Researchers found that airborne particles carrying a mammalian coronavirus remain infectious for twice as long in drier air, thanks to the protective effect of saliva. The study suggests that managing indoor air filtration and ventilation is crucial to mitigate airborne disease spread.
Researchers have developed a new diagnostic test called p-LFAs that can detect and quantify protein concentrations to identify bacterial and viral infections. The test is 1,000 times more sensitive than conventional tests, returning results in just 20 minutes.
A new model has integrated two classic approaches to improve disease spread predictions, accounting for age-specific contact patterns and location-specific data. The model outperformed previous approaches in simulation studies and case studies, providing valuable insights into disease prevention and control.
A UAB researcher discovered a new definition of Petri nets that reconciles two longstanding mathematical approaches, allowing for the reconciliation of geometric and algebraic semantics. This breakthrough has been used in epidemiological modeling, including COVID-19 research.
Researchers have discovered a pathway in cells that could be used to reprogram the body's immune system to fight chronic inflammatory and infectious diseases. A molecule derived from glucose, ribulose-5-phosphate, has been found to stop bacteria from growing and dampen inflammatory responses.
Researchers at the University of Cincinnati found a link between latent tuberculosis infection and increased inflammation in monocytes, a type of white blood cell. This connection may contribute to a higher risk of cardiovascular disease in individuals with LTBI.
The Journal of the Pediatric Infectious Diseases Society has published a supplement issue focusing on past, current, and future diversity and inclusion issues affecting pediatric infectious diseases. The collection examines the legacy of health disparities and their impact on the response to COVID-19.
Dr. Fauci highlights the rapid development and distribution of COVID-19 vaccines as a significant success in responding to emerging infectious diseases. He emphasizes the need to improve capabilities for established diseases like malaria and tuberculosis while addressing new threats.
Climate change is expanding the geographic range of endemic fungal diseases, such as Valley fever, blastomycosis, and histoplasmosis, which can mimic pneumonia. Physicians are often misdiagnosing these conditions due to a lack of training and limited testing options.
The National Institute of Allergy and Infectious Diseases has awarded over $12 million to three institutions for the development of antiviral therapies against pandemic viruses. The funding will support the optimization, development, and clinical testing of promising antiviral candidates.
Dr. Yvonne Maldonado, a renowned pediatrician, has been awarded the 2023 APS John Howland Award for her groundbreaking work in advancing child health and infectious diseases. Her tireless advocacy has led to significant improvements in preventing perinatal HIV infection and vaccine-preventable illnesses.
A recent study published in the American Journal of Epidemiology found that wastewater surveillance can detect almost all infectious diseases classified as a Public Health Emergency of International Concern. However, more research is needed to maximize the utility of this powerful science for public health benefit.
Studies on prion diseases in mice reveal coordinated gene expression changes before symptoms appear, shedding light on selective vulnerability and potential treatment targets. Researchers predict disease progression using new methods, suggesting therapies may be more effective when applied early.
The study found a significant need for stable and durable diagnostics to differentiate infected animals from vaccinated ones. The researchers propose five priorities: vaccinology, antimicrobial resistance, climate mitigation, digital health, and epidemic preparedness.
A global consortium has launched best practice surveillance protocols for Group A Streptococcus (Strep A) research, providing clear case definitions and guiding researchers in clinical trials. The new protocols aim to accelerate the development of a safe and effective Strep A vaccine.
Research at large events like concerts and festivals shows that individuals exhibit 'bursty' movement patterns, stopping and resting before moving to new locations. This intermittent behavior increases the risk of spreading infectious diseases like COVID-19.
The University of California, Davis has received a $10 million grant to continue its work on managing and preventing mosquito- and tick-borne diseases. Researchers will focus on finding effective methods to stop these diseases while training the next generation of public-health scientists.
The 2022 AAFP/EveryCat Feline Infectious Peritonitis Diagnosis Guidelines provide essential information for veterinarians to diagnose FIP, a fatal viral disease affecting young cats. The guidelines offer helpful tips, images, and tables to assist clinicians in recognizing FIP symptoms.
The Institute for Basic Science (IBS) collaborated with the National Institutes of Health (NIH) and St. Jude’s Children’s Research Hospital to increase virus research capacity and respond to infectious disease outbreaks. IBS and NIAID discussed potential research cooperation opportunities, including joint symposia and resource sharing.
A study of 57 people with mild COVID-19 found that the average duration of infectiousness was five days, and two-thirds of cases remained infectious for at least five days after symptoms began. Lateral flow tests can safely shorten self-isolation by identifying when someone is no longer contagious.
A double-blind study found that 12.5% of placebo-treated individuals and 1% of BCG-treated individuals met criteria for confirmed COVID-19, indicating a 92% vaccine effectiveness. The BCG-vaccinated group also displayed protective effects against other infectious diseases, including fewer symptoms and reduced disease events.
Scientists discover guanylate-binding proteins that can directly kill specific types of bacteria, offering new treatment options for drug-resistant infections. These proteins can also be used in combination with existing antibiotics to enhance treatment effectiveness.
Researchers at the University of Liège discovered that Ly6C hi monocytes orchestrate balance between cytotoxic and regulatory properties of CD4 T cells. This understanding opens new therapeutic avenues for managing severe immunopathologies associated with respiratory viral infections.
Researchers found that breastfeeding provides an immune boost to infants, reducing the risk of respiratory infections such as pneumonia. However, milk also mounts responses to beneficial gut bacteria, which can be disruptive and increase the risk of gastrointestinal infections.
Researchers at USAMRIID have demonstrated the use of messenger RNA (mRNA) to develop treatments for infectious diseases. The study found that administering mRNAs encoding monoclonal antibodies targeting poxviruses resulted in significant systemic levels of functional antibodies, offering potential for rapid response to disease outbreaks.
A study by Boston University researchers found that in the majority of young, healthy and vaccinated adults, the infectious period for SARS-CoV-2 is limited to five days. The findings suggest that rapid antigen testing can provide reassurance on lack of infectiousness, but masking for a full 10 days is still necessary to prevent transm...
Researchers developed a framework to investigate the bidirectional relationship between masking and disease. They found that without proper enforcement of masking, mass vaccination may not be enough to reduce epidemic size.
A WHO-sponsored series of articles presents biodiversity data on vectors of human disease, providing information to aid in the battle against prevalent diseases. The collection and sharing of data through platforms like GBIF.org are crucial for tracking and assessing species, particularly in geographic gaps.
A WHO-supported series has collected 13,700 new database records on mosquito-borne diseases, providing valuable resource for studying and containing infectious diseases. The data can be used to train machine-learning models for vector detection and classification, improving global human health.
A vaccine candidate for eastern equine encephalitis virus, western equine encephalitis virus, and Venezuelan equine encephalitis virus has been found safe and well-tolerated in a clinical trial. The vaccine induced a neutralizing antibody response against all three viruses.
The NIH has launched a Phase 1 clinical trial to evaluate an investigational preventative vaccine for Epstein-Barr virus (EBV). The study aims to assess the safety and immune response of the EBV gp350-Ferritin nanoparticle vaccine with a saponin-based Matrix-M adjuvant.
The CRISPR/Cas system is being utilized for the treatment and diagnosis of infectious diseases using biosafety materials, highlighting its design principle and efficacy. Advanced biosafety materials are used to detect viral nucleic acids and inhibit viral replication.
A 31-year-old woman, a healthcare worker, tested positive for the Omicron strain of SARS-CoV-2 just 20 days after having a Delta infection. The 20-day gap between infections is the shortest known. Fully vaccinated and boosted, she developed symptoms without immunity.
Outpatient antibiotic prescribing in Australia decreased significantly during the pandemic, with a 38% drop in winter 2020 compared to pre-pandemic years. The reduction was predominantly due to decreases in GP prescribing and targeted public education efforts.
Researchers found that vaccination greatly reduces the infectious viral load caused by COVID-19 variants Delta and Omicron. However, boosted individuals showed a significant reduction in viral load compared to unvaccinated people. The study highlights the importance of updated knowledge for combating new variants.
A new study identifies a reason for why older adults are more susceptible to infectious diseases and paves the way for potential therapeutic targets. Researchers found that sex-dimorphic elevation of N-glycan branching contributes to age-associated impairment of T cell immunity.
The NIH has awarded grants to four institutions to establish Tuberculosis Research Advancement Centers, which will provide focused mentoring, funding support, and training opportunities for new investigators. The centers aim to develop a next-generation of tuberculosis researchers and alleviate the global burden of TB through research.
New data from the MOVe-OUT trial reveals that molnupiravir significantly reduces SARS-CoV-2 infection within three days of treatment. In contrast, those receiving a placebo took up to five days to clear the virus. The study confirms molnupiravir's effectiveness in accelerating viral RNA decline and eliminating infectious virus.
A new analysis of data on molnupiravir shows the drug effectively clears active SARS-CoV-2 virus in both immunocompromised and non-immunocompromised patients. The study found similar reductions in viral replication and no infectious virus detected after treatment, indicating equal efficacy in both groups.
Achieving classical herd immunity against SARS-CoV-2 may be unlikely due to virus mutations and asymptomatic transmission. However, widespread use of current public health interventions can control COVID-19 with minimal disruption.
The omicron variant's infectiousness period is uncertain, with evidence suggesting it may not be shorter than previous variants. Dr Marjolein Irwin-Knoester recommends a maximum of 7-day isolation for most cases, striking a balance between virus infectivity and community acceptance.
Outbreaks in Hong Kong's high-rise housing have shown vertical transmission of COVID-19 via drainage stack bioaerosols, which can spread through pipes and enhance by poor ventilation. The omicron variant has contributed to the rapid spread.
The European Society of Clinical Microbiology and Infectious Diseases finds organ donation from COVID-19 patients is safe and does not transmit SARS-CoV-2. Recipients with asymptomatic infections are also now eligible for transplant, but must be triple-vaccinated.
A new study surveyed recent theoretical and empirical insights into economic and policy implications of modern infectious diseases, including COVID-19. The survey reveals distinct channels of disease impacts, highlighting the importance of prevention and pandemic preparedness through investments in healthcare systems.
A new human CD8+ T cell subset has been identified that suppresses pathogenic CD4+ T cells in autoimmune and infectious diseases. This subset, known as KIR+CD8+ T cells, is increased in the blood and inflamed tissues of patients with autoimmune conditions and COVID-19.
Researchers from the University of Nottingham have developed a new data-driven framework for modelling infectious diseases spread through populations. The framework avoids strict assumptions and enables policy makers to make data-driven decisions.
Researchers found that some painkillers and fever medications may help fight infection, while others can weaken the immune system. The review highlights the need for more studies on the impact of these medicines on infectious diseases.
A recent study found a high prevalence of HIV, tuberculosis, and malaria in the Gambela region of Ethiopia, highlighting the need for targeted health services. The research suggests that addressing these diseases at a local level could be more effective than a nationwide response.
A study led by A*STAR's Genome Institute of Singapore has identified the gene KCNJ15 as a key player in helping the immune system fight tuberculosis. The research found that TB patients have altered acetylation levels at thousands of DNA regions, which helps to reduce the ability of bacteria to reproduce inside cells.
A new study suggests that implementing primary pandemic prevention actions, such as better surveillance and wildlife management, can reduce the economic costs of emerging infectious diseases by up to 10%. These actions have a substantial co-benefit of preventing carbon dioxide emissions and conserving water supplies.
Researchers are using a salamander virus to predict the future of biodiversity amid a changing climate. The study aims to create better models to understand how climate change and infectious diseases interact, with potential implications for conserving species at risk of extinction.
A new study by the University of Exeter found that 13% of people who tested positive for COVID-19 on standard PCR tests remained clinically relevant for the virus beyond 10 days. This could pose a risk of onward transmission, and the authors recommend applying the newly adapted test to settings where vulnerable individuals are present.
Researchers developed a microfluidic chip for rapid and simultaneous diagnosis of COVID-19 and influenza diseases, achieving results within 30 minutes. The device uses the LAMP method for genetic amplification and has potential applications in various fields beyond human infectious diseases.
The Research Corporation for Science Advancement and USDA have awarded $1.25 million to early-career scientists to detect and mitigate emerging zoonotic diseases. Crystal Hepp and Jason Ladner of Northern Arizona University will receive funding for projects on serological approaches and genomic epidemiology.
Researchers found two prion gene variants in Père David's deer that may reduce susceptibility to CWD. The genetic variants were surprising given the population's small founder size and conserved prion protein gene. Studies are needed to confirm whether these variants provide protection against CWD.
Researchers developed EDS-HAT, an AI-powered system combining machine learning and whole genome sequencing to detect clusters of similar infections in real-time. The system identified 99 clusters of infections and prevented potential transmissions in 65.7% of cases, saving the hospital $692,500.
Leaders of high-containment labs argue for a nuanced approach to regulation, drawing from existing practices and considering human and financial costs. They advocate for organizational leaders to take responsibility for lab safety and security, reducing the need for government-level oversight.
A new register study at Umea University found that people with psychotic or bipolar disorders are significantly more likely to die from influenza, pneumonia, or sepsis. The proportion of deaths due to these conditions was sixfold in certain age groups, highlighting the need for preventive measures.
A study by the University of Georgia's Center for the Ecology of Infectious Diseases identified contaminated water as the most common driver of large-scale zoonotic disease outbreaks. The researchers analyzed over 4,400 outbreaks and found that unusual weather patterns and changes in vector abundance were also significant contributors.
A study published in the Journal of Infectious Diseases found that children can carry high levels of live, replicating SARS-CoV-2 virus in their respiratory secretions, with no correlation between age and viral load. The researchers also noted that viral loads are highest early in the illness in both symptomatic and asymptomatic children.