Researchers identified estrogen-related receptor gamma (ERR γ) as crucial for preventing pancreatic auto-digestion in mice. In humans, lower levels of ERR γ were found in cells affected by pancreatitis. These findings suggest new therapies regulating ERR γ activity could help prevent or treat these conditions.
A study by Salk researchers has identified an area of the brain responsible for encoding social rank in mammals, including mice. The discovery sheds light on how the brain represents social hierarchy and its impact on behavior, particularly in competitive situations.
Researchers developed a new genomic technology to analyze DNA, RNA and chromatin from a single cell, providing a comprehensive database for better understanding of brain diseases. The technology helped identify 63 cell types in the human frontal cortex region.
Researchers at the Salk Institute successfully reversed aging signs in middle-aged and elderly mice using a cellular rejuvenation approach. The treatment, which involves reprogramming cells with four specific molecules, restored youthful epigenetic patterns and improved tissue function without increasing cancer risk.
Worms use cost-benefit calculations to choose between different actions, similar to vertebrates. The study demonstrates that complex decision-making capabilities can be encoded in small biological networks.
Salk researchers have engineered mammalian cells to be activated using ultrasound, a method that paves the way toward non-invasive versions of deep brain stimulation, pacemakers, and insulin pumps. The team found a protein called TRPA1, known for its role in responding to noxious compounds, which also opens in response to ultrasound.
Researchers found that CBN preserves mitochondrial function and prevents oxidative damage to nerve cells, suggesting potential for treating age-related neurodegenerative diseases like Alzheimer's. The compound works independently of cannabinoid receptors, making it a promising therapeutic option.
The CLASSY gene family controls tissue-specific DNA methylation patterns in Arabidopsis, which has broad implications for agriculture and medicine. The study reveals that CLSY genes modulate DNA methylation patterns in different plant tissues.
Researchers at Salk Institute have discovered a new molecular pathway that controls blood glucose levels independent of insulin, offering new avenues for treating diabetes and metabolic disorders. The hormone FGF1 suppresses lipolysis and regulates glucose production in the liver.
A Salk Institute team has uncovered a neural network in the brain that connects breathing rhythm with feelings of pain and fear. This discovery could lead to the development of an analgesic that prevents opioid-induced respiratory depression, a major cause of overdose deaths.
Researchers have discovered that a common class of targeted therapies can help more colorectal cancer patients than previously thought. By analyzing cell studies and computer modeling, the team identified 10 distinct RAS mutations that do not preclude the use of EGFR inhibitors, which are already approved for other uses.
Researchers at Salk Institute discovered that neurons deep in the brain's cortex process information from borders first, then send clues back to upstream areas. This supports the importance of the 'feedback' pathway for deciphering borders.
Researchers used a machine-learning algorithm to identify differences in how the brain responds to various chemicals, including salt and benzaldehyde. The study provides insight into how brains process information and may help understand sensory processing disorders.
Researchers have sequenced the Arabidopsis genome at unprecedented detail, shedding light on centromere evolution and revealing genetic and epigenetic topography. The findings provide insights into the genomic equivalent of black holes, a region that has long been challenging to analyze.
Researchers at Salk Institute discovered that long-lived mitochondrial proteins remain stable for an extended period, protecting them from damage. This stability allows these proteins to maintain mitochondrial function even when new ones are synthesized, providing protection against errors and energy-conservation benefits.
A team of scientists led by Associate Professor Nicola Allen found that astrocyte signaling is directly related to each stage of neuronal development. The researchers determined that astrocytes respond to neurotransmitters produced by neurons to control the timing of signal production, instructing neuronal growth and development.
Researchers discovered how neurons in a small area of the brain filter distracting signals to coordinate dexterous movements. The findings may hold lessons for building better prosthetics and robots that can fine-tune their movements based on sensory input.
Researchers at the Salk Institute combined genomic and epidemiological data to reveal that some widespread beliefs about cancer-causing genes are incorrect. For example, KRAS is found to be involved in only about 11% of all cancers, not 25% as previously thought. This study could help guide genetic research for more effective treatments.
Researchers have made progress in creating a brain atlas of the mouse brain, which will help develop tools for studying the human brain. The study describes the diversity of neurons in the mouse brain and establishes new methods for characterizing cell types and neural connections.
A new study from Salk Institute researchers found that a critical threshold of miR-218 levels determines the development of ALS in animal models. The study sheds light on the complex control of gene expression and its implications for treating neurological disorders.
A new study by Salk scientists found that time-restricted eating (TRE) confers multiple health benefits, including reduced risk of type 2 diabetes, fatty liver disease, and sepsis, regardless of age and sex. TRE may also protect against infectious diseases like COVID-19 and improve insulin resistance.
Researchers identified a group of neurons in the brainstem that plays a key role in opioid-induced respiratory depression, which causes overdose deaths. Blocking these receptors can restore breathing during an overdose, offering potential new treatment targets.
Plants can respond to subtle environmental changes on the cellular level, triggering molecular changes in as little as five minutes. The study found that canopy shade leads to the removal of histones at growth-regulating genes through DNA binding of PIF7, activating their expression.
A new study reveals that inhibitory neurons increase signal transmission by targeting the weakest-responding neurons in the brain, enabling flexible information transfer. This discovery could help understand and treat disorders such as anxiety and attention deficit disorders.
Researchers discovered that tumor microenvironment contains oxidized fat molecules that suppress killer T cells' ability to fight cancer. The process involves CD36 cellular fat transporter and leads to increased lipid oxidation, triggering stress response proteins and repressing anti-tumor functions.
Researchers at Salk Institute develop efficient method to produce insulin-producing cells from stem cells, bringing hope for type 1 diabetes treatment. The new approach resulted in beta cell yields of up to 80 percent and biologically functional transplanted cells in mouse model.
A new study published in Nature Communications reveals clues about molecular changes underlying muscle loss tied to aging. The researchers found that using molecular compounds increased the regeneration of muscle cells in mice by activating precursors of muscle cells, called myogenic progenitors.
A Salk study reveals the connection between CRTC3 and melanin production, finding that eliminating the protein can reduce melanoma cell aggression. The researchers also discovered two cellular communications systems converge on CRTC3, suggesting it as a potential target for developing new treatments.
Scientists at Salk Institute successfully transformed tobacco and corn husks into silicon carbide (SiC) while sequestering up to 50,000-fold more carbon from seed to lab-grown plant. The process retains about 14 percent of the plant-captured carbon, offering a potential solution for climate change mitigation.
Researchers at Salk Institute confirm COVID-19 is primarily a vascular disease, revealing the virus' spike protein damages cells and disrupts molecular signaling. The findings provide new insight into the mechanism of disease and open doors for effective therapies.
Researchers at the Salk Institute have developed a new technique to model brain cells in older patients with Alzheimer's disease. The study reveals that affected neurons lose their cellular identity and exhibit changes similar to those seen in cancer cells, providing potential targets for therapeutics.
Salk researchers have traced the development of spinal cord neurons using genetic signatures, revealing new ways of classifying and tagging subsets of cells. The findings offer a precise way to study the function of spinal cord neurons and their role in regulating body movements.
Researchers at Salk Institute create chimeric organisms with human cells, offering insights into early human development, disease progression, and aging. The study could lead to innovative platforms for drug evaluation and address the organ shortage.
Researchers find that microglia promote the formation of dense-core plaques as part of a defense mechanism, clearing debris from neurons and potentially causing cell death. This discovery suggests that treatments targeting these protective plaques may be more effective than destroying them.
Researchers discovered a direct link between Parkin and the activation of mitophagy in Parkinson's, as well as its role in type 2 diabetes and cancer. The study found that AMPK, ULK1, and Parkin form a crucial pathway in cellular stress response.
A new study by Salk scientists identifies specific regions of the genome that neurons prioritize for DNA repair, revealing
The NIRVANA test can diagnose COVID-19 in minutes, track SARS-CoV-2 variants, and detect other viruses like influenza. It uses isothermal recombinase polymerase amplification (RPA) coupled with real-time nanopore sequencing.
A new method developed by Salk researchers enables scientists to improve microscope image quality using artificial intelligence and artificially degraded images. The 'crappifier' tool can help democratize microscopy, making it accessible to those without powerful microscopes.
Researchers have defined how antibodies recognize phosphohistidine, a central role in some cancers like liver and breast cancer. The study provides insights into antibody structures and enables scientists to engineer more efficient antibodies.
Researchers at the Salk Institute have made groundbreaking discoveries about the genome of Wolffia, a miniature aquatic plant that can grow twice as fast as other plants. The study reveals that Wolffia has shed most genes that don't contribute to growth, allowing it to focus on rapid development.
The Salk Institute's NOMIS Center is expanding its research into health and immunity thanks to a $9.5 million gift from the NOMIS Foundation. The center aims to understand how the immune system interacts with other biological processes to combat diseases such as autoimmunity, cancer, and neurodegeneration.
A new study led by Salk Institute scientists identified a strain of E. coli bacteria that causes female mice to neglect their offspring when living in the gut. The research reveals a direct link between the particular microbe and maternal behavior, adding to growing evidence that microbes in the gut affect brain health and development.
Researchers found that decreased activation of gene LEF1 disrupts neuronal function and promotes hyperexcitability in brain cells, a hallmark of bipolar disorder. Increasing LEF1 expression may lead to new drug targets and biomarkers for lithium nonresponsiveness.
A new computational model reveals how the brain maintains short-term information using specific types of neurons, including inhibitory neurons. Good working memory requires long-timescale neurons to be prevalent and strong connections between these neurons.
Researchers at the Salk Institute have created a computational model of brain activity that simulates how humans adapt to new situations. The model, which incorporates the concept of 'gating' to control information flow, outperforms previous models and mimics human mistakes seen in patients with prefrontal cortex damage. This breakthro...
Researchers at the Salk Institute have mapped the physical organization of cells in the spinal cord that help mediate critical sensorimotor reflexes. The study found that different neurons in the same space had the same function, while more similar neurons located in different areas were responsible for different reflexes.
Researchers at Salk Institute discover patterns of neural signals that facilitate perception of faint objects. The brain's ability to recognize targets is directly related to when and where traveling brain waves occur in the visual system.
The Salk Institute, along with partners at Sanford Burnham Prebys and UC San Diego, will establish a world-class center to study cellular and tissue aging in humans. The five-year grant aims to identify key drivers of aging and find new ways to increase human health span.
Researchers at Salk Institute discover that metformin's anti-inflammatory effects require communication between AMPK and mTORC1. The study sheds light on the molecular mechanisms of metformin's action and reveals its potential as a treatment for inflammatory diseases, including liver inflammation.
Salk Institute scientists develop transplantable human insulin-producing pancreatic cell clusters that evade the immune system, providing sustained blood glucose control without immunosuppressants. The cells were created using stem cell technology and a protein called WNT4 to induce a genetic switch that makes them functional.