Research on diabetes and its complications. Covers glucose prediction, nerve pain, weight-loss drugs, insulin access, and diabetes management.
A new systematic review and meta-analysis published in The BMJ provides a comprehensive understanding of the adverse outcomes associated with gestational diabetes mellitus during pregnancy. The study found that women with gestational diabetes had increased odds of caesarean section, preterm delivery, and infant complications.
A retrospective cohort study found that poor continuity of care is associated with increased health care use and sub-optimal prescribing of guideline-recommended medications in patients with CKD. Strengthening patient-provider relationships and guiding physicians on recommended prescribing can help mitigate these issues.
A study found that general practitioners use ultrasound for exploratory purposes, outside of formal training areas, raising concerns about appropriate use and scanning competency. Meanwhile, lung ultrasounds may enable primary care physicians to prescribe antibiotics directly, reducing radiation exposure and saving time.
A systematic review of qualitative studies found that rural patients experience significant challenges in accessing health care services for chronic conditions. Cultural, structural, and individual factors influence these experiences, highlighting the need for culturally appropriate interventions to improve access to care.
The five-year DIASIRE summer program will accept eight to 10 undergraduate students from across the country, providing them with valuable research skills and mentorship from OHIO faculty. Students will learn about the history and pathophysiology of diabetes, as well as epidemiological, social, and molecular/cellular research efforts.
A review of 38 randomized controlled trials found that counseling patients about contraceptive use and providing contraceptives increases use without increasing STI risk or reducing condom use. The interventions also decrease unintended pregnancy in trials designed to evaluate this outcome.
A new international study has identified the most critical vascular risk factors for dementia, highlighting the importance of controlling high blood pressure and diabetes. The research, led by Professor Emer McGrath, found that individuals with these conditions are four times more likely to develop dementia than those without them.
A new analysis from the NACMI registry found that STEMI patients with COVID-19 have a significant increased risk of in-hospital mortality compared to pre-pandemic levels. Clinical characteristics and treatment strategies differ between men and women, highlighting the need for continued research into cardiovascular health impacts of COV...
The USPSTF and ADA now recommend screening adults as young as 35 for diabetes. A new study estimates the proportion of asymptomatic adults who are eligible for screening based on these guidelines, particularly among those with prediabetes or undiagnosed diabetes.
Researchers and academics from the UK and Germany come together to discuss therapeutic footwear for people with diabetes. The workshop aims to establish new research links and develop research capacity to improve the lives of those affected.
A new study found that lean individuals with non-alcoholic fatty liver disease (NAFLD) have a higher prevalence of cardiovascular disease compared to those who are overweight or obese. Despite having lower risks for other metabolic and cardiovascular conditions, lean patients with NAFLD were more likely to develop cardiovascular disease.
Researchers studied cavefish genome-wide map of liver tissue to understand metabolism evolution and its potential applications for humans. The study found striking similarities in metabolic adaptations among cavefish populations, raising questions about universal adaptation mechanisms that could be triggered in other species like humans.
Researchers created human mini-kidneys that mimic diabetic kidneys, finding increased susceptibility to SARS-CoV-2 infection and a critical role for the ACE2 receptor. The study provides new insights into the link between diabetes and COVID-19 disease.
A new meta-analysis suggests that a healthy diet during pregnancy does not significantly reduce the risk of developing gestational diabetes in non-White European populations. The study analyzed data from various ethnic groups and found no significant association between dietary habits and the incidence of gestational diabetes.
A study published in Med found that the human microbiome's variation explains different patient responses to statins. The researchers discovered a Bacteroides enriched microbiome with lower diversity was associated with stronger LDL-lowering effects but greater disruption of blood glucose levels.
A new study analyzed 34 previous studies on the impact of diet on gestational diabetes, finding a lack of robust data for non-white European women. The findings stress the need for inclusive research methods to accurately understand the relationship between diet and gestational diabetes across all ethnicities.
A recent study found that obesity, impaired blood glucose metabolism, and high blood pressure significantly increase the risk of dying from COVID-19 in young and middle-aged people. Researchers analyzed data from the European case registry LEOSS and found that patients with all three conditions had a similar increased risk of death as ...
A Washington State University study found that young adults at risk of food insecurity had a higher incidence of diabetes 10 years later. The study analyzed data from nearly 4,000 people and found that those who experienced food insecurity risk were more likely to develop diabetes in middle adulthood.
A new wearable device can simultaneously monitor glucose, alcohol, and lactate levels, providing users with a comprehensive picture of their health. This technology has the potential to improve disease management for individuals with diabetes and other conditions, as well as enhance overall wellness through real-time tracking.
A new study suggests that tailoring diabetes screening for Black, Hispanic, and Asian Americans based on lower BMI thresholds and younger ages can significantly reduce disparities in diabetes diagnosis rates. This approach may improve health equity by identifying cases earlier and reducing mortality rates associated with diabetes.
A new study suggests that screening these groups at lower BMI and younger ages could reduce undiagnosed diabetes rates and improve health equity. The findings recommend tailored approaches to address the increased risk of diabetes among Asian, Hispanic, and Black Americans.
A study found that higher levels of active brown adipose tissue are associated with early metabolic dysfunction and pre-cooling glucose, insulin, thyroid stimulating hormone, and triglyceride levels. Activated brown fat was recruited to counteract 'pre-prediabetic' states, potentially serving as a first-line protective mechanism.
A $66,000 NIH grant will support Karry Weston's two-year study on the lack of breastfeeding in rural Missouri. The goal is to identify cultural factors influencing mothers' decisions, with a focus on improving maternal care in rural communities.
A study of 72,000 pediatric encounters found that non-Hispanic Black children were more likely to be readmitted within a year due to diabetic ketoacidosis. Healthcare disparities persist among racial and ethnic groups in pediatric care, emphasizing the need for targeted interventions.
The new COBRE grant will help WVU recruit researchers and clinician-scientists to develop innovative solutions for preventing and treating incurable vision problems. The project aims to reduce visual disparities in West Virginia by understanding the complex combination of factors that contribute to these problems.
A phase 2 randomized controlled clinical trial found that intranasal insulin increased walking speed, cerebral blood flow, and improved decision making and verbal memory. The treatment also showed promise for preventing or slowing the progression of Alzheimer's disease-related dementias in older adults.
A study led by Richard Isaacson found that individualized, multi-domain interventions improved cognition and reduced Alzheimer's risk in both men and women. Women demonstrated greater improvements in certain risk scores and biomarkers compared to men.
The Endocrine Society's scientific statement highlights the potential of extracellular vesicles in diagnosing and monitoring endocrine-related conditions, including cancer. These tiny vesicles may also serve as biomarkers for high blood pressure and have therapeutic roles.
A large cohort study of almost 125,000 patients found that diabetic foot ulcer outcomes are associated with race, ethnicity, and rurality. Higher rates were observed among rural and Black patients, highlighting the need for targeted interventions to address health disparities.
A team from UNIGE demonstrates that stem cells giving rise to beta cells cease to exist after birth, and defines the 'identity card' of other hormone-producing cells. This discovery has significant implications for developing cell-based therapies to treat diabetes.
A study of 309 people with long COVID found that fatigue, shortness of breath, and loss of sense of smell were the most persistent symptoms. The research also revealed that factors such as history of hospitalization, diabetes, and body mass index increased the risk of developing Long COVID.
Researchers at NTU Singapore's Lee Kong Chian School of Medicine found that saturated fatty acids degrade protein FIT2, leading to insulin-producing cells' loss of function and death. This impairs the body's ability to secrete enough insulin, resulting in diabetes.
CHOP researchers have developed a targeted treatment that controls blood sugar in patients with hyperinsulinism, a genetic disease. The study found exendin-(9-39) reduces likelihood of fasting hypoglycemia by 76% and protein-induced hypoglycemia by 82%
Researchers found that alterations in gut microbiota can help treat pancreatic and hormonal dysfunction in diabetes patients. The study showed that antibiotics treatment can improve insulin sensitivity and reduce glucose intolerance in obese mice and humans.
A UCLA-led team has created a roadmap tracing each step in human blood stem cell development, providing a blueprint for producing fully functional blood stem cells. The map could help expand treatment options for blood cancers and inherited disorders.
Current guidelines for treating women's obesity, hypertension and diabetes are based on men's studies. Researchers call for sex-specific guidelines to accurately treat these conditions in women, as they have different risk factors and manifestations.
A new study published in Diabetologia found that exposure to per- and polyfluoroalkyl substances (PFAS) is associated with an increased risk of developing diabetes in midlife women. The study analyzed the stored blood and urine samples from 1400 participants and found a stronger association with combined exposure to multiple PFAS.
Researchers at University Hospitals and Case Western Reserve University have discovered a new receptor, Ptprd, that controls appetite and body weight. The receptor trap drug suppresses appetite, body weight, and blood glucose levels in obese mice.
Children of exceptionally long-lived parents and their spouses experience lower risk of type II diabetes compared to the general population. The study found that low BMI, high HDL cholesterol, and certain hormones in the blood protect against developing diabetes II.
Researchers found a significant decline in in-hospital mortality and secondary endpoints for STEMI patients with COVID-19 in 2021 compared to 2020. Vaccination status showed zero hospital deaths among vaccinated patients, while unvaccinated patients experienced high death rates.
A GE Research-led team has demonstrated the ability to prevent or reverse diabetes in preclinical model systems using ultrasound-based bioelectronic medicine. The team's findings, published in Nature Biomedical Engineering, represent a significant milestone in this field and pave the way for future clinical translation.
Researchers at Karolinska Institutet have identified a new antidiabetic substance that preserves beta cell activity and prevents high blood glucose in mice. This approach may prevent the exhaustion of beta cells and improve long-term diabetes treatment.
A new University of Houston study finds racial and ethnic disparities in diabetic eye care, with Whites more likely to receive regular exams than minorities. The study also reveals that Hispanics have the highest prevalence of diabetic eye complications.
A Rutgers University study found that primary care tele-mentoring program model improved patient care for Medicaid patients with diabetes, resulting in reduced hospitalizations and spending. The program demonstrated promise for replication in other applications of the Project ECHO model.
A study found that many nursing home residents continue to receive insulin and other medications despite blood test results suggesting tight control. Only 27% of overtreated and 19% of potentially overtreated residents had their medications adjusted within 2 weeks.
Researchers at the University of Minnesota developed a new method of islet cryopreservation that enables high viability and function in a clinically scalable protocol. This breakthrough discovery could revolutionize the supply chain for islet isolation, allocation, and storage before transplant.
Researchers used a contrast pattern mining algorithm on publicly available data from 16,000 participants in the T1D Exchange Clinic Registry. The study found individuals with an immediate family history of Type 1 diabetes were more frequently diagnosed with hypertension and other co-occurring conditions.
Researchers at the University of Bergen found that genes linked to extreme obesity, appetite, and energy consumption regulate child growth. The study, published in Nature Metabolism, provides insight into mechanisms controlling appetite and energy metabolism early in life, potentially leading to better treatment for obesity.
Researchers at Université Laval found that yogurt's health benefits for obesity may be due to its impact on the gut microbiota and production of branched chain hydroxy acids (BCHA). The study, published in Nature Communications, suggests that BCHA can help improve fasting glucose and liver function in obese mice.
A new study by University of Alberta researchers estimates that excessive sugar consumption in Canada results in $5 billion annual healthcare costs due to 16 chronic diseases. Limiting free sugar intake could reduce diabetes prevalence by 27% if Canadians follow the 10% recommendation, and 44.8% if they limit consumption to less than 5...
Researchers have designed a fast-acting injectable insulin based on the venom of the Conus kinoshitai marine snail, which doesn't form clusters like human insulin. The new hybrid insulin holds promise for better diabetes control with faster action and reduced clustering.
A study published by The Endocrine Society found that eating potatoes in the morning, whole grains in the afternoon, and less processed meat in the evening may improve long-term survival in people with diabetes. This eating pattern is associated with better heart health outcomes.
A randomized study of 379 women with obesity and unexplained infertility found that intensive lifestyle changes that shed pounds led to no better chances of pregnancy than simply increasing physical activity without weight loss. The study also showed significant health benefits from weight loss, including a decrease in metabolic syndrome.
Research suggests exercise can break the vicious cycle of inflammation that leads to diabetes and depression in people with Long COVID. A 30-minute session of moderate-intensity exercise, such as walking, can be beneficial.
Researchers have identified pyruvate kinase M2 as a potential therapeutic target for preventing diabetic kidney disease in people with type 1 diabetes. The enzyme's activation may help normalize and maintain kidney function, even after seven months of elevated blood sugar levels.
Researchers from NYITCOM are using a new imaging technique to study diabetic heart failure and its causes. They hope to develop new treatments by tracing how lysosomes, the body's defense system, are impaired in heart muscle cells.
Computer simulations reveal metformin's effectiveness in targeting diabetes and some cancers, but also its negative consequences for others. Researchers emphasize the need for precision medicine to individualize treatment based on patient profiles.
A pooled data analysis found that between 30 and 60 minutes of muscle strengthening activity per week is associated with a 10-17% lower risk of death from any cause. The J-shaped curve showed no conclusive evidence that more than an hour of this activity reduces the risk further.
A Brazilian study of 2,777 patients hospitalized between January 5 and September 12, 2021 found that vaccination was the sole predictor of mortality in those over 60 with kidney failure. Vaccination also reduced hospitalization risk among non-vaccinated patients with comorbidities.
Researchers found that many newly diagnosed patients with diabetes had less severe blood sugar levels and more severe COVID-19. After hospital discharge, roughly half reverted to normal blood sugar levels, and only 8% required insulin after one year.