Articles tagged with Systems Biology
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A group of articles highlights the factors threatening job satisfaction and high-quality care delivery among nephrology specialists. Experts propose measures to improve professional lives, including fellowship training reform, practice transformation, and creating a stronger community of nephrologists.
A new ranking system assesses orthopaedic surgery residency programs based on the number of citations in high-quality journals. The study identifies top-ranked programs with over 1,000 research publications and 20,000 citations within a decade.
A new study led by Joy L. Lee found that the clinician-patient relationship has a greater impact on patient satisfaction than technology used for communication. The research also revealed provider concerns about data security and time spent on electronic communication.
Researchers found that TRPM4 performs a similar role to TRPM5 in the taste system, enabling the detection of sweet, bitter and umami foods. This discovery challenges existing dogma and has implications for understanding human health and regulating appetite.
A team of researchers has developed a DNA database to match confiscated rhinoceros horns to crime scenes and aid in prosecution. The RhODIS system uses genetic analysis to identify individual rhinos and prevent further poaching.
A Korean research team developed a world-first multimodal biomicroscopic system to analyze tumor characteristics and improve cancer resection techniques. The system combines optical multispectral imaging, high-frequency ultrasound, and radiation force imaging to detect tumors at high resolution.
A new approach identifies and measures changes in thousands of proteins as Xenopus eggs undergo fertilization, revealing details of protein destruction and release to prevent multiple fertilization. This method enables comprehensive analyses of protein dynamics and sheds light on cellular changes driving disease.
Cornell University engineers have developed a method to gather blood pressure, heart rate, and breath rate using cheap, covert systems of radio-frequency signals and microchip tags. The system integrates near-field coherent sensing, allowing for accurate measurement of internal body movement.
Duke University's Department of Biomedical Engineering faculty members Joseph Izatt, Nimmi Ramanujam and Tuan Vo-Dinh have been elected to the National Academy of Inventors for their work on optical imaging, spectroscopy and photonics-based health technologies. Their research has led to significant advancements in medical diagnostics, ...
Researchers at Keck Medicine of USC used a custom recording tool to evaluate surgeon proficiency in robotic-assisted prostate cancer surgery. The 'black box' recorder captured data on time, distance, and camera movements, allowing experts to identify novice and expert surgeons with high accuracy.
Researchers at TGen and Baylor Scott & White Research Institute are developing an early detection system for pancreatic cancer using a non-invasive blood test. The goal is to identify patients before symptoms appear or spread, improving mortality rates.
Researchers used adaptive optics technology to examine microscopic structures of the eye in living patients, obtaining high-resolution images of damaged photoreceptors. This study may lead to a deeper understanding of solar retinopathy and potentially develop new treatments.
A Northwestern University team creates quantum entanglement from a biological system using green fluorescent proteins. This finding advances scientists' understanding of biology and opens doors to exploit quantum mechanics for new applications.
A study published in JAMA found that patients treated by substitute doctors had similar death rates as those treated by regular hospital staff. However, hospitals that used substitute physicians less often had poorer patient mortality outcomes, possibly due to geographic remoteness or limited financial resources.
A new study found that even large physician practices struggle with the new payment system, and those that don't report data face significant financial penalties. The researchers suggest improving infrastructure to support smaller practices and reducing the burden on reporting performance data.
A study found that younger ophthalmologists were more likely to be associated with patient complaints compared to their older colleagues. The Vanderbilt University Medical Center's Patient Advocacy Reporting System was used to analyze patient complaints between 2002 and 2015.
Researchers at Boston Children's Hospital have developed a soft robotic system that can provide isolated support to the right or left ventricle, addressing one-sided heart failure. The system combines rigid bracing with soft robotic actuators to help diseased heart chambers pump blood effectively.
A pilot study of 15 individuals using oxycodone digital pills found that patients self-administered opioids for only a brief period and took a fraction of the prescribed dose. The technology may enable physicians to monitor adherence and identify escalating opioid use patterns, potentially reducing the risk of addiction.
The University of Liverpool's Ultra-Sensitive Optical Coherence Tomography (Ultra-OCT) system is developing a state-of-the-art imaging technology to revolutionise the detection, diagnosis, and management of corneal eye conditions. The system boasts a resolution of 2 micrometres and can scan 1,000 times faster than existing OCT machines.
A new study finds that a simple tool, Fuster-BEWAT score, can predict cardiovascular risk in healthy individuals using five health indicators: blood pressure, physical activity, body-mass index, fruit and vegetable intake, and smoking status. The Fuster-BEWAT score is as effective as the American Heart Association-recommended ICHS index.
Researchers at Hong Kong Baptist University have developed a novel targeted delivery system for CRISPR/Cas9 to achieve therapeutic genome editing of VEGFA in osteosarcoma. The aptamer-functionalised lipopolymer delivery system successfully delivered CRISPR/Cas9 to tumor cells, inhibiting malignancy and angiogenesis.
The study highlights four reasons for the failure of ACOs to achieve savings: economic barriers such as weak incentives and lack of patients, and organizational challenges like knowledge development needs and complexity. The authors recommend a flexible approach to motivating providers.
PROMIS is a patient-reported outcomes measurement system that evaluates physical, psychological, and social well-being to provide information on the subjective patient experience. Lupus patients endorse PROMIS assessments as reflecting their experience with lupus, highlighting its potential utility in validating symptoms, tracking dise...
A new computer program has been developed to help doctors detect acute kidney injury earlier, reducing its severity and improving survival rates. The program, which was tested in over half a million patients, showed a significant reduction in hospital mortality, length of stay, and dialysis rates.
A new study has found that a pioneering heart valve repair device is safe and effective, reducing the need for open-heart procedures and resulting in improved quality and frequency of repairs. The Harpoon Mitral Valve Repair System repaired the heart while it continued to beat, with no deaths or major complications.
Researchers developed a risk assessment system, HANDOC, to identify patients with streptococcal bacteria who need echocardiography for potential heart valve infection. The system showed good reliability in distinguishing high and low-risk patients.
The Choosing Wisely movement has successfully started conversations about low-value care, but its impact is limited by the difficulty in changing doctor behavior. Researchers recommend prioritizing recommendations, consolidating guidelines, and evaluating efforts to make a greater difference in quality and value in healthcare.
The study advocates for a holistic approach to understanding concussion, analyzing complex problems as whole systems and integrating research findings. Researchers hope this new method will lead to better diagnosis, evaluation, and treatment of TBI.
A new imaging system, cryo-MOST, has been developed to monitor brain changes indicative of Alzheimer's disease in mouse models. The system uses autofluorescence to image senile plaques with micron-level resolution, improving the understanding of disease progression and facilitating the development of new treatments.
A team of researchers developed a system that displays tongue movements in real time, using machine learning algorithms to control an articulatory talking head. This 'visual biofeedback' system can help patients with articulation disorders correct pronunciation problems faster.
Researchers created micro hearts, lungs, and livers that can mimic human organ responses to medications. The 'body-on-a-chip' system aims to improve drug development by identifying toxic side effects early on.
A new web-based program called RoboLog has been developed to improve the reporting of robotic surgeries performed by surgeons in training. The system provides detailed information about a resident's involvement in robotic surgeries, allowing for more accurate assessment of their competency and earlier identification of deficits.
Researchers at ETH Zurich developed a new technique using magnetic resonance imaging to study granular systems, enabling real-time imaging and measurement of particle velocities. This breakthrough has potential applications in fields such as carbon capture and could lead to higher efficiency and energy savings.
A new analysis finds that victims of gunshots and stabbings are less likely to die if transported to a trauma center by private vehicle rather than ground emergency medical services. Penetrating injuries such as knife and gun wounds showed a significant reduction in mortality rates when transported privately.
Researchers at St. Jude Children's Research Hospital found that hundreds of precursor cells, not just a handful, are involved in establishing the blood system before birth. This discovery has clinical implications, as understanding how the blood system emerges can help unravel the origins of disease and identify susceptible cells.
A study by Nemours Children's Health System found that telemedicine visits for sports medicine appointments saved patients and families an average of $50 in travel costs and 51 minutes in waiting time. Each telemedicine visit also reduced the health system's costs by $24 per patient.
Researchers aim to restore walking ability and sensation in individuals with spinal cord injuries using an implantable brain-computer interface. The technology has potential applications beyond spinal cord injuries, including stroke and traumatic brain injury recovery.
Primary care physicians spend an average of 355 minutes (5.9 hours) per day in the EHR, including 269 minutes during clinic hours and 86 minutes after hours. This excessive time spent on clerical tasks can lead to burnout and decreased productivity. The study suggests that solutions like proactive planned care, team-based care, and sha...
Researchers have developed a new technique to visualize the human cardiac conduction system in 3D, providing unprecedented details. This technology will aid cardiologists in placing prosthetic valves near the heart's conduction system, reducing risks and improving surgical outcomes for patients with congenital heart diseases.
A new blood management program at Johns Hopkins Health System has reduced unnecessary blood transfusions and saved the system over $2 million annually. The program, launched in 2012, included education and feedback to promote best practices and guideline compliance, resulting in significant cost savings.
The current approach to quality measurement in healthcare is characterized by inefficiency and imbalance, with measures that are duplicative, overlapping, or overrepresent certain areas of care. A lack of consideration for the cost of each measure hinders the ability to assess its value.
Research at Mount Sinai Hospital identified two distinct brain areas involved in decision-making: the orbital frontal cortex (OFC) and ventrolateral prefrontal cortex (VLPFC). Monkeys with OFC lesions lost ability to track reward probability, while those with VLPFC lesions showed preference for M&Ms.
Researchers used a molecular adsorbent recirculating system (MARS) to provide time for healing or transplant in patients with severe acute liver failure. The study found improved survival rates and recovery of liver function in patients who received MARS therapy.
The UMass Amherst researcher will lead a multi-university project to design artificial autonomous systems with potential applications in personalized medicine and other areas. The goal is to mimic nature's mechanisms for autonomous responses, enabling new innovations and capabilities.
Researchers developed a machine-learning approach called ICU Intervene that takes large amounts of ICU data to determine treatments for different symptoms. The system uses deep learning to make real-time predictions, learning from past cases to suggest critical care interventions.
A study by researchers at Mount Sinai identified a brain mechanism that makes siblings of bipolar patients resilient to the disease. The brain can adapt to its biological risk, opening new avenues for research on enhancing resilience.
Temple University Hospital is introducing an endoscopic keyhole craniotomy approach for treating tegmen dehiscence and temporal encephalocele, two rare conditions affecting the skull. This innovative method reduces skin incision size, retraction on the temporal lobe, and risk of brain injury.
Researchers developed a noninvasive ICP monitoring device using advanced signal analysis algorithms. The study showed strong association between noninvasive and invasive methods, with good correlation between ICP values.
A randomized, controlled clinical trial found that an online team-based game improved glucose control in veteran patients with type 2 diabetes. Participants who played the game had significant reductions in hemoglobin A1c levels, with those having severe diabetes experiencing the greatest improvement.
A team of scientists has developed a way to produce 3D data showing the cardiac conduction system, enabling more accurate computer models of the heartbeat. This breakthrough will improve our understanding of troublesome heart rhythms like atrial fibrillation and help surgeons design operations with less risk of damaging precious tissue.
Researchers developed a smartphone-based biofeedback rehabilitation system to guide patients through balance exercises, showing noticeable improvements in postural stability and reducing the risk of falls. The custom wearable belt uses vibrating actuators to provide personalized guidance, mapped in real-time on a smartphone application.
The MIT Hacking Medicine model emphasizes collaboration, design thinking, and user feedback to address healthcare issues. The program has launched numerous successful ventures and raised over $100 million in venture funding.
A new classification system, AIR score, based on patient symptoms and lab tests reduces diagnostic imaging, hospital admissions, and surgery needs. The system was tested in a study of 1068 patients with suspected appendicitis, resulting in improved care outcomes.
Researchers at Rice University and the University of Houston are developing mathematical models to understand how cells in large colonies of bacteria communicate with each other. Their goal is to design colonies that can perform computations and make sophisticated decisions, mimicking the ability of tissues to maintain homeostasis.
A new technology developed at Purdue University can monitor patients more effectively during MRI scans by recording electro-physiological signals, reducing health risks. The smart device aims to provide better imaging quality and improve the safety of medical diagnostics for diseases such as epilepsy and Parkinson's.
UNC Health Care was honored as a national leader in health IT by the American Hospital Association (AHA) for leveraging technology to enhance patient care. The system has fully integrated its electronic health record (EHR) across all hospital entities and outpatient clinics.
A study applying machine learning techniques to the Look AHEAD Trial data found that 85% of participants experienced a clinically meaningful reduction in cardiovascular mortality and morbidity through intensive weight loss intervention. However, 15% of subjects had an increased risk of cardiovascular events due to weight loss.
A new study found that dying adults in the US receive almost twice as much caregiving support per week compared to those not at the end of life. Unpaid family caregivers, particularly spouses, report high levels of physical difficulty and time constraints.
A proposed solution to disrupt healthcare disruptions is the creation of a chief primary care medical officer. This position would lead hospital efforts to create systems ensuring a complete primary care continuum, even for complex patients, resulting in improved value, reduced costs, and better health outcomes.
The study found that men have a higher plaque burden than women, and that it increases with age. The 3D vascular ultrasound technique has the potential to become a key screening tool for identifying at-risk individuals.