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Chinese Academy of Sciences Headquarters


Genes contribute to biological motion perception and its covariation with autistic traits

A study has linked individual variation in biological motion perception to genetic factors, revealing a common genetic basis for heritable aspects of BM perception and autistic traits. Genetic influences account for up to 50% of individual variation in local kinematics processing, while environmental factors shape global configuration ...

SourceChinese Academy of Sciences Headquarters·JournalProceedings of the National Academy of Sciences·DateJan 22, 2018

Glucagon receptor structure offers new opportunities for type 2 diabetes drug discovery

Scientists at SIMM have determined the crystal structure of the human glucagon receptor in complex with a glucagon analogue, providing insights into its activation mechanism. The study reveals significant conformational changes in the linker region and extracellular loop that facilitate peptide binding and initiate receptor activation.

Epigenetic signaling axis regulates proliferation and self-renewal of neural stem/progenitor cells

Researchers discovered a novel epigenetic signaling axis involving PRC1, microRNA, and PRC2 that regulates the self-renewal and proliferation of neural stem/progenitor cells. The study found that Ezh2 represses miR-203 expression, which negatively regulates self-renewal and proliferation but promotes neuronal differentiation.

SourceChinese Academy of Sciences Headquarters·JournalStem Cell Reports·DateJun 12, 2017

Large scale antibiotic resistant genes found in estuarine wetland due to human activity

A large-scale study detected high levels of antibiotic resistance genes in estuaries along China's coastline, with some samples containing up to 100 million genes per gram of sediment. The study suggests that human activity, particularly inadequate wastewater treatment, is the primary cause of this environmental pollution.

SourceChinese Academy of Sciences Headquarters·JournalNature Microbiology·DateFeb 9, 2017

CAS scientists discover BCAS2 involved in alternative mRNA splicing in spermatogonia and the transit to meiosis

Researchers from Chinese Academy of Sciences found that BCAS2 plays a crucial role in alternative mRNA splicing during mouse spermatogenesis, leading to impaired meiosis initiation. The study provides evidence for the importance of alternative splicing machinery in regulating germ cell development.

SourceChinese Academy of Sciences Headquarters·JournalNature Communications·DateJan 27, 2017