Articles tagged with Hormone Therapy
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A study found that progesterone receptor levels can predict response to progestin-based therapy in endometriosis. This discovery may lead to faster and more effective treatment options for women with the condition.
The SPPORT trial found that adding pelvic lymph node treatment and short-term hormone therapy to standard treatment extends time before cancer spreads. This combination therapy resulted in higher freedom-from-progression rates and lower distant metastasis rates compared to standard treatments alone.
The HOBOE-2 trial found that zoledronic acid plus letrozole improved disease-free survival in premenopausal women with HR+ early breast cancer, with a 5-year DFS probability of 0.93 compared to 0.85 for tamoxifen. The combination treatment reduced breast cancer recurrence and mortality by nearly half.
The PALOMA-3 study found that the CDK4/6 inhibitor palbociclib significantly improves progression-free survival in patients with HR+/HER2- advanced breast cancer. In a new analysis, palbociclib plus fulvestrant was shown to improve overall survival by 6.9 months compared to placebo plus fulvestrant.
Combining a targeted drug with hormone therapy substantially extends survival for women with advanced breast cancer. The combination treatment lived seven months longer than hormone treatment alone, with benefits strongest in women who had previously responded to hormone therapy.
A large study found that drugs approved for women's breast cancer are also effective and well-tolerated in men. Men with metastatic breast cancer received similar treatments to women, including hormonal therapy and chemotherapy, with similar outcomes.
A French prospective study found that nearly one in six premenopausal women with early-stage breast cancer do not adequately adhere to tamoxifen therapy after one year, potentially leading to increased risk of recurrence. The study aimed to identify clinical and social characteristics associated with poor adherence to endocrine therapy.
Researchers at Rush University Medical Center developed a metal-coordinated molecule, poly-zinc-liothyronine (PZL), which works well in laboratory studies and may provide an improved therapy for all hypothyroid patients. PZL's slow release of active hormone can supplement standard therapy, offering a more effective solution for treatme...
New hormone and non-hormone options are available to help women maintain a healthy sex life during menopause. Topical lidocaine, pelvic floor therapy, and vaginal laser therapy show promise in reducing pain and friction.
A new study from the University of California found that light therapy can alter circadian rhythms and sleep/wake cycles, leading to improved mood and sleep in perimenopausal women. This non-pharmacological treatment option may provide symptomatic relief for those struggling with depression and sleep problems.
A recent study analyzing 21 randomized clinical trials with 2,200 participants found that thyroid hormone therapy was not associated with improved quality of life or thyroid-related symptoms in adults with subclinical hypothyroidism. The results suggest that routine use of thyroid hormone therapy may not be necessary for this condition.
Testosterone treatment over 10 years can improve or reverse type 2 diabetes in men with low testosterone, leading to significant weight loss. The study found that average fasting blood glucose levels decreased and HbA1c levels fell in the testosterone-treated group, while worsening in the control group.
A new study reveals that black women are more likely to skip hormone therapy treatments for breast cancer, with barriers including cost, side effects, and difficulty adhering to treatment plans. The study highlights the need for culturally competent behavioral interventions to improve outcomes for all women with breast cancer.
Researchers at The University of Texas Medical Branch found that testosterone replacement therapy reduces respiratory hospitalizations in middle-aged and older men with chronic obstructive pulmonary disease (COPD). This suggests that testosterone replacement therapy may slow the progression of COPD in these individuals.
Researchers developed a new way to identify molecular markers of breast cancer tumors using machine learning. This technology can rapidly sort images of breast tumors to determine prognosis and treatment options, potentially leading to faster and more cost-effective treatments for millions of women.
Perimenopause is a window of vulnerability for depressive symptoms, with hot flashes, sleep disturbances, and life stressors contributing to its development. The new guidelines recommend using proven therapeutic options like antidepressants and cognitive behavioral therapy as front-line treatments.
A large genomic analysis has linked certain DNA mutations to a high risk of relapse in estrogen receptor positive breast cancer, while other mutations were associated with better outcomes. The study identified three genes - DDR1, PIK3R1 and NF1 - with relatively uncommon mutations that were associated with cancer recurrence and spreading.
Researchers at Cedars-Sinai Medical Center discovered how hormone therapy can cause prostate cancer to spread by transforming some cancer cells into aggressive neuroendocrine cancer-type cells. A potential simple blood test may help predict when this type of therapy resistance will occur, according to the study.
A new web-based calculator, CTS5, can accurately predict the long-term risk of breast cancer returning in other areas of the body. The tool helps clinicians decide whether to continue or stop hormone therapy, improving patient quality of life and reducing unnecessary treatment.
A meta-analysis of 99 studies found that levothyroxine, a common medication for hypothyroidism, is inadequate in controlling high cholesterol levels. The study's findings suggest that patients may require additional therapies or adjustments to their treatment plans.
Researchers studied the correlation between radiation therapy dosage to the hypothalamus and pituitary gland and development of endocrine dysfunction in pediatric and young adult patients. The study found a strong association between radiation dose and age on the development of hormone deficiencies, supporting the benefits of advanced ...
A review published in Reviews in Endocrine and Metabolic Disorders suggests that transgender women on estrogen therapy are at increased risk for cardiovascular events. The data is unclear for transgender men, but the review highlights the need for further research on hormone therapy's effects in older populations.
A new procedure has been developed to quickly diagnose drinking by the liter, a condition that can be caused by rare hormone disorders like diabetes insipidus. The test, which measures biomarkers in blood, has a high diagnostic accuracy and can treat patients with primary polydipsia through behavioral therapy.
A blood test can predict which treatment is most likely to extend a patient's life with advanced prostate cancer. Researchers found that patients who tested positive for the protein AR-V7 responded best to taxane-based chemotherapy, while those who tested negative responded better to hormone-targeting therapy.
Research suggests that reproductive factors, including number of children, miscarriages, age at first menstrual period, and reproductive period, may contribute to dementia risk in women. Women who had three or more children were found to have a lower risk of dementia, while those with earlier onset of menstruation or shorter reproducti...
A study on human brain tissue and preterm rabbits suggests that estrogen treatment can restore the balance of interneurons in the cerebral cortex, which is disrupted in premature birth. This finding implies that mimicking the in utero environment may have the potential to improve developmental outcomes for preterm infants.
A new study, based on a subgroup of KEEPS participants, found no effects of hormone therapy cessation on carotid artery intima-media thickness. The results support the use of hormone therapy for menopause symptom relief or bone loss prevention, with potential benefits on heart disease reduction.
New research reveals that gut hormones play a crucial role in addiction treatment, with ghrelin and GLP-1 analogs showing promise in reducing cravings. The study suggests that medications affecting these hormones could be repurposed to help manage drug craving and relapse.
Researchers used computer modeling to study aspirin-receptor interactions and found that low-dose aspirin treatment activated PPAR-alpha in a mouse model of Alzheimer's disease. This activation improved hippocampal plasticity and memory, suggesting the therapeutic potential of aspirin in dementia-related illnesses.
A recent study found a significant link between cross-sex hormone use in transwomen and elevated risks of venous thromboembolism, stroke, and myocardial infarction. The study analyzed data from Kaiser Permanente health systems and compared rates of vascular events among transwomen to those in cisgender men and women.
A new form of immunotherapy has been found to reactivate the response to hormone treatment in advanced prostate cancer, a study in mice and human prostate cancer cells has found. The drug blocks a protein produced by immune cells, restoring sensitivity to hormone therapy and potentially improving outcomes for men with advanced disease.
Researchers found that estrogen therapy changes microbial composition and activity in the gut, affecting how estrogens are metabolized. Probiotics may be used to manipulate the gut biome to improve estrogen-replacement therapy's benefits without increasing cancer risks.
A new study found that combination CC+AZ therapy is safe and effective for patients with elevated estradiol or low testosterone/estradiol ratios. The treatment improves testosterone levels and reduces estradiol levels by lowering conversion of testosterone to estradiol.
The TAILORx trial found no benefit from chemotherapy for 70% of women with hormone receptor-positive, HER2-negative breast cancer. Treatment with hormone therapy alone after surgery was as effective as hormone therapy plus chemotherapy in reducing invasive disease-free survival and overall survival.
A new study found that hot flashes and night sweats can persist well into women's 60s, 70s, and 80s. Researchers suggest that women with these symptoms should discuss treatment options with their healthcare providers.
Researchers found that growth hormone treatment improved cognition, reduced brain tissue loss, and promoted plasticity in the brain of mice with induced strokes. The treatment showed promise for facilitating rehabilitation and improving quality of life after a stroke.
A UK analysis of 18,730 patients found that surgery reduced the risk of dying from breast cancer by 40%, compared to primary endocrine therapy. The study suggests that surgery may be a more effective treatment option for older women with oestrogen receptor-positive breast cancer.
A study found that androgen deprivation therapy prolongs QTc interval duration, increasing risk of arrhythmia and sudden cardiac death in men with prostate cancer. Researchers urge oncologists to monitor QTc interval in patients receiving ADT.
Researchers at UTA found that 98% of veterans who participated in the Artopia program reported improved coping mechanisms for service-related trauma and everyday life through art therapy. The study showed significant reductions in mood disturbance and increased enjoyment of art therapy sessions.
A study found that only a minority of transgender teens and their parents are willing to delay hormone therapy to preserve fertility, with parents being significantly more likely to consider this option. The majority of youth and parents cited wanting more information as a major factor in their decision.
Researchers found improved measures of cardiovascular health, beneficial changes in fat tissue, and reduced risk of diabetes in obese women with PCOS who used a hot tub regularly. Heat therapy may reverse some of the inflammation in fat that causes metabolic health impairment.
A study of over 1,300 women found that entering menopause at a later age was associated with better verbal memory skills. After adjusting for other factors, the researchers found a small but significant difference in memory scores, recalling an average of 0.09 additional words per year.
Researchers at NYITCOM propose thyroid hormone therapy as a safe and effective alternative to beta blockers for patients who cannot tolerate these medications. The study found that thyroid hormone treatment improved heart function, reduced infarction size, and enhanced vessel function.
A new study published in PNAS demonstrates that a novel hormone replacement therapy can improve cognitive function and working memory capacity in patients with adrenal insufficiency. The therapy involves replicating the natural secretion patterns of cortisol, resulting in better outcomes compared to traditional constant infusion methods.
Estrogen supplementation may prevent type 2 diabetes incidence by regulating glucagon and GLP1 hormones, according to a new study published in JCI Insight. The research highlights the protective role of oestrogens on type 2 diabetes incidence, particularly in post-menopausal women.
A six-year study of 24 transgender men treated with testosterone therapy found no rise in estrogen levels and a later stabilization within normal ranges. The results support the safety of testosterone therapy for transgender men without additional risks to female reproductive tissues.
A new study published in the Journal of Clinical Endocrinology & Metabolism found that menopausal hormone therapy users tend to have less abdominal fat tissue than other menopausal women. The protective effect disappeared rapidly after treatment stopped.
A study published by the American Academy of Neurology found that estradiol therapy via skin patches maintained brain volume and reduced amyloid plaque deposits in women. Meanwhile, estrogen pills caused greater structural changes in the brain, which stopped once treatment was stopped.
New mouse studies show that tamoxifen and raloxifene improve cardiac, respiratory, and skeletal muscle functions while increasing bone density in muscular dystrophy models. The treatments delay or halt disease progression, reducing muscle pathology and inflammation.
A large population-based study found that patients on levothyroxine had lower quality of life and more comorbidity than those not taking the hormone. The study also showed that comorbidity had a greater negative impact on the quality of life of LT4 users.
Immunotherapy has shown promising results in treating metastatic breast cancer, with a median progression-free survival of 33 months and median overall survival of 82 months. The treatment has been found to improve PFS and OS in both luminal and non-luminal subtypes, offering new hope for patients with this incurable disease.
The study found that nearly half of the wives reported that their partner's health problem affected their own health, with many feeling increasingly socially isolated. The women also expressed concerns about the role change in their relationship as their husbands became less able to fulfill their usual roles.
A clinical trial found that vaginal estrogen tablets, moisturizers, and a placebo gel all improved vaginal discomfort symptoms. However, the study suggests that better treatment options are needed for postmenopausal women, who experience significant quality-of-life effects from these symptoms.
The Endocrine Society has released updated guidelines for testosterone prescribing practices, recommending reserving therapy for men with well-documented hypogonadism. The guidelines also suggest individualizing treatment decisions for older men and avoiding routine testing for healthy men.
A new class of experimental drugs has been found to reduce hot flushes in menopausal women by almost three-quarters within three days. The treatment also improves sleep and concentration significantly. The compound works by blocking the action of a brain chemical called neurokinin B, which triggers hot flushes.
A study published in PLOS ONE found that menopausal hormone therapy is not associated with adverse changes in cardiac structure and function, but may be linked to some healthier heart characteristics. The research examined 1,604 post-menopausal women and found significantly smaller left ventricular and left atrial chamber volumes.
A recent study published in Endocrine Practice found that only a quarter of transgender women could lower their testosterone levels within the female range using spironolactone and estrogen therapy. The researchers identified four groups with varying degrees of testosterone suppression, highlighting the need for further studies to unde...
Researchers at Dana-Farber Cancer Institute have identified a specific mechanism by which estrogen receptor-positive breast cancers become resistant to standard therapies and metastasize. DNA mutations in the estrogen receptor gene cause tumors to grow even without estrogen, leading to treatment-resistant disease.
Researchers from Brigham and Women's Hospital have identified unique stroke risk factors in women, including early age of menarche, low levels of dehydroepiandrosterone hormone, and oral estrogen use. The study emphasizes the need for clinicians to consider these factors, particularly in women with a history of pregnancy complications.
The Clinical Pharmacogenetics Implementation Consortium has published the first-ever clinical practice guideline for using CYP2D6 genotype to guide tamoxifen therapy in women with early-stage estrogen receptor-positive breast cancer. The guidelines recommend alternative hormonal therapies based on CYP2D6 genotype, aiming to improve tre...