant individuals and their infants.
Researchers developed a new way of measuring indoor air pollution by analyzing human movement, showing elevated levels of pollutants during occupied periods. The study provides a new approach to designing healthier indoor spaces, combining Birmingham's air-pollution expertise with radar-based sensing and optimization techniques.
A recent study published by Loma Linda University found that commercial water dispensers can harbor bacterial growth, even after disinfection, with some studies identifying contamination as soon as a few days later. The researchers recommend regular cleaning and maintenance to prevent the regrowth of microorganisms.
Climate change is projected to exacerbate agricultural droughts in Europe and western North America, even in areas with increasing rainfall. Soils will dry out faster than water can replenish them, leading to more frequent and severe crop droughts.
A new study from the University of British Columbia found that the way marketers express time can change how people experience the past and future, influencing real consumer decisions. The 'year-length effect' shows that when time is described as a length, people tend to perceive it as longer than when using years.
Researchers have developed a nanoparticle platform that enables precise delivery of disease-modifying gene therapies directly to cartilage lesions in osteoarthritis. The particles use biochemical signals to adapt their targeting based on disease severity, ensuring treatment concentrates exactly where it is needed.
A new study from Chalmers University of Technology shows that locally produced green hydrogen is the best option for reducing carbon dioxide emissions from heavy-duty road transport. This method enables all countries to become self-sufficient in energy and fuel, even in times of crisis.
A new diagnostic platform enables rapid and accurate detection of drug-resistant C. auris pathogens using CRISPR technology, allowing for more effective treatment and prevention of hospital outbreaks. The dSHERLOCK test can detect the presence of mutations causing antimicrobial resistance in just 40 minutes.
A new study published in Diabetes, Obesity and Metabolism found that blood sugar spikes after meals may increase the risk of Alzheimer's disease. Individuals with postprandial hyperglycaemia had a 69% greater risk of developing Alzheimer's disease.
Researchers have developed a new method to print custom microstructures directly into living cells, enabling the study of biological functions and instilling enhanced properties. The breakthrough uses light-sensitive materials and laser polymerization to create structures within cells.
Researchers developed the BIND screener to identify brain-related comorbidities in individuals with Duchenne muscular dystrophy. The tool showed strong accuracy in identifying neurodevelopmental and psychiatric conditions in a large international sample of participants.
Research identifies Luohan Guo's terpenoids, flavonoids, and amino acids as key compounds affecting health. The study's findings provide insights into the potential antioxidant mechanisms of monkfruit's active ingredients.
Researchers found that people living in areas connected to those most affected by the AP's ban on labeling people held less restrictive immigration policy preferences. Media language plays a significant role in shaping political attitudes and can extend to individuals' social networks.
A preclinical study shows that cannabidiol restores emotional behavior, reduces alcohol-related vulnerability, and reverses gut microbiota alterations caused by prenatal alcohol exposure. Female mice particularly benefited from CBD treatment, which normalized their emotional alterations and eliminated vulnerability to alcohol addiction.
Young adults who remain single for longer periods experience a decline in life satisfaction and increasing feelings of loneliness, particularly when entering their late twenties. Entering a first romantic relationship improves well-being across several dimensions, but the effects are less pronounced on depressive symptoms.
A recent study found that common flea and tick control medications used in dogs and cats can contaminate ecosystems with toxic chemicals. Isoxazoline antiparasitic drugs, used globally since 2013, may harm dung-feeding insects, including flies and butterflies, which are crucial for nutrient cycling and soil health.
A team of researchers has identified the HIF1 protein as a central molecular driver of tendon diseases such as Achilles tendonitis and jumper's knee. Elevated levels of this protein lead to pathogenic remodelling of tendons, making them more brittle and impairing their mechanical function.
A large-scale study of nearly 147,000 women found that early or premature menopause is not associated with an increased risk of type 2 diabetes. Despite increased fat and insulin resistance during menopause, the study found no independent relationship between age or type of menopause and the onset of diabetes.
Researchers develop a novel approach to precisely encapsulate individual probiotics into microgels, enhancing survival and targeted delivery in the gastrointestinal system. The study demonstrates improved therapeutic efficacy in treating IBD using this technology.
A team of geoscientists has identified a massive underground reservoir of freshwater beneath the Great Salt Lake, extending thousands of feet below the playa. The aquifer is believed to contain water dating back to the Ice Age, which could provide a new source for restoring lakebed crusts and reducing dust storms.
Researchers used CRISPR/Cas9 to create rice mutants with increased oleic acid content and decreased linoleic acid levels. The study demonstrates a novel strategy for designing functional rice cultivars with improved nutritional value and stable agronomic traits.
The SUSA project is driving digital transformation in European healthcare education by delivering 20 bachelor's and 26 master's programs with advanced digital health competencies. This pan-European effort aims to graduate 6558 students and upskill 660 professionals, fostering interoperability and attracting top talent.
New research suggests Virtual Reality (VR) may support personal self-disclosure by offering anonymity through avatars and calming virtual environments. Nature-based VR settings proved particularly comfortable and suitable for therapeutic conversation.
A new study uses large language models and network analysis to quantify investor emotions' fragility. High emotional vulnerability is linked to unstable stock prices and lower returns.
Researchers at Kumamoto University have successfully grown a bulk inorganic crystal from water that emits circularly polarized light. This breakthrough material has the potential to revolutionize security printing, advanced displays, and photonic technologies with simple inorganic chemistry.
Researchers developed Zr-IR825 nanoparticles by combining IR825 with biocompatible metal zirconium, improving water solubility and stability. The material exhibited outstanding photothermal conversion capabilities under near-infrared light, effectively killing tumor cells while showing low toxicity to normal cells.
Researchers developed PDJA, a novel AI-based attack framework that amplifies vulnerability and bypasses defenses in multi-agent reinforcement learning systems. The approach improves attack effectiveness and cross-layer vulnerability exploitation, opening new opportunities for evaluating the robustness of AI-driven autonomous systems.
A study by Iowa State University researchers found that anthropomorphizing language, such as using mental verbs like 'think' or 'know', is less common in news writing than expected. When used, these words often describe what AI requires to function, rather than attributing human-like qualities to the system. The research team identifie...
A new method uses tiny crystals of zircon to study the past evolution of Australian landscapes, offering insights into how the environment responds to geological processes and climate change. The approach provides valuable information on the storage and reworking of sediments near the surface over millions of years.
Researchers at Nagoya University found that about half of wood mice take time to examine nuts before selecting, potentially increasing their exposure to predators. Despite this risk, the extra time investment pays off as picky eaters are more likely to select undamaged chestnuts.
The guide, based on scientific documents, provides accessible language for parents and coaches to recognize concussions in young athletes. Early recognition and removal from sport are correlated with quicker returns to competition, emphasizing the importance of 'recognize and remove'.
A recent Buck Institute study revealed that spaceflight accelerates aging due to changes in immune cell composition and epigenetic markers. However, researchers also found evidence of intrinsic rejuvenation factors that can counteract these age-accelerating stressors.
A machine learning model has identified the most important drivers of cancer survival in nearly all countries, highlighting factors such as national wealth, access to radiotherapy and universal health coverage. The model provides data-driven roadmaps for policymakers to prioritize resources and close survival gaps.
The study found that medical tourism postoperative complications may cost the NHS up to £20,000 per patient. The analysis of existing data revealed that patients who underwent surgery abroad were more likely to experience moderate to severe complications, with treatment costs ranging from £1058 to £19,549.
Moderate-intensity physical activity for an extra five minutes a day can reduce all deaths by 10% in most adults, while reducing sedentary time by 30 minutes per day can lead to a 7% reduction in deaths.
A new study published in BMC Medicine found that higher maternal blood pressure increases the risk of preterm delivery, smaller babies, and gestational diabetes. The research used Mendelian randomization to assess the link between maternal blood pressure and 24 adverse pregnancy outcomes, revealing clear causal effects.
A new study reveals that young people are at risk of engaging in serious online offenses through gradual progression from low-risk behaviors like digital piracy. Researchers found that nearly half reported engaging in illegal online behavior early on, with many describing a pattern of repeat offending.
Smartphone apps based on psychological theories are 3 times more effective than minimal support in helping people quit smoking long-term. The apps improve sustained abstinence rates when combined with traditional interventions or pharmacotherapy.
The prevalence of overweight and obesity in Africa has surged, with a significant increase in obesity over the past two decades. Women are nearly five times more likely to be obese than men, while those with tertiary-level education are three times more likely. The study's findings highlight the need for targeted public health interven...
A new study from the University of Hawaii at Mānoa challenges a 50-year-old narrative about Native Hawaiian birds, finding no evidence they were hunted to extinction. Instead, the authors suggest climate change, invasive species, and land-use changes led to the disappearances.
Combining enzymes with biochar breaks down pollutants into less harmful compounds, improving efficiency and durability. Biochar-immobilized enzymes have demonstrated impressive results in water treatment and soil remediation.
A phase 1/2 trial investigating autologous T cell therapy targeting multiple tumor antigens showed promising results in patients with advanced and surgically resectable disease. Patients responded well to the therapy, with high disease control rates and low adverse side effects.
Researchers found that biochar can soften the impacts of swings between wet and dry conditions on soil organic carbon breakdown. The study showed that stronger moisture variability speeds up decomposition and boosts microbial activity, but biochar addition helped stabilize the soil system under variable moisture conditions.
Researchers analyzed faecal samples from 82 captive and 16 wild marsupials, revealing new microbial species and antimicrobial resistance. The study found that host family, location, and diet contributed to variance between different microbiomes.
Engineered biochar shows promise in boosting crop yields, suppressing soil-borne diseases, and remediating contaminated land. Purpose-specific design is essential for optimal performance.