The study provides a comprehensive macaque brain atlas, MacBNA, that characterizes profiles of whole-brain regions, including connectivity, anatomy, and geometric topology. This atlas will aid in understanding brain function, development, and evolution, and can be used to transfer information from monkey brains to human brains.
Researchers have engineered an AAV that efficiently crosses the blood-brain barrier and delivers genes to the brain in humanized mice. This could lead to new treatments for severe genetic brain disorders with no current cures or few treatment options.
A team of neuroscientists proposes a framework to address the complex challenges of brain health, environment, and sustainability. The 'brain economy' concept aims to create a stronger future by reversing brain capital loss, which affects cognitive abilities and socioemotional stability.
DPABINet enables users to construct brain networks, conduct graph theory analysis, and perform statistical analysis with a single click, eliminating the need for programming expertise. The platform enhances brain structural network research derived from diffusion-weighted imaging, providing a robust analysis framework.
Researchers at The University of Tokyo successfully connected lab-grown brain-mimicking tissue using axonal bundles, mimicking natural brain connections. This breakthrough enables the study of complex brain networks and their role in various neurological and psychiatric conditions.
A new study found that mums with insecure attachment traits showed more brain-to-brain synchrony with their children, while fathers and children had stronger brain-to-brain synchrony. The research suggests that high or low synchrony can signal interaction difficulties in families.
Researchers at Hiroshima University explore the ethics of growing brain organoids from human fetal brain cells, highlighting concerns over consciousness, informed consent, and medical applications. The study emphasizes the need for a global regulatory framework to navigate the complex ethical landscape of fetal brain organoid research.
Researchers at DGIST have created highly durable brain electrodes made of soft and elastic materials, sticking well to the curved brain surface. These electrodes can maintain stable performance over long-term use, enabling various applications in brain–machine interfaces and electronic medical devices.
Researchers discover a significant association between chronic knee pain and accelerated brain aging, highlighting the need for early detection and intervention strategies. Brain regions critical for cognitive function show increased signs of aging in individuals with chronic musculoskeletal pain.
A new study found that human brains are getting larger, with participants born in the 1970s having 6.6% greater brain volume and almost 15% larger brain surface area than those born in the 1930s. This increased brain size may lead to a higher brain reserve, potentially reducing the overall risk of age-related dementias.
A new study found that a viral infection can cause cognitive impairments by damaging the blood-brain barrier, leading to memory loss and learning difficulties. Researchers developed a gene therapy that stimulated the Wnt/beta-catenin pathway to prevent this damage and improve cognitive function in mice infected with SARS-CoV-2.
Researchers have developed a cost-effective method to spatially characterize and map brain epigenomes, providing a comprehensive map of the brain's biology at genome scale. The approach enables understanding of gene activity outside of DNA sequences and has implications for treating brain disorders.
Researchers at the University of Galway have developed a new method for improving stem cell-based brain repair therapy for Parkinson's disease, which shows promising results in enhancing survival and maturation of cells in the brain. The technique uses a collagen hydrogel to support and protect the cells after transplantation.
A new study by researchers at the University of Minnesota reveals that non-invasive brain stimulation can change a specific brain mechanism related to human behavior. The technique, called transcranial alternating current stimulation, modulates brain activity by shifting when brain cells are active.
A team of researchers from the Medical University of South Carolina has discovered a novel protective response by which the brain naturally repairs itself after traumatic brain injury. Protein p17 plays a crucial role in this process, triggering the restorative mechanism of mitophagy to remove damaged tissue and initiate healing.
Researchers found that different areas of the brain start with a similar organization in early development, using a shared blueprint to guide neural growth. This suggests that neurodevelopmental disorders may act similarly across diverse brain areas.
A preliminary study found that people with headaches after concussions tend to have higher levels of iron in areas of the brain, suggesting damage to brain cells. The more concussions and frequent headaches individuals experience, the greater the likelihood of increased iron accumulation in certain brain regions.
Scientists at Washington University School of Medicine discovered that neurons coordinate to produce rhythmic waves that propel fluid through dense brain tissue, washing the tissue in the process. This finding has implications for delaying or preventing neurodegenerative diseases by enhancing the brain's cleaning abilities.
A new brain stimulation technique called Patterned Low-Intensity Low-Frequency Ultrasound (LILFUS) has been developed by researchers at the Institute for Basic Science. This non-invasive method uses ultrasound to induce long-lasting changes in brain function and has shown promise in treating various neurological disorders.
A team of researchers used deep brain stimulation to localize disrupted neural pathways in patients with Parkinson's disease, dystonia, OCD, and Tourette's syndrome. The study identified specific brain circuits associated with each disorder, revealing overlapping malfunctions that suggest a complex network of brain dysfunctions.
Researchers have found a connection between the brain and its tough protective covering, the dura mater, allowing waste fluid to leave the brain while exposing it to immune cells. This discovery has implications for neural-immune system responses and aging, potentially leading to new treatments for neurodegenerative diseases.
Researchers found that older adults' brains recruit the cuneus region and frontal cortex to improve performance on fluid intelligence tasks, compensating for age-related cognitive decline. This new finding suggests alternative compensation mechanisms beyond previously assumed networks.
Brain pericytes play a crucial role in maintaining the integrity of the blood-brain barrier. A new study reveals that blood flow promotes their proliferation after entering the brain, relying on the activation of mechanosensitive ion channel Piezo1 in vascular endothelial cells and downstream Notch signaling.
Scientists have developed mini-brains from human fetal brain tissue that self-organize in vitro. These lab-grown organoids can study brain development and disease, including brain tumors. They offer a valuable means to untangle the complex network of molecules involved in directing brain development.
Researchers have discovered a brain circuit that mediates panic disorder, consisting of specialized neurons that send and receive the neuropeptide PACAP. Inhibiting PACAP signaling reduces panic symptoms, offering promising findings for future treatments.
Researchers developed a novel platform to transport therapeutic antibodies across the blood-brain barrier using a biocompatible polymer. The method showed promising results in both in vitro and mouse-model experiments, suggesting enhanced brain delivery of cancer-fighting antibodies without inducing adverse effects.
Researchers have discovered that brain cells sense continuous motion caused by everyday bodily functions, leading to friction and inflammation around implanted devices. Anti-inflammation approaches, such as coating implants with soft gels, could help prevent damage and increase device lifespan.
A new study found that regular physical activity is related to increased size of brain areas important for memory and learning. The study looked at MRI brain scans from 10,125 people and found those who engaged in activities like walking, running, or sports had larger brain volumes in key areas.
Researchers at Salk Institute assembled the most complete atlas of the mouse brain by analyzing over 2 million brain cells. The detailed atlas reveals thousands of cell types, their connections, genes, and regulatory programs active in each cell, providing new insights into human disease vulnerabilities.
Researchers created a comprehensive map of the mouse brain using artificial intelligence and analyzed over 2.3 million individual brain cells. The findings help understand how genes are switched on and off to form different cell types, shedding light on human diseases like multiple sclerosis and neuropsychiatric disorders.
A recent study published in Biological Psychiatry: Global Open Science found that smoking causes brain shrinkage and increases the risk of age-related cognitive decline and Alzheimer's disease. Quitting smoking can prevent further loss of brain tissue, but stopping does not restore the brain to its original size.
Researchers create a method to deposit small metal oxide marks in deep brain regions using electrolysis, allowing for precise localization and high-resolution imaging of neurons. The technology enables the visualization of brain-wide distribution of neurons with specific functional characteristics.
Researchers found high levels of a repair protein in the brains of former NFL athletes up to 12 years after they stopped playing, indicating persistent brain inflammation and long-term cognitive problems. The study suggests that repeated collision sports like football may have a direct link to long-term inflammation in the brain.
Researchers at the Princess Máxima Center and Hubrecht Institute developed a new cortex organoid that more accurately captures essential features of the human brain. The mini-organs can be used to model pediatric brain tumors, offering potential targets for treatment.
Scientists have found that microglia play a crucial role in regulating the number of cells that become neurons in the brain, enhancing our understanding of brain development and disorders. The discovery also reveals a unique pathway through which microglia interact with other brain cells, involving cholesterol transfer.
A massive research consortium has created the largest human brain cell atlases to date, revealing over 3,000 different kinds of brain cells. This breakthrough study provides new insights into the cellular organization of the human brain and its modular, functional nature.
Two parallel projects publish detailed cell atlases of the adult human brain and brain development, revealing over 3,000 cell types, including new insights into brain diseases and potential therapeutic targets. The freely available brain atlases will enable researchers to compare healthy brains with diseased ones.
Researchers mapped gene switches and brain cell types associated with various neuropsychiatric disorders, including schizophrenia and bipolar disorder. The study also developed AI tools to predict the influence of individual high-risk gene variants on disease.
Researchers assembled an atlas of hundreds of cell types that make up a human brain in unprecedented detail. The study uses techniques originally developed for mice to identify brain cell subtypes in human brains.
Researchers have created detailed cell maps of the human brain and nonhuman primate brain, paving the way for new generation of treatments for mental disorders. The study reveals a comprehensive inventory of brain cells, their organization, and gene regulation, setting the stage for developing targeted therapies.
The new consensus practice guideline integrates guidance for adults and children into a single guideline, providing clinicians with a comprehensive way to evaluate someone who has sustained a catastrophic brain injury. The guideline outlines the standardized procedure for trained clinicians to evaluate people for brain death, including...
The Digital Twin Brain platform combines intricate brain atlases and dynamic neural models to simulate human brain functions. This innovative approach holds promise for advancing artificial general intelligence and precision mental healthcare.
Researchers have developed a noninvasive brain biopsy technique using ultrasound and microbubbles to access brain tissue without surgery. The technique increases circulating tumor DNA by 1.6- to 5.6-fold, providing valuable genetic information for treatment decisions.
Researchers found that brain circuits in 'deep-blind' zebrafish are fully functional and can drive normal visual behavior through direct stimulation. This study challenges the long-held assumption that neural development depends on visual experience.
The University of Minnesota Medical School has received a $16 million grant from the NIH BRAIN Initiative to create detailed maps of brain connections. This project aims to better understand how complex neural pathways generate human behaviors and develop treatments for brain disorders.
The American Academy of Neurology has outlined a comprehensive plan to boost brain health by 2050, emphasizing preventive care and scientific discovery. The vision aims to optimize neurologic function across all stages of life, fostering physical, mental, and social well-being.
The Human Brain Project has achieved major breakthroughs in understanding the complex structure and function of the brain, enabling novel medical and technological applications. The project's digital atlas and personalized virtual models have provided unprecedented insights into brain conditions such as epilepsy and Parkinson's disease.
Researchers from Radboud University have successfully decoded brain signals into intelligible speech using a combination of implants and advanced artificial intelligence models. The technology has been tested with an accuracy of 92-100%, showing promise for individuals with locked-in states who are paralyzed and unable to communicate.
Experts from the Aging Biomarker Consortium propose a framework of biomarkers for brain aging, aiming to assess brain health and prevent age-related diseases. The consensus statement identifies key biomarkers reflecting 'real age', brain structure, and function.
A new study published in Nature Genetics has identified over 4,000 genetic variants linked to brain structure, revealing how the brain's organization is shaped by genetics. The research found that different sets of genes contribute to folding and size of the cortex, with some genes linked to larger or smaller head sizes.
HBP researchers used glucose uptake to locate alpha waves' generation, finding subcortical areas drive cortical activity associated with consciousness. The study reveals an inverted u-shape relation between alpha power and brain function in patients with disorders of consciousness.
Researchers have identified patterns of brain injury that underlie hidden consciousness, a phenomenon where brain-injured patients appear unconscious despite having some level of awareness. The study found that all patients with hidden consciousness had intact brain structures related to arousal and command comprehension.
Researchers created comprehensive fine-grained functional maps of infant brain networks, providing unprecedented details on brain development from birth to two years old. The study revealed novel insights into when different brain functions develop during infancy and provided valuable references for early brain developmental studies.
The study reveals altered magnitudes and coherence between oscillations in brain vasculature and brain waves in older adults. This finding has significant implications for the assessment of Alzheimer's disease and monitoring of neurodegenerative disorders.
Researchers have developed ultra-small and flexible probes that can record single-neuron activity deep within the brains of rats, eliminating the need for invasive surgery. The devices were implanted through blood vessels with no significant impact on brain function or behavior.
A new study by investigators from the Brigham and Women’s Hospital found that lesions associated with epilepsy are connected to a common brain network, suggesting the brain connections disrupted by the lesions are key. This discovery may have clinical implications for predicting epilepsy risk and targeting treatments.
Researchers built personalized brain network models to simulate brain dynamics and found that people with higher fluid intelligence took more time to solve difficult tasks compared to those with lower FI. This suggests that a synchronized brain is better at solving problems but not necessarily faster.
Researchers found that higher intelligence scores are only associated with quicker performance on simple tasks, while more difficult problems require more time and lead to better results. The brain models also showed that slower brains make fewer errors due to reduced synchrony between brain areas.
Researchers found that targeted deep-brain stimulation during a critical sleep cycle improved memory consolidation in patients with epilepsy. The study provided physiological evidence from inside the human brain supporting the main theory for how memory is consolidated during sleep.
A new study published in Neurology found an association between sleep apnea and reduced brain volume, particularly in the medial temporal lobe area of the brain. People with amyloid plaques who had more severe sleep apneas were also more likely to have lower brain volumes, suggesting loss of brain cells.