A new brain stimulation technique called Patterned Low-Intensity Low-Frequency Ultrasound (LILFUS) has been developed by researchers at the Institute for Basic Science. This non-invasive method uses ultrasound to induce long-lasting changes in brain function and has shown promise in treating various neurological disorders.
A team of researchers used deep brain stimulation to localize disrupted neural pathways in patients with Parkinson's disease, dystonia, OCD, and Tourette's syndrome. The study identified specific brain circuits associated with each disorder, revealing overlapping malfunctions that suggest a complex network of brain dysfunctions.
Researchers have found a connection between the brain and its tough protective covering, the dura mater, allowing waste fluid to leave the brain while exposing it to immune cells. This discovery has implications for neural-immune system responses and aging, potentially leading to new treatments for neurodegenerative diseases.
Researchers found that older adults' brains recruit the cuneus region and frontal cortex to improve performance on fluid intelligence tasks, compensating for age-related cognitive decline. This new finding suggests alternative compensation mechanisms beyond previously assumed networks.
Brain pericytes play a crucial role in maintaining the integrity of the blood-brain barrier. A new study reveals that blood flow promotes their proliferation after entering the brain, relying on the activation of mechanosensitive ion channel Piezo1 in vascular endothelial cells and downstream Notch signaling.
Scientists have developed mini-brains from human fetal brain tissue that self-organize in vitro. These lab-grown organoids can study brain development and disease, including brain tumors. They offer a valuable means to untangle the complex network of molecules involved in directing brain development.
Researchers have discovered a brain circuit that mediates panic disorder, consisting of specialized neurons that send and receive the neuropeptide PACAP. Inhibiting PACAP signaling reduces panic symptoms, offering promising findings for future treatments.
Researchers developed a novel platform to transport therapeutic antibodies across the blood-brain barrier using a biocompatible polymer. The method showed promising results in both in vitro and mouse-model experiments, suggesting enhanced brain delivery of cancer-fighting antibodies without inducing adverse effects.
Researchers have discovered that brain cells sense continuous motion caused by everyday bodily functions, leading to friction and inflammation around implanted devices. Anti-inflammation approaches, such as coating implants with soft gels, could help prevent damage and increase device lifespan.
A new study found that regular physical activity is related to increased size of brain areas important for memory and learning. The study looked at MRI brain scans from 10,125 people and found those who engaged in activities like walking, running, or sports had larger brain volumes in key areas.
Researchers at Salk Institute assembled the most complete atlas of the mouse brain by analyzing over 2 million brain cells. The detailed atlas reveals thousands of cell types, their connections, genes, and regulatory programs active in each cell, providing new insights into human disease vulnerabilities.
Researchers created a comprehensive map of the mouse brain using artificial intelligence and analyzed over 2.3 million individual brain cells. The findings help understand how genes are switched on and off to form different cell types, shedding light on human diseases like multiple sclerosis and neuropsychiatric disorders.
A recent study published in Biological Psychiatry: Global Open Science found that smoking causes brain shrinkage and increases the risk of age-related cognitive decline and Alzheimer's disease. Quitting smoking can prevent further loss of brain tissue, but stopping does not restore the brain to its original size.
Researchers create a method to deposit small metal oxide marks in deep brain regions using electrolysis, allowing for precise localization and high-resolution imaging of neurons. The technology enables the visualization of brain-wide distribution of neurons with specific functional characteristics.
Researchers found high levels of a repair protein in the brains of former NFL athletes up to 12 years after they stopped playing, indicating persistent brain inflammation and long-term cognitive problems. The study suggests that repeated collision sports like football may have a direct link to long-term inflammation in the brain.
Researchers at the Princess Máxima Center and Hubrecht Institute developed a new cortex organoid that more accurately captures essential features of the human brain. The mini-organs can be used to model pediatric brain tumors, offering potential targets for treatment.
Scientists have found that microglia play a crucial role in regulating the number of cells that become neurons in the brain, enhancing our understanding of brain development and disorders. The discovery also reveals a unique pathway through which microglia interact with other brain cells, involving cholesterol transfer.
Researchers have created detailed cell maps of the human brain and nonhuman primate brain, paving the way for new generation of treatments for mental disorders. The study reveals a comprehensive inventory of brain cells, their organization, and gene regulation, setting the stage for developing targeted therapies.
Researchers mapped gene switches and brain cell types associated with various neuropsychiatric disorders, including schizophrenia and bipolar disorder. The study also developed AI tools to predict the influence of individual high-risk gene variants on disease.
Researchers assembled an atlas of hundreds of cell types that make up a human brain in unprecedented detail. The study uses techniques originally developed for mice to identify brain cell subtypes in human brains.
Two parallel projects publish detailed cell atlases of the adult human brain and brain development, revealing over 3,000 cell types, including new insights into brain diseases and potential therapeutic targets. The freely available brain atlases will enable researchers to compare healthy brains with diseased ones.
A massive research consortium has created the largest human brain cell atlases to date, revealing over 3,000 different kinds of brain cells. This breakthrough study provides new insights into the cellular organization of the human brain and its modular, functional nature.
The new consensus practice guideline integrates guidance for adults and children into a single guideline, providing clinicians with a comprehensive way to evaluate someone who has sustained a catastrophic brain injury. The guideline outlines the standardized procedure for trained clinicians to evaluate people for brain death, including...
The Digital Twin Brain platform combines intricate brain atlases and dynamic neural models to simulate human brain functions. This innovative approach holds promise for advancing artificial general intelligence and precision mental healthcare.
Researchers found that brain circuits in 'deep-blind' zebrafish are fully functional and can drive normal visual behavior through direct stimulation. This study challenges the long-held assumption that neural development depends on visual experience.
Researchers have developed a noninvasive brain biopsy technique using ultrasound and microbubbles to access brain tissue without surgery. The technique increases circulating tumor DNA by 1.6- to 5.6-fold, providing valuable genetic information for treatment decisions.
The University of Minnesota Medical School has received a $16 million grant from the NIH BRAIN Initiative to create detailed maps of brain connections. This project aims to better understand how complex neural pathways generate human behaviors and develop treatments for brain disorders.
The American Academy of Neurology has outlined a comprehensive plan to boost brain health by 2050, emphasizing preventive care and scientific discovery. The vision aims to optimize neurologic function across all stages of life, fostering physical, mental, and social well-being.
The Human Brain Project has achieved major breakthroughs in understanding the complex structure and function of the brain, enabling novel medical and technological applications. The project's digital atlas and personalized virtual models have provided unprecedented insights into brain conditions such as epilepsy and Parkinson's disease.
Researchers from Radboud University have successfully decoded brain signals into intelligible speech using a combination of implants and advanced artificial intelligence models. The technology has been tested with an accuracy of 92-100%, showing promise for individuals with locked-in states who are paralyzed and unable to communicate.
Experts from the Aging Biomarker Consortium propose a framework of biomarkers for brain aging, aiming to assess brain health and prevent age-related diseases. The consensus statement identifies key biomarkers reflecting 'real age', brain structure, and function.
A new study published in Nature Genetics has identified over 4,000 genetic variants linked to brain structure, revealing how the brain's organization is shaped by genetics. The research found that different sets of genes contribute to folding and size of the cortex, with some genes linked to larger or smaller head sizes.
HBP researchers used glucose uptake to locate alpha waves' generation, finding subcortical areas drive cortical activity associated with consciousness. The study reveals an inverted u-shape relation between alpha power and brain function in patients with disorders of consciousness.
Researchers have identified patterns of brain injury that underlie hidden consciousness, a phenomenon where brain-injured patients appear unconscious despite having some level of awareness. The study found that all patients with hidden consciousness had intact brain structures related to arousal and command comprehension.
Researchers created comprehensive fine-grained functional maps of infant brain networks, providing unprecedented details on brain development from birth to two years old. The study revealed novel insights into when different brain functions develop during infancy and provided valuable references for early brain developmental studies.
The study reveals altered magnitudes and coherence between oscillations in brain vasculature and brain waves in older adults. This finding has significant implications for the assessment of Alzheimer's disease and monitoring of neurodegenerative disorders.
Researchers have developed ultra-small and flexible probes that can record single-neuron activity deep within the brains of rats, eliminating the need for invasive surgery. The devices were implanted through blood vessels with no significant impact on brain function or behavior.
A new study by investigators from the Brigham and Women’s Hospital found that lesions associated with epilepsy are connected to a common brain network, suggesting the brain connections disrupted by the lesions are key. This discovery may have clinical implications for predicting epilepsy risk and targeting treatments.
Researchers built personalized brain network models to simulate brain dynamics and found that people with higher fluid intelligence took more time to solve difficult tasks compared to those with lower FI. This suggests that a synchronized brain is better at solving problems but not necessarily faster.
Researchers found that higher intelligence scores are only associated with quicker performance on simple tasks, while more difficult problems require more time and lead to better results. The brain models also showed that slower brains make fewer errors due to reduced synchrony between brain areas.
Researchers found that targeted deep-brain stimulation during a critical sleep cycle improved memory consolidation in patients with epilepsy. The study provided physiological evidence from inside the human brain supporting the main theory for how memory is consolidated during sleep.
A Monash University study found that the shape of a person's brain, rather than its complex connections, plays a crucial role in how we think, feel, and behave. The research used magnetic resonance imaging to identify eigenmodes, natural patterns of vibration, which are influenced by the brain's structural properties.
A new study published in Neurology found an association between sleep apnea and reduced brain volume, particularly in the medial temporal lobe area of the brain. People with amyloid plaques who had more severe sleep apneas were also more likely to have lower brain volumes, suggesting loss of brain cells.
Scientists have developed a new method to genetically modify brain organoids, allowing for quick and effective analysis of gene function in early stages of brain development. This breakthrough enables comparative studies across primate species and simulates neurological diseases without animal experiments.
The CEBRA algorithm captures brain dynamics with high accuracy, allowing for the prediction of complex information such as visual stimuli and arm movements in primates. By analyzing brain signals alone, researchers can decode hidden structure in data, enabling new insights into how the brain processes information.
Scientists successfully opened the blood-brain barrier using a novel ultrasound device, delivering chemotherapy to treat glioblastoma patients. The treatment increased drug concentrations by 4-6 times and was safe and well-tolerated.
New research shows that rhythmic brain activity helps organize transient bursts of activity in the brain to maintain short-term connections. Brain rhythms coordinate overlapping populations of neurons to store different pieces of information at the same time.
A new study at Umeå University reveals that tick-borne encephalitis virus infects distinct brain cell types and regions depending on the immune system's activation status. The researchers mapped the virus's behavior in the brain, identifying specific areas and cells infected by TBE virus.
A Penn Medicine study identified a developmental sequence in brain maturation during adolescence, revealing regions supporting cognitive and social functions remain malleable until late adolescence. The study found that socioeconomic environments have a significant impact on brain development in these regions.
A new study published in Neurology shows that younger brain age is associated with superior post-stroke outcomes, suggesting a potential biomarker for stroke rehabilitation. The research team used multi-site data sets and 3D brain structural MRIs to analyze the relationship between brain age and stroke recovery.
The Human Brain Project has achieved significant scientific breakthroughs, including world-leading 3D brain atlases and personalized medicine based on computational modeling. The project's legacy will leave a lasting impact on the research community.
Researchers used microfluidic devices to track what happens to cancer cells as they migrate and take root in the brain. They found that Dkk-1 triggers cancer cell migration, and reducing its levels near tumor cells may disrupt crosstalk between brain niche cells and cancer cells.
Researchers used a novel brain imaging technique to visualize subtle brain changes in pre-symptomatic Alzheimer's patients. They found that individualized brain fingerprints can detect variations in brain function associated with worsening information processing.
Researchers at the Human Brain Project present novel clinical uses of advanced brain modelling methods, enabling clinicians to simulate epileptic seizures and identify target areas. The approach has broad applicability in neuroscience, medicine, and neurotechnology, with potential improvements in data resolution and patient specificity.
Researchers found that eating small amounts of high-fat and sugar foods regularly rewires the brain to prefer these types of foods. The brain's dopaminergic system is activated, leading to a subconscious preference for rewarding food.
A study at Imperial College London used advanced brain imaging to track DMT's effects on brain activity before, during, and after the experience. Increased connectivity across the brain and dysregulation of high-level brain systems were found in areas linked with imagination.
Researchers discovered a novel waste removal factor, CDNF, that treats brain haemorrhage by accelerating lesion resolution, reducing brain swelling, and improving functional outcomes. The treatment also alleviates cell stress and promotes scavenging by immune cells, leading to better recovery.
Researchers at Stanford University have developed a novel AI-powered approach to analyzing traumatic brain injury, using artificial intelligence to identify the most accurate model of mechanical stress on the brain. This breakthrough could lead to better understanding of when concussions lead to lasting brain damage and inspire new pro...
A new approach using nanoparticles has been shown to transport drugs across the blood-brain barrier in mice with medulloblastoma. The nanoparticles target a protein called P-selectin, which binds naturally to cancer cells, and trigger transcytosis to deliver drugs to brain tissue.
A study found that people with long COVID who experience anxiety and depression months after a mild case of COVID-19 may have brain changes that affect the function and structure of the brain. The study also revealed widespread functional changes in brain networks, suggesting potential problems with memory and thinking skills.