Researchers found that pancreatic tumor cells secrete interleukin-1β (IL-1β) to reduce anti-cancer immune responses, promoting PDA tumor growth. Blocking IL-1β with an antibody treatment doubled T cell infiltration and increased PD-1 blockade efficacy by 40%.
A novel method combining optical imaging with artificial intelligence produces accurate, real-time diagnosis of brain tumors. The system, stimulated Raman histology (SRH), reveals tumor infiltration and enables surgeons to see predicted diagnoses in under two minutes.
Pancreatic cancer cells use a process called macropinocytosis to engulf nutrients, which are then broken down into building blocks for cell growth. The study identified key molecular steps involved in boosting this process, including the activation of protein kinase A and v-ATPase.
Researchers developed a computer betting game to predict opioid reuse in addiction patients. The game measures comfort with risk-taking and finds sharp increases in scores are associated with high likelihood of reuse within the next week.
A new study found that problematic marijuana use increased by 25% among adolescents aged 12-17, while past-month frequent use rose by 23% among adults aged 26 or older after recreational legalization. The study suggests investing in substance use prevention and treatment to prevent unintended harms.
Researchers found that newly cancerous pigment stem cells migrate up and out of hair follicles to establish melanomas in nearby surface skin before spreading deeper. This discovery sheds new light on the biology of melanoma and suggests potential new ideas for treatment.
New study confirms that mechanisms preserving cell identity are based on how DNA is packaged, with histone modifications playing a key role. Chemical changes to histones determine whether chromatin regions are open or compacted, influencing gene expression and cell behavior.
A new study by NYU researchers found that children living within a half-block of fast-food outlets were 20% obese and 38% overweight. The farther away from unhealthy food sources, the lower obesity rates, with significant reductions at just one or two blocks distance.
A new study in rats reveals the extent of brain damage caused by short-term maternal abuse, which can lead to fear and memory problems. Researchers also found that the combination of stress and abuse can restrict growth of certain parts of the brain, leading to behavioral problems.
A new AI tool, trained on a large dataset of mammography images, accurately identified breast cancer with 90% accuracy when combined with radiologist analysis. The study suggests that AI can augment human radiologists' diagnoses, reducing false-positive and false-negative results.
Zebrafish larvae's ability to coordinate movement and maintain balance improves as they age, mirroring human brain function. The study suggests that the developing fish rely on their vestibular organs to oversee improvements in coordination needed to remain horizontal.
A new study has found that e-cigarette smoke caused lung cancer and bladder issues in mice exposed to nicotine. The study, published in the Proceedings of National Academy of Sciences, found that 22.5% of mice developed lung adenocarcinomas after exposure to e-cig smoke with nicotine for 54 weeks.
Certain fungi can expand their population over a thousand-fold, encouraging pancreatic cancer growth, according to a new study. The study found that treating mice with an antifungal drug reduced PDA tumor weight by 20-40 percent.
A new study finds that increasing levels of 'good' cholesterol reversed disease in the blood vessels of mice with diabetes, reversing atherosclerosis. The study also shows that raising functional HDL levels stopped inflammation and improved cardiovascular disease processes.
The study implemented randomized quality improvement projects across NYU Langone Health, finding that changing prompts for tobacco cessation counseling increased medication prescription rates. Post-discharge phone calls were largely ineffective in improving patient satisfaction or hospital readmissions.
A recent study found that men at high risk for breast cancer can benefit from mammography screening. The study involved 1,869 men who had a mammogram between 2005 and 2017, with 41 men diagnosed with breast cancer.
A new study developed a blood-based biomarker panel that can diagnose posttraumatic stress disorder (PTSD) in male combat veterans with 77% accuracy. The panel uses genomic, metabolic, and protein biomarkers to identify genetic and cellular changes associated with PTSD.
A new study suggests that metabolites produced by the body's breakdown of toxins may protect against obstructive airway disease in 9/11 first responders. Researchers identified specific compounds, including protein-building amino acids and omega-3 fatty acids, which are found in diets rich in fish and olive oil.
A review of autopsy reports reveals that early in the HIV epidemic, the average age of death was 36, increasing to 54 by 2010 due to development of antiviral therapies. However, people are still dying predominantly from underlying disease rather than just old age, with infections like pneumonia and hepatitis C contributing to deaths.
The study found that ERK was easily switched on in ancient one-celled creatures but carefully restrained as animals evolved. Researchers identified two key changes that likely brought ERK under more control across evolution.
A recent study found that over 34% of recent LSD initiates first used the drug in the summer, while 30% of marijuana, ecstasy, and cocaine use began during this time. The researchers suggest that having extra recreational time during the summer and the growing popularity of outdoor activities may contribute to these findings.
Researchers identified a molecular mechanism that may be contributing to the global obesity epidemic. The study found that a protein called RAGE on the surface of fat cells can block fat burning when stressed, leading to weight gain. Removing RAGE from fat cells reduced weight gain in mice fed a high-fat diet.
A new study reveals that high antioxidant levels may accelerate lung cancer spread, contradicting the long-held notion that antioxidants like vitamin E prevent cancer. The research highlights a complex interplay between protein BACH1, NRF2, and heme-driven oxidative stress in facilitating cancer cell migration.
A new study has found that artificial manipulation of brain signals can improve working memory in rats, with extended ripples capturing more information when learning a new place. The findings offer insights into the mammalian brain's mechanisms and may guide future treatments for memory disorders.
A new study published in Nature Digital Medicine found that smartphone-based relaxation technique RELAXaHEAD can reduce migraine headache days by four per month. The app's success rate increased from 51% to 29% after three months, suggesting its potential as a treatment option.
A new case study from NYU School of Medicine provides a roadmap for academic medical centers to bridge the gap between clinical practice and public health. The report outlines four core approaches to improving health and reducing health inequities, including engaging community partners, transforming healthcare operations, and shaping p...
A new study found that even short stays in polluted cities can cause significant breathing problems and coughing in healthy adults, which can take at least a week to recover from. The research team analyzed lung and heart health in travelers visiting highly polluted cities like India and China.
Researchers have discovered a way to predict which patients with systemic lupus erythematosus (SLE) are most likely to respond to therapy by analyzing tissue samples from their kidneys and skin. This breakthrough could lead to personalized treatment plans for SLE patients.
Researchers developed a blood test that measures tumor DNA, allowing for early detection of treatment response in patients with stage III or IV melanoma. The study found that the test detected BRAF mutations in 93% of patients before treatment and showed improved survival rates for those whose tumors shrunk after targeted therapy.
Researchers studied how egg cells in fruit flies choose the healthiest mitochondria to pass on. They found that mitochondrial selection is triggered by a drop in Mitofusin levels, allowing for the elimination of faulty mitochondria.
Researchers found that removing the ATDC gene from pancreatic cells prevented the development of pancreatic cancer in mice. The study identified ATDC as a key player in the reprogramming of adult cells into primitive, high-growth cell types, which can lead to cancer.
Researchers identified nine types of cells and subtypes in the marrow microenvironment, including vascular endothelial cells and stem cells. The study revealed a critical role of subsets of cells involved in cancer chemotherapy and immune cell production.
A new study uses AI to analyze voice patterns and diagnose post-traumatic stress disorder (PTSD) in veterans. The tool was able to distinguish between the voices of those with or without PTSD with high accuracy, suggesting a potential breakthrough in telemedicine approaches.
A new study identifies 20 common sleep myths that can lead to poor habits and serious health risks. The researchers suggest creating a consistent sleep schedule and spending at least seven hours asleep to promote overall better health.
Researchers found that Hirschsprung disease shares common genetic mechanisms with complex disorders like schizophrenia and autism. The study identified key genes, cellular mechanisms, and molecular targets for personalized treatment.
A new study by NYU School of Medicine found that shorter stays in skilled nursing facilities (SNFs) are associated with a higher risk of hospital readmission among elderly heart failure patients. Patients who stayed at SNFs for two days or less had a risk four times higher than those who stayed longer.
A new study found that cancer patients use more potent forms of medical marijuana with higher amounts of tetrahydrocannabinol (THC), relieving symptoms and side effects of cancer treatment. Non-cancer patients, on the other hand, prefer CBD-rich formulations for their therapeutic benefits.
Chronic inflammation, not aging, is the main reason why bones heal more slowly with age. Researchers found that exposure to older mice's blood serum reduces stem cell multiplication and increases inflammation. Treatment with anti-inflammatory drugs restored skeletal stem cell function and bone healing ability in aged mice.
Researchers studying Alston's singing mouse found a brain circuit that enables fast back-and-forth conversation, like human talking. The motor cortex is necessary for vocal interaction, and separate circuits enable rapid starts and stops.
Researchers at NYU Langone Health have found a strong link between systemic lupus erythematosus (SLE) and an abnormal mix of bacteria in the gut. The study showed that patients with SLE had significantly higher levels of Ruminococcus gnavus bacteria in their guts, which triggered immune reactions and disease flares.
A new study found that increased marketing of opioid products to physicians is associated with higher opioid prescribing rates and elevated overdose deaths in the US. The research suggests that even low-value payments or subtle marketing tactics can influence physician prescribing patterns, leading to more overdose deaths.
A new class of centyrins shows promise in blocking the effects of severe S. aureus bacterial infections in mice and human cell experiments. Nearly all centyrins that bind to leukotoxins prevent toxins from attaching to and destroying cells, potentially addressing antibiotic resistance.
A recent study surveyed 450 oncologists in the US, revealing that most are unaware of how to treat patients with LGBTQ+ differences but are interested in learning more. The researchers recommend establishing protocols for treating LGBTQ cancer patients and providing education and training for physicians.
A new model predicts PTSD risk with high accuracy, identifying individuals at significant risk for early intervention. The model, developed from a large international study, analyzes trauma scores and estimates each individual's risk of chronic PTSD.
A new study identified a unique strain of CA-MRSA driving antimicrobial resistance and spread, particularly in vulnerable populations. Genomic surveillance played a crucial role in tracking the outbreak and informing infection control strategies.
Researchers have developed new techniques to identify which of our genes are influenced by ancient viral DNA snippets, revealing complex interactions between viruses and human genetic material. The study found that a single transposon can control multiple genes, increasing the complexity of its impact on health and disease.
A new study found that Streptococcus pneumoniae bacteria that occupy human host tissue first are more likely to thrive than competing strains. The researchers discovered that these 'owners' release toxins to kill intruders, while also releasing protective factors to defend themselves.
A new combination therapy involving ipilimumab, nivolumab, and brentuximab vedotin safely reduces tumor size or spread in 95% of patients with recurrent Hodgkin lymphoma, achieving complete remission in 16 patients.
Researchers found that checkpoint blockade therapy can sensitize patients to better respond to future use of drugs, even when initial attempts failed. This breakthrough has significant implications for treating relapsing non-Hodgkin lymphoma and Hodgkin lymphoma patients.
A team of researchers at NYU Langone Health has successfully regrown hair strands on damaged skin by stimulating fibroblasts to secrete collagen through the sonic hedgehog signaling pathway. The study offers new hope for treating hair loss and may lead to the development of more effective drugs.