Articles tagged with Clinical Trials
The Butantan-DV dengue vaccine, developed in Brazil, shows 80.5% effectiveness against severe cases over five years, with no hospitalizations in the vaccinated group. The vaccine was 65% effective in preventing symptomatic dengue during the five-year monitoring period.
A large venous thrombosis trial has found that apixaban is safer than rivaroxaban, with 3.3% of participants experiencing clinically relevant bleeding compared to 7.1% with rivaroxaban. This trial has significant implications for clinical practice and patient care.
Research presented at EAU26 confirms that prostate cancer screening leads to a reduction in mortality, but also detects cancers that would otherwise remain undetected. The study's findings suggest that using MRI in prostate cancer screening can reduce overdiagnosis and unnecessary biopsies.
A low-cost digital intervention increased expectation to adopt health behaviors among adults using GLP-1RAs, with effects persisting for 2 weeks. The written microsteps intervention plus short video boosters may play a role in promoting sustained behavior change.
The company's ATA-200 gene therapy has shown safety, pharmacodynamics, and efficacy results in the first patients treated, offering hope for children with LGMD-R5. The therapy delivers a normal copy of the γ-sarcoglycan gene and has been awarded Orphan Drug Designation in the US and Europe.
A new PET imaging study reveals that ketamine relieves treatment-resistant depression by altering AMPAR in brain regions, providing potential biomarker for personalized treatment. The study found that ketamine increased AMPAR density in several cortical regions and decreased it in reward-related areas, strongly correlating with reducti...
A study found that only 9% of older adults with advanced cancer prioritize extending survival over maintaining quality of life. The lack of responsiveness of the current oncology care delivery system to patient preference may be a significant issue. This highlights the need for care system changes to prioritize patient needs.
ISM4808, a PHD inhibitor for chronic kidney disease-related anemia, has achieved its first milestone with successful completion of the Phase I clinical trial. The treatment stimulates endogenous erythropoietin production and improves iron utilization, offering improved efficiency and safety compared to existing treatments.
Researchers investigated low-dose lithium as a potential treatment for mild cognitive impairment in a pilot clinical trial. The study found that none of the primary outcomes met the significance threshold, but effect size estimates suggest potential benefits for future trials.
New MSK research reveals that the TCA cycle's waste-management function may present an opportunity against cancer, microplastics impair immune 'housekeeping' functions and TOX plays different roles in different immune cells. A new combination approach for treating advanced kidney cancer after immunotherapy has also been identified.
Researchers analyzed 15-year data from a clinical trial, finding that 70% of patients remained alive and 42% were considered cured after treatment. Cure modeling estimated the overall cure rate at 42% of treated patients.
A new analysis shows that 42% of treated patients were functionally cured, marking a game-changer for an incurable disease. Recurrence rates declined drastically over time, from 6.8% in the first five years to 0.6% between 15 and 20 years.
Approximately 40 cancer patients will receive LMP744 for five consecutive days, with biological analyses conducted on brain tissues before and after treatment. If results are favorable, treatment will continue for 12 cycles to evaluate parameters such as progression-free survival and overall survival.
Researchers at The Hospital for Sick Children have developed new guidelines for pediatric clinical trial reporting, incorporating child and youth-focused considerations. The SPIRIT-C 2026 and CONSORT-C 2026 guidelines aim to improve the quality, transparency, and usefulness of pediatric RCT protocols and final reports.
The Barshop Institute will conduct the VITAL-H trial, evaluating the repurposing of FDA-approved medications to delay age-related health decline in generally healthy middle-aged adults. The trial aims to preserve everyday abilities during a critical window of midlife aging.
Researchers developed a blood test to predict when Alzheimer's symptoms will start, using protein p-tau217 in plasma. The models predicted the onset of symptoms with accuracy, suggesting potential for preventive treatments.
A Phase 3 trial found stereotactic radiation targeting individual tumors improved symptom burden, cognitive outcomes, and daily function compared to whole brain radiation. Patients managed with stereotactic radiation also displayed better performance status and could remain more independent with everyday activities.
The University of California San Diego School of Medicine and UC San Diego Health are now part of the NICHD Maternal-Fetal Care Network, expanding access to research on pregnancy and newborn health. Clinical trials will focus on maternal mortality, prematurity birth rates, and infant mortality rates.
A new study uses advanced MRI to accurately diagnose progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD), two underdiagnosed conditions. This breakthrough enables precise clinical trials and transforms treatment options for patients with balance problems, falls, stiffness, or difficulties with speech and movement.
Researchers from UC San Francisco successfully decoded brain activity patterns associated with walking, enabling the development of personalized neural biomarkers for movement state classification. This breakthrough could lead to more effective adaptive DBS systems that adjust stimulation in response to a patient's activity state.
A study published in Biological Psychiatry identified speech latency as a promising biomarker to enrich clinical trials for patients with schizophrenia. By analyzing speech latency, participants with a high placebo response can be identified and excluded, leading to significant improvements in treatment outcomes.
A global study found that ropeginterferon alfa-2b controls essential thrombocythemia effectively, improves symptoms and reduces serious complications in patients who can't use hydroxyurea. The therapy is expected to be approved for treatment of high-risk blood cancer.
The University of Missouri has launched its first human clinical trial using Eye90 microspheres, a radiopharmaceutical breakthrough device manufactured on campus. The study aims to assess the safety and effectiveness of Eye90 in treating unresectable liver tumors, including hepatocellular carcinoma and metastatic colorectal cancer.
Researchers discovered that brief intermittent intense exercise is a more effective treatment for panic disorder than relaxation therapy. The 12-week program showed significant reductions in Panic and Agoraphobia Scale scores, anxiety, depression, and panic attack frequency and severity.
A ketogenic diet was found to have a modest effect in reducing depressive symptoms in patients with treatment-resistant depression. The study's results suggest that this dietary approach may be worth exploring as an adjunct therapy option.
A blind patient partially recovered natural vision through electrical stimulation of the visual cortex, independent of the implant. The recovery was sustained over time and remained even after the device was removed, suggesting individual factors may have contributed to this outcome.
Insilico Medicine received a USD 5 million milestone payment from Menarini Group after completing first-in-human dosing in a Phase 1 study of MEN2501, a small molecule inhibitor targeting cancers with chromosome instability. This achievement follows the completion of a successful Phase 1 clinical trial.
OYE-101, a novel intravenous caffeine formulation, aims to accelerate recovery from general anesthesia and deep sedation in adults. The FDA-cleared treatment also seeks to address opioid-induced respiratory depression and related overdose situations.
A recent study found that low-dose aspirin use was not associated with incident cancer incidence in older adults, contrary to previous findings. However, the study revealed a significant elevation in cancer mortality risk during the randomized clinical trial period, which did not persist after the trial ended.
A new MERS vaccine candidate has shown a stable and functional immune response in humans that persists for at least two years after a booster vaccination. The study demonstrates that such durable immunity can be achieved through targeted booster vaccinations, providing an important step toward an effective MERS vaccine.
A new study published in JAMA Network Open found that acupuncture is effective in reducing migraine without aura pain and improving functionality. The research identified specific brain network connections that predict treatment outcomes, enabling a personalized approach to pain management.
A large multinational clinical trial found that giving healthcare providers access to patient-reported outcome (PRO) data significantly improves the consistency of how treatment-related side effects are assessed in patients with cancer. This study highlights the importance of integrating the patient's voice into routine clinical evalua...
A new review of over 100 clinical trials found that 13 common labor induction methods are similarly effective, with low-dose vaginal misoprostol being the most commonly used and safest. However, some methods showed better success rates for specific outcomes, such as oxytocin with amniotomy for achieving vaginal birth within 24 hours.
Researchers have found a nonlinear dose-response relationship between exercise and hepatic steatosis, indicating that a combination of aerobic and resistance exercises can produce clinically meaningful improvements. The study suggests that exercising above 130 MET-min/week can lead to significant reductions in hepatic steatosis.
A randomized clinical trial found that a smart speaker-based intervention significantly improved mental distress, quality of life, and diabetes self-care among older adults with type 2 diabetes. This easily implemented self-management strategy may enhance health outcomes in this population.
Insilico Medicine presents three abstracts at the 2026 Crohn's & Colitis Congress highlighting clinical, preclinical safety, and efficacy data for ISM5411. The first-in-human Phase 1 results show no serious adverse events or deaths reported, with a favorable pharmacokinetic profile supporting gut restriction.
A national clinical trial found that abemaciclib, an oral cancer drug, may slow tumor growth in patients with aggressive meningiomas with specific genetic mutations. The trial showed promising results, with a median progression-free survival of 10 months and a median overall survival of 29 months.
The Phase 2 ANDROMEDA trial combines two types of PSMA-targeted radiopharmaceuticals with stereotactic body radiotherapy to delay progression and minimize side effects in patients with oligorecurrent prostate cancer. Researchers aim to determine which approach provides the most durable cancer control.
A major U.S. clinical trial has uncovered a genetic factor that may inform how to optimize the dosing of abiraterone, a widely used hormone treatment for advanced prostate cancer. Researchers found that men who carry a specific version of the gene SULT2A1 clear abiraterone from their bodies more slowly, which could affect how well it w...
A recent analysis of 692 clinical trials found that industry-sponsored trials were nearly three times more likely to fail compared to government-funded studies. Trials with higher participant numbers and broader eligibility criteria were also more likely to complete successfully.
The Mount Sinai Health System has launched an AI-powered clinical trial-matching platform, PRISM, to help connect patients with life-saving trials. The platform uses machine learning to match patients with trials based on their electronic health records and diagnosis.
A clinical trial by UC San Diego School of Medicine found that personalizing cancer treatments using molecular testing improves treatment success. The study used advanced genomic sequencing to identify unique tumor DNA profiles and developed personalized treatment plans, resulting in better treatment results for patients.
The study developed subgroup-specific mortality prediction models for high and low ventilatory ratio (VR) subgroups, achieving improved accuracy in short-term mortality prediction. Minute ventilation is a key predictor for the high VR subgroup, while respiratory rate, hypocapnia, and acidemia are unique predictors for the low VR subgroup.
This randomized clinical trial found yoga to significantly accelerate opioid withdrawal recovery and improve autonomic regulation, anxiety, sleep, and pain. The study supports the integration of yoga into withdrawal protocols as a neurobiologically informed intervention addressing core regulatory processes.
A single-dose oral cholera vaccine called PanChol has completed a phase 1 clinical trial with positive results, offering hope for combating the devastating disease globally. The vaccine was developed by Mass General Brigham and shows promise in preventing severe vomiting and diarrhea caused by Vibrio cholerae bacteria.
A new clinical trial, RECIPROCAL, seeks to optimize targeted radiation therapy for men with advanced prostate cancer by adjusting treatment based on individual PSA levels. The trial aims to minimize side effects while preserving survival benefits.
A systematic review of randomized controlled trials evaluating large language models in digestive diseases found only 14 eligible studies worldwide. Most focused on gastrointestinal and hepatobiliary diseases, with clinical decision-making and patient education being common applications. The authors emphasize the need for high-quality ...
In a prespecified exploratory analysis of the SELECT randomized clinical trial, semaglutide demonstrated significant reductions in hospital admissions and overall time spent in hospital. This finding suggests that semaglutide has broader health benefits for patients with obesity and established cardiovascular disease.
Researchers at Osaka Metropolitan University developed a new educational program to enhance evidence-based practice (EBP) knowledge and skills among hospital nurses. The study showed significant improvements in EBP knowledge and skills, as well as implementation, compared to the control group.
A large study found that women who underwent bypass surgery had a lower risk of major cardiovascular events and mortality compared to those who received stenting. However, women who underwent stenting had a slightly lower stroke risk.
Boston Children's Hospital will provide clinical research coordination for the IMPACT Network, a multisite clinical trial infrastructure enabling rapid and effective therapeutic development for autism. The grant, from ARIA, will support the development of study design protocols, recruitment strategies, and efficient workflows.
The study will select the exact phage that is appropriate for each patient's bacteria, and aims to reduce antibiotic use and healthcare costs. Bacteriophages have been shown to be effective against resistant bacteria causing urinary tract infections.
The Patient-Centered Outcomes Research Institute (PCORI) has awarded funding for new comparative clinical effectiveness research studies addressing various adult and pediatric health concerns. These studies aim to generate evidence to empower individuals and their caregivers with information to make informed health care decisions and i...
A Johns Hopkins Medicine/CDC study found no difference in linkage-to-care rates for HIV patients if next-day testing is done to quantify viral load. Despite this, participants living with HIV had higher linkage-to-care rates when receiving viral load results sooner than a day after testing.
A randomized clinical trial found digital cognitive behavioral therapy to be significantly beneficial for adults with generalized anxiety disorder. The treatment provided sustained benefits and has the potential for public health impact due to its accessibility.
A blood test may help doctors identify which patients with colon cancer can benefit from anti-inflammatory medication and chemotherapy after surgery. The test measures circulating tumor DNA levels, and high-risk patients who test positive see improved survival rates when taking celecoxib with chemotherapy.
A study found that only 6% of FDA-approved drugs reflect the US racial and ethnic makeup, with a decline in Black and Hispanic enrollment between 2021 and 2023. The researchers recommend setting diversity goals at preclinical stages and collecting biological samples to understand how people's bodies react to medications.
Mass General Brigham's new AI company, AIwithCare, has developed a software platform that leverages generative AI to screen patients for clinical trial eligibility. The tool, RECTIFIER, was found to accurately identify eligible patients and enroll them in clinical trials at a lower cost than traditional methods.
The WISDOM randomized clinical trial found risk-based breast cancer screening to be equally effective as annual screening in detecting advanced cancers. However, it did not reduce breast biopsy rates. The study suggests a safer and more efficient approach to breast cancer screening.
A prospective multicenter trial validated an improved method for predicting treatment benefits in hormone receptor-positive metastatic breast cancer with bone metastases. Metabolic change assessed by FDG-PET/CT accurately predicted progression-free survival as early as 12 weeks after treatment initiation.