Research on the trials that test new treatments in patients. Covers trial design, respiratory and cancer trials, screening tools, and treatment breakthroughs.
The company has secured $5 million in funding to support Phase 1 and pivotal trials for its therapies aimed at addressing opioid-induced respiratory depression and improving anesthesia recovery. This financing marks a transformative moment for OYE Therapeutics, positioning the company to enter clinical development with confidence.
A new treatment called MA-5 has been developed to target mitochondrial diseases, a rare and intractable condition with severe symptoms like neurological disorders and organ damage. The Phase II clinical trial is expected to slow the progression of the disease and improve hearing loss, a common complication.
A randomized clinical trial shows that semaglutide improves glycemic control and weight outcomes in individuals with schizophrenia. The study suggests using glucagon-like peptide-1 receptor agonists as an early intervention strategy to reduce cardiometabolic risk in this population.
A large clinical trial published in JAMA Surgery shows that prehabilitation can reduce disability after surgery in older adults with frailty, provided they fully participate in the program. Participants who completed at least 75% of exercises had significantly lower levels of disability after surgery.
Researchers at the University of Iowa Health Care have developed a new class of medication, pegcetacoplan, which directly targets the root cause of C3 glomerulopathy, a rare and severe kidney disease. The treatment has shown significant results, with up to 67% of children achieving complete remission and stabilization of kidney function.
Researchers argue that widely used proxies for aging may conflate genuine modifications with simpler effects on physiology. Targeting specific pathologies can extend lifespan without slowing aging process. Historically, increased human lifespan was primarily driven by reduced infectious disease mortality, not a fundamental slowing of a...
A Cochrane review found no significant effect of calcium supplementation on pre-eclampsia, contradicting long-held assumptions. The review excluded small and unreliable studies that previously suggested benefits of calcium supplementation.
The USC Epstein Family Alzheimer’s Therapeutic Research Institute is leading the charge against Alzheimer’s with advances in blood tests and treatments. Researchers aim to develop effective preventive therapies within the next decade.
A monthly injection has helped 90% of severe asthma patients reduce their reliance on daily steroid tablets. Treatment with tezepelumab improved asthma symptoms, lung function, and overall quality of life, with two-thirds of patients experiencing no asthma attacks.
The SISAQOL-IMI consortium has published key guidelines for patient-reported outcomes in cancer clinical trials, providing a harmonised framework for designing, analysing, and interpreting PRO data. The new online toolkit offers practical resources to support implementation across the research and policy landscape.
Withdrawal of tirzepatide after 36-week treatment led to 25% or greater weight regain in most participants within a year, reversing initial cardiometabolic parameter improvements. Continued obesity treatment is crucial for sustained benefits.
Andres M. Álvarez-Pinzón joins NRG Developmental Therapeutics Committee, bringing expertise in oncology clinical trials and translational medicine. Ronald Chen becomes Chair of the NRG Patient Centered Outcomes Research Committee, focusing on improving cancer outcomes through clinical trials and patient-reported outcomes.
A controlled feeding study out of South Dakota State University shows that older adults who reduced ultra-processed foods naturally consumed fewer calories, lost weight and abdominal fat, and showed improvements in insulin sensitivity and inflammation. This study provides evidence that the Dietary Guidelines for Americans can deliver s...
Two new Cochrane reviews show that HPV vaccines are effective in preventing cervical cancer and pre-cancerous changes, especially when given to young people before they are exposed to the virus. Girls vaccinated before the age of 16 were found to be 80% less likely to develop cervical cancer.
Sorfequiline, in combination with pretomanid and linezolid, showed greater activity against TB than the standard of care, indicating potential to shorten treatment time. The regimen had a comparable safety profile to the standard of care for people with drug-sensitive TB.
A systematic review and meta-analysis found that lithium supplementation did not significantly improve cognitive function in individuals with mild cognitive impairment or Alzheimer's disease. Alternative formulations like LIT-O may be a potential alternative to harness lithium's neuroprotective properties more efficiently.
A new study by Marshall University researchers found that patients undergoing knee surgery using a minimally invasive needle arthroscopy technique used significantly fewer opioids after surgery compared to those treated with standard arthroscopy. The smaller-scope approach led to less pain, better early knee function, and lower opioid ...
A nationwide telehealth clinical trial is now open at Ohio State University Wexner Medical Center for adults with advanced or metastatic pancreatic cancer with specific mutations in the fibroblast growth factor receptor (FGFR) gene. The study will test pemigatinib, a smart drug targeting these genetic mutations.
Approximately 1 in 30 clinical trials were disrupted due to grant funding terminations, disproportionately affecting infectious disease and prevention studies. The study emphasizes the need for sustainable financial support to ensure trial operations and participant safety.
Clinical trial participants are calling for more inclusive and patient-centered cancer research, highlighting the need for transparent designs and improved communication. The authors propose various improvements to trial design and delivery, including expanding eligibility criteria and involving patient advocates in trial design.
Researchers used human-induced pluripotent stem cell-derived kidney organoids to model nephronophthisis, revealing the Hippo signaling pathway's role in fibrosis. Inhibiting this pathway with drugs like verteporfin shows promise as a treatment option.
Researchers at UC Riverside and City of Hope have developed a novel Pin1 degrading compound that suppresses pancreatic cancer peritoneal metastases. The treatment targets not only cancer cells but also tumor-supporting cells, potentially overcoming treatment resistance.
A clinical trial has demonstrated that VES001 can restore normal levels of the protein progranulin in individuals with a gene mutation leading to frontotemporal dementia. This breakthrough treatment may prevent dementia in people at genetic risk, offering hope for a novel therapeutic approach.
The Phase 3 study demonstrated the safety and non-inferiority of EuTYPH-C Inj.® Multi-dose compared to a World Health Organization (WHO) prequalified comparator TCV, Typbar TCV®. The vaccine was shown to be well-tolerated across all age groups with no serious adverse events.
A randomized clinical trial found that self-administered hypnosis significantly reduced hot flash scores and daily interference compared to sham hypnosis. The study suggests that hypnosis delivered through audio files is a clinically significant method for reducing hot flashes in postmenopausal women.
The POInT trial reveals promising secondary findings: oral insulin delays clinical type 1 diabetes progression, especially in children with high-risk insulin gene variants. This opens doors to targeted, personalized prevention strategies for a genetically defined subgroup of children.
A culturally tailored community health worker intervention modestly lowered interdialytic weight gain and improved dialysis adherence among Hispanic and Latino patients with hemodialysis-dependent kidney failure. This study suggests that such interventions can enhance patient outcomes for these vulnerable populations.
The Louisiana ECHO program, which focuses on pre-, peri- and postnatal outcomes, obesity, and other areas, will continue its efforts to expand access to clinical trials for Louisiana children. The grant renewal supports the collaboration between researchers from Pennington Biomedical and Ochsner Health System, as well as two free-stand...
The DEFEND study aims to assess whether virtual exercise sessions can be successfully delivered to patients with cancer receiving chemotherapy. Researchers will evaluate the impact on physical function, fatigue, and disability.
The Mount Sinai Tisch Cancer Center has introduced a real-time data integration tool to automate the transfer of clinical data from its electronic health record system into clinical trial platforms. This technology streamlines data flow, reducing manual transcription time by up to 70% and improving data quality and workforce efficiency.
A new study suggests that supplementing with BCAAs alongside an exercise program may help reduce fatigue, improve strength, and ease symptoms of depression for older adults. The research found notable improvements in participants who combined a BCAA supplement with an eight-week exercise program.
The Lundquist Institute has been awarded $9 million by the California Institute for Regenerative Medicine (CIRM) to establish a Community Center of Excellence for Regenerative Medicine. This center will expand access to cutting-edge regenerative therapies and create skilled healthcare professionals in underserved communities.
The study highlights the frequent use of aerosol therapy in critically ill patients with acute respiratory distress syndrome (ARDS), with bronchodilators being the most commonly prescribed drugs. However, the lack of sound scientific evidence and randomized controlled trials suggests that standardized protocols are needed to align clin...
A randomized clinical trial found that an unsupervised online Tai Chi intervention improved knee pain and function compared to the control group at 12 weeks. This free web-based intervention offers a safe, accessible, and scalable option for guideline-recommended osteoarthritis exercise.
A new study may transform the diagnosis of Britain's number one cancer, lung cancer. Researchers are investigating whether low-dose CT scans can detect lung cancers earlier than current chest X-rays. The study aims to identify which patients would benefit from these more accurate scans.
A cohort study found that GLP-1 receptor agonist use was associated with a reduced risk of developing nonexudative AMD, but not progression to exudative AMD in individuals with nonexudative AMD. This study may inform future randomized trials evaluating the ocular effects of GLP-1RAs in nondiabetic populations.
A new Alliance trial is exploring the effectiveness of a combination of targeted therapy and immunotherapy for patients with advanced adrenocortical carcinoma, a rare and aggressive cancer. The study aims to improve disease control and quality of life for patients with limited treatment options.
The termination of thousands of federal grants has raised ethical concerns about clinical trial closures, particularly among children and adolescents. Researchers argue that sudden stops can break trust and harm participants, violating long-standing principles.
Black and Asian patients were underrepresented in clinical trials, leading to worse survival outcomes compared to white counterparts, despite similar progression-free survival rates. Equitable enrollment is crucial for access to cutting-edge treatments and long-term equity in cancer care.
A recent study published in CANCER found that the number and complexity of cancer clinical trials have varied greatly across low- and middle-income countries (LMICs) since 2001. While economic growth has been a contributing factor, it is not the sole determinant of cancer clinical trial growth among LMICs.
A randomized clinical trial found that colchicine did not improve functional capacity or inflammatory markers in adults with long COVID. Researchers highlight the need for new therapeutic strategies for this condition.
A randomized clinical trial showed that DMEK graft success is comparable between diabetes-positive and non-diabetes donor corneas after 1 year. The study's findings support the use of diabetes-positive donor corneas for endothelial keratoplasty procedures.
Large language models could streamline clinical trial processes by refining eligibility criteria and tailoring informed consent materials. They also show potential for faster, more accurate patient screening and real-time safety monitoring.
UCSF researchers found a key cellular switch driving pulmonary fibrosis and developed a new therapy to block it in mice. The treatment works by preventing healthy lung cells from converting to harmful cell types, reducing scarring and improving lung function.
The ISSCR 2026 Annual Meeting will bring together academic and industry leaders to explore advances in stem cell science and regenerative medicine. Scientists can submit abstracts by February 25, 2026, for oral presentations and Travel and Merit Awards.
A landmark study published in the New England Journal of Medicine reports the long-term safety and efficacy of gene therapy for children with ADA-SCID, a rare immune disorder. The treatment resulted in a 100% survival rate and over 95% cure rate, with patients able to respond to routine childhood vaccinations.
Boston Children's Hospital has received a $35 million donation from Hansjoerg Wyss to further its translational neuroscience research, focusing on rare brain disorders and intellectual disability. The gift will support clinical trials, fellowships, and pilot studies, aiming to develop new therapies for vulnerable children.
In a multicenter randomized clinical trial, rapid induction of injectable extended-release buprenorphine showed higher retention rates compared to standard induction. Administration of injection 2 after 1 week was well tolerated and reduced time below target therapeutic levels.
A recent study published in JAMA challenges the common practice of individualizing blood pressure targets based on preoperative nighttime mean arterial pressure. The findings suggest that this approach may not be effective for high-risk patients undergoing major abdominal surgery.
A new global standard has been established to harmonize outcomes measurement in dengue treatment trials, addressing a longstanding discrepancy that limits the comparison of evidence. The initiative aims to accelerate the development of treatments for dengue fever and improve clinical guidelines, with input from experts worldwide.
The new centre supports multiple clinical trials in parallel, enabling comprehensive evaluations of organ health across physiological systems. It also provides hands-on training opportunities for healthcare professionals, bridging the gap between theoretical knowledge and practical application.
Researchers have developed an innovative approach combining serial brain biopsies with multi-omics analyses to uncover dynamic changes in recurrent glioblastoma tumors. This breakthrough study reveals that CAN-3110 triggered powerful immune responses deep inside the tumor, which were invisible to standard imaging.
Researchers tested a user-carried safety device that prolongs survival under snow and gains valuable time for rescue operations. The study found that the device can sustain a buried person with patent airways for over 35 minutes.
An open-label placebo treatment was associated with improved quality of life and reduced pain-related disability in patients with migraine. However, the treatment did not reduce headache frequency in this study.
Researchers found that 27% of breast cancer cases have genetic features guiding personalized treatment immediately. The study identified over 8,300 cases suitable for future research, providing insights into prognosis and potential new treatments.
The Keck School of Medicine has been recognized for its commitment to partnering with local communities in Los Angeles to address their critical needs through outreach, education, and service. The institution's community agenda is defined in collaboration with the communities it serves.
This randomized clinical trial shows electroacupuncture significantly accelerates postprostatectomy urinary continence recovery. It may serve as a safe adjunct to standard care, supporting its integration into multimodal rehabilitation protocols.
A groundbreaking study enrolls 465 AYA cancer patients to test if chatbot technology and digital education tools increase uptake of genetic counseling and improve patient outcomes. The trial aims to address longstanding gaps in genetic services for AYAs aged 18-39, who often receive care with limited access to genetic specialists.
A phase III trial finds that intensity-modulated radiation therapy (IMRT) and proton beam therapy resulted in similar quality-of-life outcomes and low rates of side effects for people with locally advanced oropharyngeal cancer. Excellent tumor control and fewer long-term side effects were seen with both treatments.
A phase III trial suggests that post-operative radiation therapy can reduce cancer recurrence in patients with high-risk disease. Patients who received radiation experienced significantly fewer pelvic recurrences and improved locoregional recurrence-free survival compared to those who did not receive radiation.