Scientists at King's College London have found positive evidence that a natural tooth repair method has the potential to be translated into a clinical approach. The study discovered that reparative dentine produced is sufficient to repair cavities in human teeth, and the drug can activate repair up to ten times larger.
Researchers found that premature babies can catch up with their immune systems after birth, equivalent to those born at term. The study suggests that preterm and term infants converge in a similar time frame for immune development, and that early identification of infection risk can lead to improved outcomes.
A large observational study found that patients on Community Treatment Orders spent more time in psychiatric hospitals and had a higher rate of readmissions compared to those without CTOs. The study suggests that CTOs may have the opposite effect, contrary to previous uncontrolled studies.
Researchers from King's College London develop a digital twin of the heart using computer models to improve diagnosis and prediction of future heart health. The Digital Twin can also inform daily lifestyle choices and provide early warnings for potential risks.
Researchers compared oxytocin administration methods to improve treatment for social difficulties. The study found that nasal delivery using a nebuliser reached specific brain areas more effectively than standard nasal spray or intravenous injection.
Over 100 medical and scientific organisations pledge to end weight stigma, citing evidence that stigma causes physical and psychological harm. The group calls for policies to prevent weight-based discrimination in healthcare, education, and the workplace.
Researchers have developed an improved mobile phone app, QUiPP v2, to determine the risk of preterm birth in women. The app helps doctors identify women at high risk and offer timely interventions to prevent complications and improve survival rates for newborns.
The Eating Disorders Genetics Initiative (EDGI) will help researchers better understand eating disorders and enable the design of new treatments. Up to 5% of the population will experience an eating disorder, with genetic factors involved in some cases.
Researchers identified a genetic mutation affecting cellular oxygen sensing and a patient's limited exercise capacity. The von Hippel-Lindau gene is fundamental for cells to survive in low-oxygen conditions, and its impaired functionality limits the patient's exercise capacity compared to those without the mutation.
A recent study analyzed the antimicrobial resistance genes in the mouth and gut microbiome, finding distinct resistome profiles with varying levels of diversity. The researchers' findings suggest that expanding human resistome studies to other body areas is crucial for understanding the spread of antibiotic resistance.
The study found that CBD influenced the prefrontal and mediotemporal brain areas, which have unusual activity in people with psychosis. After one dose of CBD, functional connectivity between these areas was reduced, indicating improved brain function.
Researchers developed a predictive tool to identify adolescents at high risk of depression in young adulthood using data from Brazilian adolescents. The tool demonstrated strong performance in Brazil but weaker results in UK and New Zealand samples due to differences in diagnostic measures, highlighting the need for local adaptation.
Researchers found that Romanian adoptees who experienced institutional deprivation as children had smaller brains (8.6% smaller) compared to English adoptees. The study also showed a correlation between deprivation and lower IQ and ADHD symptoms, suggesting brain changes may play a mediating role.
Research found that introducing peanut and egg early to infants can reduce the risk of developing a food allergy. Despite low adherence to an introduction regime, the study showed that early introduction was effective in preventing food allergies in specific groups of infants.
Researchers from King's College London have found that fine particles (PM2.5) on the London Underground are significantly higher than in other modes of transport, posing a health risk to commuters. The study suggests that certain stations, such as Oxford Circus and London Bridge, require interventions to reduce exposure.
Researchers found that children with the lowest blood levels of EPA showed significant improvements in focused attention and vigilance after taking omega-3 supplements. However, for children with high pre-existing blood levels of EPA, omega-3 supplements had negative effects on impulsivity symptoms.
A systematic review by King's College London found evidence that chewing sugar-free gum can reduce the advancement of dental caries and could be used as a preventative agent. The review identified 12 studies exploring the impact of chewing sugar-free gum on oral health, with a preventative factor of 28%.
Researchers successfully applied phage therapy to mice with alcohol-related liver disease, eradicating the disease by targeting destructive gut bacteria. Nearly 90% of patients with cytolysin-positive alcoholic hepatitis died within 180 days, but phage therapy showed promise in treating the condition.
Researchers at King's College London have found that immunotherapy for peanut allergy reduces sensitivity to peanuts, providing some protection against accidental reactions. However, the treatment does not cure allergies and can actually increase allergic reactions in some patients, highlighting the need for continued research.
A study from King's College London found that sugary soft drinks are associated with both obesity and tooth wear among adults. The acidic nature of these drinks leads to tooth erosion, particularly in obese patients. This highlights the importance of monitoring calorie intake through acidic sugar-sweetened drinks.
New research from King's College London and The Open University discovered that old age affects memory modification by altering synaptic connections. This 'fixed' nature of memories formed in old age has implications for conditions like PTSD.
A new medical device called Sleeveballoon has been tested in rodents and produced impressive results on body weight, fatty liver, and diabetes control. The device reduces food intake by 60% and blood glucose levels by 65%, mimicking the effects of traditional bariatric surgery with a minimally invasive approach.
Researchers found evidence of impaired white matter tract development in premature babies whose mothers experienced more prenatal stress. The study highlights the importance of supporting expectant mothers and providing interventions to mitigate adverse outcomes.
A new study from King's College London found that a low FODMAP diet improved certain gut symptoms such as swelling of the stomach and flatulence in patients with IBD. The diet reduced gut inflammation and improved health-related quality of life, with 52% of patients reporting adequate relief of gut symptoms.
Researchers at King's College London have discovered that β-Galactoside-Binding Protein (βGBP) can selectively target and kill cancer cells while stimulating the immune system to provide long-term protection against cancer recurrence. The study presents a promising new strategy for treating aggressive forms of cancer.
Researchers from King's College London and UCL have identified 44 genes linked to age-related hearing loss, offering a clearer understanding of the condition's development. The study's findings may lead to new therapies for millions worldwide affected by hearing loss as they age.
Research published in Circulation found a strong link between pregnancy hypertension and an increased risk of cardiovascular disorders, including stroke and heart failure. Women with preeclampsia or other types of pregnancy hypertension are more likely to develop these conditions later in life.
A new study from King's College London found that depression and binge-drinking are more prevalent among female military partners than comparable women outside the military community. The research suggests that military partners may use binge-drinking as a coping mechanism for the stress and separation caused by deployment.
Research found that only 35% of eligible women took part in all three screening programmes, with 10% remaining unscreened. Women from areas of less deprivation and those with caring duties were more likely to take up screenings, while practices with higher proportions of unemployed patients and smokers had lower rates.
Researchers at King's College London found that early planned delivery for women with preterm pre-eclampsia reduces maternal complications and severe hypertension. The study also showed lower costs compared to the current method of care in the UK.
A study from King's College London found that moderate red wine consumption is associated with greater diversity in the gut microbiome, leading to improved gut health. This resulted in lower levels of 'bad' cholesterol and obesity.
Researchers have discovered a common origin shared by teeth and taste buds in fish with regenerative abilities. This finding holds potential for bioengineering and dental therapeutics as it suggests that oral organs can be manipulated to express characteristics of different tissue types.
A recent study published in Pigment Cell & Melanoma Research has found that genetic factors significantly influence not only the number of moles but also their location on the body. In women, the largest genetic impact is seen on the lower limbs, with a higher concentration of moles in this area compared to men.
A new study has found that ursodeoxycholic acid, the current recommended treatment for intrahepatic cholestasis of pregnancy, is ineffective in preventing preterm birth and stillbirth. The trial of 605 pregnant women with ICP found no meaningful improvement in outcomes with the drug.
Researchers at King's College London have identified a new type of cell called hepatobiliary hybrid progenitor (HHyP) that can regenerate liver tissue. HHyPs exhibit stem cell-like properties and may be able to repair liver damage, potentially bypassing the need for transplants.
A global genome-wide association study identified eight genetic variants linked to anorexia nervosa, revealing a complex interplay between metabolic and psychiatric factors. The research suggests that integrating metabolic information may help clinicians develop better treatment approaches for this potentially lethal illness.
Researchers at King's College London have identified the earliest signs of Parkinson's disease in the brain, many years before symptoms appear. The study found changes to the serotonin system as a key early warning signal for the disease.
Children with severe eczema infected with Staphylococcus aureus are at a higher risk of developing peanut, egg, and milk allergies. The bacteria may reduce the chance of young infants gaining tolerance to peanut despite early consumption.
A study suggests that Leonardo da Vinci, the iconic artist, might have had ADHD due to his chronic procrastination and difficulty completing projects. His exceptional creativity and achievements across art and science could be linked to this condition.
The number of people dying with serious health-related suffering is set to increase globally, with a 87% rise expected by 2060. Palliative care need will be most pronounced in low- and middle-income countries, with the fastest growth among older adults.
A new study from King's College London found a way to generate protective CD8 T-cells using skin vaccination, which could be used as a vaccine strategy for STIs. The researchers developed a dissolvable 'microneedle' patch that releases the vaccine, attracting immune cells to the genital tissues.
Teacher assessments were found to correlate strongly with exam scores, predicting around 90% of differences between pupils in exam performance at GCSE and A-level. The study suggests that relying on teacher assessments could be a more effective way to monitor progress and reduce the impact of high-stakes exams.
Researchers at King's College London developed a new technique using ion chromatography and mass spectrometry to detect and trace homemade explosives. This approach enables the detection of thousands of compounds simultaneously, providing valuable information for criminal investigations.
Researchers at King's College London have made a groundbreaking discovery that genetic therapy can heal heart damage caused by a heart attack. The study used microRNA-199 to stimulate cardiac regeneration in pigs, resulting in almost complete recovery of cardiac function.
A new study has found cocaine, pharmaceuticals and pesticides in UK river wildlife, highlighting the presence of 'invisible' chemical pollution that poses a risk to wildlife health. The study detected illicit drugs and banned pesticides in freshwater shrimp, revealing a surprising occurrence in smaller rural catchments.
Researchers have discovered a new way to measure brain function in milliseconds using MRE, allowing scientists to visualize responses in the brain as they unfold. This breakthrough could help diagnose and understand neurological diseases like Alzheimer's, dementia, and epilepsy.
Researchers found that using psychological techniques to communicate periodontal disease risk improved dental hygiene and reduced gum inflammation over a three month period. The study also associated the intervention with improved frequency of interdental cleaning.
A new blood test has been shown to diagnose pre-eclampsia on average two days sooner than current methods, reducing serious complications by 20%. The test measures placental growth factor (PlGF) in a woman's blood, enabling clinicians to provide timely and targeted care.
Patients often downplay minor symptoms, fearing a waste of doctor's time, and may struggle to revisit their GP after reassurance, highlighting the need for increased awareness and timely investigation.
A joint study by King's College London and Airparif found that air pollution in both cities has improved since 2010, but not enough to meet legal limits. Newer diesel cars and buses have led to declines in particle pollution, while nitrogen dioxide levels from traffic in London have deteriorated.