Articles tagged with Cancer Treatments
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Researchers have developed a novel computational approach to design protein-peptide ligand binding complexes that can trigger complex cellular responses. The new biosensors can sense flexible compounds and provide optimal sensing of molecular signals, potentially leading to improved therapeutic applications.
A new CAR T cell design approach using machine learning and artificial intelligence is being developed to improve cancer treatment. The project aims to create a hybrid knowledge- and data-driven approach to guide the design of immunotherapeutic cells.
Researchers discovered that MSH2-MSH3 plays a crucial role in selecting the right DNA repair process by interacting with other proteins during DSB repair. This interaction facilitates error-free homologous recombination and blocks error-prone polymerase theta-mediated end-joining.
Increased expression of Musashi 1 on breast cancer cells has significant implications for understanding dormancy and survival in bone marrow. Msi 1 knockdown led to a reduction in cancer stem cells with undetectable PD-L1, suggesting a potential therapeutic target.
Researchers used cancer proteomics data to identify gene candidates for therapeutic targeting, focusing on protein kinases in uterine endometrial cancer cells. Public molecular resources and multi-omics data analysis can prioritize genes of interest for future studies.
The gene LRRC4 regulates synapse formation, stability and excitatory transmission, playing a crucial role in learning, memory formation and storage. It also has key implications in neuronal disorders and aggressive brain and spinal cord cancer.
The new Winship Cancer Institute at Emory Midtown offers a unique patient-centered, multidisciplinary cancer care model integrated with innovative research. The $200 million gift from the Robert W. Woodruff Foundation enabled the construction of a state-of-the-art facility featuring five 'care communities' and 80 inpatient beds.
The LY6 gene family has been found to be overexpressed in uterine corpus endometrial carcinoma (UCEC), leading to poor patient survival. Several LY6 genes have been identified as potential tumor-associated antigens and biomarkers for UCEC detection and prognosis.
A large-scale study of patient experiences with telemedicine and in-person visits found that telemedicine consistently outperformed in-person visits in terms of access to care and provider engagement. The study analyzed survey responses from over 39,000 patients across more than 50,000 visits.
Quitting smoking early after a lung cancer diagnosis was associated with lower mortality rates. Detailed smoking history collection can improve lung cancer prognosis and treatment selection. The study's findings suggest that smoking cessation timing may impact overall survival, particularly at different clinical stages.
Researchers review current treatment updates for systemic light chain (AL) amyloidosis, highlighting the need for early diagnosis and effective maintenance therapy. The article discusses the relationship between AL amyloidosis and monoclonal gammopathy of undetermined significance (MGUS), emphasizing the importance of regular monitoring.
A new study suggests combining digital cancer risk assessment with point-of-care genetic testing can help overcome clinical workflow challenges that prevent at-risk patients from accessing genetic testing. The approach more than doubled the average uptake of genetic testing, showing promise for cancer prevention and detection.
Researchers identified three novel dual-purpose therapeutic targets using PandaOmics, which could treat both aging and glioblastoma multiforme. The target hypotheses include cyclic nucleotide gated channel subunit alpha 3 (CNGA3), glutamate dehydrogenase 1 (GLUD1) and sirtuin 1 (SIRT1).
New Finnish studies show that short bouts of light or moderate exercise can increase the number of immune cells capable of destroying cancer cells in cancer patients. The exercises were enough as short as 10 minutes to boost the immune system, with a positive impact on quality of life and prognosis.
Researchers developed glass filters to capture tumor cells from blood samples, enabling more efficient culture of these cells. The optimized filter design enhances the accuracy of cancer detection, allowing for earlier treatment and improved patient health.
Researchers have identified ATAD3A as a molecular determinant that favors the development of head and neck cancer. The protein is involved in various cellular processes, including energy metabolism and apoptosis. Targeting ATAD3A could offer a novel approach to developing effective anti-cancer therapeutics.
Researchers investigated the roles of STAT3α and STAT3β in aggressive breast cancer and found that differential silencing of these isoforms leads to changes in STAT3 activation. This study emphasizes the importance of distinguishing between STAT3 isoforms for accurate cancer diagnosis and therapy.
An international study of 1,044 patients with head and neck squamous cell carcinoma found that combining radiotherapy with chemotherapy significantly improves survival rates compared to radiotherapy alone. The benefit was particularly notable in patients between 65-79 years old with good general health.
Researchers have designed a new nanoparticle sensor that can detect cancer with a simple urine test. The sensors use DNA barcodes to analyze urine samples, which can reveal distinguishing features of a particular patient's tumor.
The study found that the global prevalence of H. pylori infection declined from 58.2% in 1980-1990 to 43.1% in 2011-2022, with a decline of about 0.39-0.83% per year. Despite this decline, over 40% of the adult population still carries the infection, posing a significant burden on healthcare systems worldwide.
A new PSMA PET scoring system, the tumor-to-salivary gland ratio (PSG score), can predict patient response to <sup> 177 </sup> Lu-PSMA therapy. Patients with high PSG scores had longer PSA progression-free survival and overall survival rates.
A multicenter study found stereotactic radiosurgery to be highly effective in controlling vestibular schwannoma growth in NF2 patients while maintaining serviceable hearing. The procedure was also shown not to cause radiation-related tumor development or malignant transformation, addressing long-standing concerns.
A new genomic catalogue of malignant peripheral nerve tumour-derived lines has challenged current diagnostic criteria, revealing misdiagnosed cell lines and a shared cell line masquerading as different types. The catalogue provides new information to develop precision therapies for these tumours.
The NCCN 2023 Annual Conference emphasized the importance of fostering welcoming environments for patients and staff, ensuring care meets latest standards, and rejecting a one-size-fits-all approach. Key findings included the need to address systemic bias, social determinants of health, and staffing issues in cancer care.
A new study found that financial toxicity of cancer impacts partners' health-related quality of life, causing anxiety, depression, fatigue, and sleep disturbances. Younger partners were more likely to report financial burden and debt.
A study led by Tokyo University of Science researchers identified Dectin-1's role in promoting colorectal cancer by enhancing PGE2 production and suppressing IL-22BP expression. The study used mouse models and clinical samples to validate the findings, which have immediate clinical implications for CRC patients.
The ACC Cardio-oncology Course aims to equip clinicians with the latest strategies and best practices for managing cardiovascular health in cancer patients. The course will feature joint presentations of oncologists and cardiologists, showcasing real-life patient care and collaboration across teams.
Research discovers how cancer cells evade immune system detection and metastasize in the body. Pre-metastatic cells and exhausted CD8+ cells are identified as key players in this process. The study explores ways to target these pathways and activate immune responses to block metastasis.
Researchers at Trinity College Dublin have discovered a new process that explains why cells have unique identities. By studying Polycomb protein complexes, the team found that different forms of these proteins recruit distinct complexes to DNA, shedding light on cellular identity and its potential impact on cancer treatments.
Researchers propose a new method of clustering colorectal cancer patients using differential presence of exons (DPE) sequencing, which can provide valuable information on CRC progression and response to therapy. This analysis may also reduce costs and time required for staging CRC patients.
A blood draw can provide valuable information on the effectiveness of peptide receptor radionuclide therapy for neuroendocrine cancer patients. Blood-based biomarkers PPQ and NETest were found to predict PRRT response with 96% and 90% accuracy, respectively. The study opens possibilities for tailoring treatment to individual patients.
Adult survivors of childhood cancer have a four times higher risk of late mortality compared to the general population. Maintaining a healthy lifestyle can reduce this risk by 20%, according to a new study published in The Lancet.
Researchers at Indiana University School of Medicine investigated the protein BVES and its crucial role in muscular dystrophy. They discovered that inhibiting proteasome degradation with Bortezomib can alleviate symptoms of BVES-deficient muscular dystrophy.
The study found that Ponatinib inhibits Src-mediated ESCC malignancy with no toxic effect on normal cells. Src interacts with Fyn or Lyn to form heterodimers, which play a key role in ESCC development. Overactivation of specific tyrosine residues can be used as biomarkers for ESCC prognosis.
A new fluorescent probe, TiY, has been developed to selectively target and kill cancer stem cells, which are responsible for tumor growth. The probe can be used to simultaneously diagnose and treat cancer, offering a promising approach to improving cancer treatment outcomes.
Research suggests that high doses of sucralose can lower activation of T-cells, an important component of the immune system, in mice. This finding could lead to a new way of using sucralose therapeutically to help dampen T-cell responses in patients with autoimmune diseases.
Researchers at Nagoya University found that localized IDH wild-type histologically diffuse astrocytomas have a poor prognosis similar to the most malignant types of brain and spinal cord tumors. This highlights the importance of proper clinical diagnosis and treatment for patients with gliomas.
Researchers discover ZBTB12, a molecular barrier that prevents dedifferentiation in human pluripotent stem cells, and shed light on the core differentiation mechanism.
Researchers found significant decreases in the levels of KRAS, RHOA, RAC1, and CDC42 after PCAI treatment, implicating their role in cancer progression and metastasis. These findings support the potential of PCAIs as potent agents for developing new anticancer therapeutics.
Researchers have developed a novel probe, CDg18, to selectively dye M2 macrophages, which are associated with cancer progression. This breakthrough enables real-time monitoring of macrophage reprogramming in cancerous tissues, holding promise for new cancer treatments.
A new technique combines machine learning with short-wave infrared fluorescence imaging to detect precise tumor boundaries with higher accuracy than traditional methods. The approach achieved a remarkable per-pixel classification accuracy of 97.5 percent and demonstrated robustness against changes in imaging conditions.
Researchers have found that valosin-containing protein (VCP) is essential for KRAS-mutant pancreatic ductal adenocarcinoma cell growth and survival. Inhibiting VCP, combined with autophagy inhibition, enhances efficacy in preclinical studies.
Researchers at the University of Wisconsin-Madison have identified a specific cell population, called CD4/CD8 double positive T cells, that causes graft-versus-host disease in bone marrow transplants. The team's findings may lead to targeted treatments and improved patient outcomes.
A new study reveals limited supportive care for pregnant women with cancer, who often delay medical help due to natural changes in their body. The research emphasizes the need for emotional support and educational programs to address psychosocial issues and long-term negative impacts.
African American cancer survivors who experienced high levels of discrimination showed greater signs of aging and frailty than those with lower levels. The study found that major discrimination increased rates of aging, leading to a greater risk of frailty.
Researchers develop unsupervised machine learning algorithm to classify osteosarcoma at diagnosis based on gene expression modules. This approach enables personalized treatment strategies for osteosarcoma patients.
Georgia Institute of Technology researchers have developed a new treatment for lymphedema using nanoparticles that can repair lymphatic vessel pumping. The approach delivers a drug to help lymphatic vessels pump, targeting the problem rather than regrowing new vessels.
Researchers have developed a new technique that combines real-time images with short-wave infrared light to differentiate between cancerous tumours and healthy tissue. This innovation has the potential to improve treatment outcomes for neuroblastoma patients by allowing surgeons to remove cancerous cells more precisely.
Researchers have designed a new RNA sensor that can selectively activate synthetic genes in specific cells, opening up possibilities for targeted therapies for cancer and other diseases. The system uses an enzyme that naturally exists in most animal cells to detect and repair mismatches in double-stranded RNA.
Researchers found encouraging responses with revumenib for advanced acute leukemias with KMT2A rearrangements or NPM1 mutations. The overall response rate was 53%, with 78% of patients achieving clearance of measurable residual disease.
Researchers from China conducted a comprehensive review of dual therapy (DT) for H. pylori eradication, highlighting its high efficacy and patient compliance with minimal adverse events. High-dose DT administered over 14 days has emerged as the most effective treatment option.
A systematic review of 33 randomized controlled trials found that yoga improved gait speed and lower extremity strength in inactive older people. However, it did not offer a benefit for frailty markers compared to exercise or tai chi.
Researchers from Swansea University and Université Grenoble Alpes demonstrate the effectiveness of selenium nanoparticles in killing ovarian cancer cell models. The study reveals a novel biological mechanism underlying the anti-cancer effect, involving histone methylatransferases and epigenetic processes.
The March issue of CHEST journal features 44 articles on topics such as asthma, critical care, and sleep medicine. The journal also includes complementary web resources, including visual abstracts.
Researchers at City University of Hong Kong identified lysyl hydroxylase 1 (LH1) as a key factor in promoting confined migration of liver and pancreatic cancer cells. The study found that LH1 promotes metastasis by stabilizing Septin2, which enhances the actin network.
Researchers have identified a new method to predict which sarcoma patients will benefit from a potential new treatment. By inhibiting the plk1 gene, they were able to target and slow down the growth of sarcoma cells. This breakthrough could lead to improved treatment options for sickest sarcoma patients in 5-10 years.
A team of researchers has discovered a potential therapeutic that can synergize with existing drugs to more effectively kill certain leukemia cells. The therapy targets a DNA repair protein and shows promise in clinical trials.
Researchers found that Fumarate Hydratase is repressed in macrophages, leading to the release of cytokines and worsening inflammation. Restoring or targeting this enzyme could lead to new anti-inflammatory therapies for diseases like Lupus and sepsis.
Researchers have identified mitochondrial signaling pathways as critical organelles that promote tumorigenesis and metastasis. In particular, the integrated stress response is found to engage with mitochondria to drive tumor growth, highlighting a new paradigm for understanding aggressive prostate cancer progression.
Researchers developed AI models based on UNet and MobileNet architectures to analyze standardized abnormalities in CT images, accurately identifying object presence and confidence. These models achieved an absolute percentage error of less than 5 percent, comparable to human professionals.