A new study found that antibodies stimulate a molecule in muscle to keep nerves attached, preserving neuromuscular synapses and slowing disease progression in a mouse model of aggressive ALS. The treatment extended the lifespan of ALS mice and improved function of critical breathing muscles.
Researchers used functional MRI scans to measure brain entropy in 892 participants and found a strong link between higher entropy and intelligence, as measured by standard IQ tests. This suggests that brain imaging could one day help assess problems in brain function for conditions like depression and autism.
A new study has found that the immune system uses a specific balance of T cell types to tolerate beneficial bacteria, while triggering inflammation in pathogenic species. The discovery could lead to new treatments for inflammatory bowel diseases like Crohn's and ulcerative colitis.
A new study challenges the long-held assumption that amyloid beta buildup in brain cells is the origin of Alzheimer's disease. Researchers found that standard diagnostic tools fail to detect future AD in many patients under age 70, and that a decline in cerebrospinal fluid clearance may be the early feature of AD.
A new study by NYU Langone Health found that extending natalizumab dosing intervals from every 4 weeks to 5-12 weeks significantly reduced the risk of developing progressive multifocal leukoencephalopathy (PML), a rare but potentially fatal brain infection. The extended dosing regimen resulted in a 94% reduction in PML risk.
Researchers at NYU School of Medicine developed a community-based health program that achieved significant control of Type 2 diabetes in a high-risk population. After six months, over 55% of participants in the intervention group had blood sugar levels under seven percent.
The study reveals how fibroblast growth factor 23 (FGF23) signals to cells through its receptor and alpha-Klotho, reversing previous conjecture on alpha-Klotho's anti-aging role. The findings also shed light on kidney disease leading to heart hypertrophy.
A national survey found that healthy and wealthy Americans dominate the market for mobile phone apps tracking sleep habits, with 28% of users reporting regular usage. The study suggests that these apps may offer a way to diagnose and treat sleep problems more effectively, but their value remains unclear.
A new study by NYU Langone Health finds that a healthcare center in India has developed a sustainable cataract surgery model, emitting 96% less carbon than the UK while producing comparable health outcomes. The model's key practices include shorter surgery durations, better re-use of surgical materials, and more efficient sterilization.
A study found that lithium chloride prevents brain damage caused by fetal alcohol exposure in mice, reducing sleep disturbances and memory loss. The drug was given to newborn mice after a single dose of 'binge' alcohol, eliminating hyperactivity and sleep deficits.
A study of over 120,000 patients found that certain bacteria in the mouth are associated with an increased or decreased risk of developing esophageal cancer. The presence of Tannerella forsythia was linked to a 21% increased cancer risk, while Streptococcus and Neisseria were associated with a 24% decrease in risk.
A new NYU report reveals that the phase-out of Teflon-like coatings, which contain PFOA, has led to a significant decrease in low-birth weight babies and related brain damage. The study estimates that this shift has saved over $13 billion in healthcare costs and improved educational prospects for thousands of children.
Research suggests that antibiotic use in mothers may alter the microbiome of their offspring, increasing the risk for inflammatory bowel disease. The study, published in Nature Microbiology, found that exposure to antibiotics can change the mix of bacterial species in maternal microbes, which are then passed on to their children.
Researchers found that blocking a key protein frees oxygen to damage iron-dependent proteins in lung and breast cancer cells, slowing their growth. The NFS1 protein is crucial for cancer cell survival in high-oxygen environments, but its inhibition may offer a new treatment option.
Researchers at NYU School of Medicine found that mammalian brains can distinguish between one odor and another in under 100 milliseconds, using fewer nerve signals than previously believed. This groundbreaking study has implications for our understanding of human olfaction and the potential for new treatments for smell disorders.
A new study concludes that extended-release naltrexone and buprenorphine-naloxone are equally safe and effective in curtailing opioid use, relapse, treatment drop-out, and overdose. Researchers found similar 24-week relapse rates for both medications, with craving for opioids lower in the naltrexone group.
Researchers at NYU School of Medicine discovered that infliximab blocks TNF-alpha, reducing inflammation in the gut and preventing transplant rejection. They also found that stimulating ATG16L1 protects against TNF-alpha driven inflammation.
A new study suggests that many pelvic tumors in women may have a common origin in the fallopian tubes, which could lead to new strategies for preventing and early detecting ovarian cancer. The research found that ovarian cancer cells share genetic similarities with cells covering the tips of fallopian tubes.
A study published in Science Advances found that mice born by C-section gained an average of 33% more weight than those born vaginally over the course of 15 weeks after weaning. The researchers also discovered significant differences in bacterial species in their guts, with mice born by C-section having a less mature microbiome structure.
Researchers at NYU School of Medicine discovered that calcium flow into cells controls the activation of genes involved in glucose metabolism, enabling T cells to multiply. The study's findings have implications for autoimmune diseases and may lead to new treatments.
A study found that mutations in the KEAP1 gene make lung adenocarcinoma cells vulnerable to oxidative stress, allowing an experimental drug called CB-839 to stop tumor growth. The discovery could lead to a more effective treatment for patients with combined KRAS and KEAP1 mutations.
A study led by NYU Langone Health found that removing a 2mm margin from suspicious moles can completely remove cancer cells with a single procedure. Researchers monitored patients for over a year and found no further suspicious growths, with 90% of biopsied moles being completely removed.
Researchers found significant reductions in fatigue severity in people with MS who underwent transcranial direct current stimulation. The treatment, which is non-invasive and can be delivered remotely, showed promise in improving fatigue levels and quality of life for patients.
A study by NYU Langone Health found that a higher-dose, shorter form of radiation is safe and effective for breast cancer patients under 50, with no increased risk of late side effects. The new technique also yields good to excellent long-term cosmetic results in 92% of patients.
Researchers found that female mice brain structures organize sex and aggressive behavior differently, with separate cell groups controlling each. In contrast, male mice brain circuits overlap in controlling both behaviors, suggesting a fundamental difference in brain organization between sexes.
New research from NYU Langone Health links wireless food stamp transactions to the buying of more healthy foods by people with low incomes. On average, SNAP beneficiaries purchased 5.4 more cups of fruits and vegetables when using EBT-equipped vendors compared to similar shoppers who paid with cash.
A new study led by NYU School of Medicine found that Hispanic and Asian women in Manhattan have a higher prevalence and severity of lupus than white women. The study also showed significant disparities in kidney disease among these demographic groups.
Children who lived near the World Trade Center on 9/11 are showing early signs of increased risk for future heart disease due to exposure to toxic chemicals. Blood tests revealed elevated levels of artery-hardening fats in their blood, linked to higher blood levels of perfluoroalkyl substances (PFASs).
A new study reveals consistent correlations between white matter structural patterns and autistic symptoms in both ASD and ADHD, highlighting potential shared disease mechanisms. The study's findings suggest that biomarkers could guide more specific diagnostic tests and treatments.
Researchers have designed a new kind of antibody that targets toxic protein structures common to Alzheimer's disease, Parkinson's disease, and related conditions. The study demonstrates the effectiveness of these antibodies in removing toxic forms without triggering immune toxicity.
A study found that vitamin C activated the enzyme TET2 in mice with genetic mutations that reduce its function, leading to the death of leukemia stem cells. High-dose vitamin C treatment was also shown to suppress the growth of cancer stem cells from human patients implanted in mice.
Researchers genetically engineered ants to lack their sense of smell, finding they couldn't communicate, forage or compete for queen status. This discovery promises to advance understanding of social communication and its relation to human disorders like autism and depression.
Exposure to air pollution during the first two trimesters of pregnancy has been shown to increase risk for preterm birth and low birth weight. The study's findings also suggest that exposure to fine particulate matter (PM2.5) can lead to decreased body length, placental weight, and anogenital distance.
A new community-based program using patient navigators in barbershops has been shown to increase early detection of colorectal cancer among black men. The study found that participants who received help were twice as likely to get screened, compared to those who did not receive extra support.
Researchers found that inhibiting the partnership between Tregs and dendritic cells might lead to effective immunotherapy for pancreatic cancer. Blocking this relationship may enable the immune system to target pancreatic tumor cells more effectively, potentially slowing tumor growth.
A randomized trial found that combining a specific care management program with memantine significantly improves daily function in Alzheimer's patients. The study shows that the medication plus care program patient group tested 7.5 times higher than the medication-only group.
The City Health Dashboard is a nationwide expansion of an innovative health data visualization tool, enabling hundreds of US cities to accurately identify their most pressing health needs. The dashboard provides 26 key measures of health and drivers of health status at the neighborhood level.
A study published in the Journal of Clinical Investigation reveals a mechanism to reverse disease in arteries by targeting an immune reaction. Researchers at NYU Langone Health discovered that certain immune cells can switch from promoting inflammation to healing, which can lead to reduced plaque growth and improved cardiovascular health.
A comprehensive review of rapidly changing data identified four neural-behavioral models associated with PTSD, pinpointing specific circuits in the brain that mediate between chemical changes and behavioral expressions. The study provides detailed tables to help healthcare providers recognize signs and symptoms of PTSD for diagnosis.
A study published in the Journal of Graduate Medical Education found that transgender actors can effectively teach new doctors to provide sensitive care. The researchers used standardized patients, including a transgender actress, to assess residents' communication skills and patient satisfaction. The results showed that the training a...
The immunotherapy drug pembrolizumab has been shown to shrink tumors in patients with metastatic triple negative breast cancer, regardless of prior treatment. In a Phase II clinical trial, the drug demonstrated activity in both PD-L1-positive and -negative tumors.
In a large-scale randomized clinical trial, cannabidiol reduced seizure frequency by 39% in patients with Dravet syndrome. The study included 120 children and adolescents aged 2-18 years, who received either CBD or placebo over a 14-week period.
Researchers found that chronic pain distorts the intensity of pain perception in other body parts by rewiring circuits in the anterior cingulate cortex. This causes a greater reaction to painful stimuli throughout the body, with far-reaching consequences for mental health and disease treatment.
Researchers analyzed data from large-scale studies of erectile dysfunction medication users and found an overall 11% increase in melanoma risk. However, they attribute the increased risk to detection bias rather than a direct cause-and-effect link between medications and melanoma.
A study published in Nature Medicine found that immune reactions to viruses can disrupt brain connections, leading to learning problems. The research team identified CX3CR1highLY6Clow monocytes as the key players in this process, releasing inflammatory signaling protein TNFα which blocks nerve cell connection formation.
A new study published in Nature Communications suggests that maintaining high levels of adenosine in rats with damaged ACLs prevents osteoarthritis. Adenosine replacement therapy could potentially delay the onset of osteoarthritis and joint replacements.
A new study published in Nature finds that the thalamus strengthens connections within the prefrontal cortex, enabling it to focus attention and make decisions. This discovery has implications for understanding cognitive deficits in diseases such as schizophrenia and improving cognition by adjusting thalamic function.
A study by NYU Langone Health found that 3.4% of US adults suffer from serious psychological distress, with 9.5% lacking health insurance and 10.5% experiencing delays in getting professional help. The research suggests a worsening mental health crisis despite increased access to care since the ACA.
Researchers observed lower body mass index (BMI) and blood pressure among low-income individuals living in the city's noisiest neighborhoods. The study suggests that neighborhood noise may have an indirect impact on health, potentially due to increased physical activity resulting from walkability.
Researchers at NYU Langone Health have uncovered a critical pathway by which pancreatic cancer cells evade the immune system, involving high levels of two proteins - dectin-1 and galectin-9. The study found that blocking this interaction can increase survival in mice with pancreatic tumors.