Research on therapies used across medicine and how they perform. Covers weight-loss injections, hormone therapy, stem-cell approaches, pain relief, and drug targets.
Researchers created an artificial blood protein inspired by woolly mammoths' ability to conserve heat. The new hemoglobin can unload oxygen to tissues in cold conditions, making it suitable for use in hypothermia treatments during heart and brain surgeries.
A survey of federally funded programs in 57 US states and territories found a need for specific, adapted diabetes treatment guidelines. Current national guidelines may not be optimal within each state's resources, and officials lack scientific evidence to adapt them.
A recent U-M study highlights the need for a shared emphasis on both obesity prevention and treatment strategies to achieve the White House's goal of eliminating childhood obesity. The study concludes that prevention programs alone cannot effectively address the epidemic affecting minority children, who are disproportionately affected.
A national clinical trial found that intensive medical therapy reduced the risk of stroke and related death, while stenting increased it. Patients who received medical therapy alone had a lower risk of stroke and death compared to those who underwent stenting.
Most US medical schools provide inadequate mental health coverage to their students, with co-pays and coinsurance rates as high as 20%, discouraging them from seeking necessary treatment. This can have serious consequences for the students' well-being and ultimately affect patient care.
A study of 17 cats with epilepsy revealed that early treatment can lead to improved outcomes and a better quality of life for affected animals. The researchers found changes in the hippocampus similar to those seen in human MTLE-HS, but without structural brain damage.
IQWiG identified various aspects that could be supplemented and specified, including recommendations on blood glucose levels and treatment of macula oedema. The report's findings suggest no compelling need for revision of the current DMP.
Researchers have found that short-term glucocorticoid treatment can reduce degenerative changes in cartilage and prevent osteoarthritis after joint injury. This innovative approach may provide hope for preventing irreversible joint damage.
The STOP-VT Study evaluated the effectiveness of catheter RF ablation with magnetic navigation in treating ischemic ventricular tachycardia. The study found that 90.9% of patients were able to remain non-inducible after treatment.
A new study in CMAJ found significant variability in death rates following withdrawal of life-sustaining therapy, with 32% of patients dying in hospital. The rate varied across centers, with about half of deaths occurring within three days.
The new ESC guidelines on peripheral artery disease emphasize the need to assess patients with coronary artery disease for symptoms or asymptomatic atherosclerosis in other vascular areas. The guidelines also highlight the importance of considering multisite artery disease and the overall clinical status of patients.
The new guideline recommends using ambulatory blood pressure monitoring to diagnose high blood pressure, which may lead to a significant reduction in the number of people misdiagnosed with hypertension. The approach is expected to be cost-effective and save money by targeting treatment at those who need it.
Researchers at Lund University have discovered a new function for vitamin C, finding that it can dissolve toxic protein aggregates in the brain that build up in people with Alzheimer's disease. The treatment has potential to delay and alleviate the progression of the disease by addressing its symptoms.
Patients with clinically diagnosed superficial vein thrombosis are four to six times more likely to develop venous thromboembolism, a dangerous and often life-threatening condition. Studies have shown that patients with
Researchers found that while deep brain stimulation has increased acceptance among referring physicians for Parkinson's disease and other movement disorders, only half of recommended patients are appropriate candidates for immediate therapy. This suggests that physicians have become more aware and accepting of the treatment, but may re...
Researchers found that individuals who trust in a benevolent God tend to worry less, while those with negative beliefs report higher levels of worry. The study suggests integrating patients' spiritual beliefs into treatment regimens can improve mental health outcomes.
A randomized controlled trial found that narrative exposure therapy significantly reduced PTSD symptoms in former child soldiers in Uganda compared to other therapies. The treatment was conducted by community-based lay therapists without a mental health background, demonstrating its feasibility and effectiveness.
Lesser toe deformities, such as hammer toes and claw toes, can cause significant pain and limit activities. Improper footwear is a common cause, while genetic and neuromuscular conditions also play a role. Nonsurgical treatments like pads and gel sleeves can be effective, but surgery may be necessary for severe cases.
Researchers at Mayo Clinic and University of Washington highlight the potential benefits of primary care physicians in establishing treatment plans for patients at risk for suicide. A simple question from a family doctor can be enough to start a person toward help and treatment.
A combination of strategies, including eliminating stagnant water and removing vegetation, significantly reduced the number of tiger mosquito eggs in treated areas. The study, published in Transactions of the Royal Society of Tropical Medicine and Hygiene, demonstrates a substantial reduction in eggs compared to control areas.
Researchers at the University of Minnesota have identified a potential therapy to boost resistance against prenatal infections by manipulating an immune suppressive cell type. This approach allows pregnant women to more efficiently fight off infections without compromising pregnancy outcome.
A 20-year study on Quebec newborns suggests that an apparent increase in congenital hypothyroidism is entirely artifactual, attributed to changes in screening methods. The results show that the number of detected cases would have remained stable if the screening threshold had been unchanged.
A study found that married men seek medical care sooner for heart attacks than their single counterparts. Men in marriage experience faster arrival times at the emergency department, highlighting potential benefits of marriage on health outcomes.
A study involving over 5,000 people with ankylosing spondylitis has identified three regions of the genome strongly associated with the condition. The findings suggest that a particular process in cells and genetic variants of ERAP1 interact to affect disease susceptibility.
A study found that cutting IVF funding in Denmark leads to significant short-term cost savings, but long-term losses. By 2059, the government would have lost €74-123 million due to fewer tax contributions from children born through IVF.
A team of researchers at Sam Houston State University will study a new mental health court in Montgomery County, evaluating its effectiveness in reducing recidivism rates and improving life skills. The three-year project aims to assess the program's cost-effectiveness and jail diversion outcomes.
Researchers found that ghrelin hormone is required for prolonged psychosocial stress to promote preference and intake of high-fat food in mice. This discovery could lead to new therapeutic targets for curbing stress-related food behavior.
A recent study published in Phytopathology reveals that fungicide applications on corn are unlikely to produce yield increases unless fungal diseases are present. Farmers should weigh the cost of treatments against potential benefits and consider the price of corn when making decisions.
The World Health Organization's latest Dengue Bulletin documents the substantial growth of dengue cases in the Americas, Africa, and Asia. The report reveals alarming increases in dengue deaths, with Brazil experiencing a 6.2% rise per year from 1999-2009.
A recent study by the Medical College of Georgia found that depressed pregnant women often receive inconsistent treatment, leading to longer hospital stays. The lack of uniformity in addressing perinatal depression is attributed to providers feeling burdened and isolated in making decisions about complex issues.
The National Institutes of Health has awarded $200 million over five years to five health research centers to speed scientific discoveries into treatments for patients. The grants support the innovation and partnerships necessary to bridge basic research and medical practice.
Studies by CHOP researcher Jeffrey H. Silber found that surgical patients in hospitals with more aggressive treatment styles had lower mortality rates within 30 days of admission compared to less aggressive hospitals.
The Distinguished Investigator Award recognizes Dr. Vince Mor for his significant contributions to health services research, while the Alice S. Hersh New Investigator Award is given to Dr. Scott Halpern for exceptional promise in early career. The Article-of-the-Year Award honors researchers Jeffrey Silber and Robert Kaestner for their...
A study found that screening high-risk employees for OSA could result in a $136 million gain over 10 years, with significant benefits to productivity and employee health. Untreated OSA can lead to job performance deficiencies such as excessive sleepiness, cognitive dysfunction, and reduced vitality.
A computer modeling study suggests that ranibizumab can reduce the magnitude of legal blindness and visual impairment caused by age-related macular degeneration in non-Hispanic white individuals. The model estimated that monthly ranibizumab usage could prevent 16,268 cases of legal blindness and 34,702 cases of visual impairment.
A study found that Iraq and Afghanistan veterans who visited a VA integrated care clinic were more likely to undergo initial mental health and social work evaluations than those visiting standard clinics. The integrated care model increased the rate of initial mental health evaluations, especially for women veterans, younger veterans, ...
Research suggests that UK government plans to divert mentally ill prisoners into mental health services are unlikely to succeed due to a lack of suitable facilities. The study found that only a small percentage of psychotic prisoners receive treatment, and those who do often face significant barriers to follow-up care after release.
The Endocrine Society released a clinical practice guideline recommending vitamin D screening and dietary intakes for children and adults at risk of deficiency. Key findings include recommended daily intake ranges, from 400 IU/day for infants and 600 IU/day for adults, to prevent vitamin D deficiency.
Researchers found that Latino smokers who have a significant other are more successful in quitting smoking, with approximately 46% of participants reporting success. The study also suggests that having a partner can buffer the negative effect of depression on smoking cessation.
Project ECHO demonstrates that primary care providers can be trained to manage complex chronic conditions via videoconferencing technology, expanding their ability to treat very sick patients. The model has been shown to improve treatment outcomes and reduce racial and ethnic disparities in minority communities.
A case report reveals NDM-1 enzyme was acquired by a Canadian resident without travel history, highlighting local transmission risk. Enhanced precautions, including isolation and screening procedures, are necessary to contain the outbreak.
A pan-European study found gout prevalence highest in the UK and lowest in France, with lower quality of life scores and more comorbidities. New treatments like pegloticase demonstrated long-term efficacy and safety, with up to 90% complete resolution of tophi and improved patient-reported outcomes.
A new UCLA study reveals that individuals with body dysmorphic disorder (BDD) exhibit abnormal brain activity when processing holistic visual elements, such as the overall shape of an object. This finding suggests that BDD patients have general abnormalities in visual processing, which may contribute to the development of the disorder.
Researchers from the University of Granada have proven that music therapy combined with guided imagery reduces pain, depression, anxiety, and improves sleep among patients suffering from fibromyalgia. The study shows that these techniques enhance well-being and personal power, allowing patients to take part in their own treatment.
Researchers have discovered that proteins in Alzheimer's fibrils can recycle and detach, potentially leading to new therapeutic strategies. The study found that Aβ40 molecules recycle more frequently than Aβ42, suggesting a potential target for modulating recycling and treating the disease.
Researchers at IUPUI are conducting a pilot study to evaluate the effectiveness of treating depression before a heart attack in reducing future heart disease risk. The study aims to investigate whether an evidence-based computerized treatment for depression can effectively lower heart disease risk.
Researchers found that scheduling admissions to reduce peaks and troughs in hospital occupancy can decrease crowding, with a median of only 7.4 patients per week needing to be rescheduled. Smoothing out weekly patterns reduces mid-week crowding and improves patient outcomes.
The Heat Wave system uses heated, humidified air delivered through an oxygen mask to rapidly transfer heat to the blood via convection. Tests show it's more effective than current treatments, decreasing treatment time for hypothermic patients to just four hours.
Researchers identified a new probiotic bacteria-derived soluble protein that provides therapeutic protection against intestinal inflammation. The protein, p40, was delivered to the colon and protected mice from colitis through an EGFR-dependent mechanism.
A new study found that exercise improves mood and reduces cigarette cravings in women smokers, but the effects are short-lived lasting several hours to days. Researchers plan to conduct larger trials to determine how frequently exercise must be done to sustain its anti-craving benefits.
Researchers have discovered a blueprint to block crucial Matrix Metalloprotease enzymes that activate the fatal inflammatory response in sepsis. Elevated levels of proMMP-1 and active MMP-1 predicted early and late death in human sepsis patients.
A new virtual reality application delivers exposure therapy for PTSD by immersing soldiers in simulated trauma-relevant environments. The system has shown encouraging clinical results, with 80% of patients experiencing clinically meaningful reductions in PTSD symptoms.
Researchers found improved hypertension control in Canada, with increased awareness and treatment rates among community-dwelling adults. Despite this progress, one-third of Canadians with hypertension still have uncontrolled blood pressure.
A new decision aid aims to improve communication between families and clinicians about end-of-life care for patients with prolonged mechanical ventilation. The study found that the decision aid reduced uncertainty and improved agreement between surrogates and healthcare providers about patient outcomes.
A study found that CPAP treatment significantly reduces daytime sleepiness and increases wakefulness in patients with very mild symptoms of obstructive sleep apnea. The treatment also improves quality of life scores, even among those who initially did not perceive a benefit from therapy.
A large-scale study found that CPAP treatment decreases cardiovascular mortality in elderly patients with obstructive sleep apnea (OSA). The study, which followed 939 patients for six years, also found that untreated severe OSA increases cardiovascular risk in this age group.
Researchers studied chiropractic manipulation and found that maximum chest compression during typical manipulations is unlikely to result in injury. The study's findings suggest safer manipulation procedures and reduced risk of adverse patient outcomes.
The report highlights the importance of involving GPs in clinical trials and making research findings more accessible to patients. It also emphasizes the need for greater international collaboration and evidence-based clinical practice guidelines to speed up the translation of research into clinical practice.
Researchers found an 81% increase in PE incidence after CTPA introduction, with a decrease in mortality and case fatality rates. However, CTPA also led to a significant increase in presumed anticoagulation complications, highlighting the need for more precise diagnostic tools.
Researchers found that implementing a tobacco-free policy at an Ohio women's substance abuse treatment center led to a 28 percentage point decrease in program completion rates. The study suggests that smoking bans may pose challenges for treatment centers, but they are not a reason to abandon tobacco-free policies entirely.