Articles tagged with Systems Biology
A study published in Anesthesiology found that a novel operating room software system improved management of lung ventilation in patients during surgery, but did not affect postoperative outcomes. The system provides a 'live' schematic organ system view and digital alerts to aid physicians in decision-making.
A computer-based language classifier predicted psychosis in at-risk youths with up to 83% accuracy, identifying disturbances in speech flow and tangential thinking as indicative of psychosis. The technology has the potential to improve prediction and prevention of psychosis by targeting cognitive deficits.
The new instrument uses OCT-based technology with an electrically tunable lens to produce higher quality images of the entire eye. This enables whole-eye imaging, improving patient experience and potentially reducing instrument costs.
A new study published in the Journal of General Internal Medicine found that implementing a default option for lower opioid tablet quantities in electronic medical records increased compliance with prescribing guidelines, resulting in fewer prescriptions written for larger quantities.
A new study by Florida Atlantic University found that some nursing homes in California inflate their self-assessment reporting to improve their Medicare star ratings. The researchers identified key predictors of inflating ratings, including financial gain and lack of direct correlation with on-site inspection results.
CONIX Research Center aims to develop novel architectures for large-scale, distributed computing systems with implications for social interaction, smart buildings and infrastructure. The center will create a substrate for networked computing that connects edge devices to the cloud, enabling performance, security, and privacy guarantees.
Researchers developed a soft robot that mimics the stingray's flattened body shape and side fins, enabling the creation of bio-electromechanical systems. The robot features living heart cells, biomaterials, and flexible electrodes, allowing it to 'flap' its fins.
A group of articles highlights the factors threatening job satisfaction and high-quality care delivery among nephrology specialists. Experts propose measures to improve professional lives, including fellowship training reform, practice transformation, and creating a stronger community of nephrologists.
A new ranking system assesses orthopaedic surgery residency programs based on the number of citations in high-quality journals. The study identifies top-ranked programs with over 1,000 research publications and 20,000 citations within a decade.
A new study led by Joy L. Lee found that the clinician-patient relationship has a greater impact on patient satisfaction than technology used for communication. The research also revealed provider concerns about data security and time spent on electronic communication.
A team of researchers has developed a DNA database to match confiscated rhinoceros horns to crime scenes and aid in prosecution. The RhODIS system uses genetic analysis to identify individual rhinos and prevent further poaching.
Researchers found that TRPM4 performs a similar role to TRPM5 in the taste system, enabling the detection of sweet, bitter and umami foods. This discovery challenges existing dogma and has implications for understanding human health and regulating appetite.
A Korean research team developed a world-first multimodal biomicroscopic system to analyze tumor characteristics and improve cancer resection techniques. The system combines optical multispectral imaging, high-frequency ultrasound, and radiation force imaging to detect tumors at high resolution.
A new approach identifies and measures changes in thousands of proteins as Xenopus eggs undergo fertilization, revealing details of protein destruction and release to prevent multiple fertilization. This method enables comprehensive analyses of protein dynamics and sheds light on cellular changes driving disease.
Cornell University engineers have developed a method to gather blood pressure, heart rate, and breath rate using cheap, covert systems of radio-frequency signals and microchip tags. The system integrates near-field coherent sensing, allowing for accurate measurement of internal body movement.
Duke University's Department of Biomedical Engineering faculty members Joseph Izatt, Nimmi Ramanujam and Tuan Vo-Dinh have been elected to the National Academy of Inventors for their work on optical imaging, spectroscopy and photonics-based health technologies. Their research has led to significant advancements in medical diagnostics, ...
Researchers at TGen and Baylor Scott & White Research Institute are developing an early detection system for pancreatic cancer using a non-invasive blood test. The goal is to identify patients before symptoms appear or spread, improving mortality rates.
Researchers at Keck Medicine of USC used a custom recording tool to evaluate surgeon proficiency in robotic-assisted prostate cancer surgery. The 'black box' recorder captured data on time, distance, and camera movements, allowing experts to identify novice and expert surgeons with high accuracy.
Researchers used adaptive optics technology to examine microscopic structures of the eye in living patients, obtaining high-resolution images of damaged photoreceptors. This study may lead to a deeper understanding of solar retinopathy and potentially develop new treatments.
A study published in JAMA found that patients treated by substitute doctors had similar death rates as those treated by regular hospital staff. However, hospitals that used substitute physicians less often had poorer patient mortality outcomes, possibly due to geographic remoteness or limited financial resources.
A Northwestern University team creates quantum entanglement from a biological system using green fluorescent proteins. This finding advances scientists' understanding of biology and opens doors to exploit quantum mechanics for new applications.
A new study found that even large physician practices struggle with the new payment system, and those that don't report data face significant financial penalties. The researchers suggest improving infrastructure to support smaller practices and reducing the burden on reporting performance data.
A study found that younger ophthalmologists were more likely to be associated with patient complaints compared to their older colleagues. The Vanderbilt University Medical Center's Patient Advocacy Reporting System was used to analyze patient complaints between 2002 and 2015.
Researchers at Boston Children's Hospital have developed a soft robotic system that can provide isolated support to the right or left ventricle, addressing one-sided heart failure. The system combines rigid bracing with soft robotic actuators to help diseased heart chambers pump blood effectively.
A pilot study of 15 individuals using oxycodone digital pills found that patients self-administered opioids for only a brief period and took a fraction of the prescribed dose. The technology may enable physicians to monitor adherence and identify escalating opioid use patterns, potentially reducing the risk of addiction.
The University of Liverpool's Ultra-Sensitive Optical Coherence Tomography (Ultra-OCT) system is developing a state-of-the-art imaging technology to revolutionise the detection, diagnosis, and management of corneal eye conditions. The system boasts a resolution of 2 micrometres and can scan 1,000 times faster than existing OCT machines.
A new study finds that a simple tool, Fuster-BEWAT score, can predict cardiovascular risk in healthy individuals using five health indicators: blood pressure, physical activity, body-mass index, fruit and vegetable intake, and smoking status. The Fuster-BEWAT score is as effective as the American Heart Association-recommended ICHS index.
Researchers at Hong Kong Baptist University have developed a novel targeted delivery system for CRISPR/Cas9 to achieve therapeutic genome editing of VEGFA in osteosarcoma. The aptamer-functionalised lipopolymer delivery system successfully delivered CRISPR/Cas9 to tumor cells, inhibiting malignancy and angiogenesis.
The study highlights four reasons for the failure of ACOs to achieve savings: economic barriers such as weak incentives and lack of patients, and organizational challenges like knowledge development needs and complexity. The authors recommend a flexible approach to motivating providers.
PROMIS is a patient-reported outcomes measurement system that evaluates physical, psychological, and social well-being to provide information on the subjective patient experience. Lupus patients endorse PROMIS assessments as reflecting their experience with lupus, highlighting its potential utility in validating symptoms, tracking dise...
A new computer program has been developed to help doctors detect acute kidney injury earlier, reducing its severity and improving survival rates. The program, which was tested in over half a million patients, showed a significant reduction in hospital mortality, length of stay, and dialysis rates.
A new study has found that a pioneering heart valve repair device is safe and effective, reducing the need for open-heart procedures and resulting in improved quality and frequency of repairs. The Harpoon Mitral Valve Repair System repaired the heart while it continued to beat, with no deaths or major complications.
Researchers developed a risk assessment system, HANDOC, to identify patients with streptococcal bacteria who need echocardiography for potential heart valve infection. The system showed good reliability in distinguishing high and low-risk patients.
The Choosing Wisely movement has successfully started conversations about low-value care, but its impact is limited by the difficulty in changing doctor behavior. Researchers recommend prioritizing recommendations, consolidating guidelines, and evaluating efforts to make a greater difference in quality and value in healthcare.
The study advocates for a holistic approach to understanding concussion, analyzing complex problems as whole systems and integrating research findings. Researchers hope this new method will lead to better diagnosis, evaluation, and treatment of TBI.
A new imaging system, cryo-MOST, has been developed to monitor brain changes indicative of Alzheimer's disease in mouse models. The system uses autofluorescence to image senile plaques with micron-level resolution, improving the understanding of disease progression and facilitating the development of new treatments.
A team of researchers developed a system that displays tongue movements in real time, using machine learning algorithms to control an articulatory talking head. This 'visual biofeedback' system can help patients with articulation disorders correct pronunciation problems faster.
Researchers created micro hearts, lungs, and livers that can mimic human organ responses to medications. The 'body-on-a-chip' system aims to improve drug development by identifying toxic side effects early on.
A new web-based program called RoboLog has been developed to improve the reporting of robotic surgeries performed by surgeons in training. The system provides detailed information about a resident's involvement in robotic surgeries, allowing for more accurate assessment of their competency and earlier identification of deficits.
Researchers at ETH Zurich developed a new technique using magnetic resonance imaging to study granular systems, enabling real-time imaging and measurement of particle velocities. This breakthrough has potential applications in fields such as carbon capture and could lead to higher efficiency and energy savings.
A new analysis finds that victims of gunshots and stabbings are less likely to die if transported to a trauma center by private vehicle rather than ground emergency medical services. Penetrating injuries such as knife and gun wounds showed a significant reduction in mortality rates when transported privately.
Researchers at St. Jude Children's Research Hospital found that hundreds of precursor cells, not just a handful, are involved in establishing the blood system before birth. This discovery has clinical implications, as understanding how the blood system emerges can help unravel the origins of disease and identify susceptible cells.
A study by Nemours Children's Health System found that telemedicine visits for sports medicine appointments saved patients and families an average of $50 in travel costs and 51 minutes in waiting time. Each telemedicine visit also reduced the health system's costs by $24 per patient.
Researchers aim to restore walking ability and sensation in individuals with spinal cord injuries using an implantable brain-computer interface. The technology has potential applications beyond spinal cord injuries, including stroke and traumatic brain injury recovery.
Primary care physicians spend an average of 355 minutes (5.9 hours) per day in the EHR, including 269 minutes during clinic hours and 86 minutes after hours. This excessive time spent on clerical tasks can lead to burnout and decreased productivity. The study suggests that solutions like proactive planned care, team-based care, and sha...
Researchers have developed a new technique to visualize the human cardiac conduction system in 3D, providing unprecedented details. This technology will aid cardiologists in placing prosthetic valves near the heart's conduction system, reducing risks and improving surgical outcomes for patients with congenital heart diseases.
A new blood management program at Johns Hopkins Health System has reduced unnecessary blood transfusions and saved the system over $2 million annually. The program, launched in 2012, included education and feedback to promote best practices and guideline compliance, resulting in significant cost savings.
The current approach to quality measurement in healthcare is characterized by inefficiency and imbalance, with measures that are duplicative, overlapping, or overrepresent certain areas of care. A lack of consideration for the cost of each measure hinders the ability to assess its value.
Research at Mount Sinai Hospital identified two distinct brain areas involved in decision-making: the orbital frontal cortex (OFC) and ventrolateral prefrontal cortex (VLPFC). Monkeys with OFC lesions lost ability to track reward probability, while those with VLPFC lesions showed preference for M&Ms.
Researchers used a molecular adsorbent recirculating system (MARS) to provide time for healing or transplant in patients with severe acute liver failure. The study found improved survival rates and recovery of liver function in patients who received MARS therapy.
The UMass Amherst researcher will lead a multi-university project to design artificial autonomous systems with potential applications in personalized medicine and other areas. The goal is to mimic nature's mechanisms for autonomous responses, enabling new innovations and capabilities.
Researchers developed a machine-learning approach called ICU Intervene that takes large amounts of ICU data to determine treatments for different symptoms. The system uses deep learning to make real-time predictions, learning from past cases to suggest critical care interventions.
A study by researchers at Mount Sinai identified a brain mechanism that makes siblings of bipolar patients resilient to the disease. The brain can adapt to its biological risk, opening new avenues for research on enhancing resilience.
Temple University Hospital is introducing an endoscopic keyhole craniotomy approach for treating tegmen dehiscence and temporal encephalocele, two rare conditions affecting the skull. This innovative method reduces skin incision size, retraction on the temporal lobe, and risk of brain injury.
A randomized, controlled clinical trial found that an online team-based game improved glucose control in veteran patients with type 2 diabetes. Participants who played the game had significant reductions in hemoglobin A1c levels, with those having severe diabetes experiencing the greatest improvement.
Researchers developed a noninvasive ICP monitoring device using advanced signal analysis algorithms. The study showed strong association between noninvasive and invasive methods, with good correlation between ICP values.
A team of scientists has developed a way to produce 3D data showing the cardiac conduction system, enabling more accurate computer models of the heartbeat. This breakthrough will improve our understanding of troublesome heart rhythms like atrial fibrillation and help surgeons design operations with less risk of damaging precious tissue.
Researchers developed a smartphone-based biofeedback rehabilitation system to guide patients through balance exercises, showing noticeable improvements in postural stability and reducing the risk of falls. The custom wearable belt uses vibrating actuators to provide personalized guidance, mapped in real-time on a smartphone application.
The MIT Hacking Medicine model emphasizes collaboration, design thinking, and user feedback to address healthcare issues. The program has launched numerous successful ventures and raised over $100 million in venture funding.
A new classification system, AIR score, based on patient symptoms and lab tests reduces diagnostic imaging, hospital admissions, and surgery needs. The system was tested in a study of 1068 patients with suspected appendicitis, resulting in improved care outcomes.