Researchers at NYU Langone Health have identified a molecular signal that controls skin and hair color, which could lead to therapies targeting vitiligo and gray hair. The study found that stimulating this pathway increases melanocyte stem cell pigment production and corrects discoloration around scars.
A clinical trial shows that high-dose methotrexate improves survival rates for children with high-risk acute lymphoblastic leukemia. The use of steroid decadron is beneficial for younger patients, but not older ones, who are at a higher risk of osteonecrosis.
Researchers found that orchestrated cell death mechanisms in pancreatic cancer can induce the growth of tumor cells by suppressing the immune system. Inhibiting these pathways may reverse immunosuppressive environments and enable T lymphocytes to attack tumors.
Researchers will test a nanoghost technology to deliver microRNAs targeting metastatic melanoma, while investigating heparanase for mesothelioma diagnosis and treatment. The partnership aims to advance global collaboration in cancer research and therapeutics.
A new study has found a direct link between pancreatic cancer and certain mouth bacteria, specifically Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans. Men and women with these bacteria in their oral microbiome were at least 50% and 59% more likely to develop pancreatic cancer, respectively.
A new study reveals that women with epilepsy have a comparable likelihood of achieving pregnancy and similar time taken to get pregnant as healthy women. The study, which followed over 200 women with epilepsy and healthy controls, found no significant differences in pregnancy outcomes or fertility rates.
A new study found that at-home cognitive remediation training using a computer program can significantly improve cognitive test scores in people with multiple sclerosis. Participants who used the program for 12 weeks showed a 29% improvement, compared to a 15% improvement in the placebo group.
A new study finds that early treatment for post-traumatic stress disorder (PTSD) significantly reduces symptoms, but does not prevent long-term suffering. The research suggests that prolonged exposure and cognitive therapy can shorten the recovery time, but may not reduce PTSD prevalence.
The study found that women have a significantly higher prevalence of peripheral artery disease, while men have a higher prevalence of carotid artery stenosis and abdominal aortic aneurysms. Diabetes is also identified as a major risk factor for developing PVD, even in patients without heart disease.
A randomized controlled clinical trial found that extended-release naltrexone significantly prevented relapses in men with previous criminal justice system involvement. The study showed a significant reduction in heroin and opioid use, as well as no overdoses during the six-month treatment period.
A new study by NYU Langone Health reveals that air pollution in the US is responsible for approximately 3% of premature births, with a total economic cost of $4.33 billion annually. The majority of these births occur in urban counties, primarily in Southern California and the Eastern U.S.
A study in mice reveals a specific brain region, the ventrolateral part of the ventromedial hypothalamus, is responsible for aggressive motivations that lead to violence. The research suggests targeting this region could lead to better control of aggressive behaviors without sedation.
A three-year pilot program at NYU Langone Medical Center reported reductions in patient length-of-stay and readmission rates among Medicare patients undergoing total joint replacements. The bundled payment initiative resulted in lower overall costs while improving quality of care and patient outcomes.
Researchers at NYU Langone Health successfully performed ultra-low dose CT scans to diagnose joint fractures with 14 times less radiation, achieving 98% sensitivity and comparable image quality. The protocol, called REDUCTION, has significant implications for public health and safety.
Researchers have developed a cooling technique that protects the brain's speech centers during surgery and identifies specific areas responsible for word formation and speech timing. The study used focal cooling to map brain functions, including speech ability, and found distinct roles for specific brain regions in forming words.
Researchers at NYU Langone Health found that non-native English speakers performed slower on sideline vision tests and had higher saccade rates compared to native English speakers. The study suggests that clinicians and trainers need to consider language when interpreting test results, which may impact concussion detection.
A new study suggests that fetal alcohol exposure leads to long-lasting slow-wave sleep fragmentation, which is associated with learning problems and impaired cognitive function. The researchers found that mice exposed to binge amounts of ethanol displayed severe sleep fragmentation, memory impairment, and hyperactivity.
A study in mice reveals that changes in the lateral septum, a brain structure tied to anxiety and fear control, trigger 'septal rage' - sudden, violent outbursts. The research may lead to better understanding of aggression in other animals, including humans.
Researchers reconstructed 3D images of intercalated discs, protein structures that connect heart muscle cells, and found clusters of proteins that work together to pass on electrical signals and pumping force. The discovery may lead to a simple blood test to detect life-threatening arrhythmias.
Researchers discovered an inherited genetic marker associated with less favorable melanoma survival, while another variant showed a stronger correlation with better survival. These findings could lead to the development of personalized treatment plans for high-risk patients.
The study, which analyzed over one million students in 1,227 elementary and middle schools across the city, found that students at schools with water jets experienced a reduction in standardized body mass index (zBMI) and the likelihood of being overweight. Easy access to water led kids to substitute it for caloric beverages.
A new study found that a blood test monitoring dead cancer cell DNA is superior at tracking the severity and potential spread of metastatic melanoma. This non-invasive test detected cancer recurrence in 85% of patients, compared to 54% with the current standard test.
A new open-label trial of prescription cannabidiol (CBD) shows significant reduction in seizure frequency and well-tolerated for most children and young adults. The study also found a sufficient safety profile with minimal adverse events, but more research is needed to definitively recommend CBD as a treatment.
Recent studies conclude that people with epilepsy have a 27-fold greater risk of sudden death than those without the disorder. Improved cause-of-death reporting and public education could prevent thousands of deaths annually.
A new study found that experimental drugs changing energy supply in cells can halt tumor growth and extend survival in mice with cancers linked to IDH1 gene mutations. The research team discovered that cancer cells with low levels of a critical metabolic chemical, NAD, are more susceptible to these drugs.
NYU Langone will launch the NYU Caregiver Integrated Support and Services Access Program (CISSAP) to offer counseling, support, and services to New York City caregivers. The program aims to improve quality of life and reduce caregiver burden for those caring for individuals with Alzheimer's disease.
A new study from NYU Langone found that reducing post-surgery care referrals to facilities did not increase readmission rates, while improving patient recovery and reducing costs. The hospital implemented a program to discharge more patients home for recovery, with significant drops in facility referrals.
The NYU Langone team performed a groundbreaking face transplant on volunteer firefighter Patrick Hardison, restoring his sight and enabling him to perform daily tasks independently. The surgery involved the transplantation of the entire scalp, eyelids, and muscles, marking significant milestones in the field.
A new study ranks drugs based on their transparency and ethical practices, finding that nearly half of all reviewed drugs had undisclosed Phase II or III trials. The 'Good Pharma Scorecard' aims to incentivize pharmaceutical companies to improve disclosure, benefiting consumers and protecting human research subjects.
Researchers at NYU Langone Health found that bariatric surgery significantly reduced psoriasis and psoriatic arthritis symptoms in patients who lost excess weight. The study suggests that obesity contributes to the development of these conditions through systemic inflammation.
A national survey of 1,604 adult smartphone users found that 58% had downloaded a health-related mobile application, with 65% reporting improved health. However, concerns about cost, disinterest, and privacy barriers hinder wider adoption. More research is needed to maximize the impact of health apps on overall health.
A study of 7,699 fast food diners in NYC and NJ found that calorie labels don't reduce overall calories consumed. While some consumers notice and respond to calorie counts, awareness decreases over time, suggesting a need for multi-faceted approaches to address obesity.
Researchers found that patients were left on ineffective antibiotics for too long before receiving potent therapy, such as isotretinoin. The study highlights the dangers of antibiotic resistance and the need for early switching to more effective treatments.
Researchers found that insulin stimulates the release of dopamine in the brain, leading to a feeling of pleasure. The study also suggests that people may choose high-carb or low-fat meals based on their insulin levels, potentially affecting weight and type II diabetes.
A novel method has been developed to examine protein structure and function at the cell level using formalin-fixed paraffin-embedded (FFPE) tissue. This allows for precise study of protein changes in Alzheimer's disease, a neurodegenerative condition.
A study published in Nature found that the thalamic reticular nucleus (TRN) plays a crucial role in multitasking by filtering out distracting sensory information. The TRN acts like a switchboard, continuously filtering sensory input and shifting attention to one sense while blocking out others.
Researchers warn that the growing popularity of e-cigarettes and alternative tobacco products among young adults poses a significant public health risk. Studies have shown that use of these products can lead to a 2.5 times increase in later cigarette use, with nicotine being the most addictive substance.
Researchers at NYU Langone Health found that GANT61 increases myelin production by 50% and recruits neural stem cells to repair damaged areas of the brain. The treatment also improves symptoms in mice with multiple sclerosis, including paralysis and leg weakness.
A new comparative effectiveness research study found that African Americans with high blood pressure have poorer cardiovascular outcomes when treated with ACE inhibitors compared to white patients. The study analyzed data from nearly 60,000 patients and found a significant racial disparity in the effectiveness of these drugs.
A large US study confirms that tiny chemical particles in the air are linked to an increased risk of death from all causes and cardiovascular disease. Fine particles can be absorbed deep into the lungs and bloodstream, contributing to potentially fatal heart and lung diseases.
A vision test that involves rapidly reading numbers can detect concussions in 86% of athletes. The King-Devick test was effective when combined with balance and cognition assessments.
A new study by NYU Langone Health has found that the presence or absence of dueling toxins in Staphylococcus aureus bacteria explains why hospital-acquired MRSA is more deadly than community-acquired forms. The study reveals a key toxin that counteracts another, more deadly toxin, opening up possible new pathways for vaccine development.
A new study by NYU Langone Medical Center researchers finds that a 'Healthy Happy Meals' bill could reduce calories, fat, and sodium in fast food meals marketed to children. The proposed legislation requires fast food meals for kids to include a serving of fruit or vegetables and be limited to 500 calories or less.
Researchers at NYU Langone Health found that even brief exposure to sudden sounds or mild trauma can form permanent brain connections, leading to improved hearing in rats. The study may lead to better understanding of how to treat hearing loss, Alzheimer's disease, and PTSD.
A new wound closure technique has been shown to significantly reduce complication rates in patients with non-idiopathic scoliosis undergoing spinal fusion surgery. The multilayered flap closure method eliminates 'dead space' and creates a better barrier, resulting in a 0% complication rate in patients who received the novel technique.
A new narrative review published in JAMA found that current psychotherapy treatments are less than optimal for PTSD, with non-medical approaches effective but not universally effective. The study suggests a need for broader and more personalized approaches to care.
A multicenter study found that hybrid cochlear implant devices led to significant improvements in hearing and speech recognition among individuals with severely damaged high-frequency hearing. The study showed that 45 participants experienced overall improvement in their hearing and speech recognition, with some achieving profound gains.
Researchers from NYU Langone Medical Center presented new findings on Alzheimer's disease treatment at the 2015 Alzheimer's Association Conference. The studies focused on the development of monoclonal antibodies that can recognize oligomeric tau and Aβ, as well as pathological structures in Parkinson's disease human brains. Additionall...
Scientists have developed a new class of monoclonal antibodies that target misfolding proteins in neurodegenerative diseases. The antibodies successfully reverse damage to brain tissue in animals, suggesting a potential therapeutic agent for Alzheimer's and Parkinson's diseases.
A new study has found a significant association between high blood pressure and the presence of phthalates in children and adolescents. The chemicals were used as replacements for DEHP, which was previously linked to detrimental effects on human health.