Researchers at UCLA Health Jonsson Comprehensive Cancer Center identify IGF2BP3 as a master switch linking cancer metabolism and RNA regulation in leukemia cells. The protein shifts energy breakdown and RNA modifications to support cell survival and multiplication.
Researchers found that mice and AI agents developed similar behavioral strategies and neural representations when coordinating their actions, suggesting fundamental principles of cooperation transcend biology and technology. Mice learned to coordinate actions through three key behaviors: approaching partners' sides, waiting for arrival...
Researchers have uncovered how mosquito-borne viruses invade the brain by exploiting specific proteins on blood-brain barrier cells. The study highlights promising molecular targets for future vaccines and antiviral drugs to prevent severe neurological complications.
Research at UCLA Health Sciences found that high-markup hospitals charge up to 17 times the true cost of care, resulting in poorer patient outcomes, including higher complication and readmission rates. Patients treated at these hospitals often experience financial toxicity or medical bankruptcy.
A large-scale randomized trial will examine whether AI supports radiologists in interpreting mammograms more accurately, reducing unnecessary callbacks and anxiety. The PRISM Trial, led by UCLA, aims to inform future policy decisions and best practices in breast cancer screening.
UCLA researchers have identified two key proteins, HuR and CEACAM1, that act as protective switches to prevent damage in damaged livers. By boosting this protection, organs deemed unsuitable for transplantation could be made suitable for use.
Dr. Eggener brings extensive expertise in prostate and testicular cancer detection, diagnosis, and treatment to UCLA Health. He aims to improve prostate cancer detection and treatment through research.
A new study from the University of California - Los Angeles Health Sciences suggests that regular mammograms may still offer significant benefits for women in their 80s. The study found that screened women were more likely to have surgery to remove the tumor and had a lower risk of cancer returning and dying compared to unscreened women.
Researchers have found that a unique surgical technique combining radiation with silicone oil shows unexpectedly low rates of cancer metastasis and death in patients with uveal melanoma. Over four years, more than 80% of patients remained free of metastatic disease.
Researchers have found a way to use antibodies to direct T cells to kill Cytomegalovirus-infected cells, offering an alternative treatment for life-threatening infections without expensive and side-effect-prone drugs.
A new form of electric brain stimulation, HD-tDCS, has been shown to be effective and faster than traditional treatments for depression. Participants who received the therapy reported significant improvements in mood scores, which were sustained during follow-up assessments.
A UCLA Health study found that only a handful of top Alzheimer's disease organizations in Los Angeles County had features or tools to improve access for Latino and Hispanic families. The study highlights the need for accessible digital solutions to close the existing digital divide among these communities.
Researchers found distinct effects of single disease-causing gene variants across different brain regions, pointing to hippocampal disruptions as a key factor in cognitive problems beyond seizures. This study provides an early step toward understanding why current treatments often fall short and may help identify new therapies.
A new scientific review reveals that stress, hardship, and social challenges reshape a person's gut bacteria and brain performance, making it harder to keep weight off. Social determinants of health play a key role in obesity risk, and addressing these conditions is crucial for long-term solutions.
The trial will evaluate the effectiveness of EAET on nearly 700 war veterans across seven US Department of Veterans Affairs centers. Previous research by Dr. Brandon Yarns found that EAET provided significant pain relief compared to traditional cognitive behavioral therapy among older adults.
A UCLA Health study found that taking an 8-strain probiotic daily reduces the risk of pouchitis, a common inflammatory condition. However, the treatment's cost-effectiveness depends on the patient's likelihood of flare-ups, with benefits only seen in patients with frequent relapses.
The CA Bridge program successfully implemented opioid use disorder treatment services across over 80% of California's emergency departments, treating 165,000 patients with nearly 45,000 instances of buprenorphine treatment. This initiative demonstrates the potential for emergency departments to serve as critical entry points for addict...
Researchers have developed AlloCAR70-NKT, an innovative cell therapy harnessing the immune system to fight cancer. The therapy demonstrates a multi-pronged attack against kidney cancer, directly killing cells and disrupting the tumor's microenvironment.
A new study led by UCLA researchers found that many patients with advanced cancer feel their treatment does not align with their personal care goals. The study reveals a significant disparity in care preferences between patients with advanced cancer and those with other serious illnesses, suggesting a need for improved communication an...
A new UCLA-led study finds that government housing assistance reduces the risk of medical bill stress by nearly seven percentage points among US renters with cancer, leading to improved quality of life and reduced poor physical and mental health outcomes.
A UCLA study reveals how a region of the medial prefrontal cortex integrates information across the brain to coordinate physiological and behavioral responses. The findings could help develop targeted therapies for stress-related and social dysfunction disorders.
A new study suggests that being overweight (BMI 25–29.9) may actually be protective in the short term after surgery for older adults, with a 0.8% 30-day all-cause mortality rate compared to 18.8% for those with normal BMI.
A new study creates a single-cell map of epigenomic regulation in human fat tissue, revealing how genetic risk factors contribute to abdominal obesity. The research identifies key regulatory regions in fat cells where obesity-linked variants reside, offering new clues to the genetic and epigenetic regulation of body fat.
Researchers found that pembrolizumab shrank or eliminated tumors in nearly 90% of participants with desmoplastic melanoma, a rare and aggressive skin cancer. The therapy offers a less invasive approach compared to surgery or radiation.
A new study from UCLA finds that the definition of Long COVID varies widely across published studies, resulting in dramatically different estimated prevalence rates. The study highlights the need for a standardized definition to advance research and improve patient care.
A novel cancer vaccine has shown encouraging early results in patients with pancreatic and colorectal cancer, two of the most difficult-to-treat malignancies. The vaccine targets KRAS mutations found in about 25% of solid tumors and drives about 90% of pancreatic cancers and 50% of colorectal cancers.
A new study found that nearly nine in ten emergency department patients have not received one or more recommended vaccines. This reveals significant gaps in preventive care among underserved populations, who often rely on emergency departments for healthcare.
A new study from UCLA Health suggests that virtual reality (VR) may offer a promising tool to ease psychological stress and support heart health. After a VR session, many patients experienced a significant impact on their psychological state, with reduced anxiety and increased vagal tone.
Researchers found that automatically mailing a stool-based screening test resulted in the highest screening rates among adults aged 45-49. The study, which included over 20,000 patients, showed that this approach can encourage timely screening and potentially save lives.
Researchers at UCLA have successfully created a continuous supply of functional T cells using genetically engineered stem cells. This breakthrough could lead to longer-lasting protection against cancer and potentially treat other diseases such as HIV or autoimmune disorders.
A UCLA-led study found that while blood-based tests offer a convenient option for screening, only 49% of patients completed a follow-up colonoscopy within six months. The study's findings highlight the need for improved follow-up care to detect and treat colorectal cancer effectively.
Researchers found that billing codes may mistakenly identify diseases in up to 45% of cases, highlighting a significant limitation in using administrative data for clinical research. The study examined records of 1.36 million patients and found discrepancies between coded diagnoses and actual disease presence.
Colorectal cancer claims more lives in Black communities than any other racial group, with incidence and mortality rates about 20% and 30% higher respectively. A new review by UCLA researchers highlights the need for equal access to screening, diagnosis, and treatment to eliminate these disparities.
Research from UCLA Health Sciences found that individuals with substance use disorders are at a higher risk of unplanned hospital readmissions. Specifically, those with opioid use disorder had the highest 30-day readmission rates.
A new study found that older adults with insomnia face triple the risk of developing depressive symptoms compared to sound sleepers. The study suggests that treatments targeted at inflammation-related depression may benefit these patients and improve their overall quality of life.
Researchers found that small group professional coaching reduced physician burnout rates by nearly 30%, with participants experiencing significant improvements in work-life balance, self-efficacy, and social support. In contrast, one-on-one coaching resulted in a 13.5% reduction in burnout rates.
Researchers found Galectin-1, a sugar-binding protein, plays a critical role in helping hepatocellular carcinoma cells resist thermal ablation and thrive after being treated with high heat. Blocking Gal-1 can make thermal ablation more effective and reduce the risk of recurrence.
A new multi-institutional clinical trial will test zipalertinib, an investigational drug targeting specific EGFR mutations in early-stage non-small cell lung cancer. The goal is to prevent recurrence and improve long-term outcomes for patients with limited treatment options.
A new study found that verbal reaction time can detect sleepiness in older adults, a common safety risk. Voice analysis method reliably detected when someone was speaking versus silent with high accuracy.
Researchers identify new group of immune cells driving autoimmune attack on insulin-producing cells in pancreas during cancer immunotherapy. JAK inhibitors, already FDA-approved for psoriasis and arthritis, show potential to prevent and even reverse type 1 diabetes in preclinical models.
Researchers found that rod bipolar cells can form new functional connections with cones when their usual partners stop working in retinitis pigmentosa. This adaptation mechanism could reveal new targets for treatments aimed at preserving vision.
Researchers identified four distinct pathways leading to Alzheimer's disease, revealing how conditions progress step-by-step toward the condition. The study validated findings in a nationally diverse population, suggesting that understanding these pathways could fundamentally change how clinicians approach early detection and prevention.
A groundbreaking study reveals that biological brains and AI systems develop similar neural patterns during social interaction, with synchronized patterns driving social behaviors. The research has significant implications for understanding human social disorders and developing socially-aware AI systems.
Researchers developed an AI model that converts fragmented electronic health records into readable narratives, enabling artificial intelligence to make sense of complex patient histories. The Multimodal Embedding Model for EHR (MEME) transformed tabular health data into 'pseudonotes' that mirror clinical documentation, achieving superi...
A new study found that Black emergency department patients are less likely to be treated with opioids, but when their preferences are not met, they are at a higher risk of misusing opioids three months later. Patients who were satisfied with their pain care had lower rates of opioid misuse.
Researchers at UCLA Health have made a groundbreaking discovery about the mechanisms underlying vascular dementia. They found that targeting inflammation in brain blood vessels can promote brain repair and functional recovery in mice. This breakthrough highlights a potential new treatment approach for this understudied form of dementia.
Eliminating the fee increased overall usage by 7.8 percentage points, particularly benefiting underserved populations, including non-English speakers and those from socioeconomically disadvantaged areas. Despite gains, some disparities persisted, highlighting the need for additional strategies to ensure equitable access.
Home care cooperatives have identified key drivers of improved care quality, including worker input, motivation, selective hiring, and high-quality training. These findings have the potential to significantly improve care quality across the home care sector.
A new analysis of published data finds no association between pre-surgery fasting and post-procedure vomiting, contradicting long-standing recommendations. Research included 801 patients in experimental groups and 990 control group patients, with results showing that aspiration pneumonia is rare.
Researchers at UCLA have discovered a chromatin-based strategy that enables cells to rapidly produce proteins when nutrients are scarce. This 'priming' mechanism, driven by the MYC gene, allows cancer cells to adapt and survive under metabolic stress.