Scientists have discovered that endogenous dendritic cell-derived interleukin-27 promotes tumor growth by recruiting regulatory T-cells. This finding suggests that targeting IL-27 could lead to more effective cancer immunotherapies.
Researchers identified 24 functional categories of genes with strong positive selection in ant lineages, including those related to nervous system development and immunity. Ant-specific signals on mitochondrial activity genes may be responsible for increased queen lifespan up to 30 years.
Researchers analyzed the mountain pine beetle's genome and identified potential genetic markers that enable its rapid habitat range expansion. The study found that the beetles can adjust their cellular functions to withstand cooler climates, facilitating a larger geographic dispersal area.
Adam Arkin, director of Berkeley Lab's Physical Biosciences Division, has made significant contributions to systems and synthetic biology. He received the 2013 Ernest Orlando Lawrence Award for his work on cellular networks and populations.
The American Society of Plant Biologists announced its 2014 award recipients, recognizing outstanding contributions to plant biology research, education, and service. The Charles Albert Shull Award went to Libo Shan for her work on plant-microbe interactions, while the Charles Reid Barnes Life Membership Award was awarded to James N. S...
Scientists have discovered a correlation between the number of duplicated genes and a species' ability to adapt to novel environments. Higher numbers of these 'small-scale duplication genes' are associated with better adaptation, while lower numbers may hinder species survival.
A new computational tool in Molecular Biology and Evolution helps public health officials investigate disease outbreaks by analyzing genomic data, correctly inferring source cases and transmission clusters. The tool complements traditional epidemiology methods, providing valuable insights into outbreak dynamics.
Researchers from UH and Rice University collaborated to engineer a synthetic gene circuit that compensates for temperature changes. The team used mathematical modeling to design the plasmid and created a genetic clock with a stable period across various temperatures.
The University of Liverpool has been awarded £2M for a state-of-the-art DNA synthesis facility, GeneMill, to support genome engineering in academia and industry. The lab will provide rapid, cost-effective, and accessible fabrication facilities for DNA parts, enabling researchers to focus on designing and testing re-engineered organisms.
Researchers at NYU Langone Health have synthesized a fully functioning chromosome in yeast using computer-aided design, overcoming the biggest hurdle in synthetic biology. The seven-year effort built a chromosome with over 270,000 base pairs, enabling new capabilities and traits in yeast cells.
A study by the Monell Chemical Senses Center found that children who prefer sweet tastes also prefer salty tastes, and that these preferences relate to measures of growth and development. The research highlights the importance of understanding the biology behind children's food preferences to promote healthy eating habits.
A study on wild green anole lizards reveals that the link between muscle function and movement is more complicated than previously thought. The researchers found that changes in motion do not always correspond to changes in muscle activity, leading to new questions about animal ecology, evolution, and adaptation.
Lignin breakthroughs provide a new approach integrating biology, chemistry and engineering to understand how plants make products and structures needed for growth and development. The research team developed models that predict how pathway enzymes affect lignin content and composition.
Scientists have successfully studied protein synthesis in adult stem cells, finding that precise protein production is essential to their function. The discovery opens up new avenues of cellular biology and may lead to a better understanding of diseases associated with protein synthesis mutations.
Researchers propose a new approach to understanding biology, shifting focus from genes to energy consumption and complex dissipative systems. The theory suggests that genes cannot determine biological activity, but rather, it is the energy flows within cells that drive emergence of properties.
Researchers at the University of Bristol and EMBL have identified the 'holo-translocon' as the machinery responsible for inserting proteins into cell membranes. This breakthrough could lead to the design of new anti-bacterial drugs and applications in synthetic biology.
Recent research in biological anthropology explores how global environmental variations shape human health and biology. The studies examine the effects of diet, energy dynamics, and chronic inflammation on human reproduction, nutrition, and disease prevalence.
The study of crab diversity has led to a new dataset with DNA and mitochondrial sequences from 140 species and 58 families. Freshwater crabs have two independent origins, separated from marine relatives after Pangaea's break-up.
The study reveals that enzymes involved in breaking down fatty acids evolved independently in both plants and animals, mirroring each other's development. This finding suggests that both groups faced similar challenges when dealing with ingested fatty acids from plants.
A study published in Molecular Biology and Evolution found that Tibetan Mastiffs have undergone genetic adaptations to survive at high altitudes. The research identified 16 genes involved in energy production critical for high-altitude survival, suggesting convergent evolution between dogs and humans.
Researchers found a new application of physics tools in understanding epigenetic memory, which is how organisms create a biological memory of certain conditions. The study highlights the interdisciplinary nature of modern molecular biology and shows how mathematical models can help clarify complex biological problems.
Researchers analyzed killer whale genomic data and found that populations declined during the last Ice Age due to a bottleneck effect, leading to low genetic diversity except in southern Africa's refuge population.
The largest sequencing study to date reveals most higher animal genes are present in all sponge groups, challenging previous thought of complex structures being absent. The study provides a framework for posing new hypotheses on determining gene function in sponges and the evolution of animal complexity.
The UK has established three new synthetic biology research centres, with £40M+ investment, to drive advancement in modern synthetic biology research and develop new technologies. The centres will focus on diverse expertise to stimulate innovation in this area.
The University of Oklahoma and Albert Einstein College of Medicine will establish an Institute of Structural Biology to advance research on the impact of proteins. Researchers will target deadly diseases and search for new cures, gaining expertise in X-ray analysis and large-scale structural genomics.
A new UK synthetic biology centre, OpenPlant, has been awarded £12 million funding to create a climate of openness in the field. The centre aims to develop and share new tools and libraries of plant DNA, fostering innovation in sustainable agriculture and medicine.
A new study published in Molecular Biology and Evolution suggests that strong natural selection acted on lactase persistence in Iberia over the last 7,000 years. The 'calcium assimilation hypothesis' is challenged as sunlight in Iberia allows for vitamin D synthesis, making calcium deficiency less of a concern.
Chromosomes' characteristic shape is explained by self-organizing supramolecular structures formed by stacked layers of chromatin. The symmetry breaking due to different surface energies in telomeres and lateral surfaces justifies the elongated structure.
Researchers analyzed pain response in chickens, discovering that heat stimulation activates TRPA1 receptors similar to cold-blooded animals. Methyl anthranilate, a repellent chemical for birds, also activates chicken TRPA1, highlighting its functional evolution and diversification among vertebrate species.
Researchers found that long-term PI3K inhibitor treatment reactivates Akt through an unknown ERK1/2 regulatory loop. This limits the effectiveness of anti-PI3K strategies against K-Ras mutant or overexpressed tumor cells. Combining MEK-ERK1/2 and PI3K inhibitors may overcome resistance in these tumors.
The Student DNA Barcoding Project is a flexible curriculum that uses student-generated research to teach about biodiversity, ecology and molecular biology. The project has been successfully used in New York City and Belize, with students exploring topics such as beetles, beehives, and conservation.
The American Society for Cell Biology's Celldance 2013 video contest recognized top videos showcasing cellular processes. The first-place winner received a $500 cash prize for his time-lapse video of muscle cell differentiation, while two second-place winners shared a $250 cash prize each.
Researchers at A*STAR's Institute of Medical Biology and Institute of Molecular and Cellular Biology have identified a gene encoding a hormone called ELABELA, which is crucial for heart formation in zebrafish embryos. The discovery holds great promise for the development of targeted therapies for heart disease and blood pressure control.
The American Institute of Biological Sciences has selected three individuals as winners of its 2013 Faces of Biology: Broader Impacts Photo Contest. The winning photos showcase the broader impacts of biological sciences, including informing natural resources management and addressing climate change.
A team of researchers from The Wistar Institute and the University of Pennsylvania are working on a five-year project to better understand melanoma biology and develop more effective treatments for the disease. They aim to overcome drug resistance by targeting different mutations and combinations of therapies.
Current Plant Biology publishes articles on interdisciplinary plant science research, combining physics, mathematics, and chemistry disciplines. The journal aims to facilitate the growth of quantitative, interdisciplinary plant biology by publishing work openly and sharing research datasets.
The FASEB MARC Program has announced travel award recipients for the 2013 International Society of Computational Biology (ISCB) Rocky annual meeting. The awards promote underrepresented groups in basic science and encourage young scientists to participate.
A recent study published in Molecular Biology and Evolution found that herbivores have a greater number of Tas2r bitter taste receptor genes than omnivores and carnivores. The researchers correlated the Tas2r gene repertoire with dietary compositions, revealing a significant relationship between plant diet fraction and Tas2r gene number.
The Synthetic Biology Project at Woodrow Wilson International Center has been awarded a €4 million EU grant to foster responsible governance of synthetic biology. The project aims to initiate mutual learning among stakeholders from science, industry, and civil society.
A study at Brown University found a connection between protein quality control in muscle tissue and lifespan in fruit flies. Suppressing the activity of activin, a protein complex involved in muscle performance, increased life span by up to 20%. The researchers also discovered a potential link between this protein interplay and human a...
Researchers reveal how neurons regulate PP1 protein through neurotransmitter NMDA, allowing PP1 to promote synaptic remodeling. A regulatory protein called inhibitor-2 also helps promote PP1 activity in neurons.
Two pioneering online biology video sites have merged to create a new platform offering world-class biologist videos for free. The new site features an expanded 'iBioEducation' section with microscopy courses, lecture series, and assessments for educators, reaching over 1.4 million views across 180 countries.
A recent molecular biology study suggests a significant reduction in population sizes of common ancestors of humans and chimpanzees, from 1.2 million to 30,000, coinciding with a great ape ancestral migration event from Eurasia to Africa.
Researchers found that engineered bacteria use time as a cue to form predictable ring patterns, contradicting established theories. This discovery has implications for understanding pattern formation in biology and could lead to the creation of biological scaffolds for new materials with energy applications.
New research published in the Journal of Leukocyte Biology suggests that cocaine makes quiescent CD4 T cells more susceptible to HIV infection. The study found significant infection and new virus production in treated cells compared to untreated ones.
Researchers at Rice University used synthetic biology to study how biochar affects microbial communication. Biochar was found to interfere with certain conversations between microbes, potentially impacting plant growth.
The National Institutes of Health has awarded a $5.9 million grant to the Geisel School of Medicine at Dartmouth for its Lung Biology Center of Biomedical Research Excellence. This funding supports cystic fibrosis research and translates basic science into clinical applications.
The researchers validated 1,799 sites and predicted an additional 1,782 sites, resulting in a combined list of 3,581 accurate sites. The team gained insights into the model organism's fundamental biology, including patterns of editing and alternative splicing.
A study has identified 114 genes on the X chromosome that have escaped silencing, including 76 previously unknown. These genes are often associated with mental impairment and may hold clues to better management of XXX syndrome.
A UA-led international collaboration studies how microbes release greenhouse gases as they access nutrients in thawing permafrost soils. The team aims to explain the relationships between microbial processes and climate change, with potential implications for solving the 'big biology problem' in climate change.
Researchers developed a high-throughput assay to track cell growth at low nutrient concentrations, revealing metabolic differences among cells of the same strain in the same environment. The study also found significant genetic variation in Sherpa populations' mitochondrial genomes, suggesting an adaptation for low oxygen environments.
Researchers developed a new method to control genes by targeting transcription, allowing for positive and negative regulation with the same protein. The technique has the potential to enable complex synthetic biology circuits and applications such as disease detection and drug production.
The American Society for Radiation Oncology (ASTRO) awarded a total of $34,500 to 42 researchers selected for the 2013 Annual Meeting Abstract Awards. The awards recognized outstanding abstracts in seven categories and honored top-rated research in radiation and cancer biology, clinical practice, and radiation physics.
Researchers applied simple math to a long-studied biological process, finding that catabolite repression is controlled by the difference between glucose and other essential nutrients. This discovery demonstrates the power of quantitative biology in elucidating complex biological processes.
Researchers at St. Laurent Institute discovered 'dark matter' in the human genome that functions in cancer biology and cell death. VlincRNAs triggered by ancient viruses may regulate gene expression in cancer cells, making them a potential target for therapy and diagnostics.
Researchers at the University of Chicago have discovered that just 12 water molecules are responsible for the long recovery period of potassium channels. This finding has significant implications for understanding fundamental biology and designing pharmaceuticals.
A study at Columbia University Irving Medical Center identifies key molecular pathways leading to late-onset Alzheimer's disease. The research highlights several new potential drug targets, including SV2A and RFN219, which are involved in the processing and trafficking of amyloid precursor protein.
Researchers at VCU are studying the biology of allergic disease with a $1.8 million NIH grant. They aim to understand how mast cells respond to signals, potentially leading to new therapies for conditions like asthma and rheumatoid arthritis.
University of Illinois bioengineers find way to permanently modify silicone polymer surface with organic material, resulting in stable adhesion for several months. The method enables practical applications in cell culture platforms, microfluidic devices, and tissue engineering.
A newly discovered threadworm, Pristionchus maxplancki, has been named after physicist Max Planck in recognition of his contributions to the fields of evolution, genetics, and ecology. The worm was discovered on a stag beetle in Japan and is now being studied by researchers at the Max Planck Institute for Developmental Biology.