A study found that a small, implanted vagus nerve stimulation device produced substantial and sustained improvements in depressive symptoms, quality of life, and daily function in patients with treatment-resistant depression. The device showed lasting benefits even after two years, with nearly one-third of participants who didn't respo...
Researchers developed a tool to predict when deadly salmonella outbreaks are likely to happen in wild songbird populations, allowing people to protect their feathered friends. The system is based on climate patterns, tree cone production, and avian migrations.
A new study from the University of Notre Dame found that satellite-derived forest maps often disagree, creating uncertainty for conservation, climate, and development policies. The discrepancies can be as high as a factor of 10, affecting millions of hectares and human lives.
A study funded by the National Cancer Institute aims to test a low-cost intervention using future-focused thoughts to help people quit smoking. The project will examine the effectiveness of episodic future thinking in reducing impulsivity and promoting healthier choices.
Dr. Timothy Riddell has been appointed as the new executive vice president and chief operating officer of Ochsner Health, with a focus on guiding the system's long-term goals for sustainability and success. He brings 28 years of experience within the Ochsner group practice to his new role.
The journal is seeking early-career scientists to serve on its editorial team, providing hands-on experience and mentorship. Selected members will play an active role in shaping the journal's scientific vision and community engagement.
Dr. Kelley's discovery of the Lost City Hydrothermal Field revolutionized scientific understanding of fluid–rock interactions and chemosynthetic ecosystems. Her work has also transformed ocean observation through the NSF's Ocean Observatories Initiative Regional Cabled Array.
Researchers discovered chemosynthetic microbial communities formed wrinkle structures in ancient turbidites, which should not have existed in the deep-water setting. The team analyzed geologic evidence and determined that the sediment layers were indeed turbidites with biotic textures.
Pennington Biomedical researchers investigated competing body weight regulation models, analyzing the interaction of energy intake and expenditure. The study highlights the need to test state-of-the-art technology and could help explain why losing weight is challenging for some individuals.
Zhongping Lee received the 2026 Nils Gunnar Jerlov Medal for his transformative contributions to understanding light interaction with the ocean. His work reshaped ocean color science, enabling robust global observations of ocean transparency and productivity from satellites.
Researchers developed ZENN, an AI framework that recognizes and adapts to hidden differences in data quality. By using thermodynamic principles, the model distinguishes meaningful signals from uncertainty and noise.
Marine darkwaves are short-term episodes of underwater darkness that can severely impact kelp forests, seagrass beds, and other light-dependent marine life. The researchers developed a framework to compare these events across the globe, finding between 25-80 marine darkwaves along the East Cape since 2002.
The American Physical Society's Global Physics Summit will convene over 14,000 physicists worldwide for groundbreaking research presentations. The event will feature both in-person and online experiences, including scientific sessions, exhibits, and networking events.
Large language models (LLMs) provide treatment recommendations for early-stage hepatocellular carcinoma (HCC) that align with clinical guidelines. However, their performance is limited in late-stage disease, where they prioritize tumor factors over liver function. LLMs should be used as a supplement to clinical expertise.
The American College of Chest Physicians released a new clinical guideline on biologic management in severe asthma. The guideline provides evidence-based recommendations for selecting biologics for different patient populations, considering factors such as baseline oral corticosteroid use and comorbid conditions.
Researchers found that targeting lipid metabolism in tumors can lead to ferroptosis, a type of cell death dependent on fat molecules. This could pave the way for new cancer treatments that target specific mechanisms responsible for lipid processing by tumors.
Researchers found two genes, mask and clu, that regulate dopamine levels in the brain and influence behavior. Silencing these genes changed sleep patterns and response to caffeine in fruit flies, providing insights into potential treatments for neurological disorders.
In a new study, terrestrial bacteria-infecting viruses were able to infect their E. coli hosts in near-weightless conditions aboard the ISS, but with distinct mutations. The dynamics of virus-bacteria interactions differed from those observed on Earth, highlighting potential insights into microbial adaptation and human health.
A deep learning model trained on stage II colorectal cancer whole slide images accurately identified features linked to recurrence risk. The study found the model surpassed clinical prognostic parameters in predicting patient outcomes.
A Phase I study led by Timothy Yap demonstrates the potential of linavonkibart to target and prevent activation of transforming growth factor-beta 1 (TGFβ1), overcoming treatment resistance in multiple cancers. The trial showed manageable safety profiles and objective responses in heavily pre-treated patients, suggesting a promising ne...
A recent SFU study analyzed 3,200 Strava posts from Metro Vancouver runners between 2010 and 2021 to understand what makes running enjoyable. The research identified six key factors shaping runner experiences: psychological aspects, social connections, weather, surroundings, physical sensations, and path conditions.
Researchers analyzed the genome of over 100 koalas and found that two retroviruses are causing cancer deaths. They also discovered that some Koala Retrovirus (KoRV) integrations may be beneficial to koala health, increasing longevity or reproductive output.
Key imidazolyl groups induce phenylalanine flipping, significantly enhancing the cellular potency of BRD9 inhibitors for treating acute myeloid leukemia (AML). The compounds demonstrated potent binding affinity and anti-tumor efficacy in the MV4-11 xenograft mouse model.
Researchers develop a new fabrication approach to produce multi-element optical components for super-resolution imaging, enabling customized imaging systems. The technique uses consumer-grade 3D printers and low-cost materials, producing high-performance lenses at a cost of less than $1 each.
Research reveals molecular interaction between environmental and genetic risk factors triggers MS. EBV and gene variants HLA-DR15 haplotype play key roles in disease onset.
A new consensus statement provides evidence-based guidance for screening, diagnosis, treatment, and return-to-play protocols for female athletes. The updated report includes a first-of-its-kind adolescent model of the Female Athlete Triad, addressing energy deficiency in growing adolescents.
A multidisciplinary team of world-leading experts is developing an off-the-shelf engineered product that could address liver failure in millions of patients. The ImPLANT project aims to create synthetic biology-based gene circuits in human induced pluripotent stem cells to drive cell differentiation into all required liver cell types.
Women with a genetic predisposition to higher body mass index are at increased risk of all-cause mortality after breast cancer diagnosis. Targeted lifestyle recommendations can mitigate this risk.
A new hybrid wireless access network called PHWAN has been proposed to improve the performance of smart factories. The framework combines different wireless systems, including 5G, Wi-Fi, and low-power industrial networks, to adapt dynamically to the needs of different machines.
Research reveals that fat located near the colon contains an unusually high number of inflammatory fat cells and immune cells, suggesting a unique function in communicating with the immune system in the gut region. This tissue may be an adaptation to the gut microbiome and could contribute to amplifying or sustaining inflammation.
A new study reveals that resilient nematodes can persist in the Atacama Desert's hostile soil, with population diversity correlating to water profile and temperature fluctuations. The findings suggest that biodiversity in arid regions may be higher than previously assumed, but also warn of ecosystem damage.
A study finds that genome regulatory elements are conserved across echinoderms and other animal groups, controlling fundamental developmental programmes. This discovery expands our understanding of gene regulation and evolutionary novelties in vertebrates.
The new program combines limb preservation, amputation care, and reconstructive solutions like osseointegration to improve identity, functional outcome, and quality of life for patients. Patients will receive coordinated, personalized, and expert care that supports their recovery and promotes sustained overall health.
Researchers develop a framework that mirrors human expert assessment to verify AI-generated answers, filtering out clear mistakes and identifying nuanced gaps. The system saves thousands of working hours and highlights the importance of contextual knowledge and internal documentation.
This issue features revolutionary research in drug design, artificial intelligence for radiopharmaceuticals, hiPSC-derived liver organoids, and precision malignancy therapy. Groundbreaking studies showcase the potential of graph neural networks, AI-driven advancements, and innovative treatments.
Researchers developed probiotic living microneedles that penetrate biofilms, reducing pathogenic burden via photothermal killing and NIR-promoted antibiotic release. In vitro and in vivo studies show >99.9% bactericidal efficiency and 93.9% wound closure rates.
Researchers have discovered a novel drug candidate that can reverse metabolic liver disease and fibrosis, addressing a critical gap in treatment options. The compound, EVT0185, has been shown to control blood sugar levels, reduce cholesterol, and destroy fat build-up that causes liver fibrosis.
A KAIST research team developed a new analysis method to detect electronic traps in semiconductors with high sensitivity. The technique enables precise identification of defect sources, improving semiconductor performance and lifetime while reducing costs. The results demonstrate a 1,000x higher sensitivity than existing techniques.
Researchers have identified five classifications of youth who have died by suicide, highlighting the importance of earlier detection and interventions. These classifications will improve primary care providers' understanding of specific risk factors and warning signs, enabling targeted prevention efforts.
Researchers at the University of Groningen developed an atomistic model that predicts the driving force for microstructural twinning in shape memory alloys. This discovery can lead to the creation of new crystalline materials with improved reversible deformations, vibration damping, and impact absorption.
The University of North Florida has been recognized for its sustained commitment to community partnership, earning the Carnegie Elective Classification for Community Engagement for the third time. This distinction reflects years of intentional work to integrate community engagement into teaching, learning, research and service.
Researchers from the UJI Optics Group have developed a new method to correct image aberrations in single-pixel microscopy using a deformable lens. This approach combines an adaptive lens with a sensor-less method that evaluates image sharpness directly from the data, producing sharper images close to the physical resolution limit witho...
Researchers created a gear mechanism that relies on fluids to generate rotation, offering potential for new mechanical devices with improved flexibility and durability. The invention holds promise by eliminating the need for interlocking teeth and allowing for controlled rotation speed and direction.
A study by Binghamton University reveals that most renters in the US are unable to access energy efficiency improvements, leading to higher heating costs and poorer health. The 'split incentive' issue, where landlords prioritize profits over upgrades, is a major barrier to change.
A study by Johns Hopkins Bloomberg School of Public Health found that people with medical debt are more likely to experience housing instability. The research analyzed data from 1,515 US adults and found that those with medical debt had a higher risk of reporting housing instability in subsequent years.
Researchers developed a method using synthetic aperture radar images to automatically detect building destruction in conflict zones without relying on expensive data. The approach successfully reconstructed spatial patterns and timing of destruction in case studies of Beirut port explosion and Mariupol
A new study suggests that current climate actions may not effectively curb global warming acceleration, as aerosol reduction weakens cooling effect. Climate policy assessments need to consider additional climate effects from co-reduced aerosols and their risks.
A Rutgers University study finds that state-level minimum wage increases are associated with lower rates of maternal hypertensive disorders, a leading cause of maternal mortality. The research found a $1 increase in the minimum wage to be linked to 64 fewer cases per 100,000 women over five years.
A team of researchers developed an AI algorithm capable of classifying complex topological phases of matter without relying on traditional mathematical tools. The breakthrough tackles the notoriously difficult realm of non-Hermitian systems and suggests that AI can surpass human capabilities in certain domains of abstract reasoning.
Researchers used single-cell technology to analyze three brain regions of patients with sporadic early onset Alzheimer's disease. They found genes within the entorhinal cortex and hippocampus have severe disruptions consistent with symptomatic involvement in the disease.
A new study from Karolinska Institutet reveals the Epstein-Barr virus can damage the brain and contribute to multiple sclerosis through molecular mimicry. The researchers found that cross-reactive T cells are significantly more common in people with MS, and targeting these cells may lead to new treatments.
Scientists have provided a groundbreaking, physical explanation for how a magnetic field slows the movement of carbon atoms through iron in steel alloys. This discovery has the potential to improve material processing and reduce energy costs by allowing engineers to better control heat treatment, while also lowering CO2 emissions.
New research shows that vulnerable populations in the US are exposed to a larger number and higher intensity of environmental burdens. The study found strong relationships between concentrated environmental burdens and vulnerable communities, with communities of color and those with limited English fluency facing the greatest risks.
eQTLs modulate gene expression through various molecular mechanisms, providing insights into disease etiology. eQTL analysis has elucidated the functional relationship between genetic variants and complex traits in diseases such as RA, T2D, breast cancer, and SZ.
A study by Bielefeld University used anonymized WhatsApp metadata to show that personalized feedback can help people understand their communication habits. Many participants adjusted their views on response speed and chat participation after seeing data-based visualizations.
Research highlights overlooked social mechanisms connecting oral health, eating and speaking difficulties, and cognitive decline. A six-year longitudinal study found poor oral health is a strong predictor of weight loss in older adults.
Cyanobacteria can absorb and break down guanidine, using it as their sole nitrogen source, according to a new study. The ability to utilize guanidine is an advantage for colonization, despite its previous classification as a toxic substance.
A team of researchers from Keio University has developed a novel system that uses Gaussian process regression to model and reproduce complex human motions. This enables robots to adapt to touch and interact with objects in dynamic environments, improving their dexterity and versatility.
A novel 18F-labeled reversible-binding radioligand, [18F]MAGL-2011, was developed for imaging monoacylglycerol lipase with positron emission tomography. The compound demonstrated favorable brain uptake and excellent in vivo binding specificity.
Researchers discovered that protein intelectin-2 has broad-spectrum antimicrobial activity against bacteria in the GI tract. It strengthens the mucus barrier and can directly neutralize or restrain bacteria, making it a potential therapeutic agent.