Researchers discovered that different types of brain tumors and brain cancer cells share common energy production processes, enabling them to adapt and grow in the brain. This study aims to identify new targets for treatment and potentially develop drugs specifically designed to target these survival mechanisms.
A new study found that women with disabilities are less likely to participate in breast and bowel cancer screenings due to practical barriers. Women with multiple disabilities or those without access to a car were particularly affected.
A new imaging technique has been developed to uncover oxygen levels in prostate tumours, potentially leading to a non-invasive way to determine which tumours are more difficult to treat. The technique uses light and sound to image the strength of blood vessels in tumours, helping doctors identify patients with harder-to-treat cancers.
Research funded by Cancer Research UK identified NOX4 as a common mechanism responsible for cancer-associated fibroblasts (CAFs) formation in tumours. Targeting this enzyme could lead to new treatments and improve existing therapies.
A new trial has shown that targeted radiotherapy can limit the side effects of breast cancer treatment without compromising its effectiveness. The study found that women who received partial-breast radiotherapy reported fewer long-term changes to their breast appearance and feel, compared to those who underwent whole-breast radiotherapy.
A simple test for bladder cancer has been developed that can predict its return in over 80% of patients, identifying the faulty protein TERT. This new method detects bladder cancers earlier than existing tests and distinguishes them from urinary tract infections, potentially helping doctors start treatment sooner.
Scientists have discovered a new type of immune cell that can predict which lung cancer patients will benefit from immunotherapy treatment. The study found that patients with high levels of tissue-resident memory T-cells in their tumour were more likely to survive, and the cells' behaviour played a key role in increasing survival rates.
Researchers found that capecitabine results in fewer side effects and improved quality of life, while being as effective as CMF in preventing breast cancer recurrence. Over 85% of patients did not experience their cancer returning for at least five years.
The STAMPEDE trial found that adding abiraterone to standard hormone therapy improves prostate cancer survival in men with high-risk disease. The drug reduced disease progression by 70% and severe bone complications by more than half, leading to a 40% increase in overall survival.
Research published in the British Journal of Cancer found that carrying excess body fat can increase cancer risk, with waistline and hip measurements being key indicators. The study combined data from over 43,000 participants and found that adding just 11cm to the waistline increased obesity-related cancer risk by 13%.
Researchers aim to use Zika virus to target glioblastoma, the most common and aggressive form of brain tumour. The virus can cross the blood-brain barrier, sparing healthy tissue and opening a potential new way to attack the disease.
A recent trial funded by Cancer Research UK found that patients who take capecitabine after surgery for bile duct cancer live for almost a year and a half longer than those not given the drug. Three-year survival improved by almost a quarter in these patients.
Research predicts achieving a 'tobacco-free' UK by 2035 will save the NHS £67m in direct costs and £548m in economic costs. The study forecasts nearly 100,000 new cases of smoking-related disease will be avoided, including 35,900 cancers over 20 years.
Researchers tracked lung tumour evolution in real-time to discover unstable chromosomes drive genetic diversity, increasing relapse risk. Circulating tumour DNA analysis reveals potential for personalised treatments to target resistant tumours.
Researchers found that removing serine and glycine from the diet of mice slowed lymphoma and intestinal cancer development. The special diet also made some cancer cells more susceptible to reactive oxygen species, which could boost conventional treatments' effectiveness. Next steps include clinical trials with cancer patients.
Scientists are developing novel molecules to target RAS, a common driving mutation in pancreatic and lung cancer. The collaboration aims to create gold standard tests for analyzing these inhibitors.
A network of clinical trials aims to find the right treatment for the right patient, using individual molecular profiles. The project will recruit 658 patients across the UK, with a focus on matching patients with suitable clinical trials already in progress.
A new study funded by Cancer Research UK finds that smokers treated for breast cancer have significantly higher risks of developing lung cancer or heart attacks due to radiotherapy. The long-term risk of death from these conditions is around 5% for smokers, compared to 0.5% for non-smokers.
A one-off bowel screening test can prevent more than half of potential bowel cancers from developing and reduce deaths by two-thirds. The test is effective in reducing cancer deaths for at least 17 years, according to a study published in The Lancet.
A recent study found that people who gained weight over their lifetime were more likely to develop esophageal and stomach cancers. The researchers analyzed data from over 400,000 people and discovered that those who became obese after a healthy weight had nearly tripled the risk of developing these cancers.
A recent study has found that e-cigarette users have significantly lower levels of toxic chemicals and carcinogens in their body compared to smokers. The study also suggests that quitting smoking altogether is the best way to minimize exposure to toxins, rather than using e-cigarettes alongside traditional cigarettes.
Scientists have created a 'map' linking cell shape to genes turned on and off, matching it to real disease outcomes. The map revealed key areas controlling gene activity, including a protein called NF-kappaB that drives cancer cell growth and spread.
A new standard of care for pancreatic cancer patients has been established with a combination chemotherapy treatment, doubling five-year survival rates. The treatment, combining gemcitabine and capecitabine, was found to be effective in increasing patient survival by 29% compared to single-drug therapy.
Researchers found that successful quitters had a considerable improvement in their depression and 66.3% described no or minimal symptoms during a one-year follow-up. Stop smoking services can be effective in supporting people with depression, particularly with increased visits.
Two studies reveal that cancer cells can tolerate genetic mutations by inactivating the BCL9L gene and slowing down division to avoid mistakes, allowing them to thrive and evolve. This understanding may lead to new ways to target cancer cells and improve treatment efficacy.
Researchers developed a blood test to predict ovarian cancer patients' response to chemotherapy using tumour DNA levels. The test identified patients whose tumour DNA count dropped by more than half after one cycle of chemotherapy as those likely to respond well to treatment.
Women taking tamoxifen for breast cancer prevention experienced nausea and vomiting, which led them to discontinue the medication. A new analysis suggests that these symptoms were sometimes mistaken for tamoxifen side effects, highlighting the importance of accurate information on preventive therapies.
Cancer Research UK is investing £226 million in cancer research over five years, focusing on translational research and supporting clinical trials. The investment aims to bring better treatments faster to cancer patients, with a particular focus on hard-to-treat cancers.
Researchers have developed a blood test that can predict how well small-cell lung cancer (SCLC) patients will respond to chemotherapy. The test analyzes patterns of genetic faults in circulating tumour cells, providing insight into treatment response and drug resistance mechanisms.
New report predicts 7,100 cancer deaths annually by 2035 linked to alcohol, with oesophageal cancer seeing largest increase. The NHS will face a £2 billion treatment bill, while over 1.2 million hospital admissions are forecasted.
Sixty-nine percent of local authorities in England have reduced funding for stop-smoking services due to budget cuts. These services are crucial for smokers' successful cessation, with specialists three times more likely to help them quit.
The project aims to improve diagnosis and tailor treatment by analyzing the genome and expressed genes of tumour cells from 250 breast cancer patients. This personalized approach will help doctors choose the best treatment for individual patients, potentially increasing survival rates and reducing side effects.
A new 'sponge on a string' pill test has been shown to accurately identify people with Barrett's oesophagus who are at low risk of developing oesophageal cancer. This non-invasive test may replace uncomfortable endoscopies for some patients, allowing them to be monitored instead.
Researchers at Queen's University Belfast have identified a way to bypass bowel cancer's defence against the drug cetuximab by blocking the ADAM17 protein. This breakthrough could lead to a new combination therapy that delays or prevents cancer recurrence, improving patient outcomes.
Researchers have discovered that the NAALADL2 molecule, which indicates more aggressive prostate cancer, can also be used to guide treatments. This new marker has the potential to distinguish between slow-growing and fast-growing prostate cancers.
Researchers use gold nanoparticles with radioactive tracers to target cancer cells' telomeres, shutting down telomerase and halting growth. The method holds promise for delivering a lethal payload to cancer cells, improving treatment outcomes.
A new study found that around 17% of women diagnosed with breast cancer visit their doctor with a symptom other than a lump. Non-lump symptoms, such as nipple abnormalities and breast pain, were more likely to delay diagnosis compared to those with a breast lump alone.
A group of circulating tumour cells has been found to be linked to the spread of prostate cancer. The cells' ability to migrate and invade through the body makes them a promising marker for predicting cancer spread. This discovery could potentially be used to monitor patients and make informed treatment decisions.
A study of over 2,000 people in the UK found that two thirds worry about emotional impact and cancer treatments, while ethnic minorities are more likely to worry about social consequences.
Research suggests that adapting people's gut bacteria through antibiotics, probiotics, or faecal transplants may increase the benefits of new immunotherapy drugs for treating cancer. Patients with advanced melanoma who had greater diversity in their gut bacteria were more likely to respond to immunotherapy treatment.
Researchers found that substantial weight gain increases the risk of obesity-related cancers, particularly for men who go from a healthy weight to morbid obesity. The study suggests that identifying people at high risk of developing cancer due to weight gain could help prevent cases and improve public health.
New research found that seizures and tumor location are key predictors of survival for patients over 70 with brain tumors. The study also revealed that those with higher pressure on the brain tend to have shorter survival times.
A team of international scientists has outlined 14 recommendations to improve the adoption of new cancer scans in clinics. The guidelines aim to address challenges such as variability in methodologies and lack of reproducibility across laboratories.
A study published in the British Journal of Cancer predicts that more than 352,000 people will be diagnosed with cancer each year in the UK by 2035, a rise of 150,000 cases annually. The projected increase is largely attributed to an ageing and growing population, as well as lifestyle factors such as obesity and smoking.
Forty percent of people in Great Britain express concerns about talking through symptoms with GP receptionists, hindering GP visits. Women and those from lower socio-economic backgrounds are more likely to report these barriers. Cancer Research UK emphasizes the need for better training of front desk staff and addressing the GP shortag...
A large study of over 1.4 million women found no increased risk of breast cancer associated with night shift work, including long-term shifts. The research combined data from multiple studies and provided new insights into the topic.
Researchers at Cancer Research UK Cambridge Institute developed an endoscope using near-infrared light to spot early warning signs of oesophageal cancer. The new technique could be used to monitor people with Barrett's oesophagus and prevent some cases of oesophageal cancer.
Researchers have identified three distinct subtypes of esophageal cancer based on genetic signatures, paving the way for tailored treatments. The study suggests patients with specific weaknesses in their DNA repair pathways or immune systems may benefit from targeted therapies, including PARP inhibitors and immunotherapy drugs.
A Cancer Research UK-funded clinical trial found that whole brain radiotherapy makes little difference in survival and quality of life for lung cancer patients with brain metastases. Patients who received radiotherapy lived five days longer but experienced only small improvements in quality of life.
Researchers identified a critical role for stem cells in cancer formation and found that specific organs are more susceptible due to high wear and tear. The study suggests behaviors like smoking or UV exposure increase the risk of developing cancer.