Research on treating disease with medication. Covers psychedelics, combination cancer therapy, opioid treatment in pregnancy, and personalized guidelines.
MIT engineers create system to measure generation rate and survival time of CTCs in real-time, revealing variability between different tumor types. The study suggests that small cell lung tumors can shed up to 100,000 CTCs per hour, while non-small cell lung tumors and pancreatic tumors shed fewer cells.
A new ex vivo drug delivery system has been shown to keep MSCs viable longer and reprogram the peripheral immune response toward organ repair. The study's results suggest that SBI-101 can impact a peripheral immune response that can be transmitted to local tissue damage in vital organs, including the kidney.
Researchers have identified a way to restore the effectiveness of drugs in clinical trials for treating AML by using human alpha(1)-acid glycoprotein (AGP) as a 'decoy' to bind and inhibit FLT3-mutated leukemia cells. The approach has potential for improving patient outcomes, particularly for patients with FLT3-mutated AML.
Researchers found that dancing and psychedelic drugs are associated with feelings of awe and social bonding in rave attendees. This study suggests that these experiences can be beneficial for therapeutic settings, potentially reducing stigma around psychedelic use.
New targeted therapies are being developed to target genetic alterations in cancer cells, such as the ARID1A mutation found in 10-50% of solid tumours. Early clinical trials suggest that these agents may be effective in treating multiple cancers, including breast, ovarian, and gastric cancer.
Researchers developed a mathematical model to study the action of SARS-CoV-2, enabling the examination of individual virus particles and their spikes. This analysis can help fine-tune prevention and treatment by providing insights into viral load, spike distribution, and cell infection potential.
A new VA study finds a strong connection between PTSD symptom severity and anxiety sensitivity among female Veterans who experienced military sexual trauma. Treating anxiety may ease core PTSD symptoms, suggesting anxiety sensitivity as a potential target for treatment.
The KEYNOTE-716 trial shows that adjuvant pembrolizumab significantly prolongs recurrence-free survival and halves distant recurrences in stage II B/C melanoma patients. This suggests that patients with high-risk stage II melanoma should be offered adjuvant therapy.
A Bristol-led research team has identified specific receptors for the neurotransmitter acetylcholine that re-route information flowing through memory circuits in the hippocampus. The discovery holds promise for developing new, safer treatments for conditions like Alzheimer's disease and schizophrenia.
MIT researchers have found that vaccinating against certain cancer proteins can boost the overall T cell response and help to shrink tumors in mice. The study identifies specific neoantigens that, when targeted with a vaccine, can reawaken dormant T cell populations and lead to tumor regression.
The USC Institute is launching a $3 million global consortium study to analyze brain imaging, genetics, and clinical data from 20 countries. The study aims to understand how Parkinson's disease progresses in the brain and explore genetic factors contributing to risk.
A study found that only about 2-2.5% of individuals with alcohol dependence in Sweden receive alcohol medication, highlighting unequal provision of treatment across sociodemographic factors and co-morbid conditions. The research suggests low knowledge among physicians and patients, as well as preference for psychological treatment over...
A new study by UBC researchers found that chemotherapy drug cisplatin is more likely to cause hearing loss in young children, particularly those under five years old. The study, published in Cancer, shows that the hearing of these children is impacted early during treatment and is affected to a greater extent than older children.
A new study examines the similarities and differences among disease activity indices used to monitor rheumatoid arthritis. Researchers found that while there are high correlations among the indices, they were not interchangeable, highlighting the need for further analysis of RA in patients using various indices.
A new precision medicine test has been developed using blood proteins to identify patients with idiopathic multicentric Castleman disease (iMCD) most likely to respond to siltuximab. The study also reveals Janus kinase (JAK) inhibitors as a promising alternative treatment option for those who do not respond to siltuximab.
A modified chemotherapy regimen for Burkitt lymphoma has been developed, combining CODOX-M and IVAC with rituximab, to reduce toxicity and improve survival rates. The study found a higher overall survival rate and lower frequency of severe side effects compared to standard regimens.
A study published by the European Society of Human Genetics found that genetic testing can identify the cause of childhood epilepsy in half of those studied, allowing for tailored treatments. This breakthrough discovery has the potential to improve treatment possibilities and avoid unnecessary procedures.
A new study suggests that a treatment for canine glioblastoma may also be effective in humans, with some dogs experiencing significant tumor shrinkage. The treatment uses an immunotherapy drug called STING agonist, which induced a robust immune response against cancer cells.
Gastrointestinal stroma tumors (GIST) are rare cancers that can be problematic to detect and treat. Researchers have identified the mutational drivers for GIST in the stomach and found a potential drug therapy, temozolomide, which showed promising results in treating patients with specific mutations.
A preclinical study found that age-related decline in two sirtuin enzymes alters mitochondrial dynamics, weakening cardiac contractions in response to ischemia-reperfusion injury. Boosting SIRT1/SIRT3 levels may help protect against such injuries, potentially reducing heart attack complications and deaths.
A study from Linköping University found that the tumour-inhibiting gene TET2 is silenced in most cases of acute lymphoblastic leukemia (ALL) in children. The gene can be reactivated by treatment with an existing drug, 5-azacytidine, suggesting a targeted therapy for ALL in children.
Researchers have identified a new potential treatment for neuroblastoma by targeting the ALT mechanism, which is responsible for chemotherapy resistance. The study found that activating ATM kinase at telomeres promotes chemotherapy resistance in ALT neuroblastoma and suggests a cancer-specific approach to treating this disease.
Researchers at Virginia Tech have developed a scalable method to harvest exosomes from unpasteurized cow's milk, enabling the production of purified exosomes for oral drug delivery. The new protocol advances pharmaceutical applications for fragile drugs and opens up a wide range of clinical applications.
Recent studies demonstrate the applications of LC-MS in characterizing Traditional Chinese Medicine formulations, real-time drug measurement, and bioactive compounds from Osmanthus fragrans. These techniques offer high sensitivity, robustness, and ease of use for quality assessment and characterization.
Researchers have developed a simple assessment tool to evaluate patients' risk of cognitive dysfunction in drug treatment programs. The tool combines cognitive measures with patient demographics and health history to produce an overall risk score, helping staff identify accommodations needed for effective treatment.
Researchers at Berkeley Lab have made significant breakthroughs in developing a highly effective COVID-19 antibody therapy and an efficient thermoelectric system that can convert waste heat to electricity. The new antibody, S309, has been shown to neutralize all known SARS-CoV-2 strains and may be more difficult for new mutants to escape.
Researchers found that some medications used to treat autoimmune rheumatic diseases can weaken the immune response to COVID-19 vaccines. Vaccination still induced an immune response in patients, but at a lower rate than in those without autoimmune diseases.
Computational modeling reveals that smaller drug particles can reach the distal region of airways, improving treatment efficacy. The study aims to enhance inhaler design and reduce drug loss, benefiting patients with respiratory illnesses.
Researchers have modelled how drugs are delivered to the respiratory tract via an inhaler to better treat lung diseases. Finer drug particles of around one micron are better able to travel further into the lungs.
Researchers found individuals with well-controlled asthma have significantly lower odds of hospitalization and ICU admission compared to those with uncontrolled asthma. Asthma patients using their medications showed a decrease in worsened COVID-19 outcomes.
Despite guidelines and legal requirements, women remain underrepresented in cardiovascular clinical trials, limiting treatment data on cardiovascular disease. Research shows that women respond differently to drugs than men, highlighting the need for sex-specific data in optimal care.
The article considers the ethical issues surrounding enrolling children with neurodevelopmental conditions, such as autism spectrum disorder and fragile X syndrome, in clinical trials. Parents may face difficult decisions about whether to enroll their children due to concerns about potential loss of positive aspects of their condition.
A four-year cohort study identified a significant link between midazolam exposure and elevated posttraumatic stress symptoms in children. Symptoms were found to be persistent for up to 12 months, highlighting the need for early intervention and psychosocial support.
A comprehensive molecular map of lung squamous cell carcinoma has identified potential new drug targets, including the gene NSD3, and highlighted immune regulation pathways that could help cancer evade immunotherapies. The study's findings have also revealed metabolic dysregulation and crosstalk between different cellular processes.
A new study developed a wearable technology-based method to assess myoclonus symptoms in the home environment. The method, which measures electrical neuromuscular function and movement, correlates well with assessments performed by experienced physicians.
Researchers at St. Jude Children's Research Hospital have developed a more accurate laboratory model for studying retinoblastoma, a rare pediatric eye cancer. The models closely mimic the biology of patient tumors and provide an important resource for studying the earliest stages of the disease as well as screening new therapies.
A new process for making RNA has been developed by researchers at the University of Massachusetts Amherst, yielding purer and more abundant RNA at a fraction of the cost. This breakthrough removes the largest stumbling block on the path to next-generation RNA therapeutic drugs.
A big data study from UNSW Sydney found that Australian cancer patients kept up their pharmaceutical treatments during last year's COVID-19 lockdowns. The researchers attribute the good news to relatively low rates of COVID-19 infections in Australia, which minimally impacted cancer treatment patterns.
Researchers at University of California San Diego School of Medicine modified remdesivir to create an oral version that can be taken earlier in COVID-19 diagnoses. The revised drug proved effective and safe in cell and animal studies.
Researchers analyzed patient specimens and clinical trial data from thousands of patients to assess the importance of immune cell molecules called Fc gamma receptors (FCGRs) in the therapeutic efficacy of two antibody drugs. High levels of FCGR2B on tumor cells were found to prevent rituximab efficacy, while obinutuzumab was not impact...
Researchers at Boston Children's Hospital report positive results with risplidam, a small-molecule drug that treats SMA by correcting the root cause: a mutated gene. Infants receiving risplidam showed improvements in motor function and lived longer than expected.
Researchers discovered how protective molecules like SPM are altered in COVID-19 patients, suggesting that increasing these molecules could limit inflammation and disease severity. The study also found that dexamethasone increased SPM production, improving white blood cell function and reducing inflammation.
A phase 2 clinical trial found that ibrutinib is a safe and effective treatment option for patients with relapsed or variant forms of hairy cell leukemia. The study, conducted at Ohio State University Wexner Medical Center, showed improved cancer control for this high-risk patient group.
A new way to target the RAS protein, responsible for 20-30% of all known cancers, has been found by a team from the University of Leeds. This breakthrough could lead to greater treatments for more patients, paving the way for hundreds of other disease targets.
A new analysis by Temple University researchers found that endovascular stenting is highly effective in treating superior vena cava syndrome, with a success rate of nearly 99%. The therapy has also shown low restenosis and recurrence rates, making it the preferred option for patients with this condition.
A large study of over 1.8 million women has found no link between fertility drugs and an increased risk of breast cancer. The research, published in Fertility and Sterility journal, provides reassurance to women seeking fertility treatments.
The company's 3D Predict assay has been validated for predicting responses to temozolomide in glioblastoma patients, with predictive accuracy comparable to its previous results in ovarian cancer. The test identifies future responders and non-responders, enabling personalized treatment strategies.
A study of 614 children found that corticosteroids reduced inflammation levels by half within a day, with similar recovery rates to immunoglobulin treatments. Corticosteroids may be a cheaper alternative to immunoglobulin, which is in short supply and expensive.
Dr. Larson has been named recipient of the prestigious Paul C. Aebersold Award for his contributions to cancer imaging and radionuclide therapy. He is a world-renowned expert in radiopharmaceutical therapy and molecular imaging.
A new radiopharmaceutical, 18F-DASA-23, has successfully visualized the 'master switch' protein PKM2 in glioblastoma patients. This allows for non-invasive assessment of treatment response and potential early detection of therapeutic effectiveness.
A new study analyzing medical evidence on domestic mass shooters in the US finds that a majority of perpetrators have psychiatric disorders without treatment, increasing risk of violence. The researchers identified signs and symptoms of brain illness in 32 out of 35 perpetrators, with most having schizophrenia or other diagnoses.
Research suggests that Nintendo Wii therapy can significantly improve balance in children with cerebral palsy, even when combined with conventional physical therapy. The analysis found medium to large effects of the therapy on functional balance and dynamic balance, respectively.
Researchers have developed a new categorization system for vasculitis based on its underlying immunological causes, which may lead to more effective treatments and better patient outcomes. The study identified key differences in disease response to various treatments, paving the way for new clinical trials.
Scientists have created a miniature 3D bone marrow model that can predict patient responses to Eltrombopag therapy for platelet disorders. The model uses silk protein scaffolding and patient-derived cells to recreate human bone marrow conditions.
Researchers found that selective serotonin reuptake inhibitors can reduce deterioration of intellectual abilities in individuals with a microdeletion of chromosome 22. The study suggests a potential neuroprotective effect and opens up new research possibilities.
A new type of penile traction therapy (PTT) device has been shown to increase penile length and preserve erectile function in men who have undergone prostate cancer surgery. The device, marketed under the brand name RestoreX, works by applying gentle, dynamic pressure to stretch and shape the penis.
The American Gastroenterological Association (AGA) recommends early introduction of biologics for patients with moderate-to-severe luminal and fistulizing Crohn's disease. Biologics are the most effective treatment option, which should be used early rather than delaying their use until other treatments fail.
A breakthrough study by Anglia Ruskin University experts suggests that cataract treatment could shift from surgery to drug therapy, offering exciting implications for public health. The research found the role of aquaporin proteins in lens development and highlights the potential for nanotechnologies to support drug-based therapies.
A Phase 1 study of Z-endoxifen in patients with solid tumors reported partial responses in three patients and prolonged stable disease in eight. The study suggests that Z-endoxifen can benefit patients who have progressed on tamoxifen treatment, particularly those with desmoid tumors.
A recent study found that only 6% of people with alcohol use disorder receive treatment, despite most having access to healthcare. The researchers suggest that primary care doctors may not feel comfortable addressing drinking issues due to lack of training, leading to a gap in treatment.