A new study suggests that infusing healthy hematopoietic stem and progenitor cells into mice with sepsis can improve bacterial clearance, reduce tissue damage, and prolong survival. The infusion also boosts immunomodulatory cells, which regulate immune responses and decrease inflammation.
Researchers at Baylor College of Medicine developed a human nose organoid model that replicates the complex interactions between human cells and viruses. The model showed divergent responses to SARS-CoV-2 and RSV infection, providing insights into disease progression and potential new therapies.
Researchers propose using NFT digital contracts to enable patients to specify who can access their personal health information and track sharing. This could help democratize health data and give individuals more control over their health information.
A team of researchers at Baylor College of Medicine has developed a new approach to classify meningiomas into three biologically distinct groups, one of which is reliably malignant. This classification system, which integrates multiple molecular profiling approaches, provides better prognosis and reveals tumors that require more aggres...
A study by Baylor College of Medicine, Yale University and others found altered gene expression and cell interactions in epithelial, endothelial and macrophage cells in COPD. The research provides new insights into cellular injury and inflammation in the disease.
Researchers identified an estrogen-activated neurocircuit that stimulates thermogenesis and physical activity, increasing energy expenditure and preventing obesity. The circuit responds to changes in ambient temperature and nutritional status, and its conservation in males suggests a potential role in weight regulation.
A study by Baylor College of Medicine found that Rev-erbα/β in cardiomyocytes mediates a normal metabolic rhythm, enabling the cells to use lipids as energy during resting time. Removing Rev-erbα/β disrupts this rhythm, leading to progressive dilated cardiomyopathy and lethal heart failure.
Researchers at Baylor College of Medicine have identified MAPK4 as a key player in triple-negative breast cancer growth and resistance to therapies. Eliminating or inhibiting MAPK4 reduces TNBC cell growth and sensitizes cells to PI3K inhibitors.
Scientists at Baylor College of Medicine identified two rare inherited vitamin B12 conditions that share the same gene but exhibit distinct clinical features. The study found that additional genes, including RONIN and HCFC1, are affected, leading to a more complex syndrome.
Researchers have developed a novel strategy to enhance the reprogramming efficiency of human fibroblasts, significantly increasing their ability to become functional heart muscle. This approach uses endothelial cell plasticity to facilitate the desired change, offering new hope for patients with congestive heart failure.
Researchers discovered that Alzheimer's disease risk genes disrupt the brain's natural protective mechanism against neurodegeneration. The study found that reactive oxygen species and amyloid-beta accelerate disease development in animal models.
Researchers found that COVID-19 patients have significantly increased levels of oxidative stress and oxidant damage, as well as markedly reduced levels of glutathione. This study suggests that supplementation with GlyNAC may be beneficial to combat these defects in COVID-19 patients.
Researchers developed a neural network model called STANN that provides new insights into the brain's cellular architecture and functionality. The model predicts precise locations of different cell types and their communication patterns within morphological layers.
Researchers have found that individuals with extremely treatment-resistant schizophrenia carry a higher burden of rare, damaging genetic variants than those with typical schizophrenia. This study suggests that focusing on patients with severe forms of the illness could improve the detection of disease-associated genetic variants.
Recent research reveals that endothelial cells produce all necessary coagulation proteins for thrombin generation, enabling the clotting process to occur on their surfaces. This finding shifts our understanding of blood clot development and treatment strategies.
A recent study published in Cell Reports reveals that SRC-2 is essential for coordinating biological responses to food scarcity, including modifying metabolism and behaviors to ensure survival. Additionally, SRC-2 is also involved in weight gain when food is abundant, leading to obesity.
Researchers have identified a novel mechanism that coordinates the assembly of components inside cells that control gene expression, revealing a widespread role for disordered protein interactions. The findings suggest that disrupting these interactions can lead to impaired gene expression, providing potential new targets for treatment.
Researchers developed a new live cell quantitative analysis of ER dynamics using fluorescence recovery after photobleaching (FRAP) to study the effects of endocrine disrupting chemicals on gene expression. The method enables faster and more accurate testing of larger numbers of compounds, revealing complex dynamics between receptor mob...
Researchers at Baylor College of Medicine identified over 300 genes with altered expression in advanced cancers due to genomic structural variations. The study found associations between tumor genomic rearrangements and altered metabolism-associated gene expression, suggesting potential mechanisms for therapy resistance. These findings...
Researchers uncover intricate cellular response to rotavirus damage in intestinal epithelium, finding tuft cells contribute to repair process through production of immature enterocytes. The study provides new understanding of gut healing mechanisms and potential therapeutic targets.
In a mouse model of Alzheimer's disease, researchers found that restoring normal sleep reduced amyloid-beta plaque accumulation. The thalamic reticular nucleus played a previously unsuspected role in symptoms associated with Alzheimer's, and its restoration could be a potential therapeutic approach.
A genetic signature has been discovered that can identify drivers of poor outcomes in advanced estrogen-receptor positive (ER+) breast cancer. The signature detects the presence of mutations and translocations in the ER gene that confer tumor independence from estrogen, making it resistant to current therapies.
A potential new therapy for urinary tract infections has been discovered using the FDA-approved anti-inflammatory drug dimethyl fumarate, which activates the NRF2 pathway. This balance between eliminating bacteria and minimizing tissue damage is crucial to treating UTIs.
Researchers have developed a new approach to deliver therapeutic nucleic acids using nanoparticles coated with antibodies. This system targets cancer cells while sparing normal cells, showing improved efficacy and reduced toxicity compared to previous methods.
A study by researchers at Baylor College of Medicine reveals that supercoiling and looping in DNA can transmit mechanical stress along the backbone, promoting separation of strands and exposure of DNA bases. This phenomenon, known as 'action at a distance,' suggests a new perspective on how DNA activities are regulated.
Researchers have identified a specific gene, RARA, associated with acute myeloid leukemia (AML) in children that is sensitive to the treatment tamibarotene. Studies found that AML cells with high levels of RARA are more responsive to tamibarotene, suggesting its potential as a new treatment for pediatric AML.
Researchers at Baylor College of Medicine discovered that KLF4 forms droplets in the cell nucleus that recruit other transcription factors to mediate gene expression. This process involves biomolecular condensation, where KLF4 interacts with chromatin regions to form a separate liquid phase.
Researchers at Baylor College of Medicine discovered changes in brain activity triggered by LSD, explaining altered behaviors such as reduced running speed and increased resting time. The study suggests that LSD disrupts the normal communication between brain regions, leading to a 'fuzzy' map of the environment.
Researchers at Baylor College of Medicine have developed a novel technology that enables scientists to track genetic manipulations in fruit flies more efficiently. The system uses drug-based markers for selection or counter-selection of genes, reducing the need for manual screening and increasing productivity by at least 10 times.
A study by Baylor College of Medicine researchers discovered that platelets help mediate an allergic immune response against yeast, clearing it from the lungs. This mechanism involves candidalysin, a peptide toxin that triggers Th2 and Th17 responses, providing essential protection against yeast invasion.
Researchers at Baylor College of Medicine developed a new drug discovery technology to screen billions of compounds for potential treatments against viruses. They identified an inhibitor of the viral protein Mpro, which is needed for virus propagation, and demonstrated its potential in preventing SARS-CoV-2 replication.
A pilot study found that a single injection of leukocyte-rich platelet-rich plasma (PRP) significantly improved functional mobility, pain, and quality of life in patients with knee osteoarthritis. The study supports the use of this combined approach to evaluate emerging biological therapies for musculoskeletal disorders.
A genetic analysis of humans and rhesus macaques identified the NPSR1 gene as a risk factor for endometriosis. The study found that rare variants in this gene are associated with stage III/IV disease, leading to potential nonhormonal treatment targets for improved therapy.
Researchers found no negative impact on families during the infant's first year of life after genome sequencing, even if genetic risk or carrier status were revealed. The study showed lower self- and partner-blame in families with sequencing information, suggesting it provided some degree of peace of mind.
A pilot study at Baylor College of Medicine found that genetic testing led to clinically significant findings in approximately one-third of patients. The results showed a high rate of genetically actionable issues, with implications on patient care and clinical management.
Researchers at Baylor College of Medicine developed a machine learning algorithm that analyzes DNA methylation patterns in blood samples to identify individuals with schizophrenia. The study achieved an 80% accuracy rate and identified epigenetic markers that differ between people diagnosed with the condition and those without it.
Researchers discovered elevated cryptic transcription in aging mammalian stem cells, which is thought to contribute to the aging process. The study found that strategies controlling cryptic transcription may have pro-longevity effects.
Restoring the molecular clock by reactivating key components BMAL1 and RORa suppressed neuroblastoma tumor growth in laboratory tests. The strategy also sensitized tumors to chemotherapy, providing a potential future treatment option.
Researchers at Baylor College of Medicine discovered two distinct brain circuits that regulate hunger-driven and non-hunger driven feeding behaviors. The study identified serotonin receptors and ion channels as potential molecular targets to suppress overeating and improve treatment options for obesity.
A new study finds that autodegredation, a process where mature cells break down specialized structures, enables regeneration in adult tissues. Genes Atf3 and Rab7b are upregulated during this process, allowing cells to return to the cell cycle and potentially contributing to cancer development.
Researchers developed novel imaging approach to visualize eggs and embryos in live animals, revealing complex dynamics of egg and embryo transport. The findings have important implications for studies of fertilization, embryogenesis, and in vitro fertilization.
A novel screening method using untargeted metabolomics profiling can improve the diagnostic rate for inborn errors of metabolism in newborns, identifying many more disorders than traditional methods. This approach offers a faster, more efficient, and less expensive diagnostic journey for individuals with rare metabolic disorders.
Researchers at Baylor College of Medicine found that a modular network organization is critical for persistent neural activity in the brain. The study revealed that each hemisphere makes its own copy of information and coordinates with the other hemisphere to ensure coherent information during working memory.
Researchers have engineered a new genetic circuit called Equalizers to buffer protein output from variations in gene dosage. This allows for consistent protein expression, crucial for studying proteins and understanding their functions. The innovation combines two types of gene dosage compensation circuits, improving overall performanc...
Researchers at Baylor College of Medicine have developed a novel gene therapy that shows promise in treating human heart failure. The treatment targets the Hippo signaling pathway, which can inhibit heart repair, and has been shown to improve heart function and promote tissue renewal in pig models after a heart attack.
Researchers identified T cells that are paralyzed and ineffective in preventing LCH lesion formation, instead being tricked into entering an exhausted state. A new therapeutic option combining immunotherapy targeting PD-1 receptors with MAPK inhibition demonstrates promising results.
Researchers discovered a brain mechanism that regulates whole-body glucose balance without altering body weight, indicating a promising therapeutic target for type 2 diabetes. By modulating this mechanism, it may be possible to regulate blood sugar levels in obese individuals with diabetes without requiring weight loss.
Researchers compared hg19 and hg38 reference genomes using exome sequencing data from over 1,500 participants. They identified 206 genes with discordant variants, including those associated with Mendelian diseases and common disease phenotypes.
Researchers at Baylor College of Medicine discover a protein signaling mechanism driving joint and tendon dysfunction in OI, finding that inhibiting this pathway can prevent tendinopathy problems. The study used mouse models with deleted Fkpb10 gene, leading to contracture, joint inflammation, and cartilage piece formation.
A team of biologists has developed a new classification system for cell nuclei, revealing how species can switch between different nuclear types. The researchers discovered that mutations in a protein called condensin II can convert human cells into fly-like nuclei, and created a computer program to simulate the effects.