Articles tagged with Diabetes
Researchers at NTU Singapore's Lee Kong Chian School of Medicine found that saturated fatty acids degrade protein FIT2, leading to insulin-producing cells' loss of function and death. This impairs the body's ability to secrete enough insulin, resulting in diabetes.
CHOP researchers have developed a targeted treatment that controls blood sugar in patients with hyperinsulinism, a genetic disease. The study found exendin-(9-39) reduces likelihood of fasting hypoglycemia by 76% and protein-induced hypoglycemia by 82%
Researchers found that alterations in gut microbiota can help treat pancreatic and hormonal dysfunction in diabetes patients. The study showed that antibiotics treatment can improve insulin sensitivity and reduce glucose intolerance in obese mice and humans.
A UCLA-led team has created a roadmap tracing each step in human blood stem cell development, providing a blueprint for producing fully functional blood stem cells. The map could help expand treatment options for blood cancers and inherited disorders.
Researchers at University Hospitals and Case Western Reserve University have discovered a new receptor, Ptprd, that controls appetite and body weight. The receptor trap drug suppresses appetite, body weight, and blood glucose levels in obese mice.
Children of exceptionally long-lived parents and their spouses experience lower risk of type II diabetes compared to the general population. The study found that low BMI, high HDL cholesterol, and certain hormones in the blood protect against developing diabetes II.
Current guidelines for treating women's obesity, hypertension and diabetes are based on men's studies. Researchers call for sex-specific guidelines to accurately treat these conditions in women, as they have different risk factors and manifestations.
A new study published in Diabetologia found that exposure to per- and polyfluoroalkyl substances (PFAS) is associated with an increased risk of developing diabetes in midlife women. The study analyzed the stored blood and urine samples from 1400 participants and found a stronger association with combined exposure to multiple PFAS.
Researchers found a significant decline in in-hospital mortality and secondary endpoints for STEMI patients with COVID-19 in 2021 compared to 2020. Vaccination status showed zero hospital deaths among vaccinated patients, while unvaccinated patients experienced high death rates.
A GE Research-led team has demonstrated the ability to prevent or reverse diabetes in preclinical model systems using ultrasound-based bioelectronic medicine. The team's findings, published in Nature Biomedical Engineering, represent a significant milestone in this field and pave the way for future clinical translation.
A new University of Houston study finds racial and ethnic disparities in diabetic eye care, with Whites more likely to receive regular exams than minorities. The study also reveals that Hispanics have the highest prevalence of diabetic eye complications.
Researchers at Karolinska Institutet have identified a new antidiabetic substance that preserves beta cell activity and prevents high blood glucose in mice. This approach may prevent the exhaustion of beta cells and improve long-term diabetes treatment.
A Rutgers University study found that primary care tele-mentoring program model improved patient care for Medicaid patients with diabetes, resulting in reduced hospitalizations and spending. The program demonstrated promise for replication in other applications of the Project ECHO model.
Researchers at the University of Minnesota developed a new method of islet cryopreservation that enables high viability and function in a clinically scalable protocol. This breakthrough discovery could revolutionize the supply chain for islet isolation, allocation, and storage before transplant.
A study found that many nursing home residents continue to receive insulin and other medications despite blood test results suggesting tight control. Only 27% of overtreated and 19% of potentially overtreated residents had their medications adjusted within 2 weeks.
Researchers at the University of Bergen found that genes linked to extreme obesity, appetite, and energy consumption regulate child growth. The study, published in Nature Metabolism, provides insight into mechanisms controlling appetite and energy metabolism early in life, potentially leading to better treatment for obesity.
Researchers used a contrast pattern mining algorithm on publicly available data from 16,000 participants in the T1D Exchange Clinic Registry. The study found individuals with an immediate family history of Type 1 diabetes were more frequently diagnosed with hypertension and other co-occurring conditions.
A study published by The Endocrine Society found that eating potatoes in the morning, whole grains in the afternoon, and less processed meat in the evening may improve long-term survival in people with diabetes. This eating pattern is associated with better heart health outcomes.
Researchers at Université Laval found that yogurt's health benefits for obesity may be due to its impact on the gut microbiota and production of branched chain hydroxy acids (BCHA). The study, published in Nature Communications, suggests that BCHA can help improve fasting glucose and liver function in obese mice.
A new study by University of Alberta researchers estimates that excessive sugar consumption in Canada results in $5 billion annual healthcare costs due to 16 chronic diseases. Limiting free sugar intake could reduce diabetes prevalence by 27% if Canadians follow the 10% recommendation, and 44.8% if they limit consumption to less than 5...
Researchers have designed a fast-acting injectable insulin based on the venom of the Conus kinoshitai marine snail, which doesn't form clusters like human insulin. The new hybrid insulin holds promise for better diabetes control with faster action and reduced clustering.
A randomized study of 379 women with obesity and unexplained infertility found that intensive lifestyle changes that shed pounds led to no better chances of pregnancy than simply increasing physical activity without weight loss. The study also showed significant health benefits from weight loss, including a decrease in metabolic syndrome.
Research suggests exercise can break the vicious cycle of inflammation that leads to diabetes and depression in people with Long COVID. A 30-minute session of moderate-intensity exercise, such as walking, can be beneficial.
Researchers have identified pyruvate kinase M2 as a potential therapeutic target for preventing diabetic kidney disease in people with type 1 diabetes. The enzyme's activation may help normalize and maintain kidney function, even after seven months of elevated blood sugar levels.
A pooled data analysis found that between 30 and 60 minutes of muscle strengthening activity per week is associated with a 10-17% lower risk of death from any cause. The J-shaped curve showed no conclusive evidence that more than an hour of this activity reduces the risk further.
Researchers from NYITCOM are using a new imaging technique to study diabetic heart failure and its causes. They hope to develop new treatments by tracing how lysosomes, the body's defense system, are impaired in heart muscle cells.
Computer simulations reveal metformin's effectiveness in targeting diabetes and some cancers, but also its negative consequences for others. Researchers emphasize the need for precision medicine to individualize treatment based on patient profiles.
A Brazilian study of 2,777 patients hospitalized between January 5 and September 12, 2021 found that vaccination was the sole predictor of mortality in those over 60 with kidney failure. Vaccination also reduced hospitalization risk among non-vaccinated patients with comorbidities.
Researchers found that many newly diagnosed patients with diabetes had less severe blood sugar levels and more severe COVID-19. After hospital discharge, roughly half reverted to normal blood sugar levels, and only 8% required insulin after one year.
Research found walkable neighborhoods with access to parks and outdoor activities are associated with a lower risk of obesity and diabetes. Studies showed that living in highly walkable areas reduced the incidence of pre-diabetes by up to 50% compared to low walkability areas.
Researchers at MDI Biological Laboratory discovered that age-related chronic inflammation is caused by disruption of chromatin architecture. This leads to misexpression of genes lacking CpG islands, resulting in inflammation and loss of cellular function. The findings provide a unifying theory for the age-related degenerative diseases.
A VA research team found increased risks of mental health disorders, including depression, anxiety, and sleep disorders, in individuals who had COVID-19 infection. The study analyzed medical records of nearly 154,000 patients with COVID-19 and compared them to over 11 million people without COVID-19.
A study published in eLife suggests that repressing hypoxia-inducible factor-1 (HIF-1) may help reduce oxidative stress and tissue damage in diabetes. Researchers found that high glucose levels suppress HIF-1 activity, leading to increased reactive oxygen species production.
A new Northwestern Medicine study reveals that more than half of young women in the US have at least one risk factor for poor heart health before pregnancy. Optimizing heart health before and during pregnancy can prevent complications, deliver a healthy baby, and even reduce the risk of heart disease years later.
Salk researchers have engineered mammalian cells to be activated using ultrasound, a method that paves the way toward non-invasive versions of deep brain stimulation, pacemakers, and insulin pumps. The team found a protein called TRPA1, known for its role in responding to noxious compounds, which also opens in response to ultrasound.
A new study finds that women with a history of gestational diabetes are at greater risk for a range of cardiovascular conditions, including coronary artery disease and heart failure. The research, which analyzed data from 219,330 women, suggests that preventative measures during pregnancy may help prevent cardiovascular disease later i...
Researchers have discovered that a small protein called glucagon-like peptide-1 (GLP-1) couples the body's control of blood sugar and blood pressure. This finding could lead to new treatment strategies for patients with hypertension and/or diabetes.
Researchers have discovered a new method to predict heart attacks by analyzing the gene expression of foamy macrophages, revealing a person's cardiovascular health. The study found that foamy cells can be both beneficial and detrimental depending on their behavior in individuals with certain conditions.
A new study found that patients with chronic non-communicable diseases are more than twice as likely to die from any cause if they also have a psychiatric comorbidity. Comorbid psychiatric disorders were associated with higher all-cause mortality rates, ranging from 5.5-21.1%.
Researchers at Boston Children's Hospital have developed an organoid platform that identifies drugs that enhance enteroendocrine cell action, potentially reversing diabetes, obesity and gastrointestinal conditions. The system identified three chemicals that drive the formation of EE cells and hormone production.
The CHAMPS program, a multi-year quality improvement initiative in Mississippi, increased breastfeeding rates by 10 percentage points overall, with significant gains among Black mother-baby dyads. Rooming-in practices also improved, leading to reduced infant mortality and morbidity.
Researchers discovered distinct gut microbiomes in Black and white US women, with potential associations to insulin resistance. The study highlights the importance of understanding individual microbiome variations in relation to metabolic health.
Researchers discovered that Black women have a greater relative abundance of Actinobacteria, associated with reduced insulin sensitivity and elevated inflammation. The study highlights the importance of understanding the role of gut microbiome in cardiometabolic health disparities among Black women.
Researchers at Beth Israel Deaconess Medical Center used single-cell RNA-sequencing analysis to study skin cells in patients with diabetic foot ulcers. The study revealed specific fibroblast subtypes play a crucial role in healing these ulcers, suggesting targeting these cells as a potential therapeutic option.
Researchers at Salk Institute have discovered a new molecular pathway that controls blood glucose levels independent of insulin, offering new avenues for treating diabetes and metabolic disorders. The hormone FGF1 suppresses lipolysis and regulates glucose production in the liver.
A study of over 6,000 women found that US-born Black women are at higher risk of preeclampsia, but this is not solely due to their racial background. Factors such as biology, social and cultural elements, and access to healthcare also play a role in this disparity.
A study conducted at the University of Turku found that following a healthy diet in early pregnancy can significantly reduce the risk of developing gestational diabetes. The research revealed that a diet high in saturated fats and low in essential nutrients increases inflammation and raises the risk of gestational diabetes.
The American Academy of Neurology has issued a guideline on oral and topical treatments for painful diabetic neuropathy, updating the 2011 AAN guideline. The guideline recommends several drug classes, including tricyclic antidepressants, serotonin-norepinephrine reuptake inhibitors, gabapentinoids, and sodium channel blockers.
A global study found that hospitalized COVID-19 patients with metabolic syndrome had a 20% higher risk of developing acute respiratory distress syndrome (ARDS) and dying. The study examined records of over 46,000 patients in 181 hospitals across 26 countries.
A small study published in the Journal of Clinical Endocrinology & Metabolism found that exercising at high altitude can lead to lower blood sugar levels in individuals with type 1 diabetes. This may increase the risk of hypoglycemia, which can be life-threatening if not treated promptly.
A recent study published by Queen Mary University of London has found that certain risk factors for heart disease are linked to changes in the structure and appearance of the heart. The research analyzed images from over 30,000 people's heart MRI scans using a new imaging toolkit called radiomics.
A new study published in Frontiers in Endocrinology has identified a promising target for an anti-hypoglycaemia drug by boosting the brain's AMPK fuel gauge. The researchers found that the compound increases the release of glucagon from the pancreas, defending against hypoglycaemia.
Research shows autistic adults on Medicaid have higher odds of co-occurring physical and mental health conditions, including diabetes, obesity, and epilepsy, compared to the general population. Racial and ethnic disparities are also evident, with Black, Hispanic, and Asian adults facing higher odds of certain conditions.
A Geisinger study found that adults with rare genetic causes of mental health disorders are more likely to have chronic illnesses like diabetes and dementia. The research also discovered that these individuals had twice as many annual emergency room visits compared to a control group without the genetic conditions.
Researchers at Kobe University discover that adding Vitamin B2 to stressed cells increases mitochondrial energy production and prevents cellular senescence. This finding has potential implications for preventing age-related disorders and extending healthy lifespans.
Researchers discovered a new hormone, fabkin, that regulates metabolism and controls insulin production in pancreatic beta cells. Blocking fabkin's activity prevented the development of both forms of diabetes in mice, suggesting its potential as a therapeutic target.
A small clinical trial found that eating during the nighttime increased glucose levels, while restricting meals to the daytime prevented this effect. The study suggests that better alignment between internal and external circadian rhythms may drive these benefits.
A study by the CDC found a strong association between obesity and diabetes, both of which are widespread in the U.S., and severe COVID-19 disease. In South Carolina, chronic diseases disproportionately affect Black communities, increasing their risk of developing severe COVID-19.
A new meta-analysis published in the European Journal of Preventive Cardiology suggests that Sodium-glucose co-transporter-2 (SGLT2) inhibitors can improve outcomes for heart failure patients with preserved ejection fraction. The medication has been shown to reduce the risk of death from heart-related causes and hospitalization by 22%.
A recent study published in JAMA Open Network evaluates the performance of the EyeArt AI system, detecting diabetic retinopathy with high sensitivity and specificity. The results demonstrate the ability to accurately detect vision-threatening diabetic retinopathy without physician oversight, facilitating efficient diabetic eye exams.