A study published in JAMA Oncology found that shorter courses of androgen deprivation therapy can effectively control prostate cancer without increasing risks. The ideal duration of ADT depends on cancer risk, allowing for more personalized treatment plans.
A study published in JAMA Network Open finds that veterans with cardiometabolic conditions such as diabetes and high blood pressure are at a 10-14% higher risk of dying during days with extreme heat compared to other days. The researchers also found that homeless veterans faced a 25% higher risk of death vs. housed veterans.
A new report warns that AI can worsen health disparities in brain disease diagnoses if proper safeguards are not implemented. Researchers call for diverse perspectives, AI education, and strong governance to ensure equitable implementation.
Researchers found that fewer than 1 in 4 eligible younger adults completed colorectal cancer screenings after the USPSTF lowered the recommended screening age to 45. Despite investigating unmet social needs, no significant differences were found in testing uptake for this early midlife cohort.
The new department will drive the next generation of discovery and patient-centered care through advanced imaging and therapy. Key collaborations include UCLA Health, David Geffen School of Medicine, and UCLA Health Jonsson Comprehensive Cancer Center.
Dr. Sedrak receives King Hussein Cancer Research Award for innovative work on accelerated aging in cancer survivors, with a focus on developing new strategies to prevent or reverse age-related effects. His research aims to improve health span and quality of life for cancer patients, holding promise for other age-related diseases.
The new clinical cancer research center will support lung and genitourinary cancers, serving as a central hub for seven VA medical centers. The grant aims to improve access to precision oncology trials and patient care for veterans diagnosed at later stages.
A new editorial highlights the importance of primary care in preventing heart disease in breast cancer survivors. The study found that most women do not go on to develop serious cardiac disease, but those with higher-risk chemotherapy, older age, or multiple cardiovascular risk factors may benefit from closer monitoring.
A UCLA study finds that DNA copy-number changes enable melanoma cells to resist immune attacks, leading to tumor relapse. The researchers suggest a strategy to make tumors more prone to self-destruction after immune attacks, potentially extending the effectiveness of immunotherapy.
A new UCLA Health study found that a child's early gut microbiome may influence their risk of developing depression, anxiety or other internalizing symptoms in middle childhood. The effect appears to be related to the way bacteria are linked to communication across emotion-related brain networks.
A research team provides a framework to support doctors in their patient care while ensuring AI doesn't undermine their expertise. The framework addresses key issues like timing, trust, and over-reliance on AI.
A new standardized discharge system at UCLA Health reduced patient departure delays from nearly 3 hours to under 90 minutes for four common conditions and decreased hospital length-of-stay by 2.5 days, according to a pilot study published in BMJ Open Quality.
A new UCLA study reveals that breast milk from women living with HIV contains significantly lower levels of tryptophan, an essential amino acid important for infant immune function and brain development. The study suggests that this depletion may be a common denominator explaining the immune, growth, and cognitive differences seen in c...
A 52% increase in complicated cases of diverticulitis was found among patients under 50, with a shift towards younger demographics and more aggressive disease presentations. Treatment strategies have evolved, but the exact causes of this trend remain poorly understood.
A new study found that adding chemotherapy to radiation therapy causes a greater decline in quality of life for women with early-stage cervical cancer. The trial measured patient-reported outcomes, including symptoms and side effects, highlighting the need for supportive care during treatment.
A UCLA Health study found that women continue to face barriers in accessing lung transplants despite recent national policy changes. The new Composite Allocation Score system aimed to improve fairness, but inequities persist, with women still 16% less likely to undergo transplantation.
Researchers found that combining zanzalintinib, a targeted therapy drug, with atezolizumab, an immune checkpoint inhibitor, improved survival rates by 20% compared to standard treatment regorafenib. The new combination also delayed cancer progression and showed promising results in patients with metastatic colorectal cancer.
UCLA investigators unveil decade-long survival data for immunotherapy in advanced lung cancer and promising results for novel therapies targeting PSMA, DKK1, and FGFR3 in various aggressive cancers. These breakthroughs hold promise for improved treatment outcomes and quality of life for patients with difficult-to-treat diseases.
A new survey conducted by UCLA found that nearly 1 in 4 transplant hepatologists in the US screen positive for unhealthy alcohol use. The study highlights the critical need for accessible physician wellness programs and reduced stigma around doctors seeking help.
Researchers have developed a non-invasive blood test that can detect Amyotrophic Lateral Sclerosis (ALS) earlier and with higher accuracy by measuring cell-free DNA. The test distinguishes between ALS patients and healthy individuals, as well as those with other neurological conditions.
Researchers at UCLA Health have identified a sex-chromosome linked gene that drives inflammation in the female brain, making women more susceptible to conditions like Alzheimer's disease and multiple sclerosis. Deactivating this gene and using diabetes medication metformin showed promising results in reducing symptoms in female mice.
A new study found that child neurologists often lack knowledge and education on motor difficulties in children with autism. Motor impairments are common in autistic children, affecting their development, language skills, and social interactions. The study recommends more training for medical students and residents to recognize and addr...
Research finds primary caregivers in urban under-resourced communities highlight the importance of parent input to boost equitable access to out-of-school-time activities. Key strategies include broad outreach, structural investments, and family engagement to improve participation and quality., The study suggests that enrichment and re...
Researchers create novel antibody-based treatment that combines diagnostic and therapeutic capabilities to target LRRC15-expressing tumors, slowing growth and extending survival. The approach shows promise in preclinical models by priming tumors for immune response and boosting immunotherapy's effectiveness.
A new UCLA Health study found that inhalers for asthma and COPD generate over 2 million metric tons of carbon emissions annually. Metered-dose inhalers account for 98% of emissions due to potent greenhouse gas propellants, while dry and soft powder mist inhalers are less harmful.
A study found that stereotactic body radiotherapy (SBRT) after prostate surgery is safe and effective in preventing cancer recurrence, with low side effects and manageable treatment. The results suggest SBRT may be a faster and simpler option for men at risk of recurrent prostate cancer.
Dr. Amar Kishan has been recognized for his groundbreaking research on radiation treatments for genitourinary system cancers. He is the recipient of the 2025 Steven A. Leibel Memorial Award, presented by ASTRO and ABR Foundation.
A new PSMA-targeting radioligand therapy added to stereotactic body radiotherapy (SBRT) more than doubled progression-free survival in men with recurrent prostate cancer, delaying the start of hormone therapy by up to 24 months. The study found minimal side effects and identified biological markers that may predict treatment benefits.
Researchers from UCLA presented findings on targeted radioactive therapy, new SBRT approaches and advances in MRI- and 5DCT-guided imaging. The LUNAR clinical trial looked at adding a targeted therapy before ablative radiotherapy for men with recurrent prostate cancer.
In-home gun homicides of children have more than doubled since 2010, with nearly two-thirds of child victims aged 12 and under killed at home. The study found that these cases are often linked to intimate partner violence and child abuse, with parents being the most common assailants.
Researchers at UCLA Health Jonsson Comprehensive Cancer Center identify IGF2BP3 as a master switch linking cancer metabolism and RNA regulation in leukemia cells. The protein shifts energy breakdown and RNA modifications to support cell survival and multiplication.
Researchers found that mice and AI agents developed similar behavioral strategies and neural representations when coordinating their actions, suggesting fundamental principles of cooperation transcend biology and technology. Mice learned to coordinate actions through three key behaviors: approaching partners' sides, waiting for arrival...
Researchers have uncovered how mosquito-borne viruses invade the brain by exploiting specific proteins on blood-brain barrier cells. The study highlights promising molecular targets for future vaccines and antiviral drugs to prevent severe neurological complications.
Research at UCLA Health Sciences found that high-markup hospitals charge up to 17 times the true cost of care, resulting in poorer patient outcomes, including higher complication and readmission rates. Patients treated at these hospitals often experience financial toxicity or medical bankruptcy.
A large-scale randomized trial will examine whether AI supports radiologists in interpreting mammograms more accurately, reducing unnecessary callbacks and anxiety. The PRISM Trial, led by UCLA, aims to inform future policy decisions and best practices in breast cancer screening.
UCLA researchers have identified two key proteins, HuR and CEACAM1, that act as protective switches to prevent damage in damaged livers. By boosting this protection, organs deemed unsuitable for transplantation could be made suitable for use.
Dr. Eggener brings extensive expertise in prostate and testicular cancer detection, diagnosis, and treatment to UCLA Health. He aims to improve prostate cancer detection and treatment through research.
A new study from the University of California - Los Angeles Health Sciences suggests that regular mammograms may still offer significant benefits for women in their 80s. The study found that screened women were more likely to have surgery to remove the tumor and had a lower risk of cancer returning and dying compared to unscreened women.
Researchers have found that a unique surgical technique combining radiation with silicone oil shows unexpectedly low rates of cancer metastasis and death in patients with uveal melanoma. Over four years, more than 80% of patients remained free of metastatic disease.
Researchers have found a way to use antibodies to direct T cells to kill Cytomegalovirus-infected cells, offering an alternative treatment for life-threatening infections without expensive and side-effect-prone drugs.
A new form of electric brain stimulation, HD-tDCS, has been shown to be effective and faster than traditional treatments for depression. Participants who received the therapy reported significant improvements in mood scores, which were sustained during follow-up assessments.
A UCLA Health study found that only a handful of top Alzheimer's disease organizations in Los Angeles County had features or tools to improve access for Latino and Hispanic families. The study highlights the need for accessible digital solutions to close the existing digital divide among these communities.
Researchers found distinct effects of single disease-causing gene variants across different brain regions, pointing to hippocampal disruptions as a key factor in cognitive problems beyond seizures. This study provides an early step toward understanding why current treatments often fall short and may help identify new therapies.
A new scientific review reveals that stress, hardship, and social challenges reshape a person's gut bacteria and brain performance, making it harder to keep weight off. Social determinants of health play a key role in obesity risk, and addressing these conditions is crucial for long-term solutions.
The trial will evaluate the effectiveness of EAET on nearly 700 war veterans across seven US Department of Veterans Affairs centers. Previous research by Dr. Brandon Yarns found that EAET provided significant pain relief compared to traditional cognitive behavioral therapy among older adults.
A UCLA Health study found that taking an 8-strain probiotic daily reduces the risk of pouchitis, a common inflammatory condition. However, the treatment's cost-effectiveness depends on the patient's likelihood of flare-ups, with benefits only seen in patients with frequent relapses.
The CA Bridge program successfully implemented opioid use disorder treatment services across over 80% of California's emergency departments, treating 165,000 patients with nearly 45,000 instances of buprenorphine treatment. This initiative demonstrates the potential for emergency departments to serve as critical entry points for addict...
Researchers have developed AlloCAR70-NKT, an innovative cell therapy harnessing the immune system to fight cancer. The therapy demonstrates a multi-pronged attack against kidney cancer, directly killing cells and disrupting the tumor's microenvironment.
A new study led by UCLA researchers found that many patients with advanced cancer feel their treatment does not align with their personal care goals. The study reveals a significant disparity in care preferences between patients with advanced cancer and those with other serious illnesses, suggesting a need for improved communication an...
A new UCLA-led study finds that government housing assistance reduces the risk of medical bill stress by nearly seven percentage points among US renters with cancer, leading to improved quality of life and reduced poor physical and mental health outcomes.