Articles tagged with Clinical Trials
A phase 1 trial involving 40 patients showed significant responses to the new cell therapy IMA203, with half of non-responders achieving lasting response. The therapy targets PRAME peptide produced by many tumors and was well-tolerated.
Researchers identified a potential new treatment, lorundrostat, which reduced systolic blood pressure in individuals with uncontrolled or treatment-resistant hypertension. The study found a significant 15-point reduction in systolic blood pressure compared to placebo.
A new clinical trial will test the effectiveness of two anti-inflammatory medicines as potential treatments for long COVID. The trial, funded by the Schmidt Initiative for Long Covid, will enroll hundreds of people across four continents and examine whether upadacitinib and pirfenidone can reduce or eliminate symptoms.
A study published in JAMA found that metformin reduced knee arthritis pain over six months in patients with symptomatic knee osteoarthritis and overweight or obesity. The treatment was shown to have a moderate effect on pain reduction, with the metformin group reporting a 31.3 point decrease compared to the placebo group.
A randomized clinical trial suggests that metformin can be an effective treatment for symptomatic knee osteoarthritis in people with overweight or obesity. The study's results support the use of metformin for this condition, but further confirmation is needed in larger clinical trials.
A new collaboration aims to develop an affordable and accessible monoclonal antibody therapeutic for CCHFV, treating thousands globally. USAMRIID discovered the antibody in mice, and LifeArc is supporting development of a fully humanized antibody.
A 12-week randomized clinical trial shows varenicline combined with behavioral counseling effectively increased vaping abstinence in youth who vape nicotine but do not regularly smoke tobacco. This study provides hope for a novel treatment approach to help combat the growing youth vaping epidemic.
The study shows that two-thirds of adults with severe peanut allergy can tolerate five peanuts without reacting after undergoing oral immunotherapy. The treatment improves quality of life and reduces fear of food, allowing participants to enjoy everyday situations without anxiety.
Researchers at UCLA Health are launching a clinical trial to test whether wearable nerve stimulation can ease ADHD symptoms in children with prenatal alcohol exposure. The study aims to improve focus and behavior by gently stimulating the trigeminal nerve, which is linked to attention and executive function.
The Colorectal Cancer Alliance is strengthening its commitment to Project Cure CRC, a nonprofit dedicated to ending the disease through innovative research and patient navigation. The organization has awarded three new grants and will present two poster sessions at the AACR Annual Meeting.
A randomized clinical trial of transcranial pulsed current stimulation found significant improvements in social functioning and sleep in children with autism spectrum disorder. The treatment, which targeted the prefrontal-cerebellar region, was well-tolerated and showed promise as a viable alternative to pharmaceutical interventions.
Adding an experimental cancer drug to standard TB treatment reduces lung damage and prevents post-TB lung disease in mice. Researchers found that the drug doubled pulmonary apoptosis and reduced lung scarring by 40% compared to standard treatments.
Participants who took the supplement showed improvements in grip strength, lower body mobility, and reductions in body weight. The supplement appeared to reduce stem cell turnover, regulate immune function, and influence gene activity related to stress response.
Swim Across America has awarded two $450,000 grants to support novel gene and base editing techniques in advanced cancer research. These grants will accelerate the development of potential gene-edited cancer treatments that could transform how we treat patients.
Researchers at the University of Calgary investigate the effectiveness of transcranial magnetic stimulation combined with intensive speech therapy for treating poststroke aphasia. The study found significant improvements in speech, confidence, and mood among participants, offering new hope for those affected by stroke.
A randomized clinical trial found no association between immediate skin-to-skin contact and improved neurodevelopmental outcomes in very preterm neonates. However, the intervention was shown to enhance breastfeeding practices up to 12 months compared to standard care.
Researchers are exploring the use of immunotherapy drugs and a tumor-busting 'oncolytic' virus to tackle high-grade neuroendocrine tumors. A new clinical trial, led by Dr. Aman Chauhan, aims to unlock the mysteries of renal cell carcinoma through detailed laboratory and clinical studies.
The Lung-MAP 3.0 trial introduces a simplified genomic screening process, allowing most patients to be matched to a targeted treatment sub-study based on prior testing results. This expansion increases access to investigational treatments for patients with advanced non-small cell lung cancer.
Using intravascular imaging (IVI) to guide stent implantation reduces death, stent thrombosis, and repeat procedures in severely calcified lesions. IVI outperforms conventional angiography in improving patient outcomes.
A new, easier-to-administer sustained-release formulation of flucytosine has entered Phase II clinical trials in Malawi and Tanzania. The trial aims to address the growing concern of cryptococcal meningitis, a major health threat to people with weakened immune systems, particularly those with advanced HIV.
Researchers evaluated different types of Glasgow Outcome Scale Extended (GOSE) scores among US trauma center patients. They found that GOSE-All scores capture the combined effect of brain and extracranial injuries, while GOSE-TBI scores exclude extracranial injury effects.
A new class of antibiotic has been shown to be effective in treating MRSA infections, with a daily dose of epidermicin NI01 demonstrating equal efficacy to the current standard of care. The findings justify further pre-clinical development and could lead to new gel-type therapies for skin infections.
Researchers have initiated a clinical trial using an investigational medicine to lower amyloid precursor protein, targeting Alzheimer's disease in adults with Down syndrome. The study aims to prevent the development of Alzheimer's disease by addressing its underlying genetic cause.
A new clinical trial at the University of Miami Miller School of Medicine is testing a novel combination of immunotherapy drugs and an oncolytic virus to treat high-grade neuroendocrine cancer. The trial aims to find safe combination doses and compare effectiveness with standard-of-care treatment.
NGR Oncology has created a new Sarcoma Subcommittee to improve outcomes for adults with cancer, focusing on building a robust program, collaborating with the Children's Oncology Group, and promoting sarcoma research. The subcommittee is led by Chair Dian Wang, MD, PhD, and Vice-Chairs William Tseng, MD, and Brian A Van Tine, MD, PhD.
A phase 3 trial demonstrated a 31% delay in confirmed disability progression in patients with non-relapsing secondary progressive multiple sclerosis. Tolebrutinib, an oral Bruton's tyrosine kinase inhibitor, showed promise as a potential treatment option for this form of the disease.
A recent study published in the International Journal of Cardiology analyzed data from multiple clinical trials to assess the therapeutic impact of pulmonary artery denervation (PADN) on pulmonary hypertension patients. PADN showed significant reductions in mean right atrial pressure, mean pulmonary artery pressure, and pulmonary vascu...
A new study published in The Lancet Infectious Diseases found that antiviral medication Paxlovid was not effective in reducing long COVID symptoms. However, individual participants experienced varying outcomes, and researchers hope to better understand the biological mechanisms behind these differences.
A meta-analysis of randomized clinical trials found that glucagon-like peptide-1 receptor agonists (GLP-1RAs) were associated with a statistically significant reduction in all-cause dementia. Cardioprotective glucose-lowering therapies, however, did not show an overall reduction in dementia risk.
Researchers found that combining imipridones with radiation therapy and temozolomide slowed glioblastoma growth and prolonged survival in mice. The treatment also boosted immune responses and suppressed MGMT protein expression, making it more effective.
Researchers from Florida Atlantic University challenge the current aspirin guidelines based on a flawed trial, advocating for healthcare providers to make individual clinical judgments about prescribing aspirin. They stress that patients should consult their primary care provider to balance the benefits of clot prevention against bleed...
A clinical trial has shown that administering clotting factor concentrate (4F-PCC) significantly reduces the risk of severe bleeding after major open-heart surgery. This innovative treatment approach offers a more effective alternative to frozen plasma for managing surgical bleeding.
A new study suggests that blood cancer patients receiving Bruton Tyrosine Kinase inhibitors should continue their therapy while getting vaccinated against COVID-19. The IMPROVE trial found no improvement in antibody responses when BTKi therapy was paused for three weeks around the time of vaccination.
A new paper highlights emerging alternatives to traditional diabetes medicines, such as continuous glucose monitors and lifestyle interventions like GEM, which can improve patient adherence and long-term health outcomes.
A centralized notification pathway increased hypertension treatment in individuals with left ventricular hypertrophy. This study highlights the potential of leveraging underutilized cardiovascular data to enhance healthcare delivery.
The MOPEVACLAS vaccine candidate is being tested in a Phase I clinical trial for its safety and immune response in humans. The vaccine targets Lassa fever, a hemorrhagic disease responsible for thousands of deaths worldwide each year.
The Finerenone Trial found that sudden death was the primary cause of higher cardiovascular mortality in patients with heart failure and mild or preserved ejection fractions. The study suggests that finerenone may not significantly impact cardiovascular mortality, but its effects on overall mortality are unclear.
Patients with low surgical risk undergoing transcatheter (TAVR) or surgical aortic valve replacement (SAVR) show comparable death, stroke, and reintervention rates at five years. The study found that TAVR is as effective as surgery in improving symptoms, functional class, and overall quality of life.
A new transcatheter valve has shown high survival rates and improved quality of life in patients with aortic regurgitation. The trial found an overall mortality rate of 8.1% at one year, meeting non-inferiority to open heart surgery outcomes.
Early IABP use did not improve 60-day survival or transition patients to long-term treatment compared to standard medical care. The trial found that the device offered no additional benefit, leading to its early termination.
A study found that intravenous iron supplementation resulted in a 20% lower risk of cardiovascular death or first heart failure hospitalization, as well as improved symptoms and quality of life. The benefits were most pronounced in the first year after treatment, suggesting a meaningful association between iron dosage and outcomes.
The BHF PROTECT-TAVI trial found no reduction in stroke rate for patients undergoing TAVR with an embolic protection device. Despite its large sample size, the study showed that cerebral embolic protection devices do not improve outcomes for TAVR patients.
A randomized clinical trial found prothrombin complex concentrate to have superior hemostatic efficacy compared to frozen plasma in patients requiring coagulation factor replacement during cardiac surgery. The study also showed safety advantages for the use of prothrombin complex concentrate.
A new clinical trial found that oral semaglutide can significantly reduce cardiovascular events in people with type 2 diabetes and pre-existing cardiovascular disease. The medication decreased the risk of major cardiac events by 14% compared to placebo, with nonfatal myocardial infarction seeing the greatest reductions in risk.
A new study finds that prothrombin concentrate is superior to frozen plasma in controlling bleeding during heart surgery, reducing major bleeding events by nearly 50%. The concentrated product caused fewer adverse effects and saved hospitals resources, suggesting a potential shift in treatment guidelines.
The C-Path-led initiative brought together clinical trial sponsors, eCOA technology providers, and regulators to identify and address eCOA implementation issues. Key resources developed during the initiative include guidance on COA data collection and a more open, collaborative environment.
The study found significant improvements in symptoms for participants with major depressive disorder, generalized anxiety disorder, and eating disorders. Participants reported trusting and communicating with Therabot comparable to working with a therapist.
A new review highlights how breast cancer cells change their communication and growth patterns, helping tumors survive, spread, and resist treatment. The review explores disrupted signaling pathways, including PI3K/Akt/mTOR and RAS/RAF/MEK/ERK, which can promote tumor progression and resistance to treatment.
Researchers aim to transform rectal cancer into a disease treatable with radiation therapy, avoiding long-term surgery side effects. Papaverine is investigated as a sensitizer that boosts oxygen content in tumor cells, allowing for maximal tumor destruction.
A new surgical technique called NeuroSAFE has been shown to preserve erectile function in men with prostate cancer, with 39% of patients experiencing no or mild dysfunction after treatment. This is compared to 23% of those who received standard surgery.
A single-arm trial evaluated the safety and efficacy of first-line camrelizumab, apatinib, and chemotherapy in untreated extensive-stage small-cell lung cancer patients. The treatment demonstrated an ORR of 88.9% and median PFS and OS of 7.3 and 17.3 months, respectively.
A new study has shown that high-resolution ultrasound can diagnose prostate cancer as effectively as MRI, with improved resolution and lower costs. The technology, called micro-ultrasound, is expected to speed up diagnosis, reduce hospital visits, and make imaging more accessible, particularly in less developed healthcare systems.
A simple urine test has shown promising results in detecting early-stage kidney cancer recurrence, with a high sensitivity and specificity rate. The GAGome test can accurately identify patients at risk of recurrence, potentially reducing the need for invasive scans and enabling faster treatment access.
A new study shows that comprehensive clinical assessments (CCAs) are equally effective to guiding treatment for women with overactive bladder or urinary incontinence, avoiding invasive urodynamics testing. CCA includes a medical questionnaire, physical examination, and tests such as urinalysis, revealing similar patient-reported outcom...
The study of 19,000 patients shows immune checkpoint inhibitors greatly improved survival rates for those living with MSI-H colorectal cancer. Researchers found factors that may improve therapy's effectiveness against MSS tumors under certain conditions.
A sub-analysis of 20-year follow-up data from the European Randomized study of Screening for Prostate Cancer (ERSPC) reveals that men who consistently decline prostate cancer screening appointments have a 45% higher risk of dying from the disease compared to those who attend screening appointments.
A study found no increased risk of suicidal events among adults taking GLP-1 receptor agonists for diabetes or obesity, but continued monitoring is warranted to identify at-risk patients. The findings ease concerns about these potential adverse effects, allowing extended use of GLP-1 RAs.
The collaboration aims to enhance clinical trial efficiency, reducing data entry time by up to 37 seconds per CRF. This enables researchers to focus more on patient care, improving the overall experience.
A clinical trial shows that removing amyloid plaques from the brain can delay Alzheimer's symptoms, supporting the amyloid hypothesis. The treatment reduced the risk of developing dementia in people destined to develop early-onset Alzheimer's disease.
A new study confirms that a shorter, higher-dose-per-day radiation course is as effective as conventional radiotherapy for treating early-stage prostate cancer without increasing side effects. The study found similar cancer control rates and fewer gastrointestinal issues with the new approach.