Articles tagged with Drug Safety
Despite federal legislation, Yale researchers found that shortages for acute-care drugs used to treat critically ill patients have increased since the passage of FDASIA. The median duration of these shortages was approximately eight months, posing risks of medical error and reduced effectiveness.
A large trial of over 8000 participants found no significant increase in neuropsychiatric side effects with varenicline or bupropion. Varenicline was shown to be more effective in helping people stop smoking than other treatments, with similar efficacy across smokers with and without psychiatric disorders.
Research finds that proton pump inhibitors, widely used for heartburn and ulcers, can lead to kidney function decline, chronic kidney disease, and kidney failure. Long-term use of these medications significantly increases the risk of developing kidney problems.
Researchers at University of Queensland have developed a new plant-derived drug, T20K, that can block the progression of multiple sclerosis. The treatment, extracted from the Oldenlandia affinis plant, has shown success in an animal model and may offer a new quality of life for people with the debilitating disease.
A significant association has been found between HLA-B*59:01 and Clozapine-induced agranulocytosis and granulocytopenia, suggesting the allele may serve as a marker for prioritizing patients at low risk of developing these severe side effects. Further analysis is needed to clarify the mechanism behind this association.
A new drug, Arimoclomol, has shown promise against muscle wasting disease inclusion body myositis (IBM) by reversing key symptoms in mice and improving muscle strength. A patient safety trial also found the drug to be safe and well-tolerated.
A study found that white patients and those with lower incomes were slower to discontinue diabetes medication rosiglitazone after a FDA safety alert. Patients living in higher- versus lowest-socioeconomic status communities discontinued the drug significantly earlier.
A new article explores the effect of frailty on diabetes in older people, suggesting a regressive course with increased risk of hypoglycemia. The review highlights the importance of regular medication reviews and gradual reduction or withdrawal of hypoglycemic medications.
Researchers have identified an effective and safe treatment for Huntington's disease, using IONIS-HTTRx to inhibit huntingtin protein production. The drug has shown promising results in mice and monkeys, with motor skill improvements and reduced cortical huntingtin levels.
Researchers at Queen Mary University of London have discovered that the antimalarial drug Artesunate can reduce organ failure following injury in rats. The study's findings suggest that Artesunate could be a highly effective option for treating major trauma patients, particularly those experiencing hemorrhagic shock.
Researchers found liraglutide, a promising diabetes drug, can lead to pancreatic beta cell burnout in mice after six months of high-dose treatment. The study highlights the need for further investigation into the potential risks of this medication.
Researchers created a nanoparticle formulation of a targeted cancer drug that selectively targets tumors while sparing healthy tissue. The nanoparticle-encapsulated version showed improved efficacy and reduced side effects in rodent trials.
A portable method to detect tainted medicines and supplements has been developed by a CWRU researcher, potentially improving public health globally. The device uses Nuclear Quadrupole Resonance spectroscopy to authenticate good medicines and supplements, while also addressing the issue of counterfeit products.
Cystic fibrosis drug ivacaftor has been shown to improve disease markers and pancreatic function in young children with a specific mutation. The study's findings suggest a potential window of opportunity for early intervention and mitigation of organ damage.
Researchers and experts advocate for increased access to drug safety and effectiveness data from Health Canada to facilitate independent scrutiny of pharmaceuticals. This push aims to motivate institutional change and improve the overall quality of regulatory decisions.
A new antiplatelet drug called PZ-128 has shown safe and fast effects in preventing blood clots, with reversal of its effects possible within 24 hours. The study found that the more PZ-128 was administered, the better it blocked platelet aggregation, with up to 100% effectiveness.
Researchers found that RNs are more likely than LPNs to detect medication order discrepancies involving high-risk medications, suggesting RNs are better equipped for comprehensive assessment and resident safety. This finding highlights the need to distinguish differences in responsibilities between RNs and LPNs in nursing homes.
Once-weekly GLP-1RAs lack clear-cut benefits and harms, making it challenging to choose the most suitable medication. The medications share similar outcomes for blood pressure and lipids but have differences in terms of HbA1c reduction and body weight, as well as risk of nausea and heart rate increase.
Researchers have successfully mapped the 3D structure of cubosomes, a biological 'capsule' that delivers molecules with high efficiency. The breakthrough can help promote the use of cubosomes in medicine and food science.
Research suggests that prescription medication can impair drivers' abilities, with Benzodiazepines increasing the risk of crashes. The symposium aims to address the issue through increased awareness and testing procedures.
A recent UK study found that around 1 in 100 patients are at risk of receiving an inappropriate prescription, highlighting the need for regular drug reviews. The study also emphasizes the importance of considering the risks of prescribing multiple drugs, particularly for older patients and those with multiple conditions.
A former FDA principal deputy commissioner proposes a solution to the dietary supplement regulation gridlock by focusing on improving safety rather than efficacy. The proposed framework includes pre-market registration, clearer disclaimers, and better standards for identifying substances to protect consumers from unsafe products.
A study of Canadian patients found that off-label prescription drug use was associated with a higher incidence of adverse drug events (ADEs), particularly when the use lacked strong scientific evidence. The study also found that patients using multiple medications had a significantly increased risk for ADEs.
A study at Massachusetts General Hospital found medication errors and adverse drug events occurred in almost 1 out of every 2 surgical operations, with a third resulting in harm to patients. The study analyzed over 275 operations and identified common causes of errors, including labeling mistakes and incorrect dosages.
A recent study by researchers found that FDA's 'breakthrough' designation significantly increases the percentage of people who rate a drug as effective and believe in its strong evidence. The study suggests that neutral terms with clear explanations may help consumers make more accurate judgments about these drugs.
Researchers use liquid chromatography-mass spectrometry screening to detect sibutramine and sildenafil in supplements. They tested over 100 products, including syrups and capsules sold in China and online.
A study found that tailored mobile health technologies can help patients with chronic kidney disease take their medications appropriately, with a 5% error rate. The technologies were designed to provide safe and easy-to-use medication guidance for patients.
A new anti-basigin drug has cured mice of established malaria infection with minimal side effects, offering hope for treating the deadly disease. The drug's development path may be less complex than traditional clinical trials, as it builds on existing knowledge of the protein's role in cancer and graft-versus-host disease.
Peter Fisher argues that homeopathy is misunderstood and that some reviews have omitted key evidence, while Edzard Ernst claims that most independent systematic reviews have failed to show homeopathy's effectiveness due to methodological flaws.
Researchers at the University of Arizona College of Pharmacy have discovered a link between nonalcoholic steatohepatitis (NASH) and drug metabolism. NASH, an increasingly common but often undiagnosed liver disease, can cause toxic levels of certain medications to be retained in the body.
Use of bisphosphonates declined by 50% from 2008 to 2012 following media reports on rare fractures. The study published in Journal of Bone and Mineral Research reveals a dramatic drop in osteoporosis medication use.
The FDA has published a paper highlighting its scientific approaches and regulatory processes for approving promising hepatitis C drugs. The agency emphasizes flexibility in considering innovative trial designs without compromising efficacy standards.
A recent study has found that women using newer types of combined oral contraceptives containing drospirenone, desogestrel, gestodene, and cyproterone have a significantly increased risk of venous thromboembolism (VTE) compared to those using older progestogens like levonorgestrel and norethisterone.
The Hastings Center Report delves into the impact of patient-satisfaction surveys on healthcare quality, arguing they may compromise care and raise costs. The issue also examines the role of courage in healthcare, highlighting its limitations in certain contexts.
A new class of PCSK9 antibodies has been shown to reduce mortality, lower LDL-cholesterol, and improve cardiovascular outcomes in patients with dyslipidemia. The treatment was well-tolerated and proved safe, providing a promising alternative for those who do not respond to statins.
A study of 1,964 patients found extending natalizumab dosing up to 8 weeks is well-tolerated and effective in treating MS disease activity. No cases of progressive multifocal leukoencephalopathy were reported in the extended dosing group.
A global pandemic of fake medicines threatens decades of progress in combating HIV/AIDS, malaria, and tuberculosis. Up to 41% of drug samples studied failed to meet quality standards, highlighting the urgent need for improved surveillance and detection methods.
A new study published in Annals of Emergency Medicine has reevaluated the safety of droperidol for sedating emergency patients with acute behavioral disturbance. The study found that droperidol is effective and safe when used alone, but combinations with benzodiazepines may increase adverse effects.
A study found that cannabidiol, a non-psychoactive component of marijuana, significantly reduced seizures in children with severe epilepsy. The drug was shown to decrease seizures by an average of 54 percent and improve convulsive seizure activity. However, side effects were reported in 6% of participants.
A new investigation by The BMJ reveals that NHS doctors could prescribe the affordable and effective sight loss drug Avastin for patients with wet age-related macular degeneration. If allowed, this could release £102 million annually to reinvest in other frontline patient services.
The FDA approves new antibiotics with minimal evidence of efficacy against antimicrobial resistance. Despite this, industry and medical societies claim the drugs address the issue, sparking concerns over safety and efficacy standards.
A study published in the Journal of Patient Safety found that redesigned IV medication labels can significantly reduce the risk of medication errors in the operating room. The research used simulated surgical emergency scenarios and showed a higher correct selection rate with redesigned labels compared to standard labels.
A nationwide clinical trial found that Eylea performed better for those with moderate or worse vision loss, while Lucentis and Avastin performed similarly for people with mild DME. The study recruited 660 participants across the US, showing improved visual outcomes for patients treated with Eylea.
A clinical trial examined the safety and effectiveness of lisdexamfetamine in treating moderate to severe binge eating disorder. The study found that higher doses of lisdexamfetamine (50-70mg/day) were effective in decreasing binge-eating days and episodes, with a significant improvement in four-week cessation rates.
A phase 3 trial found zirconium cyclosilicate effectively lowered potassium levels to normal range and maintained them for up to 4 weeks. The treatment was well-tolerated and showed consistent results across patient subgroups, with 84% of patients achieving normal potassium levels within 24 hours.
A new study highlights the difficulty women with epilepsy face when becoming pregnant, as certain medications used to control seizures may be linked to developmental problems in children. The review of 28 studies found that children born to women who took sodium valproate had lower cognitive abilities than those whose mothers did not t...
A modified form of a medication called niclosamide may hold the key to battling type 2 diabetes by reducing liver fat and improving insulin function. The research aims to find a safe and practical way to diminish fat content in the liver, which could safely treat patients of all weights.
A National Institute for Occupational Safety and Health (NIOSH) study found that nearly 2,100 oncology nurses and healthcare personnel do not always follow recommended safe handling practices for antineoplastic drugs. The lack of adherence increases exposure risk to cancer-causing agents, leading to adverse health outcomes.
Researchers developed a new test that determines which drugs are unlikely to work by analyzing their structural similarity to naturally occurring substances. The 'rule of 0.5' shows a strong correlation between marketed drugs and metabolites, indicating that molecules with low similarity are unlikely to succeed.
Researchers have developed a novel drug capsule coated with tiny needles that can deliver drugs directly into the lining of the stomach, bypassing the need for injections. The capsules successfully delivered insulin to pigs, causing a faster and larger reduction in blood glucose levels than traditional injections.
Commentaries in Annals of Internal Medicine argue that Proposition 46's mandatory physician drug testing could deter help-seeking and reporting, potentially harming patients. The authors instead advocate for addressing physician impairment through more nuanced solutions.
A retrospective single-center study found that restarting infliximab therapy after a drug holiday is safe and effective for IBD patients. The average duration of infliximab holiday was 15 months. Patients who were in remission at the time infliximab was discontinued showed a 78 percent response rate at one year.
A federal law aimed at reducing the use of 'club drugs' has failed, and instead put users at greater risk due to reduced access to safety measures like medical help and free water. The RAVE Act, enacted in 2003, targeted club owners but hindered their ability to provide necessary services.
The 340B program is facing critical issues such as eligibility definition, compliance, and transparency. RAND researchers estimate that the program accounts for $6 billion in outpatient drug spending and provides savings of $1.6 billion for eligible safety net providers.
A recent study found that 32% of newer drugs received a black box warning or were withdrawn for safety reasons, compared to 21.2% of older drugs. The study suggests that the FDA's expedited approval process may have led to the release of unsafe drugs.
The mHealth app industry has tremendous potential to broaden access to medical treatment and control costs, but lacks sufficient regulation by the FDA. A study published in the New England Journal of Medicine notes that only about 100 out of 100,000 apps have been cleared by the FDA, while opponents see this as a deterrent to innovation.
A new investigation by The BMJ raises concerns about the top-selling blood-thinning drug dabigatran, citing withheld company information and potential flaws in regulatory decisions. Key findings suggest that monitoring blood levels could reduce major bleeding risks by up to 30-40%.
Research into bedaquiline, a new drug for multidrug-resistant tuberculosis (MDR-TB), should proceed cautiously in people with drug-sensitive tuberculosis. The drug has shown promising activity against MDR-TB but also presents safety concerns, including increased risk of liver and cardiac toxicity.
Researchers found that only five trials were focused specifically on drug safety, and 14 drugs were approved without condition-specific trials or trials in children. The study calls for increased regulatory emphasis on long-term safety and efficacy, particularly for chronic use medications.
The study's findings highlight the importance of API hydration in determining physical properties, such as stability and solubility. The research provides valuable insights into the mechanistic relationships between dehydration stages and lattice structure changes.